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Isolation, characterization and modulatory potentials of β-stigmasterol, ergosterol and xylopic acid from Anchomanes difformis on mitochondrial permeability transition pore in vitro

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Chinese Herbal Medicines 2023年第4期15卷 533-541页

作者： Kehinde oluseun Sodeinde Akinwunmi oluwaseun Adeoye Adedeji Adesipo Adebayo AAdeniyi John Adeolu Falode Tajudeen olabisi obafemi Samuel olalekan olusanya Linette Twigge Jeanet Conradie timothy o.mosaku Department of Chemistry Federal University Oye-EkitiEkiti State 371104Nigeria Biomembrane Toxicology and Drug Discovery UnitDepartment of BiochemistryFederal University Oye-EkitiEkiti State 371104Nigeria Department of Biochemistry Afe Babalola UniversityAdo-EkitiEkiti State 360001Nigeria Department of Chemistry University of Free StateBloemfontein 9301South Africa Department of Civil Engineering Covenant UniversityOgun State 112104Nigeria

objective: Secondary metabolites and polyphenolic compounds from medicinal plants have been demonstrated to have multiple biological functions with promising research and development prospects. This study examined the effect of β-stigmasterol(with ergosterol) and xylopic acid isolated from Anchomanes difformis on liver mitochondrial permeability transition pore(mPTP).Methods: The compounds were isolated by vacuum liquid chromatography. Mitochondrial swelling was assessed as changes in absorbance under succinate-energized ***:1H and13C NMR spectroscopic elucidation of the isolates affirmed the presence of β-stigmasterol with ergosterol(1:0.3) and xylopic acid. The isolates reversed the increase in lipid peroxidation and inhibited the opening of mitochondrial permeability transition pores caused by calcium and *** inhibition of m PTP offers a promising therapeutic target for the treatment of mitochondrial-associated ***: Reduction in the activity of calcium ATPase and the expression of Caspase-3 and-9 were observed, suggesting that they could play a role in protecting physicochemical properties of membrane bilayers from free radical-induced severe cellular damage and be useful in the management of diseases where much apoptosis occurs.

关键词： Anchomanes difformis(Blume)Engl ergosterol mitochondrial membrane modulation β-stigmasterol transition pore xylopic acid

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Prevalence, Pattern and Factors Associated with Psychiatric Disorders among Persons Arrested for Violent Crimes in Ife/Modakeke Area, Southwestern Nigeria

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Journal of Behavioral and Brain Science 2014年第12期4卷 535-543页

作者： Musiliu Adejare Lawal Samuel Kolawole mosaku Bolanle Adeyemi ola olufemi Morakinyo Department of Psychiatry Federal Medical Centre Ido-Ekiti Ekiti State Nigeria Department of Mental Health College of Health Sciences Obafemi Awolowo University Ile-Ife Nigeria Department of Behavioural Medicine Faculty of Clinical Sciences Lagos State University College of Medicine Lagos Nigeria

Background: Association between violence and mental disorders has contributed immensely to the stigma associated with mental illness in the society;because people erroneously see mentally ill individuals as dangerous, they will not want to associate with them. Aims: To assess the prevalence and pattern of psychiatric disorders among a sample of the violent offenders and to examine any relationship between psychiatric disorders and crimes. Method: This was a two-phase cross-sectional study in three police stations in Ile-Ife/Modakeke area of Nigeria. In the first phase, we screened 400 consecutive adults arrested for violent crimes using the General Health Questionnaire—30. In the second phase, all 36 persons with probable psychopathology were then interviewed with the Present State Examination to make a definitive diagnosis. Results: The mean age of all the subjects was 29.9 years (SD ± 7.3). The male to female ratio was 11:1. Respondents were mostly single (54%);most had secondary education or less (82%) and about 60% were currently using psychoactive substances (drugs). About 8.5% of all the subjects had a diagnosable psychiatric disorder;paranoid schizophrenia was the commonest psychiatric disorder (41.2%). Mentally ill subjects were three times more likely to commit homicidal offence than non-mentally ill subjects. Conclusion: There exists a significant but weak relationship between mental illness and violent crimes.

关键词： Prevalence Psychiatric Violent Crimes Nigeria

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