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Incidence of T3151 mutation in BCR/ABl-positive CMl and All patients

Frontiers in Biology 2016年第5期11卷 404-411页

作者： Fatemeh Norozi Javad Mohammadi-asl tina Vosoughi Mohammad Ali Jalali Far Areal Saki Malehi Najmaldin Saki health Research Institute Thalassemia and Hemoglobinopathy Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Targeted therapy of Philadelphia-positive All and CMl patients using imatinib （IM） has caused significant changes in treatment course and has increased the survival of patients. A small group of patients show resistance to IM. Acquired mutations in tyrosine kinase domain of BCR-ABl protein are a mechanism for development of resistance. T315I is one of the most common acquired mutations in this domain, which occurs in ATP binding site and inhibits the formation of hydrogen bond with IM. The aim of this study was to evaluate the prevalence of this mutation in BCR/ABl-positive CMl and All patients. METhODS： To conduct this study, 60 BCR-ABl-positive patients （including 50 CMl and 10 All patients） who were subject to treatment with IM were selected. After taking the samples, presence of T315I mutation was assessed using ARMS- PCR on cDNA and its polymorphism was evaluated by sequencing. RESUlTS： The results showed that among 60 patients, only three patients had T315I mutation, which was detected using ARMS technique. The three patients bearing mutation were afflicted with CMl and no significant association was found between blood parameters with duration of treatment in presence of mutation. CONClUSIONS： The mutation was found in three CMl patients, which indicated lower likelihood and diagnostic value of this mutation in All patients. Given the negative direct sequencing results in T3151 patients, it can be concluded that ARMS- PCR is a more sensitive technique when the number of cancer cells is low in patients during treatment.

关键词： BCR-ABl T315I mutation imatinib CMl All

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Number One love

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The World of Chinese 2019年第4期 82-84页

作者： tina XU 不详

Every life can be defined by two great love stories, says philosopher Alain de Botton. The first, the quest for sexual love, is the staple of music and literature."The second-the story of our quest for love from the world-is a more secret and shameful tale, yet this second love story is no less intense than the first. There is heartbreak here too."

关键词： Number One love shameful tale heartbreak

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ThE lIGhT INSIDE

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The World of Chinese 2021年第4期 82-84页

作者： tina XU 不详

Director Khashem Gyal on film as a religion and how real culture is"inner"culture对话藏族导演卡先加:用镜头"追光"Director Khashem Gyal stands on the stage in a panel of emerging directors at the Guangzhou International Documentary Film Festival,in front of a screen showing the Chinese characters for his name written in the wrong *** moderator greets each speaker with familiarity and turns to Khashem Gyal,exclaiming in welcome and genuine surprise,"We don’t know you very well."

关键词： Director turns wrong

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SCENE ChANGE

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The World of Chinese 2020年第4期 60-63页

作者： tina XU 不详

Playwright and composer Jason Ma honors Chinese heritage in American theater对话剧作家马智培:将华人历史搬上美国音乐剧舞台When Jason Ma was crowned math champion of his school in southern California at age 13,he quips that his immigrant father"must have been very pleased."Yet he claims his math prowess never quite recovered after his parents took him to see his first musical.

关键词： crown wright heritage

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Recent developments of lactic acid bacteria and their metabolites on foodborne pathogens and spoilage bacteria:Facts and gaps

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Food Bioscience 2022年第3期47卷 1312-1329页

作者： hafize Fidan Tuba Esatbeyoglu Vida Simat Monica Trif Giulia Tabanelli tina Kostka Chiara Montanari Salam A.Ibrahim FatihÖzogul Department of Tourism and Culinary Management University of Food Technologies4002PlovdivBulgaria Institute of Food Science and human Nutrition Gottfried Wilhelm Leibniz University HannoverAm Kleinen Felde 3030167HannoverGermany University Department of Marine Studies University of SplitRuđera Boškovića 3721000SplitCroatia Centre for Innovative Process Engineering (CENTIV) Gmbh 28857SykeGermany Department of Agricultural and Food Sciences University of Bologna40127BolognaItaly Food Microbiology and Biotechnology laboratory North Carolina Agricultural and Technical State UniversityGreensboroNC27411USA Department of Seafood Processing Technology Faculty of FisheriesCukurova University01330AdanaTurkey

lactic acid bacteria(lAB)are common microorganisms found in various ecosystems including in plants,fermented foods,and the human *** the biodiversity of lactic acid microflora and characterization of lAB is a new approach to form a variety of starter communities to create innovative nutritional food *** has been growing interest in lAB isolated from non-dairy environments as these bacteria exhibit significant metabolic diversity and have unique taste-forming *** may be prevented,or treated by lAB but the treatment of disease conditions with lAB is highly dependent on the host's microbiome and diet and varies in both effectiveness and side effects from individual to *** perspectives on the study of lAB may be related to the expansion of our knowledge in the fields of genetics and genetic *** application of genetic science may help to improve existing strains and develop new strains with characteristics designed for specific ***,the preservative effects of lAB and their metabolites,as well as their interaction on the growth of food borne pathogens and food spoilage microorganisms were *** addition,the competitive models for microbial growth between lAB and other microorganisms as well as the role of lAB in the elimination of toxic compounds in food products were ***,the review provided an overview of the risks and benefits of using lAB in the food industry.

关键词： lactic acid bacteria Starter culture Fermented products Food-borne pathogens Microbial interaction

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Yan lianke’s memoir is a vivid meditation on life,death,and dignity in rural China

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The World of Chinese 2020年第3期 80-82页

作者： tina XU 不详

Some historical eras“leave tangible traces like knife marks,while others pass by like rain and clouds,detectable only by a faint scent,”muses 61-year-old author Yan liankc on the years of his childhood in the opening pages of his *** poetic than didactic,much more scent than scar,Three Brothers:Memories of My Family does not aim for a comprehensive history of China in the 1960s and 70s,but sketches richly sensory vignettes of rural families weathering political storms.

关键词：阎连科 sketch storm

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BATED BREATh

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The World of Chinese 2020年第3期 84-86页

作者： tina XU 不详

Three hours before sunrise,hostler Jiang Mcilin straps white sacks of supplies onto the saddle,and prepares to head up to the coal mines."No explosives today;there’s an inspection,"he explains to the camera.

关键词：纪录片 today inspection

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SEEKING GhOSTS

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The World of Chinese 2021年第5期 80-81页

作者： tina XU 不详

how the memoirs of a Chinese American author,haunted by her parents,can help us relate to our own families There's something familiarabout Seeing Ghosts,KatChows brave new ***'s not just because it takesthis Shenzhen-dwelling reviewer to Guangzhou, where herfather grew up before expatriatingto the US via hong Kong. It's notjust the description of rising intothe middle class in a 1980s and '90s America that still feels like recenthistory.

关键词： families something Ghost

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long-term survival of occult hepatitis B associated hepatocellular carcinoma following surgery and antiviral therapy

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hepatoma Research 2020年第8期6卷 29-35页

作者： tina Boortalary Ernest Rosato Christopher Roth Xiangdong David Ren Selena Ylin hie-Won hann Department of Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Surgery Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Radiology Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Reniguard life Sciences Inc. MalvernPA 19355USA JBS Science Inc.DoylestownPA 18902USA Division of liver Disease Prevention Center Division of Gastroenterology and HepatologyThomas Jefferson University HospitalPhiladelphiaPA 19107USA.

Occult hepatitis B infection(OBI)is characterized by absent hepatitis B surface antigen(hBsAg),low or undetectable serum hepatitis B viral DNA(hBV-DNA),and detectable DNA in the *** is debate over whether OBI increases the risk of hepatocellular carcinoma(hCC).We present a patient with negative hBsAg and a large hCC tumor who underwent a large right hepatic ***,the etiology of hCC was unknown,but through more sensitive molecular testing,it was believed to be due to *** this case report,we discuss the patient’s clinical course,the effect of antiviral therapy,mechanism of carcinogenesis in OBI,and the need for more rigorous hBV DNA assay testing for the detection of OBI.

关键词： Occult hepatitis B infection OBI-associated hCC hBsAg negative hCC

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MOUNTAIN EChOES

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The World of Chinese 2021年第1期 74-77页

作者： tina XU 不详

In the past ycar,the mountainous liangshan Yi Autonomous Prefecture has been declared a"final battleground"in the national campaign against *** newly built roads were traversed daily by dozens of journalists from arou... 详细信息

关键词： collective exhibition beyond

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