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Air pollution and liver cancer: A systematic review

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Journal of Environmental Sciences 2023年第4期126卷 817-826页

作者： ting gan Hilary Bambrick Shilu Tong Wenbiao Hu School of Public Health and Social Work Queensland University of TechnologyQueensland 4059Australia National Centre for Epidemiology and Population Health Australian National UniversityAustralian Capital Territory 2601Australia Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Air pollution has previously been linked to several adverse health outcomes, but the potential association between air pollution and liver cancer remains unclear. We searched Pub Med, EMBASE, and Web of Science from inception to 10 October 2021, and manually reviewed the references of relevant papers to further identify any related literature investigating possible associations between air pollution and liver cancer. Risk estimates values were represented by statistical associations based on quantitative analyses. A total of 13cohort studies obtained from 11 articles were included, with 10,961,717 participants. PM_(2.5)was the most frequently examined pollutant(included in 11 studies), followed by NO_(2)and NOx(included in 6 studies), and fewer studies focused on other pollutants(PM_(2.5)absorbance,PM_(10), PM_(2.5–10), O_(3), and BC). In all the 16 associations for liver cancer mortality, 14 associations reported the effect of PM_(2.5)on liver cancer mortality. Eight associations on PM_(2.5)were significant, showing a suggestive association between PM_(2.5)and liver cancer mortality. Among24 associations shown by risk estimates for liver cancer incidence, most associations were not statistically significant. For other air pollutants, no positive associations were presented in these studies. PM_(2.5)was the most frequently examined pollutant, followed by NO_(2)and NOx, and fewer studies focused on other pollutants. PM_(2.5)was associated with liver cancer mortality, but there was no association for other air pollutants. Future research should use advanced statistical methods to further assess the impact of multiple air pollutants on liver cancer in the changing socio-environmental context.

关键词： Air pollution PM_(2.5) Liver cancer Incidence Mortality Systematic review

Efficacy of acupoint injection in the treatment of chronic eczema and its influence on peripheral blood T cells

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World Journal of Clinical Cases 2024年第17期12卷 3019-3026页

作者： Hui-Hui gan Gao Yang ting-ting Shen Department of Dermatology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells.METHODS Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group(n=40),which received conventional Western medicine treatment,or an observation group(n=40),which received routine Western medicine treatment plus acupoint injection of triamcinolone acetonide.Response and adverse reaction rates,as well as differences in the levels of serum cytokines IFN-γ,IL-2,IL-4,and IL-10 before and after treatment were investigated.RESULTS No difference in overall response rates were found between the observation and control groups(100%vs 90%,respectively;P>0.05);however,the observation group had a higher marked response rate than the control group(87.5%vs 52.5%;P0.05).The observation group exhibited higher post-treatment INF-γand IL-2 but lower IL-4 levels than the control group(P0.05).CONCLUSION Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema.Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels,inhibition of inflammatory reactions,and mitigation of immune imbalance.

关键词： Eczema Acupoint injection T cells Immune imbalance

Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis

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World Journal of Hepatology 2024年第2期16卷 241-250页

作者： ting Li Li-Li Wang Ya-Ping Li Jian gan Xi-Sheng Wei Xiao-Rong Mao Jun-Feng Li Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina Department of Radiology First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT)is a commonthsn complication after splenectomy in patients with cirrhosis.However,the predictors of postoperative PVT are not known.AIM To investigate the predictors of PVT after splenectomy in patient with cirrhosis.METHODS A total of 45 patients with cirrhosis who underwent splenectomy were consecutively enrolled from January 2017 to December 2018.The incidence of PVT at 1 months,3 months,and 12 months after splenectomy in patients with cirrhosis was observed.The hematological indicators,biochemical and coagulation parameters,and imaging features were recorded at baseline and at each observation point.The univariable,multivariable,receiver operating characteristic curve and timedependent curve analyses were performed.RESULTS The cumulative incidence of PVT was 40.0%,46.6%,and 48.9%at 1 months,3 months,and 12 months after splenectomy.Multivariable analysis showed that portal vein diameter(PVD)≥14.5 mm and monthsdel end-stage liver disease(MELD)score>10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy(P10(P10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy in patient with cirrhosis.

关键词： Cirrhosis Splenectomy Portal vein thrombosis Predictors

Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong Zhu Chengwu Feng Jing Chen Wei gan Yuan Ma Yonghua Hu Klodian Dhana Trudy Voortman Jie Shen ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since 2014.CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register data.Results Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were identified.Higher FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's disease.Comparing the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause dementia.Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype.We observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS category.For brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.The association of cardiovascular risk burden wit

关键词： Cardiovascular diagnosis burden

Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin gan-Rong Huang Ai-Xing Guan Wen-ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the host.Although selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains unclear.AIM To investigate how selenium acts on virulence factors and reduces their toxicity.METHODS H.pylori strains were induced by sodium selenite.The expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western blotting.Transcriptomics was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and H.pylori colonization,inflammatory reactions,and the cell adhesion ability of H.pylori were assessed.RESULTS CagA and VacA expression was upregulated at first and then downregulated in the H.pylori strains after sodium selenite treatment.Their expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect H.pylori virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and CagT.Of these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium selenite.Moreover,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th cycle.Cag1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction.The extent of H.pylori colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of H.pylori-infected mice,and the cell adhesion ability of H.pylori was significantly weakened.CONCLUSION These results demonstrate that H.pylori displayed virulence attenuation after the 10th d of sodium selenite treatment.Sodium s

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

Noncanonical autophagy in systemic lupus erythematosus

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Rheumatology & Autoimmunity 2021年第2期1卷 83-91页

作者： ting gan Xu-jie Zhou Renal Division Peking University First HospitalBeijingChina Key Laboratory of Chronic Kidney Disease Prevention and Treatment Ministry of EducationPeking UniversityBeijingChina Key Laboratory of Renal Disease Ministry of Health of ChinaBeijingChina

Background:Noncanonical autophagy is generally described as a lysosomal degradation process that requires only a subset of the core autophagy-related proteins to form functional autophagosomes.Review:Accumulating evidence implicates noncanonical autophagy pathways in expanding the versatility of the immune system via regulation of functions that include antigen presentation,dead cell clearance,inflammatory cytokine production,and immune cell homeostasis.In this review,we use microtubuleassociated protein 1 light chain 3-associated phagocytosis(LAP)as an example of noncanonical autophagy,describing its distinctive molecular machinery and highlighting recent advances in its functioning in immunity.We also discuss the direct and indirect evidence supporting the pathogenic significance of abnormal levels of LAP in systemic lupus erythematosus(SLE).Future Perspectives:A better understanding of the role of noncanonical autophagy in SLE may reveal crucial information about the disease pathology,providing direction for therapeutic developments and improved prognosis.

关键词： autoimmunity autophagy LC3-associated phagocytosis noncanonical autophagy systemic lupus erythematosus

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存在物理约束的时变转动惯量航天器姿态控制

航空动力学报 2024年第1期39卷 160-168页

作者：殷春武甘婷徐琳西安建筑科技大学信息与控制工程学院西安710055 西安创联电气科技(集团)有限责任公司西安710065

对存在角速度和控制输入有界的快速机动航天器姿态控制问题,设计了一种自适应双环姿态跟踪控制器。将虚拟有界角速度作为运动学方程的虚拟控制输入,使姿态控制问题降阶为角速度跟踪问题;构建递归自适应算法估计时变转动惯量及其微分,并... 详细信息

对存在角速度和控制输入有界的快速机动航天器姿态控制问题,设计了一种自适应双环姿态跟踪控制器。将虚拟有界角速度作为运动学方程的虚拟控制输入,使姿态控制问题降阶为角速度跟踪问题;构建递归自适应算法估计时变转动惯量及其微分,并基于障碍李亚普诺夫函数和线性回归算子,设计了角速度跟踪误差有界的变增益自适应姿态控制器。结果表明:该控制策略能使抓捕非合作目标航天器的姿态呈指数收敛到期望轨迹,且收敛轨迹不受外部干扰和抓捕瞬间的强干扰影响;在整个控制过程中,航天器的角速度小于0.4 rad/s,控制力矩小于10 N·m,满足了航天器对角速度和控制输入有界的物理限制。

关键词：姿态控制双环控制障碍李亚普诺夫函数角速度在轨捕获

From model to implementation: a network algorithm programming language

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Science China(Information Sciences) 2020年第7期63卷 205-221页

作者： Jian WANG Jie AN Mingshuai CHEN Naijun ZHAN Lulin WANG Miaomiao ZHANG ting gan State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences University of Chinese Academy of Sciences School of Software Engineering Tongji University Network Integration Technology Research Department Huawei Technologies Co. Ltd. School of Computer Science Wuhan University

Software-defined networking(SDN) is a revolutionary technology that facilitates network management and enables programmatically efficient network configuration, thereby improving network performance and flexibility. However, as the application programming interfaces(APIs) of SDN are low-level or functionality-restricted, SDN programmers cannot easily keep pace with the ever-changing devices, topologies, and demands of SDN. By deriving motivation from industry practice, we define a novel network algorithm programming language(NAPL) that enhances the SDN framework with a rapid programming flow from topology-based network models to C++ implementations, thus bridging the gap between the limited capability of existing SDN APIs and the reality of practical network management. In contrast to several state-of-the-art languages, NAPL provides a range of critical high-level network programming features:(1) topology-based network modeling and visualization;(2) fast abstraction and expansion of network devices and constraints;(3) a declarative paradigm for the fast design of forwarding policies;(4) a built-in library for complex algorithm implementation;(5) full compatibility with C++ programming; and(6) userfriendly debugging support when compiling NAPL into highly readable C++ codes. The expressiveness and performance of NAPL are demonstrated in various industrial scenarios originating from practical network management.

关键词： software-defined networking(SDN) network algorithm programming language(NAPL) network abstraction

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芒果切片热风干燥特性及模型

食品与机械 2024年第4期40卷 179-186,209页

作者：黄敏甘婷易萍黄方李丽广西壮族自治区农业科学院农产品加工研究所广西南宁530007 广西果蔬贮藏与加工新技术重点实验室广西南宁530007 广西农产品贮藏保鲜与加工科技成果转化中试研究基地广西南宁530007

目的:为对芒果热风干燥过程进行预测与控制。方法:以新鲜金煌芒为试验材料,研究热风温度(60,65,70℃)和芒果切片厚度(0.8,1.0,1.2 cm)对芒果热风干燥曲线、干燥特性曲线、水分有效扩散系数等的影响,并选取常用的适用于果蔬的6种干燥模... 详细信息

目的:为对芒果热风干燥过程进行预测与控制。方法:以新鲜金煌芒为试验材料,研究热风温度(60,65,70℃)和芒果切片厚度(0.8,1.0,1.2 cm)对芒果热风干燥曲线、干燥特性曲线、水分有效扩散系数等的影响,并选取常用的适用于果蔬的6种干燥模型进行拟合、分析及验证,选出最适合芒果热风干燥的模型。结果:随温度的升高,切片厚度的减小,加快了芒果片的干燥速率,所需的干燥时间越短。水分有效扩散系数随温度和厚度的增大而增大,为1.40139×10^(-10)~3.65546×10^(-10)m^(2)/s。Logarithmic模型的R^(2)最大、X^(2)和RMSE最小,分别为0.99887,0.000124779,0.00137。结论:Logarithmic模型预测值与试验值验证基本吻合,可以较好反映芒果片在干燥过程中水分含量的变化规律。

关键词：芒果热风干燥干燥特性干燥模型 Logarithmic模型