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Journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly J Rivenbark timothy D phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

Decreased bioavailability of aminomethylphosphonic acid(AMPA)in genetically modified corn with activated carbon or calcium montmorillonite clay inclusion in soil

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Journal of Environmental Sciences 2021年第2期33卷 131-143页

作者： Sara E.Hearon Meichen Wang Thomas J.McDonald timothy D.phillips Veterinary Integrative Biosciences Department College of Veterinary Medicine and Biomedical Sciences Texas A&M Uniuersity College StationTx 77845USA Department of Environmental and Occupational Health School of Public Health Texas A&M UniversityCollege Station400 Bizzell St College StationTX 77843USA

The widespread use of pesticides has resulted in detectable residues throughout the environment,sometimes at concentrations well above regulatory ***,the development of safe,effective,field-practical,and economically feasible strategies to mitigate the effects of pesticides is *** is an organophosphorus herbicide that is degraded to aminomethylphosphonic acid(AMPA),a toxic and persistent metabolite that can accumulate in soil and sediment and translocate to *** this study,we investigated the binding efficacy of activated carbon(AC)and calcium montmorillonite(CM)clay to decrease AMPA bioavailability from soil and AMPA translocation to *** isotherms and thermodynamic studies on AC and CM were conducted and showed tight binding(enthalpy values>-20 k J/mol)for AMPA with high capacities(0.25 mol/kg and 0.38 mol/kg,respectively),based on derivations from the Langmuir model.A hydra assay was utilized to indicate toxicity of AMPA and the inclusion of 1%AC and CM both resulted in 90%protection of the hydra(**p≤0.01).Further studies in glyphosate-contaminated soil showed that AC and CM significantly reduced AMPA bioavailability by 53%and 44%,*** in genetically modified(GM)corn showed a conversion of glyphosate to AMPA in roots and sprouts over a 10-day exposure *** of AC and CM reduced AMPA residues in roots and sprouts by 47%-61%.These studies collectively indicate that AC and CM are effective sorbents for AMPA and could be used to reduce AMPA bioavailability from soil and AMPA residues in GM corn plants.

关键词： Glyphosate AMPA Activated carbon Calcium montmorillonite Sorbent

Transradial versus transfemoral access for anterior circulation mechanical thrombectomy: analysis of 375 consecutive cases

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Stroke & Vascular Neurology 2021年第2期6卷 207-213页

作者： timothy John phillips Matthew Thomas Crockett Gregory D Selkirk Ruchi Kabra Albert Ho Yuen Chiu Tejinder Singh Constantine Phatouros William McAuliffe Neurological Intervention and Imaging Service of Western Australia Sir Charles Gairdner HospitalPerthWestern AustraliaAustralia Neurological Intervention and Imaging Service of Western Australia Fiona Stanley HospitalPerthWestern AustraliaAustralia Neurological Intervention and Imaging Service of Western Australia Royal Perth HospitalPerthWestern AustraliaAustralia

Objective To compare transradial artery access(TRA)to the gold standard of transfemoral artery access(TFA)in mechanical thrombectomy(MT)for stroke caused by anterior circulation large vessel *** The clinical outcomes,procedural speed,angiographic efficacy and safety of both techniques were analysed in 375 consecutive cases over an 18-month period in a high volume statewide neurointerventional *** There was no significant difference in patient characteristics,stroke parameters,imaging techniques or intracranial *** median time elapsed between CT scanning and reperfusion was 96.5 min(IQR 68-123)in the TFA group and 95 min(IQR 68-123)in the TRA group(p=0.456).Of 336 patients who were independent at presentation 58%(124/214)of the TFA group and 67%(82/122)of the TRA group had a modified Rankin score of 0-2 at 90-day follow-up(p=0.093).Cross-over from radial to femoral was 4.6%(4/130)compared with 1.6%cross-over from femoral to radial(4/245),but did not meet the predetermined level of statistical significance(OR2.92,95% CI 0.81 to 10.52,p=0.088) and did not impact median procedural *** angiographic reperfusion,first pass reperfusion,embolisation to new territory and symptomatic intracranial haemorrhage were similar in both *** was a significant difference in major access site complications requiring an additional *** of the TRA cases had a major access site complication but 6.5%(16/245)of the TFA cases did(p=0.003).Conclusion This study suggests that using TRA for anterior circulation MT is fast,efficacious,safe and not inferior to the gold standard of TFA.

关键词： service radial cases

Complications, imaging results, and midterm clinical outcomes of pipeline embolisation device in the treatment of cerebral aneurysms

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World Journal of Neuroscience 2014年第1期4卷 58-67页

作者： Hamed Asadi timothy phillips Richard Dowling Bernard Yan Peter Mitchell Melbourne Brain Centre Department of Medicine Royal Melbourne Hospital University of Melbourne Parkville Australia Neurological Intervention & Imaging Service of Western Australia Perth Australia

Background: The introduction of pipeline embolisation device (PED) has improved the feasibility of endovascular treatment of intracranial aneurysms. The device allows for endoluminal reconstruction across the aneurysm neck but is permeable enough that flow is preserved across the pressure gradients into sidebranch arteries. In spite of higher rates of aneurysm occlusion, there is lack of data concerning medium to long-term clinical and imaging results. Methods: This study was a prospective single center analysis of complications, imaging results, and medium term clinical outcomes after PED treatment of intracranial aneurysms. We included cases over a 17-month period in a tertiary interventional neuroradiology center. We collected data on demographics, vascular risk factors, clinical presentation, angiographic results post treatment, angiographic follow-up and clinical follow-up. Results: Thirty-three patients were included, 25 females and 8 males, with mean age of 55 years;3 presented with acute subarachnoid hemorrhage and 30 for elective treatment. Thirty-seven aneurysms were treated: 35 Internal Carotid Artery (ICA), 1 basilar trunk fusiform, and 1 vertebral artery intradural dissecting aneurysms. No deaths have occurred. Five patients suffered transient neurological complications (15%). Overall aneurysm occlusion was demonstrated in 85% of patients at the end of one year. Discussion:?Overall, the technique of flow diversion and endoluminal reconstruction differs greatly from the established endosaccular packing techniques of standard coiling, balloon remodeling, or stent assisted coiling. Our midterm follow-up confirms that, the rates of clinically significant complications compare favorably with published data on stent assisted coiling, potentially making these devices a truly revolutionizing technique.

关键词： Cerebral Aneurysm Flow Diverting Stents Pipline Embolisation Device Endovascular Treatment

Relative Competitiveness of Nimblewill (Muhlenbergia schreberi) with Tall Fescues and Kentucky Bluegrass

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American Journal of Plant Sciences 2014年第26期5卷 3777-3787页

作者： Pedro V. D. Moraes Willian W. Witt timothy D. phillips Patricia Rossi Luis E. Panozzo Federal Technologic University of Paraná UTFPR Dois Vizinhos Brazil University of Kentucky Lexington USA Federal University of Pelotas Pelotas Brazil

Nimblewill (Muhlenbergia schreberi) is a warm-season perennial grass (weed) native to the United States and Canada with low palatability. This species is dominant in many horse pastures in which bluegrass (Poa pratensis) is the primary forage. Tall fescues infected with endophyte fungae gives tall fescue plants greater competitividade ability and enviromental stress tolerance than their noninfected counterparts. The purpose of this study was to compare the relative competitiveness of nimblewill with bluegrass and tall fescues (Lolium arundinaceum) with or without endophytic fungi (strain AR584) through experiments using a replacement series design. Replacement series experiments were conducted in pots to evaluate the growth of species in a pure stand and in a mix stand with variables rates. Species competitiveness was evaluated based on the relative yield and relative yield total (and competitiveness index) of the dry weight of shoots from species grown together. Nimblewill was found to be more competitive than bluegrass, and all tall fescues were more competitive than nimblewill. Our results demonstrated that the presence of endophytes in three different tall fescues did not alter the competitiveness of these fescues with nimblewill, but the tall fescue Kentucky 31 was more competitive between tall fescues. Based on our finding, we concluded that fescues are recommended, especially without the endophytic fungi to suppress nimblewill in implantation of pastures to horses.

关键词： Competition Pastures Weed Endophytic Fungi

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饲料中霉菌毒素的控制

饲料广角 2001年第21期 50-52页

作者：孙安权 H.C. Ng timothy D.phillips 奥格营养有限公司

世界上每年大约有25%的谷物遭受各种霉菌污染,因污染程度不同,造成不同地区损失差异较大.西方国家多对饲料中的黄曲霉毒素有规定,且丹麦不仅限制饲料中而且也检查肉品中的黄曲霉毒素.

关键词：饲料霉菌毒素霉菌脱霉素控制吸附剂

应用CRISP清单,提升我国全科医学和基本医疗研究报告的质量

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中国全科医学 2025年第4期28卷 393-401页

作者：杨辉汪洋陈庆奇刘晨曦顾杰赵洋秦江梅曹新阳 Elizabeth Sturgiss William R.phillips 许岩丽 Monash大学公共卫生与预防医学学院澳大利亚墨尔本市VIC 3168 上海市全科医学与社区卫生发展研究中心 200090 同济大学附属杨浦医院全科医学科上海市200090 香港大学家庭医学及基层医疗学系中国香港特别行政区999077 华中科技大学同济医学院医药卫生管理学院湖北省武汉市430000 复旦大学附属中山医院全科医学科上海市200032 复旦大学附属中山医院国际医疗部上海市200032 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010 国家卫生健康委卫生发展研究中心北京市100044 《中国全科医学》杂志社有限公司北京市100053 School of Primary and Allied Health Care Monash UniversityMelbourneVictoriaAustraliaVIC 3168 University of Washington SeattleWashington98195

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全... 详细信息

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全科医学和基本医疗研究的内涵和发展现状的基础上,归纳了该领域的科研报告中目前存在的主要问题,如“以作者为中心”“过度重视塑造权威性”“盲目生搬国际经验”“缺乏对方法学的透明报告”“在论文中压入大量冗繁信息”以及“遮蔽关键信息”等。最后,编辑团队推荐和鼓励中国的全科医学和基本医疗服务研究的作者、编辑和学术评议专家尝试使用CRISP清单,在改善中国全科医学和基本医疗研究报告质量的同时,进一步完善该工具在学科发展研究、临床研究、卫生服务研究、卫生政策研究、教育和培训研究以及社区流行病学研究等亚领域中的应用。

关键词：全科医学基本医疗研究报告内容共识

A humanized mouse model to study human immune response in xenotransplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 494-498页

作者： Peta phillips Center for Transplant and Renal Research Westmead Millennium InstituteWestmead HospitalWestmeadNSW Sydney 2145Australia

BACKGROUND: A major barrier to the clinical application of xenotransplantation as a treatment option for patients is T cell-mediated rejection. Studies based on experimental rodent models of xenograft tolerance or rejection in vivo have provided useful information about the role of T cell immune response in xenotransplantation. However not all observations seen in rodents faithfully recapitulate the human situation This study aimed to establish a humanized mouse model of xenotransplantation, which mimics xenograft rejection in the context of the human immune system. METHODS: NOD-SCID IL2rγ -/- mice were transplanted with neonatal porcine islet cell clusters (NICC) followed by reconstitution of human peripheral blood mononuclear cells (PBMC). Human leukocyte engraftment and islet xenograft rejection were confirmed by flow cytometric and histological analyses. RESULTS: In the absence of human PBMC, porcine NICC transplanted into NOD-SCID IL2rγ -/- mice revealed excellent graft integrity and endocrine function. Human PBMC demonstrated a high level of engraftment in NOD-SCID IL2rγ -/- mice. Reconstitution of NICC recipient NOD-SCID IL2rγ -/- mice with human PBMC led to the rapid destruction of NICC xenografts in a PBMC number-dependent manner. CONCLUSIONS: Human PBMC-reconstituted NOD-SCID IL2rγ -/- mice provide an ideal model to study human immune responses in xenotransplantation. Studies based on this humanized mouse model will provide insight for improving the outcomes of clinical xenotransplantation.

关键词： humanized mice xenotransplantation neonatal porcine islet cell cluster xenorejection tolerance

Experimental Phenomena of Improved Ohmic COnfinement Induced by Modulated Toroidal Current on the HT—7 Tokamak

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Chinese Physics Letters 2002年第10期19卷 1467-1469页

作者：毛剑珊 P.phillips 等 InstituteteofPlasmaPhysics ChineseAcademyofSciencesPOBOx1126Hefei230031 FusionResearchCenter C1510UniversityofTexasatAustinTx78712USA

The phenomena of improved ohmic confinement have been observed during the modulation of the toroidal current on the Hefei superconducting Tokamak-7 (HT-7). In the experiment, the programming ohmic heating field was modulated. A toroidal frequency-modulated current induced by modulated loop voltage was added on the plasma equilibrium current. The ratio of ac amplitude of the plasma current to the main plasma current is about 12-30%. These improved plasma confinement phenomena include the facts that the average electron density and the central electron temperature both increase, the Dα radiation from the edge is reduced, the magnetohydrodynamics is obviously suppressed by oscillating plasma current, and the global energy confinement time increases by 27-45%. It is found that the faster the modulation is, the more effective the improved ohmic confinement phase.

关键词： Modulation

Thermodynamics Properties of Mesoscopic Quantum Nanowire Devices

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Chinese Physics Letters 2007年第5期24卷 1339-1341页

作者： Attia A. AwadAlla Adel H. phillips Department of Physics Faculty of Science Beni-Suef University Beni-Suef Egypt Department of Physics and Department of Mathematics Faculty of Engineering Ain Shams University Egypt

We investigate the thermodynamics properties of mesoscopic quantum nanowire devices, such as the effect of electron-phonon relaxation time, Peltier coefficient, carrier concentration, frequency of this field, and channel width. The influence of time-varying fields on the transport through such device has been taken into consideration. This device is modelled as nanowires connecting to two reservoirs. The two-dimensional electron gas in a GaAs- AlGaAs heterojunction has a Fermi wave length which is a hundred times larger than that in a metal. The results show the oscillatory behaviour of dependence of the thermo power on frequency of the induced field. These results agree with the existing experiments and may be important for electronic nanodevices.

关键词： THERMOPOWER TRANSPORT