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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong ting xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Oscillation Theorems for Quasilinear Elliptic Differential Equations

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Acta Mathematica Sinica,English Series 2007年第7期23卷 1189-1198页

作者： Zhi ting xu School of Mathematical Sciences South China Normal University

By using vector Riccati transformation and averaging technique, some oscillation criteria for the quasilinear elliptic differential equation of second order,ΣNi,j=1Di[Ψ（y）Aij（x）｜Dy｜^p-2Djy]＋p（x）f（y）=0,are obtained. These theorems extend and include earlier results for the semilinear elliptic equation and PDE with p-Laplacian.

关键词： oscillation quasilinear elliptic equation second order vector Riccati transformation

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Oscillation Criteria for Second Order Mixed Nonlinear Elliptic Equations

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 1049-1060页

作者： Zhi-ting xu School of Mathematical Sciences South China Normal University

By using the refinement of the standard integral averaging technique, we obtain some oscillation criteria for second order mixed nonlinear elliptic equations. The results established in this paper extend and improve s... 详细信息

关键词： oscillation elliptic equations mixed nonlinear integral averaging technique

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Oscillation Theorems for Nonlinear Second Order Elliptic Equations

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Acta Mathematicae Applicatae Sinica 2007年第4期23卷 569-578页

作者： Zhi-ting xu School of Mathematical Sciences South China Normal University Guangzhou 510631 China

Some oscillation theorems are given for the nonlinear second order elliptic equation N∑i,j=1 Di[aij（x）ψ（y）｜｜△↓y｜｜^p-2 Djy]＋c（x）f（y）=0The results are extensions of modified Riccati techniques and inclu... 详细信息

关键词： Oscillation, nonlinear second order elliptic equation, Riccati techniques

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Oscillation of Second Order Semilinear Elliptic Equations with Damping

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2165-2178页

作者： Zhi ting xu School of Mathematical Sciences South China Normal University Guangzhou 510631 P. R. China

We obtain some new Kamenev-type oscillation theorems for the second order semilinear elliptic differential equation with damping N ∑i,j=1Di[aij（x）Djy]＋N∑i=1bi（x）Diy＋c（x）f（y）=0 under quite general assumptions. These results are extensions of the recent results of Sun [Sun, Y. G.： New Kamenev-type oscillation criteria of second order nonlinear differential equations with damping. J. Math. Anal. Appl., 291, 341-351 （2004）] in a natural way. In particular, we do not impose any additional conditions on the damped functions bi （x） except the continuity. Several examples are given to illustrate the main results.

关键词： Oscillation damped semilinear elliptic differential equations second order

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Philos-type Oscillation Theorems for Second Order Damped Elliptic Equations

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Acta Mathematicae Applicatae Sinica 2009年第2期25卷 291-304页

作者： Zhi-ting xu School of Mathematical Sciences South China Normal University Guangzhou 510631 China

Using general means, we establish several new Philos-type oscillation theorems for the second order damped elliptic differential equationΣi,j=1 N Di[aij（x）Djy]＋Σi=1 N bi（x）Diy＋c（x）f（y）=0under quite general assumptions. The obtained results are extensions of the well-known oscillation results due to Kamenev, Philos, Yan for second order linear ordinary differential equations and improve recent results of xu, Jia and Ma.

关键词： Oscillation elliptic differential equations second order damped

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Averaging Technique for the Oscillation of Second Order Damped Elliptic Equations

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Acta Mathematica Sinica,English Series 2008年第5期24卷 829-842页

作者： Zhi ting xu School of Mathematical Sciences South China Normal University Guangzhou 510631 P. R. China

By using the averaging technique, we establish some oscillation theorems for the second order damped elliptic differential equation N↑∑↓i,j=1 Di[AIY（x）Djy]＋N↑∑↓i=1 bi（x）Diy＋c（x）f（y）=0 which extend and... 详细信息

关键词： oscillation averaging technique second order elliptic differential equation damped

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Research on Detection Method of Interest Flooding Attack on Content Centric Network

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Computers, Materials & Continua 2020年第8期64卷 1075-1089页

作者： Yabin xu ting xu Xiaowei xu Beijing Key Laboratory of Internet Culture and Digital Dissemination Research Beijing100101China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Information Science and Technology UniversityBeijing100101China School of Computer Beijing Information Science&Technology UniversityBeijing100101China Department of Information Science University of Arkansas at Little RockLittle Rock72204USA

To improve the attack detection capability of content centric network(CCN),we propose a detection method of interest flooding attack(IFA)making use of the feature of self-similarity of traffic and the information entropy of content name of interest *** the one hand,taking advantage of the characteristics of self-similarity is very sensitive to traffic changes,calculating the Hurst index of the traffic,to identify initial IFA *** the other hand,according to the randomness of user requests,calculating the information entropy of content name of the interest packets,to detect the severity of the IFA attack,***,based on the above two aspects,we use the bilateral detection method based on non-parametric CUSUM algorithm to judge the possible attack behavior in *** experimental results show that flooding attack detection method proposed for CCN can not only detect the attack behavior at the early stage of attack in CCN,but also is more accurate and effective than other methods.

关键词： CCN interest flooding attack self-similar feature information entropy bilateral detection method

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How does the host-specialized aphid deal with food deficiency？

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Insect Science 2014年第3期21卷 334-341页

作者： ting-ting xu ting-ting Ma Xiang-Dong Liu Department of Entomology Nanjing Agricultural University Nanjing China

Aphis gossypii Glover shows obvious host specialization, with cucurbit- and cotton-specialized biotypes or host races in many regions. Because its annual natal hostcrops senesce earlier the cucurbit-specialized biotype may suffer food deficiency. The method this biotype uses to overcome this challenge is still poorly understood. In orderto understand the potential of the cucurbit-specialized biotype aphids in host shift and usage, the performance of this biotype on cotton （Gossypium hirsutum）, a common butpoor quality host plant, was explored in this study. The cucurbit-specialized aphids could establish populations on cotton only when these plants had at least nine leaves, and subsequent populations developed rather slowly. The presence of whitefly populations on cotton improved the success rate of cucurbit-specialized aphids. The cucurbit-specialized aphidswere mainly distributed on the older leaves of cotton, with only a few settling on the upper leaves. The cucurbit-specialized aphids reared on cotton for 40, 54 and 61 days stillmaintained strong preference for their natal host plant, cucumber （Cucumis sativus）, rather than cotton, and their net reproductive rates and intrinsic rates of natural increase weredramatically lower when they were transferred onto new six-leaf cotton plants or detached leaves. Therefore, we concluded that the cucurbit-specialized aphids have the potentialto utilize mature or whitefly-stressed cotton plants, but that this feeding experience on cotton did not alter their specialization for cucurbits. Some cotton plants could act as atemporary host for the cucurbit-specialized aphids to overcome food deficiency arising from senescing cucurbits.

关键词： Aphidgossypii cotton-melon aphid host shift host specialization temporary host whitefly-stressed cotton

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Understanding light pollution: Recent advances on its health threats and regulations

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Journal of Environmental Sciences 2023年第5期127卷 589-602页

作者： Miao Cao ting xu Daqiang Yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

The prevalence of artificial lights not only improves the lighting conditions for modern society,but also poses kinds of health threats to human *** there are regulations and standards concerning light pollution,few of them are based on the potential contribution of improper lighting to ***,a better understanding of the health threats induced by light pollution may promote risk assessment and better regulation of artificial lights,thereby a healthy lighting *** review is based on a careful collection of the latest papers from 2018 to 2022 about the health threats of light pollution,both epidemiologically and *** addition to summing up the novel associations of light pollution with obesity,mental disorders,cancer,etc.,we highlight the toxicological mechanism of light pollution via circadian disruption,since light pollution directly interferes with the natural light-dark cycles,and damages the circadian photoentrainment of *** by reviewing the alternations of clock genes and disturbance of melatonin homeostasis induced by artificial lights,we aim to excavate the profound impacts of light pollution based on accumulating studies,thus providing perspectives for future research and guiding relevant regulations and standards.

关键词： Light pollution Circadian rhythm Melatonin Clock genes

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