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Allosteric DNAzyme-based encoder for molecular information transfer

Chinese Chemical Letters 2024年第7期35卷 235-241页

作者： Minghao hu Tianci Xie Yuqiang hu Longjie Li ting Wang Tongbo Wu School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China GI Cancer Research Institute Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430023China State Key Laboratory of Bioelectronics National Demonstration Center for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Dynamic DNA nanotechnology plays a significant role in nanomedicine and information science due to its high programmability based on Watson-Crick base pairing and nanoscale *** DNA machines and networks have been widely used in various fields,including molecular imaging,biosensors,drug delivery,information processing,and logic *** serve as crucial components for information compilation and transfer,allowing the conversion of information from diverse application scenarios into a format recognized and applied by DNA ***,there are only a few encoder designs with DNA ***,the molecular priority encoder is hardly *** this study,we introduce allosteric DNAzyme-based encoders for information *** design of the allosteric domain and the recognition arm allows the input and output to be independent of each other and freely *** pre-packaged mode design achieves uniformity of baseline dynamics and dynamics *** also integrated non-nucleic acid molecules into the encoder through the aptamer design of the allosteric ***,we developed the 2^(n)-n encoder and the EndoⅣ-assisted priority encoder inspired by immunoglobulin's molecular structure and effector *** our knowledge,the proposed encoder is the first enzyme-free DNA encoder with DNA output,and the priority encoder is the first molecular priority encoder in the DNA reaction *** encoders avoid complex operations on a single molecule,and their simple structure facilitates their application in complex DNA circuits and biological scenarios.

关键词： DNAzyme Encoder Nucleic acids DNA circuit DNA strand displacement Dynamic DNA nanotechnology

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孕产妇的运动阻碍因素与运动行为促进策略研究

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福建体育科技 2024年第1期43卷 47-54页

作者：李若冰胡廷进季谋芳王睿琳湖南理工学院体育学院湖南岳阳414006 郑州轻工业大学体育学院河南郑州450000

目的:探究孕产妇运动锻炼的阻碍因素,为临床与运动实践中采用运动锻炼方式解决孕产妇健康问题提供参考。方法:采用访谈法获取文本资料,运用扎根理论法,借助Nvivo12.0软件编码,进行质性研究。结果:共收集19份访谈资料,整理分析资料文本后... 详细信息

目的:探究孕产妇运动锻炼的阻碍因素,为临床与运动实践中采用运动锻炼方式解决孕产妇健康问题提供参考。方法:采用访谈法获取文本资料,运用扎根理论法,借助Nvivo12.0软件编码,进行质性研究。结果:共收集19份访谈资料,整理分析资料文本后,提炼出4个核心范畴、24个主范畴、58个范畴,并构建了理论模型。结论:孕产妇自身运动认知、身体条件状况是主要阻碍因素,而孕产期主要照顾者运动健康知识水平、婴幼儿护理问题是孕产妇运动的保障条件,服务机构质量水平、社会压力是阻碍孕产妇运动的关键因素,极端天气、传染性疾病则是保障性因素。建议:(1)加快研制本土化孕产妇运动指南,大力宣传孕产期运动健康观念;(2)制定标准化的社会管理体系,规范孕产健康机构的服务供给内容;(3)重视孕产妇运动健康促进,提供多渠道的孕产妇运动健康教育服务;(4)优化孕产妇社会劳动政策,完善社会支持体系。

关键词：孕产妇运动阻碍因素扎根理论

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Meteorological factors, ambient air pollution, and daily hospital admissions for depressive disorder in Harbin: A time-series study

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World Journal of Psychiatry 2023年第12期13卷 1061-1078页

作者： ting hu Zhao-Yuan Xu Jian Wang Yao Su Bing-Bing Guo Department of Five Therapy The First Psychiatric Hospital of HarbinHarbin 150026Heilongjiang ProvinceChina Medical Section The First Psychiatric Hospital of HarbinHarbin 150026Heilongjiang ProvinceChina Department of Out-Patient The First Psychiatric Hospital of HarbinHarbin 150026Heilongjiang ProvinceChina Science and Education The First Psychiatric Hospital of HarbinHarbin 150026Heilongjiang ProvinceChina Department of 22 Therapy Harbin Psychiatric Baiyupao HospitalHarbin 150000Heilongjiang ProvinceChina

BACKGROUND The literature has discussed the relationship between environmental factors and depressive disorders;however,the results are inconsistent in different studies and regions,as are the interaction effects between environmental *** hypo-thesized that meteorological factors and ambient air pollution individually affect and interact to affect depressive disorder *** To investigate the effects of meteorological factors and air pollution on depressive disorders,including their lagged effects and *** The samples were obtained from a class 3 hospital in Harbin,*** hos-pital admission data for depressive disorders from January 1,2015 to December 31,2022 were *** and air pollution data were also collected during the same *** additive models with quasi-Poisson regre-ssion were used for time-series modeling to measure the non-linear and delayed effects of environmental *** further incorporated each pair of environ-mental factors into a bivariate response surface model to examine the interaction effects on hospital admissions for depressive *** Data for 2922 d were included in the study,with no missing *** total number of depressive admissions was *** to high correlations existed between environmental *** temperature(AT)and wind speed(WS)significantly affected the number of admissions for *** extremely low temperature(-29.0℃)at lag 0 caused a 53%[relative risk(RR)=1.53,95%confidence interval(CI):1.23-1.89]increase in daily hospital admissions relative to the median *** low WSs(0.4 m/s)at lag 7 increased the number of admissions by 58%(RR=1.58,95%CI:1.07-2.31).In contrast,atmospheric pressure and relative humidity had smaller *** the six air pollutants considered in the time-series model,nitrogen dioxide(NO_(2))was the only pollutant that showed significant effects over non-cumulative,cumulative,immediate,and lagg

关键词： Mental health Depressive disorder Hospital admissions Meteorological factors Air pollution Time-series

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An Integrated Framework for Geothermal Energy Storage with CO_(2)Sequestration and Utilization

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Engineering 2023年第11期30卷 121-130页

作者： Yueliang Liu ting hu Zhenhua Rui Zheng Zhang Kai Du Tao Yang Birol Dindoruk Erling Halfdan Stenby Farshid Torabi Andrey Afanasyev State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China School of Petroleum Engineering China University of Petroleum(Beijing)Beijing 102249China College of Carbon Neutrality Future Technology China University of Petroleum(Beijing)Beijing 102249China Equinor ASA Stavanger 4035Norway Department of Petroleum Engineering Cullen College of EngineeringUniversity of HoustonHoustonTX 77204USA Center for Energy and Resources Engineering Department of ChemistryTechnical University of DenmarkKongens Lyngby 2800Denmark Petroleum Systems Engineering University of ReginaReginaSK S4S 0A2Canada Institute of Mechanics Moscow State UniversityMoscow 119192Russia

Subsurface geothermal energy storage has greater potential than other energy storage strategies in terms of capacity scale and time *** dioxide(CO_(2))is regarded as a potential medium for energy storage due to its superior thermal ***,the use of CO_(2)plumes for geothermal energy storage mitigates the greenhouse effect by storing CO_(2)in geological *** this work,an integrated framework is proposed for synergistic geothermal energy storage and CO_(2)sequestration and *** this framework,CO_(2)is first injected into geothermal layers for energy *** resultant high-energy CO_(2)is then introduced into a target oil reservoir for CO_(2)utilization and geothermal energy *** a result,CO_(2)is sequestrated in the geological oil reservoir *** results show that,as high-energy CO_(2)is injected,the average temperature of the whole target reservoir is greatly *** the assistance of geothermal energy,the geological utilization efficiency of CO_(2)is higher,resulting in a 10.1%increase in oil displacement *** to a storage-potential assessment of the simulated CO_(2)site,110 years after the CO_(2)injection,the utilization efficiency of the geological body will be as high as 91.2%,and the final injection quantity of the CO_(2)in the site will be as high as 9.529×10^(8)*** 1000 years sequestration,the supercritical phase dominates in CO_(2)sequestration,followed by the liquid phase and then the mineralized *** addition,CO_(2)sequestration accounting for dissolution trapping increases significantly due to the presence of residual *** importantly,CO_(2)exhibits excellent performance in storing geothermal energy on a large scale;for example,the total energy stored in the studied geological body can provide the yearly energy supply for over 3.5×10^(7) normal *** of this integrated approach holds great significance for large-scale geothermal energy storage

关键词： Geothermal energy storage CO_(2)sequestration Carbon neutrality Large-scale CO_(2)utilization

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Effect of dietary supplement of inactivated Lactobacillus plantarum Ep-M 17 on growth performance,immune response,disease resistance,and intestinal microbiota in Penaeus vannamei

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Journal of Oceanology and Limnology 2024年第2期42卷 676-694页

作者： ting WU Xiaoman hu Wenlong XU Yang DU Jiong CHEN State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingbo 315211China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo UniversityNingbo 315211China

Our previous study found that feeding with Lactobacillus plantarum Ep-M17 could effectively affect the growth performance,immune response,and gut microbiota of Penaeus ***,high temperature and pressure during feed pelletizing is the main problem that can lead to a decrease in the activity of probiotics or cause their *** investigation needs to investigate whether inactivated Ep-M17 can exert similar effects as live ***,we evaluated the effects of inactivated *** Ep-M17 on growth performance,immune response,disease resistance,and gut microbiota in *** show that adding inactivated Ep-M17 to the feed also promoted body weight gain and increased relative immune protection in ***,histological examination revealed that the administration of inactivated Ep-M17 led to improvements in the density and distribution of microvilli in the intestines and enhancements in the abundance of B and R cells in the ***,the inactivated Ep-M17 supplementation resulted in increased activity levels of nutrient immune-related enzymes in both the shrimp hepatopancreas and ***,it stimulated the expression of Lvlec,PEN-3a,Crustin,LGBP,Lysozyme,and proPo genes in both the hepatopancreas and ***,the inactivated Ep-M17 also increased bacterial diversity in the gut of shrimp and promoted the abundance of specific flora,facilitating the host organism’s metabolism and immunity to improve the disease resistance of ***,supplementation of inactivated *** Ep-M17 in shrimp diets can exert similar effects as live *** Ep-M17 effectively improving growth performance,gut microbiota,immune response,and disease resistance in ***.

关键词： Penaeus vannamei Lactobacillus plantarum Ep-M17 inactivated probiotics immune response gut flora

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Comparison of Omicron and Delta Variant Infection COVID-19 Cases—Guangdong Province,China,2022

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China CDC weekly 2022年第18期4卷 385-388页

作者： ting hu Meng Zhang Aiping Deng Yingtao Zhang Bosheng Li Yan Li Min Kang Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina School of Public Health Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?The Omicron variant has been listed as a variant of concern,but the characteristics still remain *** is added by this report?The vaccinated proportion of 65 imported coronavirus disease 2019 cases that were infected with Omicron variant in this study was 89.23%,which was higher than Delta *** imported cases infected with Omicron were tested positive using polymerase chain reaction after entering Guangdong within 3 days,a shorter period than Delta.

关键词： listed Guangdong Delta

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MgO/Carbon nanocomposites synthesized in molten salts for catalytic isomerization of glucose to fructose in aqueous media

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Green Chemical Engineering 2022年第4期3卷 359-366页

作者： Yuchao Shao Dong-Yang Zhao Wenjing Lu Yuyang Long Weicheng Zheng Jun Zhao Zhong-ting hu College of Environment Zhejiang University of Technology(ZJUT)Hangzhou310014China HKBU Institute of Research and Continuing Education Shenzhen518057China Institute of Bioresource and Agriculture Department of BiologyHong Kong Baptist UniversityHong Kong SARChina School of Environment Tsinghua UniversityBeijing100084China Industrial Catalysts Institute of ZJUT Hangzhou310014China Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling Instrumental Analysis CenterSchool of Environmental Science and EngineeringZhejiang Gongshang UniversityHangzhou310012China Hangzhou Research Institute of China Coal Technology&Engineering Group Hangzhou311201China

Isomerization of glucose into fructose has always been an important step in the biorefining *** study synthesized a novel Mg-decorated carbonaceous catalyst by molten salt method for the application of glucose *** morphology of carbon microspheres was formed with high specific surface area and pore *** effects of Mg loading,catalyst dosage,reaction temperature,and reaction time were investigated and *** highest fructose yield of 34.58%and fructose selectivity of 81.17%were achieved by the catalyst named Mg(100mg)/Carbon at hydrothermal temperature of 100℃ with reaction time of 1.5-2 h,showing the superiority of the *** results of recycling tests indicated Mg(100mg)/Carbon has good recyclability and can restore its activity after a simple *** the possible mechanism of glucose isomerization by Mg(100mg)/Carbon was *** study provided a new method for overcoming the difficulty of high energy barrier required for glucose isomerization in the biorefining process.

关键词： Glucose isomerization Heterogeneous catalyst Molten salt method Magnesium Hydrothermal

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安肠组方联合磷酸铝凝胶对宫颈癌放疗致放射性肠炎患者炎症因子、免疫功能以及肠道菌群的影响

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广州中医药大学学报 2024年第5期41卷 1160-1166页

作者：孙月红何新颖贾大鹏杜强胡婷婷杨洪娟孙云川河北省沧州中西医结合医院河北沧州061000

【目的】探究安肠组方(由仙鹤草、生地榆、茯苓、白头翁、白术、炒白芍等中药组成)联合磷酸铝凝胶对宫颈癌放疗后所致放射性肠炎患者炎症因子、免疫功能以及肠道菌群的影响。【方法】将78例宫颈癌放疗后所致放射性肠炎患者随机分为联合... 详细信息

【目的】探究安肠组方(由仙鹤草、生地榆、茯苓、白头翁、白术、炒白芍等中药组成)联合磷酸铝凝胶对宫颈癌放疗后所致放射性肠炎患者炎症因子、免疫功能以及肠道菌群的影响。【方法】将78例宫颈癌放疗后所致放射性肠炎患者随机分为联合组41例和参照组37例。参照组给予磷酸铝凝胶治疗,联合组给予安肠组方联合磷酸铝凝胶治疗,疗程为15 d。观察2组患者治疗前后中医证候积分、血清白细胞介素2(interleukin-2,IL-2)、降钙素原(procalcitonin,PCT)、T淋巴细胞亚群CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平及肠道菌群的变化情况,并评价2组患者的临床疗效。【结果】(1)疗效方面,治疗15 d后,联合组的总有效率为90.24%(37/41),参照组为70.27%(26/37),组间比较,联合组的临床疗效明显优于参照组(P<0.05)。(2)中医证候方面,治疗后,2组患者的黏液脓血便、腹泻、里急后重、腹痛等中医证候积分均较治疗前降低(P<0.05),且联合组的降低幅度均明显优于参照组(P<0.01)。(3)炎症因子方面,治疗后,2组患者的血清IL-2、PCT水平均较治疗前降低(P<0.05),且联合组的降低幅度均明显优于参照组(P<0.01)。(4)免疫功能方面,治疗后,2组患者的T淋巴细胞亚群CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高(P<0.05),CD8^(+)水平均较治疗前降低(P<0.05),且联合组对CD4^(+)、CD4^(+)/CD8^(+)水平的升高幅度及对CD8^(+)水平的降低幅度均明显优于参照组(P<0.01)。(5)肠道菌群方面,治疗后,2组患者的乳酸杆菌、双歧杆菌、大肠埃希菌水平均较治疗前升高(P<0.05),且联合组的升高幅度均明显优于参照组(P<0.01)。【结论】安肠组方联合磷酸铝凝胶对宫颈癌放疗后所致放射性肠炎患者进行治疗,能显著改善患者的临床症状,减轻炎症反应,提高免疫功能,平衡肠道菌群,临床疗效显著。

关键词：安肠组方磷酸铝凝胶宫颈癌放疗放射性肠炎炎症因子免疫功能肠道菌群

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The Associated Factors of SARS-CoV-2 Reinfection by Omicron Variant—Guangdong Province,China,December 2022 to January 2023

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China CDC weekly 2023年第18期5卷 391-396页

作者： Chunsheng Cai Yihong Li ting hu Rongwei Liang Kaibin Wang Congrui Guo Yan Li Meng Zhang Min Kang Guangdong Field Epidemiology Training Program Guangzhou CityGuangdong ProvinceChina Zhongshan Center for Disease Control and Prevention Zhongshan CityGuangdong ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina huaiji County Center for Disease Control and Prevention Zhaoqing CityGuangdong ProvinceChina Tianhe District Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Futian District Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reinfection by variants is being reported commonly and has caused waves of epidemic in many *** of dynamic zero policy,the SARSCoV-2 reinfection was less reported in *** is added by this report?SARS-CoV-2 reinfections were observed in Guangdong Province between December 2022 and January *** study estimated that the reinfection incidence was 50.0%for the original strain primary infections,35.2%for the Alpha or Delta variants,and 18.4%for the Omicron variant;The reinfection incidence within 3-6 months after primary infection by Omicron variant was 4.0%.Besides,96.2%reinfection cases were symptomatic while only 7.7%sought medical *** are the implications for public health practice?These findings suggest a reduced likelihood of an Omicron-driven epidemic resurgence in the short term but emphasize the importance of maintaining vigilant surveillance of emerging SARS-CoV-2 variants and conducting population-based antibody level surveys to inform response preparedness.

关键词： policy Guangdong conducting

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海管清洗预膜剂研究

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全面腐蚀控制 2024年第4期38卷 115-119页

作者：刘言霞张勇陆原张国欣胡廷中海油(天津)油田化工有限公司天津300450

结垢将导致海管集输量下降和腐蚀问题,因此需要通过通球等手段去除,但经常通球导致了缓蚀剂膜不断被破坏,为了缩短成膜过程,需要开发一种清洗预膜剂。本文通过研究发现,氨基磺酸和柠檬酸在4:1复配时具有很好的协同效应,药剂添加量为0.5... 详细信息

结垢将导致海管集输量下降和腐蚀问题,因此需要通过通球等手段去除,但经常通球导致了缓蚀剂膜不断被破坏,为了缩短成膜过程,需要开发一种清洗预膜剂。本文通过研究发现,氨基磺酸和柠檬酸在4:1复配时具有很好的协同效应,药剂添加量为0.5%时除垢率能达到100%;而在有机酸液中添加15%喹啉季铵盐可以有效控制酸洗液的腐蚀和配方的自腐蚀性。该药剂的预膜时间为300分钟,预膜时间短,预膜效果优异,满足现场需求。

关键词：除垢预膜除垢率腐蚀速率预膜时间

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