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Has the risk of colorectal cancer in inflammatory bowel disease decreased?

World Journal of Gastroenterology 2013年第43期19卷 7561-7568页

作者： Nynne Nyboe Andersen tine jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic *** magnitude of the risk of CRC in IBD remains a continuing subject of *** early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe *** population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly *** present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased ***,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains ***,recent studies have reported a decline in risk of CRC over *** programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption.

关键词： Inflammatory bowel disease Colorectal cancer Risk Ulcerative colitis Crohn’s disease

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Risk of infections associated with biological treatment in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第43期20卷 16014-16019页

作者： Nynne Nyboe Andersen tine jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

Tumor necrosis factor-α(TNF-α)inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease,rheumatoid arthritis and *** most commonly used TNF-αantagonists are infliximab,adalimumab,and certolizumab pegol,and though highly effective in lowering inflammation,the efficacy must be weighed against the potential for adverse *** treatment-induced immunosuppression is suspected to increase the risk of infections,including the risk of reactivation of latent tuberculosis,as the TNF-αcytokine plays an important role in the immune *** this topic highlight a short overview of the infection risk associated with TNF-αinhibiter therapy is outlined with a focus on the overall risk of serious infections,mycobacterial infection and latent viral infections.

关键词： Inflammatory bowel disease Biological treatment Tu

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Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity

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World Journal of Gastroenterology 2016年第21期22卷 5050-5059页

作者： Frederik Trier Moller Lina Knudsen Marcus Harbord Jack Satsangi Hannah Gordon Lene Christiansen Kaare Christensen tine jess Vibeke Andersen Research Unit for Molecular Diagnostics Hospital of Southern Jutland Institute of Regional Health Research University of Southern Denmark Division of Epidemiology and Disease Surveillance Statens Serum Institut Department of Gastro-enterology Chelsea and Westminster Hospital Centre for Molecular Medicine University of Edinburgh Western General Hospital Danish Ageing Research Centre Institute of Public Health University of Southern Denmark Department of Clinical Medicine University of Aalborg

AIM: To describe the establishment of a Danish inflammatory bowel diseases(IBD) twin cohort with focus on concordance of treatment and inflammatory ***: We identified MZ twins, likely to be discordant or concordant for IBD, by merging information from the Danish Twin Register and the National Patient Register. The twins were asked to provide biological samples, questionnaires, and data access to patient files and public registries. Biological samples were collected via a mobile laboratory, which allowed for immediate centrifugation, fractionation, and storage of samples. The mean time from collection of samples to storage in the-80 ℃ mobile freezer was less than one hour. The diagnoses where validated using the Copenhagen diagnostic ***: We identified 159 MZ IBD twin pairs, in a total of 62(39%) pairs both twins agreed to participate. Of the supposed 62 IBD pairs, the IBD diagnosis could be confirmed in 54 pairs. The cohort included 10 concordant pairs, whereof some were discordant for either treatment or surgery. The 10 concordant pairs, where both pairs suffered from IBD, included eight CD/CD pairs, one UC/UC pair and one UC/IBDU pair. The discordant pairs comprised 31 UC, 5 IBDU(IBD unclassified), and 8 CD discordant pairs. In the co-twins not affected by IBD, calprotectin was above 100 μg/g in 2 participants, and above 50 μg/g in a further 5 ***: The presented IBD twin cohorts are an excellent resource for bioinformatics studies with proper adjustment for disease-associated exposures including medication and inflammatory activity in the co-twins.

关键词： Digestive system diseases Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Epidemiolog

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Risk of cardiovascular disease in inflammatory bowel disease

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 359-365页

作者： Nynne Nyboe Andersen tine jess Department of Epidemiology Research Statens Serum InstitutDK-2300 Copenhagen Denmark

Abundant scientific evidence supporting an association between inflammatory bowel disease(IBD) and venous thromboembolic events, caused by an IBD related hypercoagulability, is acknowledged and thromboprophylactic treatment strategies are now implemented in the management of IBD patients. In contrary, the risk of arterial thromboembolic disease, as ischemic heart disease, cerebrovascular events, and mesenteric ischemia in patients with IBD remains uncertain and the magnitude of a potentially increased risk is continuously debated, with ambiguous risk estimates among studies. The evident role of inflammation in the pathogenesis of atherosclerosis forms the basis of a biological plausible link; the chronic systemic inflammation in IBD patients increases the risk of atherosclerosis and thereby the risk of thrombotic events. Further, studies have shown that the burden of traditional risk factors for atherosclerosis, such as obesity, diabetes mellitus, and dyslipidemia is lower in IBD populations, thus further strengthen the role of non-traditional risk factors, as chronic inflammation in the linking of the two disease entities. Likewise, mortality from cardiovascular disease in IBD remains questioned. The aim of the current review is to give an up-date on the existing evidence of the possible association between IBD and cardiovascular disease and to discuss traditional and non-traditional risk factors.

关键词： Inflammatory bowel disease cardiovascular disease Risk Ulcerative colitis Crohn’s disease

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