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中国台湾地区汉族青少年高血压3阶段结合多位点测试和基因表达分析的全基因组关联研究

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中华高血压杂志 2014年第12期22卷 1198-1198页

作者： Chiang KM Yang HC Liang YJ Chen JW Hwang SM Ho HY ting ct Lin TH Sheu SH Tsai WC Chen JH Leu HB Yin WH Chiu TY Chen CI Lin SJ Thomas GN Tomlinson B Guo Y Gui HS Sham PC Lam TH Pan WH 练桂丽叶鹏

虽然已经进行了多次大规模的全基因组关联研究（genome—wide association studies，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young... 详细信息

虽然已经进行了多次大规模的全基因组关联研究（genome—wide association studies，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young—onset hypertension，YOH）被认为是更有希望治疗的疾病，因为其受到遗传因素的影响更大。

关键词：全基因组高血压基因表达分析青少年台湾地区 hypertension 中国测试

Primary stratification and identification of suspected corona virus disease 2019(COVID-19) from clinical perspective by a simple scoring proposal

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Military Medical Research 2020年第4期7卷 503-506页

作者： ting-ting Zhou Feng-Xian Wei Department of Respiratory Medicine Lanzhou University Second HospitalLanzhou 730030GansuChina Lanzhou University Second Clinical Medical College Lanzhou UniversityCuiyingmen 82Chengguan DistrictLanzhou 730030GansuChina

In this Commentary,we would like to comment on the article titled"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)"as a featured article in Military Medical *** the guideline,except for"confirmed cases","suspected cases","close contact"and"suspicious exposure"were defined by clinical perspective based on epidemiological risk,clinical symptoms and auxiliary *** with our experience,we introduced a simple scoring proposal additionally based on not only ct imaging as strongly recommended by the guideline but also blood routine test,especially for primary screening of such patients in the out-patient department.

关键词： COVID-19 Suspected cases Primary screening ct imaging Blood test

How to implement the‘one patient,one vote’principle under the framework of estimand

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Statistical Theory and Related Fields 2023年第3期7卷 202-212页

作者： Naitee ting Department of Biostatistics and Data Sciences Boehringer Ingelheim PharmaceuticalsIncDanburyCTUSA

The scientific foundation of a modern clinical trial is randomization–each patient is randomized to a treatment group,and statistical comparisons are made between treatment *** the study units are individual patients,this‘one patient,one vote’principle needs to be fol-lowed–***’pointofview,eachpatient is equally important,and they need to be treated equally in data *** is critical that statisti-cal analysis should respect design and study design is based on *** from both statistical and medical points of view,data analysis needs to follow this‘one patient,one vote’*** ICH E9(R1),five strategies are recommended to establish‘estimand’.This paper discusses how to implement these strategies using the‘one patient,one vote’principle.

关键词： Estimand LOCF one patient one vote

Dechlorination of carbon tetrachloride by the catalyzed Fe-Cu process

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Journal of Environmental Sciences 2007年第7期19卷 792-799页

作者： XU Wen-ying GAO ting-yao The National Engineering Research Center for Urban Pollution Control Tongji University Shanghai 200092 China.

The dectrochemical reduction characteristics of carbon tetrachlofide （ct） were investigated using cyclic voltammetry in this study. In addition, the difference in reduction mechanisms of ct between Master Builders＇ iron and the catalyzed Fe-Cu process was discussed. The results showed that ct was reduced directly on the surface of copper rather than by atomic hydrogen produced at the cathode in the catalyzed Fe-Cu process. The reduction was realized largely by atomic hydrogen in Master Builders＇ iron. The entire ct in 350 ml aqueous solution with 320 mg/L was reduced to trichloromethane and dichloromethane in 2.25 h when 100 g of scrap iron with Fe/Cu ratio of 10：1 （w/w） were used. Moreover, the reduction rate slowed with time. ct could be reduced at acidic, neutral and alkaline pH from solution by Fe-Cu bimetallic media, but the mechanisms were different. The degradation rate was not significantly influenced by pH in the catalyzed Fe-Cu process; in Master Builders＇ iron it clearly increased with decreasing pH. The kinetics of the reductions followed pseudo-first order in both cases. Furthermore, the reductions under acidic conditions proceeded faster than that under the neutral and alkaline conditions. The catalyzed Fe-Cu process was superior to Master Builders＇ iron in treating ct-containing water and this advantage was particularly noticeable under alkaline conditions. The reduction was investigated in the cathode （Cu） and anode （Fe） compartments respectively, the results showed that the direct reduction pathway played an important role in the reduction by the catalyzed Fe-Cu process. The catalyzed Fe-Cu process is of practical value.

关键词： carbon tetrachloride electrochemical reduction characteristics catalyzed Fe-Cu process reduction mechanisms

DNA End Resection:Facts and Mechanisms

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 126-130页

作者： ting Liu Jun Huang Department of Cell Biology and Program in Molecular Cell Biology Zhejiang University School of Medicine Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang University

DNA double-strand breaks（DSBs）,which arise following exposure to a number of endogenous and exogenous agents,can be repaired by either the homologous recombination（HR）or non-homologous end-joining（NHEJ） pathways in eukaryotic cells.A vital step in HR repair is DNA end resection,which generates a long 30single-stranded DNA（ss DNA） tail that can invade the homologous DNA *** generation of 30 ss DNA is not only essential for HR repair,but also promotes activation of the ataxia telangiectasia and Rad3-related protein（ATR）.Multiple factors,including the MRN/X complex,C-terminal-binding protein interacting protein（ct IP）/Sae2,exonuclease 1（EXO1）,Bloom syndrome protein（BLM）/Sgs1,DNA2 nuclease/helicase,and several chromatin remodelers,cooperate to complete the process of end *** we review the basic machinery involved in DNA end resection in eukaryotic cells.

关键词： DNA end resection Homologous recombination DNA double-strand breaks Chromatin remodeling factors Genome stability

Diagnosis of upper gastrointestinal perforation complicated with fistula formation and subphrenic abscess by contrast-enhanced ultrasound:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8858-8863页

作者： ting-ting Qiu Rong Fu Yan Luo Wen-Wu Ling Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastrointestinal perforation complicated by subphrenic abscess is a surgical *** diagnosis relies mainly on X-ray or computed tomography(ct),while the value of ultrasound,especially contrast-enhanced ultrasound(CEUS),has been *** SUMMARY A 37-year-old man presented with fever and edema of the lower extremities for 10 *** had a history of laparoscopic repair of gastroduodenal perforation 6 mo *** first-time intravenous CEUS indicated a diagnosis of subphrenic *** received antibiotic therapy and ultrasound-guided percutaneous drainage of the ***,second-time intravenous CEUS revealed an unsatisfactory therapeutic *** CEUS was proposed,and this examination detected communication between the abscess and the *** gastrointestinal perforation complicated by fistula formation and subphrenic abscess was diagnosed with the help of *** ct and esophagogastroduodenoscopy confirmed the *** patient recovered after the perforation was repaired by *** Intravenous and intracavitary CEUS provides helpful information for the diagnosis of upper gastrointestinal perforation complicated by fistula formation and subphrenic abscess.

关键词： Contrast-enhanced ultrasound Gastrointestinal perforation Fistula Abscess Diagnosis Case report

Differential roles of RIG-Ⅰ like receptors in SARS-CoV-2 infection

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Military Medical Research 2022年第2期9卷 262-264页

作者： Duo-Meng Yang ting-ting Geng Andrew G.Harrison Peng-Hua Wang Department of Immunology School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA

Retinoic acid-inducible gene Ⅰ (RIG-Ⅰ) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune *** we investigate their functions in human epithelial cells,the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).A deficiency in MDA5,RIG-Ⅰ or mitochondrial antiviral signaling protein (MAVS) enhanced viral *** expression of the type I/III interferon(IFN) during infection was impaired in MDA5;and MAVS;,but not in RIG-Ⅰ;,when compared to wild type (WT) *** mRNA level of full-length angiotensin-converting enzyme 2 (ACE2),the cellular entry receptor for SARS-CoV-2,was approximately 2.5-fold higher in RIG-Ⅰ;than WT *** data demonstrate MDA5 as the predominant SARS-CoV-2 sensor,IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-Ⅰ in epithelial cells.

关键词： Severe acute respiratory syndrome coronavirus 2 Pathogen pattern recognition receptor Melanoma differentiation-associated protein 5 Retinoic acid-inducible geneⅠ

Bolt insertion damage and mechanical behaviors investigation of CFRP/CFRP interference fit bolted joints

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Chinese Journal of Aeronautics 2022年第9期35卷 354-365页

作者： Yangjie ZUO ting YUE Ruisong JIANG Zengqiang CAO Liu YANG School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China Xi’an Space Engine Co.Ltd Xi'an 710100China School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Xi’an ASN Technology Group Co.Ltd Xi'an 710072China

Interference fit has advantages in improving fatigue behaviors of composite bolted joints,however, interference fit bolt insertion tends to cause damages in laminates weakening joint mechanical properties. Therefore, an experimental study was conducted to investigate bolt insertion damages of Carbon Fiber Reinforced Polymer(CFRP)/CFRP interference fit bolted *** behaviors of joints were also evaluated experimentally under both quasi-static loads and cyclic loads. Scanning Electron Microscope(SEM) and high-resolution X-ray micro-ct scan were used to examine micro damages in laminates. Damage and failure behaviors of joints were characterized. The results demonstrated that the hole entrance in upper laminate and the laminate boundary near the hole wall were the most critical regions for damages during bolt insertions. However, the influence of those damages on quasi-static failure loads and fatigue failure modes of joints was minimal. Delamination and matrix cracking occurred first in laminates following fiber and matrix fracture in quasi-static tensile tests. Interference fit could improve the fatigue resistance of the laminate hole, however, the bolt seemed to suffer a more critical local fatigue loading *** paper can contribute to composite structure designs, especially in understanding damage and failure behaviors of composite bolted joints.

关键词： Bolted joints Composite Damage Failure Fatigue life Interference fit

Rare case of Helicobacter pylori -related gastric ulcer: Malignancy or pseudomorphism?

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World Journal of Gastroenterology 2013年第12期19卷 2000-2004页

作者： ting-ting Li Feng Qiu Zhi-Qiang Wang Lu Sun Jun Wan Department of Geriatric Gastroenterology Chinese PLA General Hospital Department of Neurology Chinese Navy General Hospital Department of Geriatric Gastrointestinal Endoscopy Chinese PLA General Hospital Department of Pathology Chinese PLA General Hospital

Helicobacter pylori (H. pylori ) is a pathogen and the most frequent cause of gastric ulcers. There is also a close correlation between the prevalence of H. pylori infection and the incidence of gastric cancer. We present the case of a 38-year-old woman referred by her primary care physician for screening positron emission tomography-computed tomography (PET-ct), which showed a nodular strong accumulation point with standardized uptake value 5.6 in the gastric fundus. Gastroscopy was then performed, and a single arched ulcer, 12 mm in size, was found in the gastric fundus. Histopathological examination of the lesion revealed chronic mucosal inflammation with acute inflammation and H. pylori infection. There was an obvious mitotic phase with widespread lymphoma. Formal anti-H. pylori treatment was carried out. One month later, a gastroscopy showed a single arched ulcer, measuring 10 mm in size in the gastric fundus. Histopathological examination revealed chronic mucosal inflammation with acute inflammation and a very small amount of H. pylori infection. The mitotic phase was 4/10 high power field, with some heterotypes and an obvious nucleolus. Follow-up gastroscopy 2 mo later showed the gastric ulcer in stage S2. The mucosal swelling had markedly improved. The patient remained asymptomatic, and a follow-up PET-ct was performed 6 mo later. The nodular strong accumulation point had disappeared. Follow-up gastroscopy showed no evidence of malignant cancer. H. pylori-associated severe inflammation can lead to neoplastic changes in histiocytes. This underscores the importance of eradicating H. pylori , especially in those with mucosal lesions, and ensuring proper follow-up to prevent or even reverse early gastric cancer.

关键词： Helicobacter pylori Gastric ulcer Gastric cancer Positron emission tomography-computed tomography Gastroscopy