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WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling Huang Yi Xiao ting lan Youguang Lu Li Huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence

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World Journal of Clinical Cases 2024年第2期12卷 293-301页

作者： Yan-Xia He Yang Lv ting-ting lan Fang Deng Yuan-Yuan Zhang Department of Obstetrics and Gynecology Wuhan Children’s HospitalWuhan 430015Hubei ProvinceChina Center for Reproductive Medicine Department of Obstetrics and GynecologySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for *** has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and *** To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with *** A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May *** cases were divided into two groups,namely the observation group and the control group,with 40 cases in each *** nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior *** study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both *** After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control *** The integration of timing theory and behavior

关键词： Timing theory Behavior change Primipara Bad mood Quality of life

Clinical nursing value of predictive nursing in reducing complications of pregnant women undergoing short-term massive blood transfusion during cesarean section

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World Journal of Clinical Cases 2024年第1期12卷 51-58页

作者： Li Cheng Li-Ping Li Yuan-Yuan Zhang Fang Deng ting-ting lan Department of Obstertrics Wuhan Third HospitalWuhan 430000Hubei ProvinceChina Department of Gynaecology Wuhan No.1 HospitalWuHan 430030Hubei ProvinceChina Center for Reproductive Medicine Department of Obstetrics and GynecologySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Cesarean hemorrhage is one of the serious complications,and short-term massive blood transfusion can easily cause postoperative infection and physical stress ***,predictive nursing intervention has important clinical significance for *** To explore the effect of predictive nursing intervention on the stress response and complications of women undergoing short-term mass blood transfusion during cesarean section(CS).METHODS A clinical medical record of 100 pregnant women undergoing rapid mass blood transfusion during sections from June 2019 to June *** to the different nursing methods,patients divided into control group(n=50)and observation group(n=50).Among them,the control group implemented routine nursing,and the observation group implemented predictive nursing intervention based on the control ***,compared the differences in stress res-ponse,complications,and pain scores before and after the nursing of pregnant women undergoing rapid mass blood transfusion during *** The anxiety and depression scores of pregnant women in the two groups were significantly improved after nursing,and the psychological stress response of the observation group was significantly lower than that of the control group(P<0.05).The heart rate and mean arterial pressure(MAP)of the observation group during delivery were lower than those of the control group,and the MAP at the end of delivery was lower than that of the control group(P<0.05).Moreover,different pain scores improved significantly in both groups,with the observation group considerably less than the control group(P<0.05).After nursing,complications such as skin rash,urinary retention,chills,diarrhea,and anaphylactic shock in the observation group were 18%,which significantly higher than in the control group(4%)(P<0.05).CONCLUSION Predictive nursing intervention can effectively relieve the pain,reduce the incidence of complications,improve mood and stress response,and serve as a

关键词： Predictive care Rapid mass blood transfusion Cesarean section Stress response Complications

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三相土壤分形导热系数模型

科学技术与工程 2024年第7期24卷 2724-2733页

作者：李文岚婷苏顺玉武汉科技大学城市建设学院武汉430000

土壤热导率的预测准确性对地源热泵和钻孔热能等地热相关结构设计至关重要,基于土壤复杂、随机、自相似性的微观结构特征,使用分形理论,考虑土壤的孔隙率和颗粒排列等参数对土壤弯曲度的影响,建立三相土壤有效导热系数毛细孔物理模型和... 详细信息

土壤热导率的预测准确性对地源热泵和钻孔热能等地热相关结构设计至关重要,基于土壤复杂、随机、自相似性的微观结构特征,使用分形理论,考虑土壤的孔隙率和颗粒排列等参数对土壤弯曲度的影响,建立三相土壤有效导热系数毛细孔物理模型和对应的有效导热系数数学模型,将模型预测结果与已有实验数据进行了对比。结果表明:增加土壤颗粒排列等参数后的模型对孔隙率在0.21~1的土壤热导率预测有较高的准确性,且不同孔隙率的三相土壤热导率与土壤颗粒排列阻塞参数有关,孔隙率越大、阻塞参数越小模型预测越接近实验结果;弯曲度改变对热电比模型的串并联比例有直接影响,土壤颗粒排列对弯曲度的影响随孔隙率的增大而减小,弯曲度与三相土壤热导率的变化趋势成反比。相关结果有助于地埋管与管外三相土壤换热效率的研究。

关键词：三相土壤弯曲度导热系数分形理论

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基于空间交叉卷积的轻量级人体姿态估计算法

传感技术学报 2024年第3期37卷 439-445页

作者：方益石守东方靖森叶永芳蓝艇宁波大学信息科学与工程学院浙江宁波315211

针对改进轻量级OpenPose网络在预测阶段仍有较大参数量会降低模型推理速度,不利于在边缘设备部署的问题,提出一种基于改进卷积方法的人体姿态估计网络,使用空间交叉卷积来代替部分标准卷积,减少网络预测阶段的参数量。网络的输入为单目... 详细信息

针对改进轻量级OpenPose网络在预测阶段仍有较大参数量会降低模型推理速度,不利于在边缘设备部署的问题,提出一种基于改进卷积方法的人体姿态估计网络,使用空间交叉卷积来代替部分标准卷积,减少网络预测阶段的参数量。网络的输入为单目摄像头捕获的RGB图像,以MobileNetV3-Large为主干网络,并在其中加入了CBAM注意力模块,提取不同重要程度的空间和通道特征。获取图像特征后,送入两个分支中分别预测关键点位置和关键点组合关系。以空间交叉卷积代替两个分支中的部分标准卷积核,相对标准卷积能够减少80%的参数量。实验结果表明,相较于原方法,所提方法在精度下降较小的情况下,总参数量降低了22%,部署在CPU端的测试结果显示,速度能够达到6 FPS,提升了4倍。

关键词：人体姿态估计轻量级网络空间交叉卷积 OpenPose 边缘设备

基于斑马鱼模型和网络药理学研究四方木皮的抗炎作用及其机制

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中国中药杂志 2024年第11期49卷 3070-3080页

作者：陈柳燕吴传梅梁潘韦金凤蓝婷婷郭敏李永华汝梅广西中医药大学药学院广西南宁530200 广西中医药大学广西高校中药民族药资源保护与利用重点实验室广西南宁530200 梧州市人民医院广西梧州543000

通过网络药理学-分子对接的方法,探讨四方木皮抗炎的作用机制,并用斑马鱼炎症模型进行验证。利用网络药理学预测四方木皮抗炎的有效成分、潜在核心靶点和信号通路。用脂多糖(LPS)诱导斑马鱼炎症模型,以细胞凋亡率和活性氧(ROS)生成率等... 详细信息

通过网络药理学-分子对接的方法,探讨四方木皮抗炎的作用机制,并用斑马鱼炎症模型进行验证。利用网络药理学预测四方木皮抗炎的有效成分、潜在核心靶点和信号通路。用脂多糖(LPS)诱导斑马鱼炎症模型,以细胞凋亡率和活性氧(ROS)生成率等指标来评价四方木皮水提物和70%乙醇提取物的抗炎活性,用q PCR验证预测的主要靶点。预测发现,四方木皮的潜在抗炎靶点有121个,PPI分析显示,四方木皮抗炎主要作用于信号传导和转录激活因子3 (signal transducer and activator of transcription 3,STAT3)、血管内皮生长因子A (vascular endothelial growth factor A,VEGFA)、表皮生长因子(epidermal growth factor,EGF)、肿瘤坏死因子(tumor necrosis factor,TNF)、肿瘤蛋白p53(tumor protein p53,TP53)、基质金属蛋白酶9(matrix metalloprotein 9,MMP9)、c-fos原癌蛋白(c-fos proto-oncogene protein,FOS)、环状素受体1(estrogen receptor 1,ESR1)、趋化因子8(c-x-c motif chemokine ligand 8,CXCL8)、白细胞分化抗原8(cluster of differentiation 8,CD8)等靶点;基因本体(Gene Ontology,GO)分析显示,生物过程主要作用于抑制细胞凋亡过程、基因表达的正调控、细胞增殖的正向调节;京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)分析表明,MAPK信号通路、PI3K-Akt信号途径、HIF-1信号通路等可能在四方木皮抗炎中起关键作用;分子对接显示,5种关键成分与核心靶点均具有较强的结合力。斑马鱼动物实验表明,四方木皮可显著抑制炎症导致的ROS形成,降低幼鱼体内细胞死亡,抑制了组织中炎症反应的增强。此外,与空白组相比,模型组中核因子(nuclear factor,NF)-κB、TP53、FOS、衔接蛋白复合物-1(adaptor protein complex-1,AP-1)、丝裂原活化蛋白激酶P38(mitogen-activated protein kinases P38,P38)的转录水平显著上调;与模型组相比,四方木皮水提物和70%乙醇提取物组的斑马鱼组织中NF-κB、TP53、FOS、AP-1、P38的m RNA表达明显下调。四方木皮通过多成分、多靶点发挥抗炎作用,且其抗炎作用可能与抑制MAPK信号通路有关。

关键词：四方木皮抗炎斑马鱼网络药理学分子对接

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鄱阳湖蓝藻时空分布特征及其驱动因子研究

长江流域资源与环境 2024年第3期33卷 605-614页

作者：胡芳刘聚涛杨平温春云张兰婷张洁江西省水利科学院江西南昌330029 鄱阳湖流域生态水利技术创新中心江西南昌330029

富营养化引起的局部水体蓝藻水华问题给鄱阳湖水生态环境保护带来挑战。为弄清鄱阳湖蓝藻时空分布特征及其影响因素,于2019~2020年对鄱阳湖蓝藻进行了现场监测,并通过冗余分析(RDA),探讨了影响蓝藻时空分布的主要驱动因子。结果表明:调... 详细信息

富营养化引起的局部水体蓝藻水华问题给鄱阳湖水生态环境保护带来挑战。为弄清鄱阳湖蓝藻时空分布特征及其影响因素,于2019~2020年对鄱阳湖蓝藻进行了现场监测,并通过冗余分析(RDA),探讨了影响蓝藻时空分布的主要驱动因子。结果表明:调查期间,共检出浮游植物7门128种,其中蓝藻15种,占总种类数量的11.72%,蓝藻种类数呈丰水期>平水期>枯水期,主湖区>入江水道>东湖区的分布规律。蓝藻细胞密度为0~2.19×10^(7)cells/L,各点位蓝藻占比为0%~83.98%,其中蓝藻细胞密度主湖区>东部湖区>入江水道,丰水期>平水期>枯水期,2020年>2019年。假鱼腥藻(Pseudanabaena sp.)为东部湖区蓝藻优势种,微囊藻(Microcystis sp.)、假鱼腥藻为主湖区和入江水道蓝藻优势种。水温(T)、悬浮物(SS)、高锰酸盐指数(COD_(Mn))、风速(VW)是主湖区蓝藻群落分布的主要影响因子,特殊的湖流和风场也是影响该湖区蓝藻分布格局的重要因素;透明度(SD)、SS和COD_(Mn)是入江水道蓝藻群落分布的主要影响因子;东部湖区蓝藻群落分布是各因子综合影响的结果。此外,磷已不是鄱阳湖蓝藻暴发的限制性营养元素,削减磷污染负荷也是鄱阳湖蓝藻水华防范的重要手段。

关键词：蓝藻时空分布特征驱动因子鄱阳湖

基于WSR-AHP方法的线路工程施工进度风险评价

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项目管理技术 2024年第1期22卷 85-89页

作者：冯亚娟兰婷辽宁工程技术大学工商管理学院辽宁葫芦岛125105

线路工程建设具有风险高、施工和管理难度大等特点,这对线路工程建设风险管理提出了新的要求和挑战。根据项目建设风险特点和现状,建立基于层次分析法(AHP)的决策矩阵和线路工程项目建设风险管理评价指标体系,以有效降低线路工程建设风... 详细信息

线路工程建设具有风险高、施工和管理难度大等特点,这对线路工程建设风险管理提出了新的要求和挑战。根据项目建设风险特点和现状,建立基于层次分析法(AHP)的决策矩阵和线路工程项目建设风险管理评价指标体系,以有效降低线路工程建设风险,保证项目建设顺利进行。以建昌—叙府线路工程为例进行分析,研究发现:在一级评价指标中,人理维度和物理维度对该线路工程施工进度风险影响较大,权重系数分别为44.3%和38.7%;在二级评价指标中,政策变化和现场管理对该线路工程施工进度影响较大,权重系数分别为25.4%和20.6%。

关键词： WSR-AHP 线路工程风险评价施工进度

女性血脂异常对辅助生殖助孕结局影响的研究进展

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中国细胞生物学学报 2024年第4期46卷 682-690页

作者：兰婷高姗姗赵世刚山东大学生殖医学与子代健康全国重点实验室妇儿与生殖健康研究院国家辅助生殖与优生工程技术研究中心济南250012

诸多研究表明,代谢异常对女性生育结局具有显著影响。对于接受辅助生殖技术(assisted reproductive technology,ART)治疗的代谢异常女性患者,其临床结局应受到高度重视。该文围绕女性血脂代谢异常,综述其在ART治疗中对助孕结局、母婴围... 详细信息

诸多研究表明,代谢异常对女性生育结局具有显著影响。对于接受辅助生殖技术(assisted reproductive technology,ART)治疗的代谢异常女性患者,其临床结局应受到高度重视。该文围绕女性血脂代谢异常,综述其在ART治疗中对助孕结局、母婴围产期安全以及后代健康状况的影响,并探讨相关机制和治疗策略的最新研究进展,旨在为妇幼健康领域的诊疗提供更多参考信息和临床策略,以期提升代谢异常女性在接受ART治疗时的助孕效果与安全性,为这一特殊人群的健康生育保驾护航。

关键词：辅助生殖血脂卵母细胞胚胎子代