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Asymptotic Analysis for U-Statistics and Its Application to Von Mises Statistics

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Open Journal of Statistics 2011年第3期1卷 139-144页

作者： timur Zubayraev 不详

Let - be i.i.d. random variables taking values in a measurable space ( Χ, B ). Let φ1: Χ →□ and φ: Χ2→□ be measurable functions. Assume that φ is symmetric, i.e. φ(x,y)=φ(y.x), for any x,y∈Χ . Consider U-statistic, assuming that eφ1(Χ)=0, eφ(x, X)=0 for all x∈X, eφ2(x,X)eφ21(X)e will provide bounds for ΔN=supx|F(x)-F0(x)-F1(x)|, where F is a distribution function of T and F0 , F1 are its limiting distribution function and edgeworth correction respectively. Applications of these results are also provided for von Mises statistics case.

关键词： U-Statistics Von Mises Statistics Symmetric Statistics

Taxonomy,phylogeny,molecular dating and ancestral state reconstruction of Xylariomycetidae(Sordariomycetes)

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Fungal Diversity 2022年第1期112卷 1-88页

作者： Milan C.Samarakoon Kevin D.Hyde Sajeewa S.N.Maharachchikumbura Marc Stadler e.B.Gareth Jones Itthayakorn Promputtha Nakarin Suwannarach erio Camporesi timur S.Bulgakov Jian-Kui Liu School of Life Science and Technology Center for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Research Center in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Institute of Microbiology Technische Universität BraunschweigSpielmannstraße 738106 BrunswickGermany Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand A.M.B.Gruppo Micologico Forlivese"Antonio Cicognani"Via Roma 18ForliItaly Department of Plant Protection Federal Research Centre the Subtropical Scientific Centre of the Russian Academy of SciencesYana Fabritsiusa Street 2/28SochiKrasnodar RegionRussia 354002

Xylariomycetidae(Ascomycota)is a highly diversified group with variable stromatic *** research focused on inconspicuous stromatic xylarialean taxa from China,Italy,Russia,Thailand and the United *** morpho-logical descriptions,illustrations and combined ITS-LSU-rpb2-tub2-tef1 phylogenies revealed 39 taxa from our collections belonging to Amphisphaeriales and Xylariales.A new family(Appendicosporaceae),five new genera(Magnostiolata,Mela-nostictus,Neoamphisphaeria,Nigropunctata and Paravamsapriya),27 new species(Acrocordiella photiniicola,Allocryp-tovalsa sichuanensis,Amphisphaeria parvispora,Anthostomella lamiacearum,Apiospora guiyangensis,***,Biscogniauxia magna,eutypa camelliae,Helicogermslita clypeata,Hypocopra zeae,Magnostiolata mucida,Melanostictus longiostiolatus,***,Nemania longipedicellata,***,***,***,Neoamphispha-eria hyalinospora,Neoanthostomella bambusicola,Nigropunctata bambusicola,***,***,Occul-titheca rosae,Paravamsapriya ostiolata,Peroneutypa leucaenae,Seiridium italicum and Vamsapriya mucosa)and seven new host/geographical records are introduced and *** time estimates indicate that Delonicicolales diverged from Amphisphaeriales+Xylariales at 161(123-197)*** and Xylariales diverged 154(117-190)MYA with a crown age of 127(92-165)MYA and 147(111-184)MYA,***(Amphisphaeriales)has a stem age of 89(65-117)*** character state reconstruction indicates that astromatic,clypeate ascomata with aseptate,hyaline ascospores that lack germ slits may probably be ancestral Xylariomycetidae having plant-fungal endo-phytic *** Amphisphaeriales remained mostly astromatic with common septate,hyaline *** variations may have developed mostly during the Cretaceous *** ascospores are common in Xylariales,but they first appeared in Amphisphaeriaceae,Melogrammataceae and Sp

关键词： 33 new taxa Amphisphaeriales Appendicosporaceae evolution Stromata Xylariales

Giant cell arteritis in a patient with fever of unknown origin

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Open Journal of Internal Medicine 2013年第2期3卷 58-59页

作者： timur Selcuk Akpinar Busra Alpaslan Raim Iliaz Goknur e. Isik Bulent Saka Department of Internal Medicine Division of Geriatrics Istanbul Medical Faculty Istanbul University Istanbul Turkey Department of Internal Medicine Istanbul Medical Faculty Istanbul University Istanbul Turkey Department of Nuclear Medicine Istanbul Medical Faculty Istanbul University Istanbul Turkey

Fever of unknown (FUO) origin challenging clinical condition. The causes of FUO are diverse: possible etiologies include infectious diseases, chronic granulomatous diseases, malignity, connective tissue disorders and vasculitis. Giant cell arteritis which affects the aorta and its main branches, contributes up to 17% of cases with fever of unknown origin above age 50. There is increasing evidence for a role for18F-FDG PeT/CT in the diagnosis of vasculitis and18F-FDG PeT/CT is a useful technic for evaluation of the FUO. Clinical studies show that FDG-PeT is a useful diagnostic aid in obscure cases of fever of unknown origin. We report here a case of a 54-year-old woman who present to our clinic with FUO due to giant cell vasculitis.

关键词： Fewer of Unknown Origin Vasculitis PeT/CT

Towards a natural classification of Ophiobolus and ophiobolus-like taxa;introducing three novel genera Ophiobolopsis, Paraophiobolus and Pseudoophiobolus in Phaeosphaeriaceae (Pleosporales)

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Fungal Diversity 2017年第6期87卷 299-339页

作者： Rungtiwa Phookamsak Dhanushka N.Wanasinghe Sinang Hongsanan Chayanard Phukhamsakda Shi-Ke Huang Danushka S.Tennakoon Chada Norphanphoun erio Camporesi timur S.Bulgakov Itthayakorn Promputtha Peter e.Mortimer Jian-Chu Xu Kevin D.Hyde Key Laboratory for Plant Biodiversity and Biogeography of east Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina World Agro Forestry Centre East and Central Asia132 Lanhei RoadKunming 650201YunnanChina Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy A.M.B.Circolo Micologico“Giovanni Carini” C.P.314BresciaItaly Societa`per gli Studi Naturalistici della Romagna C.P.144BagnacavalloRAItaly Russian Research Institute of Floriculture and Subtropical Crops Yana Fabritsiusa Street2/28Krasnodar RegionSochiRussia 354002

Ophiobolus is a large genus of Phaeosphaeriaceae comprising more than 350 possible species,most of which are saprobes on herbaceous plants in europe and North *** species are polyphyletic and the type of Ophiobolus is not represented in ***,an increased taxon sampling of ophiobolus-like taxa and epitypification of the type species,*** is *** phylogenetic analyses of combined LSU,SSU,TeF1-a and ITS sequence data position *** in a sister clade with *** and several entodesmium species in Phaeosphaeriaceae with high ***,entodesmium is synonymized under *** with it type species,*** also clusters within the Ophiobolus clade and is synonymized under *** rossicus *** introduced and a reference specimen is designated for *** ophiobolus-like taxa(Ophiobolus sensu lato)can be distinguished as three main groups,which are introduced as new *** is introduced to accommodate the new species,Ophiobolopsis *** new genus Paraophiobolus is introduced to accommodate *** *** *** *** genus is characterized by hyaline to pale yellowish ascospores,some green-yellowish at maturity,with a swollen cell,terminal appendages and ascospores not separating into part *** *** introduced to accommodate six new species and two new combinations,***,***,***,***,***,***,*** and *** is characterized by subhyaline to pale yellowish or yellowish ascospores,with a swollen cell,lack of terminal appendages and ascospores that do not separate into part spores and is related to *** updated tree for Phaeosphaeriaceae based on multigene analysis is also provided.

关键词： 7 new combinations 11 new taxa Dothideomycetes epitypification

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

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Light(Science & Applications) 2020年第1期9卷 346-357页

作者： timur e.matov Roman e.Noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of electrical engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPe LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

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Neuroscience & Medicine 2013年第4期4卷 223-252页

作者： timur Kolomin Maria Shadrina Petr Slominsky Svetlana Limborska Nikolay Myasoedov Department of Chemistry of Physiologically Active Compounds Institute of Molecular Genetics Russian Academy of Sciences Moscow Russia Department of Molecular Basis of Human Genetics Institute of Molecular Genetics Russian Academy of Sciences Moscow Russia

Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products;thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the

关键词： Semax Selank Regulatory Peptides ACTH Tuftsin Neuroprotection Nootropes Anxiolytics

Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated： a prospective study using patient-reported outcome measures

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Asian Journal of Andrology 2017年第1期19卷 62-66页

作者： Karan Wadhwa Lina Carmona-echeveria timur Kuru Gabriele Gaziev eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner Department of Urology Addenbrookes Hospital Cambridge UK Department of Urology University Hospital Heidelberg Germany Department of Biochemistry University of Cambridge Cambridge UK Cancer Research Centre and Statistics and epidemiology Unit Division of Health Sciences Warwick Medical School University of Warwick Coventry UK Department of Urology Southend University Hospital Southend UK Department of Urology Kings College Hospital London UK CamPARI Prostate Cancer Clinic Addenbrookes Hospital Cambridge UK.

We aimed to determine short-term patient-reported outcomes in men having general anesthetic transperineal （TP） prostate biopsies. A prospective cohort study was performed in men having a diagnostic TP biopsy. This was done using a validated and adapted questionnaire immediately post-biopsy and at follow-up of between 7 and 14 days across three tertiary referral hospitals with a response rate of 51.6%. Immediately after biopsy 43/201 （21.4%） of men felt light-headed, syncopal, or suffered syncope. Fifty-three percent of men felt discomfort after biopsy （with 95% scoring 〈5 in a 0-10 scale）. Twelve out of 196 men （6.1%） felt pain immediately after the procedure. Despite a high incidence of symptoms （e.g., up to 75% had some hematuria, 47% suffered some pain）, it was not a moderate or serious problem for most, apart from hemoejaculate which 31 men suffered. eleven men needed catheterization （5.5%）. There were no inpatient admissions due to complications （hematuria, sepsis）. On repeat questioning at a later time point, only 25/199 （12.6%） of men said repeat biopsy would be a significant problem despite a significant and marked reduction in erectile function after the procedure. From this study, we conclude that TP biopsy is well tolerated with similar side effect profiles and attitudes of men to repeat biopsy to men having TRUS biopsies. These data allow informed counseling of men prior to TP biopsy and a benchmark for tolerability with local anesthetic TP biopsies being developed for clinical use.

关键词： attitude to rebiopsy patient-reported outcome measures patient satisfaction prostate cancer diagnosis transperineal biopsies transrectal biopsies

Regeneration of Spent Catalyst and Impregnation of Catalyst by Supercritical Fluid

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International Journal of Analytical Mass Spectrometry and Chromatography 2016年第4期4卷 51-65页

作者： Farid M. Gumerov Bernard Le Neindre timur R. Bilalov Ajrat A. Sagdeev Federal State Budgetary educational Institution of Higher Professional education “Kazan National Research Technological University” Kazan Russia Université Paris 13 Sorbonne Paris Cité Laboratoire des Sciences des Procédés et des Matériaux CNRS (UPR 3407) F-93430 Villetaneuse France Federal State educational Institution of Higher Professional education Nizhnekamsk Chemical Technology Institute Nizhnekamsk Russia

The possibility and feasibility of using supercritical fluid СО2 extraction process have been investigated and described in the book as part of the task of spent catalysts regeneration. The analysis of deactivating compounds has been carried out for industrial catalysts such as: 1) palladium catalyst G-58e of ethane-ethylene fraction hydrogenation;2) nickel/kieselguhr catalyst of process of separating acetylenic compounds from isoprene;3) active aluminum oxide catalyst of methyl phenyl carbinol dehydration process;4) palladium catalyst LD-265 of hydrocarbons hydrogenation process;5) nickel-molybdenum catalysts DN-3531 and Criterion 514 of kerosene hydrotreating process. The results of the study of catalyst deactivating compounds solubility in pure supercritical carbon dioxide and supercritical carbon dioxide are modified with polar additive. The results of the solubility study are described using the Peng-Robinson equation of state. The results of the implementation of the supercritical fluid СО2 extraction process with respect to deactivated industrial catalyst samples have been provided. A comparison of the characteristics of samples of catalysts regenerated using the traditional approach and the SC-CO2 extraction process has been conducted. The possibility of using supercritical fluid CO2 impregnation process in the synthesis of a palladium catalyst has been investigated. The synthesis of palladium chloride-based organometallic complexes has been carried out. The results of the study of solubility thereof in supercritical carbon dioxide have been provided. A dynamic supercritical fluid CO2 impregnation process condition has been implemented. A comparison of the characteristics of palladium catalyst samples synthesized using the conventional approach and SC-CO2 impregnation process has been conducted and presented in the book.

关键词： Palladium Catalyst G-58e Nickel/Kieselguhr/Diatomite Catalyst Active Aluminum Oxide Catalyst Palladium Catalyst LD-265 Nickel-Molybdenum Catalysts DN-3531 and Criterion 514 Catalyst Regeneration Catalyst Activity Benzonitrile Complex of Palladium Chloride Styrene Complex of Palladium Chloride Cyclohexene Complex of Palladium Chloride

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam e.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann eva Pawlus Kian eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification