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Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 919-932页

作者： Xiao-ting ma Xiu Liu Kai Ou Lin Yang Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Treatment options for patients with gastric cancer(GC)continue to improve,but the overall prognosis is *** use of PD-1 inhibitors has also brought benefits to patients with advanced GC and has gradually become the new standard treatment option at present,and there is an urgent need to identify valuable biomarkers to classify patients with different characteristics into *** To determined the effects of differentially expressed immune-related genes(DEIRGs)on the development,prognosis,tumor microenvironment(TME),and treatment response among GC patients with the expectation of providing new biomarkers for personalized treatment of GC *** Gene expression data and clinical pathologic information were downloaded from The Cancer Genome Atlas(TCGA),and immune-related genes(IRGs)were searched from *** were extracted from the intersection of the differentially-expressed genes(DEGs)and IRGs *** enrichment pathways of key genes were obtained by analyzing the Kyoto Encyclopedia of Genes and Genomes(KEGGs)and Gene Ontology(GO)*** identify genes associated with prognosis,a tumor risk score model based on DEIRGs was constructed using Least Absolute Shrinkage and Selection Operator and multivariate Cox *** tumor risk score was divided into high-and lowrisk *** entire cohort was randomly divided into a 2:1 training cohort and a test cohort for internal validation to assess the feasibility of the risk *** infiltration of immune cells was obtained using‘CIBERSORT,’and the infiltration of immune subgroups in high-and low-risk groups was *** GC immune score data were obtained and the difference in immune scores between the two groups was *** We collected 412 GC and 36 adjacent tissue samples,and identified 3627 DEGs and 1311 IRGs.A total of 482 DEIRGs were *** analysis showed that DEIRGs were mainly distributed in immunoglobulin complexes,receptor ligand activity,and s

关键词： Differentially expressed immune-related gene Immunotherapy Gastric cancer Risk score

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Feasibility study of the photonuclear reaction cross section of medical radioisotopes using a laser Compton scattering gamma source

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Nuclear Science and Techniques 2024年第9期35卷 168-177页

作者： Yu-Ning Gu Wei-Juan Zhao Xi-Guang Cao Yu-Xuan Yang ting-Kai ma Zheng-Li Liao Fei-Long Xu Yu-Gang ma School of Physics and Microeletronics Zhengzhou UniversityZhengzhou 450001China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China

In recent years,the gap between the supply and demand of medical radioisotopes has increased,necessitating new methods for producing medical *** reactions based on gamma sources have unique advantages in terms of producing high specific activity and innovative medical ***,the lack of experimental data on reaction cross sections for photonuclear reactions of medical radioisotopes of interest has severely limited the development and production of photonuclear transmutation medical *** this study,the entire process of the generation,decay,and measurement of medical radioisotopes was simulated using online gamma activation and offline gamma measurements combined with a shielding gamma-ray *** on a quasi-monochromatic gamma beam from the Shanghai Laser Electron Gamma Source(SLEGS),the feasibility of this measurement of production cross section for surveyed medi-cal radioisotopes was simulated,and specific solutions for measuring medical radioisotopes with ultra-low production cross sections were *** feasibility of this method for high-precision measurements of the reaction cross section of medical radioisotopes was demonstrated.

关键词： Medical radioisotope Photonuclear reaction GEANT4 Shanghai Laser Electron Gamma Source(SLEGS) Low-background gamma-ray spectrometer

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Strategies that regulate LSD1 for novel therapeutics

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge Dai Bing Cheng Shaotong Li Enhui Guo Junwei Fu ting ma Bin Yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

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Li-Rich Organosulfur Cathode with Boosted Kinetics for High-Energy Lithium-Sulfur Batteries

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Energy & Environmental materials 2024年第4期7卷 118-125页

作者： ting ma Jiaojiao Deng Yuxiao Lin Qinghua Liang Liang Hu Xiaohu Wang Jun Liu Xinsheng Zhao Yinwei Li Ding Nan Xiaoliang Yu College of Chemistry and Chemical Engineering Inner Mongolia University Inner Mongolia Key Laboratory of Graphite and Graphene for Energy Storage and Coating School of Materials Science and Engineering Inner Mongolia University of Technology Shenzhen Key Laboratory on Power Battery Safety and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate School (SIGS) School of Physics and Electronic Engineering Jiangsu Normal University Key Laboratory of Rare Earth Ganjiang Innovation Academy Chinese Academy of Sciences Department of Mechanical Engineering Research Institute for Smart EnergyThe Hong Kong Polytechnic University

Organosulfur materials containing sulfur-sulfur bonds are an emerging class of high-capacity cathodes for lithium ***,it remains a great challenge to achieve rapid conversion reaction kinetics at practical testing conditions of high cathode mass loading and low electrolyte *** this study,a Li-rich pyrolyzed polyacrylonitrile/selenium disulfide（pPAN/Se2S3） composite cathode is synthesized by deep lithiation to address the above challenges.

关键词： Electrolytes

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Botulinum toxin type A in treating early-stage patients with small-angle acute acquired comitant esotropia

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1094-1101页

作者： Run-ting ma Die-Wen-Jie Hu Lian-Hong Zhou Wen-Ping Li Yuan-Jin Li Bei-Xi Yi Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To investigate botulinum toxin A(BTXA)efficacy on small-angle(≤25Δ)acute acquired concomitant esotropia(AACE)in early-stage ***:The electronic medical record data of AACE patients during march 2019 and June 2023 were collected in this retrospective and hospital-based cohort study.A total of 72 small-angle AACE patients received BTXA extraocular muscle *** were grouped by onset-to-treatment time(Group A:≤6mo,Group B:>6mo).Deviation of esotropia,eye alignment and stereopsis were analyzed at the period of pre/post-injection(1wk,1,3,and 6mo).Orthophoria rate at 6mo(horizontal deviation0.05)between two groups except onset-to-treatment time(2mo vs 11mo,P0.05);while in 3 and 6mo Group A was significantly smaller than group B(all Pmall deviation(≤25Δ)in early *** treatment(>6mo)may reduce BTXA *** BTXA intervention benefits long-term eye alignment and stereopsis recovery.

关键词： acute acquired comitant esotropia botulinum toxin type A stereopsis

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Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

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Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-Lang Jin Yi-ting ma Jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-Feng Deng Hong-Wei Zhou Wei-Xing Chen Wen-Huan Huang School of materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-Jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

关键词： Covalent organic framework(COF) Excited-state intramolecular proton transfer(ESIPT) Copper ion detection Copper ion adsorption Renewability

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流体域内热量传递过程的导热-对流并联热阻分析方法

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中国科学：技术科学 2024年第9期54卷 1789-1796页

作者：王秋旺李香璇王婷麻世鸿张波马挺西安交通大学热流科学与工程教育部重点实验室西安710049

热阻理论被广泛用于传热过程问题的分析,传统的热阻分析方法往往只适用于一维、稳态、无内热源的热传导问题.然而,在能源电力、石油化工、航空航天等工程应用中还涉及热对流问题.针对此问题,本文提出了流体域内、多维导热-对流并联热阻... 详细信息

热阻理论被广泛用于传热过程问题的分析,传统的热阻分析方法往往只适用于一维、稳态、无内热源的热传导问题.然而,在能源电力、石油化工、航空航天等工程应用中还涉及热对流问题.针对此问题,本文提出了流体域内、多维导热-对流并联热阻分析方法以及总体热阻的概念,构建了热阻网络模型,并通过分析通道内强制对流问题证明了导热-对流并联热阻分析方法的实用性.流体域内的面积对流热阻与温度梯度及速度大小和方向密切相关,速度越大,面积对流热阻越小,同时面积对流热阻存在“负热阻”现象,相当于流体域内的“热源”或“热汇”.研究结果表明,导热-对流并联热阻网络的建立对于分析流动传热过程,以及指导传热过程的调节和优化具有重要意义.

关键词：热电比拟方法局部热阻对流热阻传热调控并联热阻

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基于高光谱数据的地表水化学需氧量反演

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光谱学与光谱分析 2024年第4期44卷 997-1004页

作者：王雪映刘适搏朱继伟马婷婷中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049 长春长光格瑞光电技术有限公司吉林长春130102 吉林省水文水资源局吉林长春130022

化学需氧量(COD)是地表水质量评价的重要指标。传统的COD检测方法存在需使用有毒试剂、易造成二次污染等缺点,高光谱法可避免上述缺点,在COD检测方面有着广阔的应用前景。为了探索在室内利用高光谱技术反演地表水COD浓度的可行性方法,... 详细信息

化学需氧量(COD)是地表水质量评价的重要指标。传统的COD检测方法存在需使用有毒试剂、易造成二次污染等缺点,高光谱法可避免上述缺点,在COD检测方面有着广阔的应用前景。为了探索在室内利用高光谱技术反演地表水COD浓度的可行性方法,以吉林省内流域的129个地表水样本为研究对象,将样本集以3∶1划分为训练集和测试集,使用高光谱成像系统收集样本的DN值并计算相应的水体光谱反射率,采用导数法进行数据预处理,通过Pearson相关性分析判断光谱数据与COD浓度实测值间的相关程度并提取特征谱数据。利用全谱数据和特征谱数据分别建立基于粒子群算法优化的最小二乘支持向量机(PSO-LSSVM)反演模型,通过决定系数R^(2)、均方差RMSE和相对偏差RPD分析比较这几种模型的预测精度和可靠性。研究结果表明:经过导数法预处理后,地表水COD浓度与光谱反射率的相关性明显增强;利用导数光谱数据建模的预测结果优于用原始光谱数据建模的预测结果;提取特征谱数据所建立的模型比利用全谱数据建立的模型有更好的预测效果。其中采用一阶导数预处理方法并利用特征谱建立的地表水COD浓度反演模型预测结果最好,验证集决定系数R^(2)=0.8567,均方差RMSE=3.8229,相对偏差RPD=2.6414。以上研究初步证实了在室内基于高光谱数据对地表水COD浓度进行反演的可行性,为高光谱技术用于地表水COD检测提供了新的方法和思路。

关键词：高光谱化学需氧量导数法最小二乘支持向量机粒子群算法

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复合材料点阵夹芯板非线性组合共振特性研究

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动力学与控制学报 2024年第4期22卷 23-29页

作者：马婷张伟北京工业大学材料与制造学部北京100124 广西大学土木建筑工程学院南宁530004

复合材料点阵夹芯板在1:3内共振和外部组合共振同时发生时的非线性共振问题被研究.首先,基于哈密顿原理和分层位移场理论建立了复合材料夹芯板的振动偏微分方程,然后利用多尺度方法求解了伽辽金离散后的常微分方程,并得到了内共振和组... 详细信息

复合材料点阵夹芯板在1:3内共振和外部组合共振同时发生时的非线性共振问题被研究.首先,基于哈密顿原理和分层位移场理论建立了复合材料夹芯板的振动偏微分方程,然后利用多尺度方法求解了伽辽金离散后的常微分方程,并得到了内共振和组合共振同时存在下夹芯板的协调方程.最后利用数值方法得到了协调方程稳态平衡解随系统参数变化的分岔图.研究了不同点阵芯子胞元构型,外激励频率以及外激励幅值对复合材料点阵夹芯板非线性组合共振特性所产生的影响.

关键词：夹芯板组合共振点阵非线性内共振

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Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer

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World Journal of Clinical Oncology 2024年第5期15卷 635-643页

作者： Xiao-ting ma Kai Ou Wen-Wei Yang Bi-Yang Cao Lin Yang Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Although treatment options for gastric cancer(GC)continue to advance,the overall prognosis for patients with GC remains *** present,the predictors of treatment efficacy remain controversial except for high microsatellite *** To develop methods to identify groups of patients with GC who would benefit the most from receiving the combination of a programmed cell death protein 1(PD-1)inhibitor and *** We acquired data from 63 patients with human epidermal growth factor receptor 2(HER2)-negative GC with a histological diagnosis of GC at the Cancer Hospital,Chinese Academy of Medical Sciences between November 2020 and October *** of the patients screened received a PD-1 inhibitor combined with chemotherapy as the first-line *** As of July 1,2023,the objective response rate was 61.9%,and the disease control rate was 96.8%.The median progression-free survival(mPFS)for all patients was 6.3 *** median overall survival was not *** analysis showed that patients with a combined positive score(CPS)≥1 exhibited an extended trend in progression-free survival(PFS)when compared to patients with a CPS of 0 after receiving a PD-1 inhibitor combined with oxaliplatin and tegafur as the first-line *** exhibited a trend for prolongation as the expression level of HER2 *** on PFS,we divided patients into two groups:A treatment group with excellent efficacy and a treatment group with poor *** mPFS of the excellent efficacy group was 8 months,with a mPFS of 9.1 months after excluding a cohort of patients who received interrupted therapy due to *** mPFS was 4.5 months in patients in the group with poor efficacy who did not receive *** good/poor efficacy as the endpoint of our study,univariate analysis revealed that both CPS score(P=0.004)and HER2 expression level(P=0.015)were both factors that exerted significant influence on the efficacy of treatment the combina

关键词： First line Gastric cancer Human epidermal growth factor receptor 2 Programmed cell death protein 1 Progression-free survival

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