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Intestinal injury can be reduced by intra-arterial postischemic perfusion with hypertonic saline

World Journal of Gastroenterology 2013年第2期19卷 209-218页

作者： Oleg Kornyushin Michael Galagudza Anna Kotslova Gelfia Nutfullina Nina Shved Alexey Nevorotin Valeriy Sedov timur vlasov Department of Surgery I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Department of Pathophysiology I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Institute of Experimental Medicine V.A.Almazov Federal HeartBlood and Endocrinology Centre197341 St.PetersburgRussia Department of Pathology I.P.Pavlov Federal Medical University197022 St.PetersburgRussia Laboratory of Electron Microscopy I.P.Pavlov Federal Medical University197022 St.PetersburgRussia

AIM:To investigate the effect of local intestinal perfusion with hypertonic saline(HTS) on intestinal ischemia-reperfusion injury(IRI) in bothex vivo andin vivo rat ***:All experiments were performed on male Wistar rats anesthetized with pentobarbital sodium given intraperitoneally at a dose of 60 mg/*** vivo vascularly perfused rat intestine was subjected to 60-min ischemia and either 30-min reperfusion with isotonic buffer(controls),or 5 min with HTS of 365 or 415 mOsm/L osmolarity(HTS 365mOsm or HTS 415mOsm,respectively) followed by 25-min reperfusion with isotonic *** vascular intestinal perfusate flow(IPF) rate was determined by collection of the effluent from the portal vein in a calibrated *** intestinal contraction rate was monitored *** intestinal injury or area of necrosis(AN) was evaluated histochemically using 2.3.5-triphenyltetrazolium chloride *** vivo,30-min ischemia was followed by either 30-min blood perfusion or 5-min reperfusion with HTS 365mOsm through the superior mesenteric artery(SMA) followed by 25-min blood *** blood pressure(BP) was measured in the common carotid artery using a miniature pressure *** injury was evaluated in both preparations using the Chui ***:Ex vivo,intestinal IRI resulted in a reduction in the IPF rate during reperfusion(P < 0.05 vs sham).The postischemic recovery of the IPF rate did not differ between the controls and the HTS 365mOsm *** the HTS 415mOsm group,postischemic IPF rates were lower than in the controls and the HTS 365mOsm group(P < 0.05).The intestinal contraction rate was similar at baseline in all *** increase in this parameter was observed during the first 10 min of reperfusion in the control group as compared to the sham-treated group,but no such increase was seen in the HTS 365mOsm *** controls,AN averaged 14.8% ± 5.07% of the total tissue *** of HTS 365mOsm for 5 mi

关键词： Intestinal ischemia-reperfusion injury Superior mesenteric artery Perfusion Hypertonic saline Acute mesenteric ischemia Intestinal perfusate flow rate

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