检索结果-南通市图书馆

Effect of thinning intensity on the stem CO_(2) efflux of Larix principis-rupprechtii Mayr

Forest Ecosystems 2021年第4期8卷 841-855页

作者： Kuangji Zhao timothy j.fahey Xiangzhen Wang jie Wang Fang He Chuan Fan Zhongkui jia Xianwei Li Sichuan Province Key Laboratory of Ecological Forestry Engineering on the Upper Reaches of the Yangtze River College of ForestrySichuan Agricultural University611130 ChengduChina Key Laboratory for Silviculture and Conservation of the Ministry of Education College of ForestryBeijing Forestry University100083 BeijingChina Department of Natural Resources Cornell University14853 New YorkUSA

Background:Stem CO_(2) efflux(E_(S))plays a critical role in the carbon budget of forest *** is a core practice for sustainable management of *** is therefore necessary and urgent to study the effect and mechanism of thinning intensity(TI)on E_(S).Methods:In this study,five TIs were applied in Larix principis-rupprechtii Mayr 21-,25-,and 41-year-old stands in North China in *** infrared gas analyzer(Li-8100 A)was used to measure ES and its association with environmental factors at monthly intervals from May to October in 2013 to *** addition,nutrients,wood structure and nonstructural carbon(NSC)data were measured in August ***:The results show that ES increased with increasing *** maximum ES values occurred at a TI of 35%(3.29,4.57 and 2.98μmol·m^(-2)·s^(-1))and were 1.54-,1.94-and 2.89-fold greater than the minimum E_(S) value in the CK stands(2.14,2.35 and 1.03μmol·m^(-2)·s^(-1))in july for the 21-,25-and 41-year-old forests,*** E_(S) of the trees in low-density stands was more sensitive to temperature than that of the trees in high-density *** sugars(SS)and temperature are the main factors affecting *** the stand density is low enough as 41-year-old ***-rupprechtii forests with TI 35%,bark thickness(BT)and humidity should be considered in addition to air temperature(T_(a)),wood temperature(T_(w)),sapwood width(SW),nitrogen concentration(N)and SS in the evaluation of *** a change in stand density is ignored,the CO_(2) released from individual 21-,25-and 41-year-old trees could be underestimated by 168.89%,101.94% and 200.49%,***_(2) release was estimated based on the stem equation in combination with the factors influencing ES for ***:We suggest that it is not sufficient to conventional models which quantify ES only by temperature and that incorporating the associated drivers(***,SS,SW and N)based on stand density into conventional model

关键词： Stem CO_(2)efflux Thinning intensity Environmental factors Nutrient content Wood structure Nonstructural carbon Larix principis-rupprechtii

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多米尼加共和国高海拔新热带山地森林的林火与植被动态

引用

AMBIO－人类环境杂志 2008年第7期37卷 466-471页

作者： Ruth E.Sherman Patrick H.Martin timothy j.fahey Steve D. Degloria 梁虹康奈尔大学自然资源系康奈尔大学作物栽培与土壤学系

2005年3～4月,多米尼加共和国中央山脉幅员1000 km^2的热带山地森林曾发生严重火灾。林火范围涵盖了我们在1999年建立的永久植被样地网络,这一网络设立的目的是检测森林环境、植被与干扰的相互作用。我们采用快鸟(QuickBird)卫星影像和... 详细信息

2005年3～4月,多米尼加共和国中央山脉幅员1000 km^2的热带山地森林曾发生严重火灾。林火范围涵盖了我们在1999年建立的永久植被样地网络,这一网络设立的目的是检测森林环境、植被与干扰的相互作用。我们采用快鸟(QuickBird)卫星影像和野外调查绘制了景观区域内的林火程度和等级图示。96%的松林发生火灾,但在沿大部分群落交错区边界的松林-云林中被迅速扑灭。地形因素和林火等级对群落交错区的林火特征无显著影响。该结果验证了我们之前的假设,即林火是构成这一山区松林和云林之间不连续边界的主要因素。植被结构和组成对景观内林火特征与蔓延的调节具有直接作用。

关键词：林火特征植被动态山地森林多米尼加共和国热带高海拔不连续边界

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Shifts in the Holstein dairy cow milk fat globule membrane proteome that occur during the first week of lactation are affected by parity

引用

journal of Animal Science and Biotechnology 2021年第2期12卷 534-548页

作者： Mallory C.Honan Megan j.fahey Amanda j.Fischer-Tlustos Michael A.Steele Sabrina L.Greenwood Department of Animal and Veterinary Sciences The University of VermontBurlingtonVT 05405USA Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada Department of Agriculture Food&Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2P5Canada

Background:The milk fat globule membrane(MFGM)proteomes of colostrum and transition milk are rich sources of proteins that are likely important for neonatal calf *** addition,characterization of these proteomes could also yield valuable information regarding mammary gland physiology of the early postpartum lactating *** objectives of this research were to characterize the MFGM proteomes of colostrum and transition milk through sample collections at four timepoints postpartum,including the first milking(M1,colostrum),second milking(M2,transition milk),fourth milking(M4,transition milk),and fourteenth milking(M14,mature milk),and compare these proteomes between multiparous(MP;n=10)and primiparous(PP;n=10)Holstein dairy *** MFGM proteins were labeled using Tandem Mass tagging and analyzed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).Protein identification was completed using MASCOT and Sequest in Proteome Discoverer *** scaled abundance values were analyzed using PROC MIXED in SAS to determine the effects of milking(MIL),parity(PAR),and MIL×*** adaptive false-discovery rate(FDR)-adjusted P values were determined using PROC *** characterization and bioinformatic analysis were completed using a combination of PANTHER,Blast,and ***:A total of 104 common proteins were identified in each of the MFGM *** analysis revealed that 70.2%of identified proteins were affected by *** these,78.1%were lower in M14 compared with M1,including immune-related proteins lactotransferrin,lactadherin and *** affected 44.2%of *** the proteins affected by PAR,84.8%were higher in MP cows compared with PP cows,including apolipoprotein E and histones 2A,2B,3,and 4 *** subfamily 1 member 1A and annexin 5 were higher in samples from PP ***×parity affected 32.7%of identified proteins,including lactotransferrin,gelsolin,vitamin D binding protein,and S100 ***

关键词： Colostrum LC-MS/MS Parity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Can inhibition of telomerase increase pancreatic cancer cell's susceptibility to chemotherapeutic reagents?

引用

Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 155-160页

作者： Thomas j.Ⅲ fahey Department of Surgery Cornell University Medical College New York NY USA

Objectives: To clarify the inhibition of pancreatic can-cer cells by interference with the hTR component of thetelomerase reverse transcriptase enzymatic complexand evaluate susceptibility of antisense hTR pancreaticcancer cells to chemotherapeutic ***: A 593 bp of full length hTR cDNA was sub-cloned into a mammalian expression vector pcDNA3.1(-) in antisense orientation to construct an antisensehTR expression plasmid. The plasmids were introducedinto Pancl cells, a human pancreatic carcinoma cellline, by lipofectin, and G418-resistant stable trans-formants were expanded. Resulting stable clones werescreened for the presence of hTR insert by PCR withT7 and BGH reverse primers located on the flanks ofthe multiclonal site of pcDNA3.1 vector. Cell growth rate,hTR expression, telomerase activity, and anchorage-in-dependent growth property were analyzed. Finally, sus-ceptibility of antisense hTR cells to chemotherapeuticreagents was ***: Significant downregulation of endogenous hTRwas evident in the antisense-hTR transformed cells,and telomerase activity was markedly decreased com-pared to control cells in standard TRAP assays. Fur-thermore, the proliferation and the anchorage-inde-pendent growth ability in antisense-hTR expressingcells were significantly decreased compared with thecontrol parental cells. However, no crisis or senescencephenomena was observed. Antisense hTR appears toincrease Pancl cell's susceptibility to chemotherapeuticreagent cDDP, but not to differentiation reagent DM-SO, COX2 inhibitor sulinbac, NS-398, curcumin, andchemotherapeutic reagent adriamycin(ADM).Conclusions: These data indicate that hTR is probablya critical component of human telomerase activity andthat downregulation of the RNA component of humantelomerase is an effective target for anticancer strategyand antisense hTR can increase Pancl cell's susceptibilityto cDDP.

关键词： Telomerase hTR Antisense Pancreatic carcinoma cellline chemotherapeutic reagents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of

引用

Chinese journal of Cancer Research 2018年第1期30卷 72-83页

作者： Barry H.Smith Lawrence S.Gazda Thomas j.fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson j.Ocean Richard D.Hall David j.Wolf The Rogosin Institute New York NY 10021 USA The Rogosin Institute-Xenia Division Xenia OH 45385 USA New York Presbyterian-Weill Cornell Medical Center New York NY 10021 USA Bob Evans Farms Inc. New Albany OH 43054 USA

Objective： The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival（OS） responses, to the use of one such system, implantable macrobeads [RENCA macrobeads（RMBs）], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer（m CRC） are described ***： Forty-eight m CRC patients（30 females; 18 males）, who had failed all available, approved treatments,underwent RMB implantation（8 RMB/kg body weight） up to 4 times in phase I and phase IIa open-label ***, labs [tumor and inflammation markers, lactate dehydrogenase（LDH）] and positron emission tomography-computed tomography（PET-CT） imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy（as defined by biological responses）. PET-CT maximum standard uptake value（SUVmax）（baseline and d 90; SUVmax ≥2.5）, LDH,and carcinoembryonic antigen（CEA） and/or cancer antigen 19-9（CA 19-9） response（baseline, d 30 and/or d 60）were assessed and compared to ***： Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose（FDG）-positive lesions（phase I, 39; 2 a, 82） were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV（10） plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders（R）（d 0–60, 290.4–333.9）, but increased steadily in Non-responders（NR）（d 0–60, 382.8–1,278.5）（d 60, P=0.050）. Responders to RMBs, indicated by the changes in the above markers, correlated with OS（R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006）.Conclusions： The correlations of the tumor marker, tumor volume

关键词： Clinical trial systems-biology RENCA macrobeads metastatic colorectal cancer colon cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Different dose radioiodine therapy for low-/intermediate risk on follicular variant papillary thyroid carcinoma

Different dose radioiodine therapy for low-/intermediate ris...

引用

中国中西医结合学会医学影像专业委员会第十七次全国学术大...

作者：李玮 Rasa Zarnegar Eric Mirallie Laurent Brunaud jian TAN Thomas j.fahey Tianjin Medical University General Hospital New York Presbyterian Hospital–Weill Cornell Medicine Clinique de Chirurgie Digestive et Endocrinienne Endocrinienne et Cancérologique Unité Multidisciplinaire de la Chirurgie de L’obésité (UMCO)

Follicular variant papillary thyroid carcinoma(FVPTC) is included in the class of differentiated thyroid cancer and is currently treated as classical variant papillary thyroid carcinoma(cPTC). However, FVPTC has unique tumour features and can behave differently than cP TC. The aim of this study was to investigate whether a low-dose of radioiodine is as effective as a high-dose for remnant ablation on FVPTC patients after total thyroidectomy and to postoperatively judge the recurrence of low-intermediate risk FVPTC. Methods: All data from cPTC and FVPTC patients treated with I-131 at three high-volume centres in China, the United States and France from 2004～2014 were reviewed. The demographic, tumour behaviour, lymph node metastasis, local recurrence and patient survival data were compared between FVPTC and cPTC patients. Then, low-intermediate risk FVPTC patients were divided into three groups: low [3700 MBq(100 mCi)];the postoperative I-131 activities were analysed to evaluate the effectiveness of I-131 therapy for thyroid remnant ablation. Results: A total of 799 surgical cases of FVPTC and cPTC treated with I-131 were identified, including 631 cases of cPTCs and 168 FVPTCs. FVPTC has a larger primary nodule size than cPTC(p <0.05). Lymph node metastases and local recurrence were more prevalent in the cPTC cases than in the FVPTC cases(p<0.01). Then, 139 low-intermediate risk FVPTC patients were divided into 3 groups based on their I-131 dose. For the low-, intermediate-and high-dose groups, the success rates of the ablation were 82.0%, 80% and 81.3%, respectively. The ablation results did not differ significantly between the three groups(p = 0.912). Conclusion: FVPTC has unique tumour features and behaviours. Low-dose ablation may be sufficient in FVPTC patients with low-intermediate risk disease.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective

引用

World journal of Gastrointestinal Oncology 2017年第9期9卷 341-353页

作者： Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas j.faheyⅢ Department of Surgery New York Presbyterian HospitalWeill Cornell MedicineNew YorkNY 10065United States

Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets.

关键词： Epigenetics Carcinoid Neuroendocrine MicroRNA Methylation Histone modifications Chromatin remodeling LncRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stable expression of antisense hTR inhibits in vitro pancreatic cancer cell growth

引用

Chinese Medical journal 2002年第8期115卷 1196-1200,152页

作者：滕理送陈石妹 Thomas j.fahey Ⅲ 浙江大学医学院附属第一医院杭州310003 CornellUniversityMedicalCollege

OBjECTIVE: To clarify growth inhibition in pancreatic cancer cells by interference with the hTR component of the telomerase reverse transcriptase enzymatic complex. METHODS: A 593 bp full length hTR cDNA was subcloned into a mammalian expression vector pcDNA3.1(-) in the antisense orientation to construct an antisense hTR expression plasmid. These were introduced into panc1 cells, a human pancreatic carcinoma cell line, by lipofectin and G418-resistant stable transformants were expanded. Resulting stable clones were screened for the presence of the hTR insert by PCR with T7 and BGH reverse primers located on the flanks of the multiclonal site of the pcDNA3.1 vector. Cell growth rate, hTR expression, telomerase activity and anchorage-independent growth properties were analyzed. RESULTS: Significant downregulation of endogenous hTR was evident in the antisense-hTR transformed cells and telomerase activity was markedly decreased compared to control cells in standard TRAP assays. Furthermore, cell proliferation and the anchorage-independent growth ability in antisense-hTR expressing cells were significantly decreased compared with control parental cells. However, no crisis or senescence phenomena were observed. CONCLUSIONS: These data indicate that hTR may be a critical component of human telomerase activity and suggest that downregulation of the RNA component of human telomerase is a possible target for anticancer strategies.

关键词： DNA-Binding Proteins Humans Pancreatic Neoplasms RNA, Antisense Reverse Transcriptase Polymerase Chain Reaction Telomerase Tumor Cells, Cultured

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《分析地球化学》

引用

地球与环境 1973年第1期 33-33页

作者： joseph j.fahey ,徐仲伦

本书共十章,开始是地球化学绪论。在以下的章节论述了岩石和矿物的常量元素和微少量元素的定性、定量分析、发射光谱法、火焰光度法、X射线光厝法、X射线绕射法、萤光法以及色层法。有九页是参考文献和一个非常全面的索引。

关键词：地球化学岩石地球科学砷黄铁矿毒砂红砷镍矿红镍矿硫化矿物辉铜矿铜矿物矿物碳酸盐碳化合物

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

儿科PET/CT的操作和剂量学

引用

中华核医学与分子影像杂志 2019年第5期39卷 314-320页

作者：王宽垠(译) 刘振(译) 兰晓莉(审校) Frederic H. fahey Alison Goodkind Robert D. MacDougall Leah Oberg Sonja I.Ziniel Richard Cappock Michael j. Callahan Neha Kwatra S. Ted Treves Stephan D. Voss 华中科技大学同济医学院附属协和医院核医学科武汉430022 Division of Nuclear Medicine and Molecular Imaging Department of Radiology Boston Children′s Hospital Boston Massachusetts Department of Radiology Harvard Medical School Boston Massachusetts Section of Pediatric Hospital Medicine Department of Pediatrics University of Colorado School of Medicine and Children′s Hospital Colorado Aurora Colorado Department of Radiology Brigham and Women′s Hospital Boston Massachusetts

在儿科PET/CT诊疗领域,迄今还没有统一的CT扫描方法的指南。考虑到儿童更易受电离辐射的影响,在最短时间内和最小暴露剂量条件下提供具有诊断质量的图像十分必要。该文描述了CT辐射剂量测定以及儿童PET/CT采集的基本要点。根据对北美19... 详细信息

在儿科PET/CT诊疗领域,迄今还没有统一的CT扫描方法的指南。考虑到儿童更易受电离辐射的影响,在最短时间内和最小暴露剂量条件下提供具有诊断质量的图像十分必要。该文描述了CT辐射剂量测定以及儿童PET/CT采集的基本要点。根据对北美19所儿科PET/CT机构的调查,描述了儿科PET/CT技术的多样性。调查结果表明,尽管大多数机构采用自动管电流调制,但在实际应用中各机构间仍存在2~3倍的差异,这说明需要统一的指南。该文介绍了作者所在机构研发的多序列PET/CT采集技术,此技术可以兼顾在重要部位视野内获得有诊断质量的CT图像,以及在其余部位应用低辐射技术进行显像。这种方法使患者所受辐射剂量减少,同时将PET和具有诊断质量的CT集成在单次采集中。儿科PET/CT的标准化在保证适中水平的图像质量的同时,为患者提供了减少辐射剂量的机会。

关键词：儿科辐射剂量测定 PET/CT 计算机体层摄影术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：