检索结果-南通市图书馆

伊贝沙坦预防链脲佐菌素诱导糖尿病大鼠肾损伤的作用机制(英文)

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2003年第1期24卷 69-75页

作者：刘必成,陈琪,罗冬冬,孙静,phillips A O,阮雄中,刘乃丰南京医科大学病理生理学系南京医科大学病理生理学系东南大学附属中大医院肾脏科东南大学附属中大医院肾脏科英国威尔士大学肾脏研究所英国伦敦皇家福利医院肾脏科东南大学心脏病研究所南京 210002 南京 210002 南京 210009 中国南京 210009 中国卡的夫 CF14 4XN 英国伦敦 NW3 2PF 英国南京 210009 中国

目的:探讨血管紧张素Ⅱ受体拮抗剂伊贝沙坦（Irb）对链脲佐菌素（STZ）诱导的糖尿病大鼠的肾保护作用机制。方法:SD大鼠随机分为3组:正常对照组（N组,n=7）,糖尿病肾病组（DN组,n=6）Irb治疗组（DNI组,n=7）。SD大鼠单侧肾切除后,腹腔注... 详细信息

目的:探讨血管紧张素Ⅱ受体拮抗剂伊贝沙坦（Irb）对链脲佐菌素（STZ）诱导的糖尿病大鼠的肾保护作用机制。方法:SD大鼠随机分为3组:正常对照组（N组,n=7）,糖尿病肾病组（DN组,n=6）Irb治疗组（DNI组,n=7）。SD大鼠单侧肾切除后,腹腔注射STZ诱导糖尿病模型,观察治疗后第4, 8,12周的血糖（BG）、体重（BW）、尿白蛋白排泄、24小时尿总蛋白的改变,同时观察12周时肌酐清除率（Ccr）、肾重（KW）、肾脏肥大指数（KW/BW）、肾组织总蛋白含量（RTP）、肾小球面积（AG）和体积（VG）、肾小球毛细血管基底膜（GBM）厚度的改变。通过免疫组化观察肾组织结缔组织生长因子（CTGF）和转化生长因子-β1（TGF-β1）的表达。结果:DN组和DNI组间BG无差异（p>0.05）。Irb可显著抑制大鼠尿白蛋白、24小时尿总蛋白的排泄,抑制过度增高的Ccr（均为P<0.01）。而且Irb可显著抑制糖尿病大鼠KW、KW/BW、RTP、AG和VG的增加（P<0.05或P<0.01）。我们首次证实Irb能够显著抑制GBM的增厚和CTGF的表达（均为P<0.01）。另外,大鼠肾脏CTGF的表达与TGF-β1的表达和肾小球体积呈显著正相关（均为P<0.01）。结论:早期应用Irb对糖尿病大鼠的肾保护作用可能与抑制肾脏肥大和肾脏CTGF表达有关。

关键词：转化生长因子-β 结缔组织生长因子糖尿病肾病伊贝沙坦

Monosegment ALPPS hepatectomy preserving segment 4 for colorectal liver metastases:literature review and our experience

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2018年第2期7卷 105-115页

作者： Fiammetta Soggiu Francesco Giovinazzo Jack Straiton Giulia Turri Jim phillips Bassam Al-Kari Irfan Ahmed Mohammad Habib Hepatobiliary and Pancreatic Surgery Unit NHS GrampianAberdeenUK Department of Radiology NHS GrampianAberdeenUK

Monosegment 4±1 Associating Liver Partition and Portal Vein ligation for Staged hepatectomy(ALPPS)for bilateral colorectal liver metastases decreases the risk of drop-out of two stage hepatectomy,triggering a rapid and significant increase in future liver remnant(FLR)with promising oncological *** report two cases of segment 4+1 monosegment ALPPS for multiple colorectal liver metastases performed at our *** the literature,seven similar cases have been *** and long term outcomes of our two patients were reported along with a review of data from the *** patients showed a FLR increase from 13%to 37%and from 14%to 41%of total liver volume,*** was compared to a median growth from 19%at baseline to 34%before stage 2,in the *** 20 and 27 months since resection both patients are alive and *** the literature,median overall survival and disease free survival were 13 months(range,5–24 months)and 5 months(range,3–23 months),*** 4±1 ALPPS is associated with promising oncological outcomes and a significant FLR *** may be safely performed in selected patients as a salvage procedure,reducing the risk of the dropout of two-stage hepatectomy.

关键词： Associating Liver Partition and Portal Vein ligation for Staged hepatectomy(ALPPS) liver resection colorectal liver metastases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“远东的北约”:国民党与区域军事合作

社会科学研究 2010年第6期 133-141页

作者： Steven phillips 郭书愚美国陶森大学历史系四川大学历史文化学院

1949年蒋介石国民党政权在大陆垮台,蒋氏梦想创建一个地区性"反共军事联盟"——一个远东的北大西洋公约组织来增强台湾、南朝鲜和菲律宾的合作。这既体现出蒋介石对缺乏美国支持的失望,也是对来自共产主义政权或运动的现实安全威胁的反... 详细信息

1949年蒋介石国民党政权在大陆垮台,蒋氏梦想创建一个地区性"反共军事联盟"——一个远东的北大西洋公约组织来增强台湾、南朝鲜和菲律宾的合作。这既体现出蒋介石对缺乏美国支持的失望,也是对来自共产主义政权或运动的现实安全威胁的反应。为此,蒋介石先后会晤了菲律宾总统埃尔皮迪奥.季里诺、南朝鲜总统李承晚。但美国政府并不仅仅是坐等尘埃落定,而是积极致力于暗中破坏蒋介石的努力,多边军事联盟胎死腹中。学界既存有关冷战时期蒋介石的军事和外交战略研究重心几乎完全集中于蒋氏与美国利益的绑结,而实际上,蒋介石与美国也存在深度互不信任和矛盾冲突。美国破坏蒋介石倡建地区军事合作的努力即是具体实例,对此的考察也有助于增进我们对当时远东地区开展多边合作障碍重重的认知。

关键词：蒋介石区域军事合作皮迪奥·季里诺美台关系

Translated and annotated version of the 2015-2020 National Mental Health Work Plan of the People's Republic of China

在线全文

学校读者我要写书评

暂无评论

上海精神医学 2016年第1期28卷 4-17页

作者： Wei XIONG Michael R.phillips Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine

The following document is a translation of the 2015-2020 National Mental Health Work Plan of the People's Republic of China which was issued by the General Office of China's State Council on June 4, 2015. The original Chinese version of the document is available at the official government website: http://***/zhengce/content/2015-06/18/content_***. The translators have added annotations at the end of the document that provide background information to help contextualize content that may be unclear to readers unfamiliar with China and explain their decisions when translating terms that can have multiple interpretations.

关键词：中华人民共和国卫生工作翻译规划精神注释国务院办公厅官方网站

Experimental Results of MHD Suppression with Modulated LHCD on the HT-7 Tokamak

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2005年第3期7卷 2816-2818页

作者：毛剑珊罗家融沈飙赵君煜胡立群徐国盛徐汉东沈慰慈 P.phillips 高翔 Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Fusion Research Center C1510 Univ. of Texas at Austin. TX 78712 USA

Modulation of lower hybrid current drive was used successfully to suppress MHD activity. This was achieved in discharges with MHD m = 2 tearing modes during the discharge conditions Ip = 110 kA, Bt = 1.75 T, ne0 - 1.1 × 1013 cm-3. The delivering time of LHCD pulse is less then 30 μs. The amplitude, interval and the period of LHCD modulation pulse can be adjusted very conveniently. The modulation LHCD can be delivered very fast at any time during the discharge. The modulation LHCD period was always much shorter than the plasma resistive time (Tη ≈100 ms). So the profile of plasma current is changed much faster than the plasma resistive time. The different forms of LHCD modulating can be proved.

关键词： HT-7 tokamak tearing mode modulation of lower hybrid current drive

A framework to evaluate whether to pool or separate behaviors in a multilayer network

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2021年第1期67卷 101-111页

作者： Annemarie VAN DER MAREL Sanjay PRASHER Chelsea CARMINITO Claire L.O'CONNELL Alexa phillips Bryan M.KLUEVER Elizabeth A.HOBSON Department of Biological Sciences University of CincinnatiCincinnatiOH45221USA United States Department of Agriculture Wildlife ServicesNational Wildlife Research CenterFlorida Field StationGainesvilleFL32641USA

A multilayer network approach combines different network layers,which are connected by interlayer edges,to create a single mathematical *** networks can contain a variety of information types and represent different aspects of a ***,the process for selecting which information to include is not always *** data on 2 agonistic behaviors in a captive population of monk parakeets(Myiopsitta monachus),we developed a framework for investigating how pooling or splitting behaviors at the scale of dyadic relationships(between 2 individuals)affects individual-and group-level social *** designed 2 reference models to test whether randomizing the number of interactions across behavior types results in similar structural patterns as the observed *** the behaviors were correlated,the first reference model suggests that the 2 behaviors convey different information about some social properties and should therefore not be ***,once we controlled for data sparsity,we found that the observed measures corresponded with those from the second reference ***,our initial result may have been due to the unequal frequencies of each ***,our findings support pooling the 2 *** of how selected measurements can be affected by data properties is warranted,but nonetheless our framework disentangles these efforts and as a result can be used for myriad types of behaviors and *** framework will help researchers make informed and data-driven decisions about which behaviors to pool or separate,prior to using the data in subsequent multilayer network analyses.

关键词： behavioral interactions monk parakeet Myiopsitta monachus network analysis social context social relationships

An objective measure for the assessment and management of fluid shifts in acute major burns

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2018年第1期6卷 21-32页

作者： Pippa Kenworthy Michael phillips Tiffany L.Grisbrook William Gibson Fiona M.Wood Dale W.Edgar Fiona Wood Foundation Fiona Stanley HospitalPerthWestern AustraliaAustralia School of Physiotherapy and Exercise Science Curtin UniversityPerthWestern AustraliaAustralia Burns Service of Western Australia Fiona Stanley HospitalPerthWestern AustraliaAustralia Burn Injury Research Node Notre Dame UniversityFremantleWestern AustraliaAustralia Harry Perkins Institute of Medical Research The University of Western AustraliaPerthWestern AustraliaAustralia School of Physiotherapy Notre Dame UniversityFremantleWestern AustraliaAustralia Adult State Burns Service Fiona Stanley HospitalMurdoch DriveMurdochWestern Australia 6150Australia.

Background: Major burns are life threatening. Fluid resuscitation is required for survival to maintain intravascular volumes and prevent hypovolemic shock. Bioimpedance spectroscopy (BIS) has been recognised as a potential method of monitoring fluid shifts after burn and in other disease states. The aims of this study were to examine the reliability of BIS across different dressing conditions and electrode positions, establish the influence of Acticoat?on BIS variable measures and determine the validity of whole-body BIS to assess net fluid shift in the presence of moderate to major burns. Methods: An observational longitudinal cohort study was conducted from December 2014 to February 2016. Patients with over 15% total body surface area (TBSA) burns and injury less than 48 h were enrolled in the study. BIS triplicate measures were collected in an open wound and with an ActicoatTMdressing (at 5 half hour intervals). Standard and alternate electrode placements were utilised for the reliability analysis and standard placement only for determining the validity of BIS in moderate to major burns. The ImpediMde SFB7 was used to collect whole-body and segmental BIS measures. Stata statistical software, release 14 was utilised to analyse all results. Descriptive analyses were performed and were reported using the means and standard deviations (SD). Results: BIS-repeated measures established BIS raw resistance (R), and predicted volume variables were reliable in any condition (intra-class correlation coefficient (ICC) 0.996-0.999, 95% confidence intervals (CI) 0.996-0.999) without a systematic difference. Acticoat?dressings significantly influenced all BIS-predicted volumes (p≤0.01) as determined by multilevel mixed effects (MLME) linear regression analysis. Validity of BIS was demonstrated by resistance variables significantly decreasing with increasing net ionic fluid shift and increased TBSA (severity of injury) and calculated fluid volumes increasing with increasing net f

关键词： Bioelectrical impedance Oedema Wounds Fluid resuscitation Dressings

Cheat Sheet or Open-Book？ A Comparison of the Effects of Exam Types on Performance, Retention, and Anxiety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psychology Research 2012年第8期2卷 469-478页

作者： Afshin Gharib William phillips Noelle Mathew Dominican University of California California USA

A Theoretical Study of the Mechanism of the Water Catalyzed HCl Elimination Reactions of CHXCl（OH）（X=H,Cl） and HClCO in the Gas Phase and in Aqueous Solution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Theoretical Study of the Mechanism of the Water Catalyzed ...