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Upper Gastrointestinal Cancers in Rwanda: Epidemiological, Clinical and Histopathological Features in Patients Presenting to a Tertiary Referral Hospital

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Open Journal of Gastroenterology 2022年第10期12卷 286-298页

作者： Felicien Shikama Steve P. Bensen Robert Giraneza Prosper Ndayisaba Elisée Hategekimana Eric Rutaganda Aloys Tuyizere tindoho nkakyekorera Benoit Seminega Francois Ngabonziza Placide Kamali Vincent Dusabejambo Dirk J. van Leeuwen Martin Munyaneza Frederick L. Makrauer Audrey H. Calderwood Centre Hospitalier Universitaire de Butare (CHUB) Department of Gastroenterology Kigali Rwanda Dartmouth Hitchcock Medical Center (DHMC) Section of Gastroenterology and Hepatology New Hampshire USA Department of Internal Medicine Ruhango District Hospital Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Pathology Kigali Rwanda Centre Hospitalier Universitaire de Kigali (CHUK) Department of Gastroenterology Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Internal Medicine Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Radiology Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of General Surgery Kigali Rwanda Section of Gastroenterology and Hepatology Brigham and Women’s Hospital Boston USA

Background: Scant data on upper gastrointestinal cancers in Rwanda exist to guide potential prevention efforts. We evaluated the epidemiological, clinical and histopathological data among patients with gastric and esophageal tumors at a tertiary Referral Hospital in Rwanda. Methodology: We performed a retrospective review of histologically-confirmed esophageal and gastric cancers in adults age ≥ 18 yrs. old presenting to a university teaching hospital (Centre Hospitalier Universitaire de Butare) from 2014-2019. Variables included age at diagnosis, sex, clinical presentation, tumor location and histopathological type. Results: There were 149 upper gastrointestinal cancers, of which 137 (92%) were gastric and 12 (8%) were esophageal. Gastric cancer patients had a mean age at presentation of 56.9 ± 12.3 years (range 21 - 87). Presenting symptoms were epigastric pain (78.8%), weight loss (53.3%), post-prandial vomiting (52.6%), early satiety (29.9%), epigastric mass (24.8%), hematemesis (19.7%) and melena (16.8%). The location was antrum 50.3%, corpus 21.8%, fundus 8%, and cardia 8%. Tumor type was adenocarcinoma in 94.1%. Helicobacter pylori infection was present in 108 (78.8%). Esophageal cancer patients had a mean age of 54.4 ± 9.5 years (range 35 - 72). Presenting symptoms were dysphagia (100%) and weight loss (83%). The most common site was lower third esophagus (9/12), and adenocarcinoma cancer subtype accounted for 5/12 (41.6%) cases. Conclusion: Gastric adenocarcinoma was the most commonly diagnosed upper gastrointestinal cancers and was associated with a high prevalence of H. pylori infection. This study lays the foundation for future work to improve cancer outcomes in Rwanda.

关键词： Epidemiology Upper Gastrointestinal Cancer H. pylori Rwanda

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