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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. k. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson timothy Butler Mathijs A. Sanders Nicholas Williams Tim H. H. Coorens Jon Teague keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter J. Campbell Foad J. Rouhani & Huw Naylor Sarah J. Aitken & Matthew Hoare Sarah J. Aitken & Susan e. Davies Sarah J. Aitken Ming Yang efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUk Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NeAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NeAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDeB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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e^(p/q)是无理数的一个简单证明

数学译林 2022年第2期41卷 188-189页

作者： Thomas Beatty timothy W.Jones 陆柱家(译) 陆昱(校) 不详

利用中值定理的一个简单应用,我们证明了e的有理数幂是无理数.

关键词：中值定理无理数有理数简单应用

Plant Biosystems Design Research Roadmap 1.0

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BioDesign Research 2020年第1期2020卷 53-90页

作者： Xiaohan Yang June I.Medford kasey Markel Patrick M.Shih Henrique C.De Paoli Cong T.Trinh Alistair J.McCormick Raphael Ployet Steven G.Hussey Alexander A.Myburg Poul erik Jensen Md Mahmudul Hassan Jin Zhang Wellington Muchero Udaya C.kalluri Hengfu Yin Renying Zhuo Paul e.Abraham Jin-Gui Chen David J.Weston Yinong Yang Degao Liu Yi Li Jessy Labbe Bing Yang Jun Hyung Lee Robert W.Cottingham Stanton Martin Mengzhu Lu timothy J.Tschaplinski Guoliang Yuan Haiwei Lu Priya Ranjan Julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Biology Colorado State UniversityFort CollinsCO 80523USA Department of Plant Biology University of CaliforniaDavisDavisCAUSA Feedstocks Division Joint BioEnergy InstituteEmeryvilleCAUSA Department of Biodesign Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular engineering University of TennesseeKnoxvilleTN 37996USA SynthSys and Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK Department of Biochemistry Genetics and MicrobiologyForestry and Agricultural Biotechnology Institute(FABI)University of PretoriaPretoria 0002South Africa Department of Food Science University of CopenhagenRolighedsvej 26DK-1858FrederiksbergCopenhagenDenmark State key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiang 311300China State key Laboratory of Tree Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China Department of Plant Pathology and environmental Microbiology and the Huck Institute of the Life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomics and Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Plant Science and Landscape Architecture University of ConnecticutStorrsCT 06269USA Division of Plant Sciences Bond Life Sciences CenterUniversity of MissouriColumbiaMOUSA Donald Danforth Plant Science Center St.LouisMOUSA environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Human life intimately depends on plants for food,biomaterials,health,energy,and a sustainable *** plants have been genetically improved mostly through breeding,along with limited modification via genetic engineering,yet they are still not able to meet the ever-increasing needs,in terms of both quantity and quality,resulting from the rapid increase in world population and expected standards of living.A step change that may address these challenges would be to expand the potential of plants using biosystems design *** represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological *** biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant *** this perspective,we present a comprehensive roadmap of plant biosystems design covering theories,principles,and technical methods,along with potential applications in basic and applied plant biology *** highlight current challenges,future opportunities,and research priorities,along with a framework for international collaboration,towards rapid advancement of this emerging interdisciplinary area of ***,we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception,trust,and acceptance.

关键词： Plant utilizing breeding

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滑车上神经解剖：对偏头痛手术治疗的意义

中国美容整形外科杂志 2015年第2期26卷 I0020-I0020页

作者： Jeffrey e. Janis Daniel A. Hatef Robert Hagan timothy Schaub Jerome H. Liu Hema Thakar kelly M. Bolden Justin B. Heller T. Jonathan kurkjian 叶美辰高景恒张晨袁继龙德克萨斯大学西南医学中心整形外科美国德克萨斯州达拉斯贝勒医学院整形外科美国德克萨斯州休斯顿亚利桑那州斯科茨代尔马里兰州巴尔的摩加利福尼亚州洛杉矶私人诊所美国密苏里州圣路易斯俄勒冈健康与科学大学整形外科俄勒冈州波特兰加利福尼亚皮肤研究所美国加利福尼亚州山景《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景偏头痛主要是由于头、颈部的肌肉、筋膜和血管处的外周神经受压迫和刺激引起的。许多患者的偏头痛症状常出现在前额，可能是因为皱眉肌的滑车上神经受到压迫。为了确定其关系，对其进行解剖研究。方法对25例新鲜尸头的眉部区域进行... 详细信息

背景偏头痛主要是由于头、颈部的肌肉、筋膜和血管处的外周神经受压迫和刺激引起的。许多患者的偏头痛症状常出现在前额，可能是因为皱眉肌的滑车上神经受到压迫。为了确定其关系，对其进行解剖研究。方法对25例新鲜尸头的眉部区域进行解剖。识别面部两侧的皱眉肌，探讨其与滑车上神经的关系。结果面部两侧均有滑车上神经。本研究发现3个可能发生压迫的位点：神经通过额切迹或额孔进入眉部处，神经进入皱眉肌处，从皱眉肌穿出处。在眼轮匝肌脂肪垫后分成2个分支，这2个分支与皱眉肌有4种解剖关系：2支均进入肌肉中；1支进入肌肉中，1支仍向深部穿行；2支均向深部穿行；分支仍继续分出细小的分支，不能找到其具体的解剖位置。结论一些患者接受眶上神经减压术，但没有效果。这些患者可能是滑车上神经受到压迫。一般在中线1．8cm内的标准的皱眉肌切除术是对手术有利的。必要时，需检测额切迹或额孔的形态。

关键词：滑车上神经神经解剖手术治疗偏头痛皱眉肌神经减压术外周神经头痛症状

Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris *** for Artemisia annua *** Western Uganda

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TMR Integrative Medicine 2023年第4期7卷 1-13页

作者： Ivan kahwa Clement Olusoji Ajayi Reenu Yadav Nagendra Singh Chauhan kamal Shah Abdelgadir Alamin Abdelgadir efrata Ashuro Shegena Salome Daniel timothy Omara John Baptist Asiimwe Hilda Ikiriza Shabnoor Iqbal Casim Umba Tolo Anke Weisheit Patrick engeu Ogwang Pharm-BioTechnology and Traditional Medicine Centre Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy Faculty of MedicineMbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy IES UniversityBhopal-462044Madhya PradeshIndia Drugs Testing Laboratory Avam Anusandhan kendra Raipur(CG)492010India Institute of Pharmaceutical Research GLA UniversityMathuraUttar Pradesh 281406India Department of Pharmacognosy Faculty of PharmacyUniversity of GeziraP.O Box 20Wad MadaniSudan Department of Pharmaceutics and Pharmacy Practice Kampala International UniversityP.O.Box 9790Dares SalaamTanzania Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Konrad-Lorenz-Straße 243430Tulln an der DonauAustria Aga khan University P.O.Box 8842KampalaUganda Department of Biology Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Zoology Government College UniversityFaisalabadPunjab 38000Pakistan

Background:Different parts of Artemisia vulgaris L.(***)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and ***,anecdotal evidence shows that the plant is often substituted for Artemisia annua L.(***)by herbalists in Western Uganda due to similarities in their *** of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine *** safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly ***:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of *** leaves compared to *** to ease its correct ***:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf *** leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for *** and dark green for ***)can be used by the local community to distinguish between *** artemisinin content was higher in *** leaves(1.72%)than in ***(1.43%),but the reverse was observed for the total flavonoid ***:This observation could justify the change in the use of *** by the indigenous community in western *** studies should consider the pharmacognostic comparison of *** with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

关键词： Artemisinin traditional medicine misidentification microscopic studies

身高、体质指数和社会经济地位之关系：对英国生物样本库的孟德尔随机化研究

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英国医学杂志中文版 2016年第7期19卷 363-363页

作者： Jessica Tyrrell Samuel e Jones Robin Beaumont Christina M Astley Rebecca Lovell Hanieh Yaghootkar Marcus Tuke katherine S Ruth Rachel M Freathy Joel N Hirschhorn Andrew R Wood Anna Murray Michael N Weedon timothy M Frayling 莫云凌邓晓春不详解放军空军航空医学研究所附属医院内四科

目的确定身高、体质指数（BMI）与社会经济状况的5个方面是否存在因果关系。方法孟德尔随机化研究测试身高、BMI与社会经济状况之间的因果关系有何不同。孟德尔随机化方法运用基因型随机分配理论，这样不会受到非基因混杂因素的干扰。

关键词：体质指数社会经济地位英国生物样本库

人乳头瘤病毒衣壳蛋白C末端结构臂具有免疫原性并参与病毒—宿主细胞的相互作用

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科学新闻 2017年第4期 179-179页

作者： Zhihai Li Xiaodong Yan Hai Yu Daning Wang Shuo Song Yunbing Li Maozhou He Qiyang Hong Qingbing Zheng Qinjian Zhao Ying Gu Jun Zhang Mandy e.W.Janssen Giovanni Cardone Norman H.Olson timothy S.Baker 李少伟 Ningshao Xia 厦门大学生命科学学院

文章简介宫颈癌是全球女性第二大常见恶性肿瘤,人乳头瘤病毒(HPV)是导致女性宫颈癌发生的主要原因。HPV型别众多,主要的高危型型别种类多达15种,且型别间免疫血清交叉保护能力极低,目前国际上已上市的预防性多价HPV疫苗均不能为接种者... 详细信息

文章简介宫颈癌是全球女性第二大常见恶性肿瘤,人乳头瘤病毒(HPV)是导致女性宫颈癌发生的主要原因。HPV型别众多,主要的高危型型别种类多达15种,且型别间免疫血清交叉保护能力极低,目前国际上已上市的预防性多价HPV疫苗均不能为接种者提供完全保护。长期以来,高分辨率HPV的病毒结构信息的缺乏限制了对HPV病毒的组装模式和感染机制的深入理解,进

关键词： HPV 宿主细胞宫颈癌型别低温电镜

Appoptosin介导的caspase对tau蛋白的剪切在进行性核上性麻痹致病过程中的作用机制

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科学新闻 2016年第1期 75-75页

作者： Yingjun Zhao I-Chu Tseng Charles J.Heyser edward Rockenstein Michael Mante Anthony Adame Qiuyang Zheng timothy Huang Xin Wang Pharhad e.Arslan Paramita Chakrabarty Chengbiao Wu Guojun Bu William C.Mobley Yun-wu Zhang Peter St.George-Hyslop eliezer Masliah Paul Fraser 许华曦厦门大学神经科学研究所

文章简介进行性核上性麻痹(Progressive Supranuclear Palsy,PSP)是一种以Tau蛋白异常聚集和缠结为特征的运动障碍疾病。迄今为止人们对该疾病的致病机制知之甚少。之前的研究发现单核苷酸突变(SNP)(rs1768208 C/T)是PSP发病的高风险因... 详细信息

文章简介进行性核上性麻痹(Progressive Supranuclear Palsy,PSP)是一种以Tau蛋白异常聚集和缠结为特征的运动障碍疾病。迄今为止人们对该疾病的致病机制知之甚少。之前的研究发现单核苷酸突变(SNP)(rs1768208 C/T)是PSP发病的高风险因子。本研究通过对正常人和PSP患者的大脑样品进行检测,发现rs1768208 C/T中高的T等位基因频率与促凋亡蛋白appoptosin水平增高相关联,而appoptosin水平的增高与caspase-3的激活及caspase对tau蛋白的剪切相关。

关键词：蛋白 tau 介导 caspase Appoptosin

Abstracts from the 15th International Myopia Conference

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eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel kathleen Abarr Luying Yan keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying kuo Ching-Hsiu ke I-Hsin kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide kurihara kazuno Negishi klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William k. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian king-kit Li Quan Liu Chi-ho To timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho eileen Phan Abraham Hang emily eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State key Laboratory Cultivation Base and key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated