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Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years

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World Journal of Hepatology 2024年第7期16卷 1009-1017页

作者： Tung Huynh Delana MyAn Bui tina Xiwen Zhou Ke-Qin Hu Department of Pharmacy University of California Irvine Medical CenterOrangeCA 92868United States University of Houston HoustonTX 77204United States Chicago Medical School at Rosalind Franklin University North ChicagoIL 60064United States Division of Gastroenterology and Hepatology University of California IrvineSchool of MedicineOrangeCA 92868United States

BACKGROUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(CHB).We have showed switching from TDF to TAF for 96 weeks resulted in further alanine aminotransferase(AlT)improvement,but data remain lacking on the long-term benefits of TDF switching to TAF on hepatic *** To assess the benefits of TDF switching to TAF for 3 years on AlT,aspartate aminotransferase(AST),and hepatic fibrosis improvement in patients with *** A single center retrospective study on 53 patients with CHB who were initially treated with TDF,then switched to TAF to determine dynamic patterns of AlT,AST,AST to platelet ratio index(APRI),fibrosis-4(FIB-4)scores,and shear wave elastography(SWE)reading improvement at switching week 144,and the associated *** The mean age was 55(28-80);45.3%,males;15.1%,clinical cirrhosis;mean baseline AlT,24.8;AST,25.7 U/l;APRI,0.37;and FIB-4,*** 144 weeks TDF switching to TAF,mean AlT and AST were reduced to 19.7 and 21,*** baseline to switching week 144,the rates of AlT and ASTle)/25(female)andle)/19(female)were persistently increased;hepatic fibrosis was also improved by APRIly;mean APRI was reduced to 0.27;FIB-4,to 1.38;and mean SWE reading,from 7.05 to 6.30 kPa after a mean of 109 weeks *** renal function was stable and the frequency of patients with glomerular filtration rate>60 ml/min was increased from 86.5%at baseline to 88.2%at switching week *** Our data confirmed that switching from TDF to TAF for 3 years results in not only persistent AlT/AST improvement,but also hepatic fibrosis improvement by APRI,FIB-4 scores,as well as SWE reading,the important clinical benefits of long-term hepatitis B virus antiviral treatment with TAF.

关键词： Tenofovir alafenamide Tenofovir disoproxil fumarate Switching Hepatic fibrosis improvement Aspartate aminotransferase to platelet ratio index Fibrosis-4 Shear wave elastography

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

Neuroprotective potential of traditional Ayurvedic Kadha:age-related neurological disorders:a comprehensive literature review

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Traditional Medicine Research 2024年第9期9卷 51-77页

作者： Sarvin Sadreddini Mohammad Javad Emami Kazemabad Sogand Sheikholeslami Kosar Chitzan-Zadeh Mohammad Taha Kouchaki Midia Rashidi Amir Abbas Ghayerin Shahin Sabaghi Ghazal Tavakoli Sepehr Nanbakhsh tina Mansourian Arefeh Tabashiri Fariba Arbab Mojeni Mohammed Namiq Amin Zahra Taheri Seyed Esmaeil Sedighi Taraneh Tarkashvand Parham Amirazodi Mobina Fathi Shirin Yaghoobpoor Niloofar Deravi School of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Qom University of Medical SciencesQom ***Iran School of Medicine Hamadan University of Medical SciencesHamadan ***Iran School of Medicine Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Faculty of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Iran University of Medical SciencesTehran ***Iran School of Medicine Shahid Beheshti University of Medical SciencesTehran ***Iran School of Medicine Mazandaran University of Medical SciencesSari ***Iran School of Medicine Kermanshah University of Medical SciencesKermanshah ***Iran Faculty of Pharmacy Pharmaceutical Sciences BranchIslamic Azad UniversityTehran ***Iran Department of Biology Faculty of SciencePayamNoor UniversityTehran ***Iran Faculty of Medicine Islamic Azad University of Medical ScienceTehran 193951495Iran International Campus Shahid Sadoughi University of Medical SciencesYazd ***Iran

Despite modern medicine’s advancements,age-related neurological diseases like Alzheimer’s disease and Parkinson’s disease remain challenging due to high costs,side effects,and limited ***,a traditional Indian medicine system,offers Kadha tea as a potential herbal *** review explores Kadha’s components(basil(Ocimum basilicum l.),black pepper(Piper nigrum l.),Cinnamon(Cinnamomum verum ***),ginger(Zingiber officinale Roscoe),and raisin(Vitis vinifera l.))and their interaction with various neurological *** suggest Kadha exhibits anti-inflammatory,antioxidant,and antiviral properties,potentially impacting Alzheimer’s disease,Parkinson’s disease,neurotoxicity,neuroinflammation,and brain *** focusing on specific disease mechanisms and Kadha’s intergrade effects,this review aims to elucidate its potential role in managing age-related neurological disorders.

关键词： Ayurveda Kadha neuroprotective neurological disorders traditional medicine

Approaches for handling high-dimensional cluster expansions of ionic systems

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npj Computational Materials 2022年第1期8卷 1254-1264页

作者： Julia H.Yang tina Chen luis Barroso-luque Zinab Jadidi Gerbrand Ceder Department of Materials Science and Engineering BerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Disordered multicomponent systems attract great interest due to their engineering design flexibility and subsequent rich space of ***,detailed characterization of the structure and atomic correlations remains challenging and hinders full navigation of these complex spaces.A lattice cluster expansion is one tool to obtain configurational and energetic *** in theory a cluster expansion can be applied to any system of any dimensionality,the method has primarily been used in binary systems or ternary *** we apply cluster expansions in high-component ionic systems,setting up the largest cluster expansion ever attempted to our *** doing so,we address and discuss challenges specific to high-component ionic systems,namely charge state assignments,structural relaxations,and rank-deficient *** introduce practical procedures to make the fitting and analysis of complex systems tractable,providing guidance for future computational studies of disordered ionic systems.

关键词： properties cluster ionic

Children are not little adults:blood transfusion in children with burn injury

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Burns & Trauma 2017年第3期5卷 158-163页

作者： tina l. Palmieri Shriners Hospital for Children Northern California and the University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA 95817 USA

Blood transfusion in burns larger than 20%total body surface area (TBSA) are frequent due to operative procedures, blood sampling, and physiologic response to burn injury. Optimizing the use of blood transfusions requires an understanding of the physiology of burn injury, the risks and benefits of blood transfusion, and the indications for transfusion. Age also plays a role in determining blood transfusion requirements. Children in particular have a different physiology than adults, which needs to be considered prior to transfusing blood and blood products. This article describes the physiologic differences between children and adults in general and after burn injury and describes how these differences impact blood transfusion practices in children.

关键词： Blood transfusion Pediatric Burn injury

An Accurate Dynamic Forecast of Photovoltaic Energy Generation

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1683-1698页

作者： Anoir Souissi Imen Guidara Maher Chaabene Giuseppe Marco tina Moez Bouchouicha Signal Image et Maîtrise de l’Energie(SIME Laboratory)Tunis1008Tunisia Dipartimento di Ingegneria Elettrica Elettronica e InformaticaCatania95125Italy laboratoire lIS-Equipe SIIM Département GMP IUT Toulon83041France

The accurate forecast of the photovoltaic generation(PVG)process is essential to develop optimum installation sizing and pragmatic energy planning and *** paper proposes a PVG forecast model for a PVG/Battery *** forecasting strategy is built on a Medium-Term Energy Forecasting(MTEF)approach refined dynamically every hour(Dynamic Medium-Term Energy Forecasting(DMTEF))and adjusted by means of a Short-Term Energy Forecasting(STEF)*** MTEF predicts the generated energy for a day ahead based on the PVG of the last 15 *** for STEF,it is a combination between PVG Short-Term(ST)forecasting and DMTEF methods obtained by selecting the least inaccurate PVG estimation every 15 *** algorithm results are validated by measures taken on a 3 KWp standalone PVG/Battery *** proposed approaches have been integrated into a management algorithm in order to make a pragmatic decision to ensure load supply considering relevant constraints and priorities and guarantee the battery *** results show that STEF provides accurate results compared to measures in stable and perturbed *** NMBE(Normalized Mean Bias Error)is equal to-0.58%in stable days and 26.10%in perturbed days.

关键词： Energy Forecasting MTEF DMTEF STEF ARIMA model photovoltaic energy

Considerations for pediatric burn sedation and analgesia

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Burns & Trauma 2017年第4期5卷 218-228页

作者： Alice Fagin tina l. Palmieri Arkansas Children's Hospital 1 Children's Way Little Rock AR 72202 USA Shriners Hospitals for Children Northern California and University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA USA

Burn patients experience anxiety and pain in the course of their injury, treatment, and recovery. Hence, treatment of anxiety and pain is paramount after burn injury. Children, in particular, pose challenges in anxiety and pain management due to their unique physiologic, psychologic, and anatomic status. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. The purpose of this review is to describe the challenges associated with management of anxiety, pain, and sedation in burned children and to describe the different options for treatment of anxiety and pain in burned children.

关键词： Pediatric Sedation Burns

Pediatric burn resuscitation:past, present, and future

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Burns & Trauma 2017年第3期5卷 164-172页

作者： Kathleen S. Romanowski tina l. Palmieri Department of Surgery University of Iowa Hospitals and Clinics 200 Hawkins Drive JCP 1500 Iowa City IA 52242 USA Shriners Hospitals for Children Northern California Sacramento California USA University of California Davis Davis California USA

Burn injury is a leading cause of unintentional death and injury in children, with the majority being minor (less than 10%). However, a significant number of children sustain burns greater than 15%total body surface area (TBSA), leading to the initiation of the systemic inflammatory response syndrome. These patients require IV fluid resuscitation to prevent burn shock and death. Prompt resuscitation is critical in pediatric patients due to their small circulating blood volumes. Delays in resuscitation can result in increased complications and increased mortality. The basic principles of resuscitation are the same in adults and children, with several key differences. The unique physiologic needs of children must be adequately addressed during resuscitation to optimize outcomes. In this review, we will discuss the history of fluid resuscitation, current resuscitation practices, and future directions of resuscitation for the pediatric burn population.

关键词： Burns Resuscitation Pediatric

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苏格兰之旅

疯狂英语（初中天地） 2005年第10期 33-35页

作者： tina robinson 小虎

苏格兰组成了大不列颠岛的北部。它分为三大地区——(北部)高地、中部低地和南部高地。苏格兰以山峦景色和湖泊闻名遐尔。其西岸的大部分地区都被海水湖分割。最出名的淡水湖可能是尼斯湖。我们从安尼克古堡继续前往苏格兰。爱丁堡是苏... 详细信息

苏格兰组成了大不列颠岛的北部。它分为三大地区——(北部)高地、中部低地和南部高地。苏格兰以山峦景色和湖泊闻名遐尔。其西岸的大部分地区都被海水湖分割。最出名的淡水湖可能是尼斯湖。我们从安尼克古堡继续前往苏格兰。爱丁堡是苏格兰的首府,也是英国的第二大金融中心。

关键词：苏格兰爱丁堡城堡方格呢维多利亚