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A new method for quantifying mitochondrial axonal transport

Protein & Cell 2016年第11期7卷 804-819页

作者： Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang Sheng Lu Shengyu Yao timothy zhou Jianghong Liu Li Zhu Sidan Du Jane Y. Wu University of Chinese Academy of Sciences Beijing 100049 China School of Electronic Science & Engineering Nanjing University Nanjing 210093 China State Key Laboratory for Brain & Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

Axonal transport of mitochondria is critical for neuronal survival and function. Automatically quantifying and analyzing mitochondrial movement in a large quantity remain challenging. Here, we report an efficient method for imaging and quantifying axonal mitochondrial trans- port using microfluidic-chamber-cultured neurons together with a newly developed analysis package named ＂MitoQuant＂. This tool-kit consists of an automated program for tracking mitochondrial movement inside live neuronal axons and a transient-velocity analysis program for analyzing dynamic movement patterns of mitochondria. Using this method, we examined axonal mitochondrial movement both in cultured mammalian neurons and in motor neuron axons of Drosophila in vivo. In 3 different paradigms （temperature changes, drug treatment and genetic manipulation） that affect mitochondria, we have shown that this new method is highly efficient and sensitive for detecting changes in mitochondrial movement. The method significantly enhanced our ability to quantitatively analyze axonal mitochondrial movement and allowed us to detect dynamic changes in axonal mltochondrial transport that were not detected by traditional kymographic analyses.

关键词： mitochondrial transport image processing and analysis FUS proteinopathy and mitochondrial transport defect

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Green innovation unleashed: Harnessing tungsten-based nanomaterials for catalyzing solar-driven carbon dioxide conversion

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Chinese Chemical Letters 2025年第2期36卷 136-145页

作者： Weidan Meng Yanbo zhou Yi zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and Technology National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery East China University of Science and Technology Shanghai Institute of Pollution Control and Ecological Security Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization East China University of Science and Technology

Carbon dioxide photocatalytic reduction (CO2-PR) is an efficient method for controlling CO2emissions and generating cleaner energy while mitigating global warming. Tungsten oxides (WxOy) have attracted considerable attention for CO2-PR due to their excellent spectral absorbance. However, comprehensive reviews are lacking on the use of WxOyfor CO2-PR. Therefore, this review provides a detailed summary of t research progress made with WxOy-based catalysts in CO2-PR. It also explains the fundamental principles of CO2-PR and evaluates key performance indicators that affect the activity of WxOy-based photocatalysts,including yield, selectivity, stability, and apparent quantum yield. Additionally, this review explores opportunities for synthesizing high-performance WxOy-based photocatalysts and highlights their potential for the green preparation of C1/C2 products through CO2-PR. These innovative strategies aim to address the challenges and pressures associated with energy and environmental issues, particularly by enhancing artificial photosynthesis efficiency.

关键词： Carbon dioxide photoreduction Mechanism Performance evaluation Selectivity Tungsten-based nanocatalyst

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Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 279-281页

作者： Yan zhou Guanghui Wen Jialing zhou Tao Yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

关键词： Time varying control systems

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Phenyl-extended resorcin[4]arene opens up a new avenue for highly efficient iodine adsorption

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Science China Chemistry 2025年第2期68卷 405-406页

作者： Jingyu Chen Jiong zhou Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China

Macrocyclic arenes have become an important tool in supramolecular chemistry due to their special structure,easy functionalization and prominent host–guest *** design and synthesis of macrocyclic arenes with novel structures and excellent performances have been the focus of research in the field of supramolecular chemistry,including calixarenes,pillararenes,biphenarenes,and hybridarenes[1].These macrocyclic arenes have demonstrated significant potential and value in diverse research fields,such as crystal engineering,adsorption and separation,sensing and detection,as well as drug delivery[2].

关键词： properties adsorption iodine

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Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第1期68卷 96-117页

作者： Jianhong Liu Qiang zhou Yuxiao Lin Xinsheng Zhao Guangmin zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs).The active electrode is one of the most important parts of SC,which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature *** with the SC electrodes aimed for room-temperature application,the SC electrodes for operating at wide-temperature scene often face greater *** this review,the main challenges of SC electrodes under various temperature conditions,including low,high and cross-fade temperatures,are *** relevant performance decay and failure mechanisms of wide-temperature SC electrodes are *** addition,this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active ***,the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词： supercapacitor wide-temperature electrode design active materials

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Identifiability and sloppiness of structured systems with a matrix fraction description using finite frequency responses

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Science China(Information Sciences) 2025年第2期68卷 200-215页

作者： Yunxiang MA Tong zhou Department of Automation Tsinghua University Department of Automation and BNRist Tsinghua University

This paper investigates the identifiability of structured systems with a matrix fraction description and attacks practical difficulties in estimating parameters under finite frequency responses. The numerator and denominator polynomial matrices depend affinely on system parameters, which can represent a broad range of systems, especially circuits and mechanical systems. Except for assuming that the denominator matrix is invertible, no further assumptions are adopted. A criterion is provided for validating this assumption utilizing graph theories and matroids. A sufficient and necessary criterion for global identifiability based on the rank of a numerical matrix is given and can be recursively verified with each frequency point,which is computationally attractive for large-scale systems. For an identifiable system, an ellipsoid approximation is obtained for the set of parameters whose corresponding system frequency responses deviate within a specific range from those of the system at a specific parameter value. Using this approximation, explicit expressions for absolute and relative sloppiness have been derived, which can be used to quantify the difficulty of identifying system parameters. Comparisons with the well-known Fisher information matrix have also been performed through a mechanical system, revealing significant differences in quantifying parameter estimation hardness.

关键词： identifiability sloppiness structured system matrix fraction graph theory matroid

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Construction of eco-friendly dual carbon dots ratiometric fluorescence probe for highly selective and efficient sensing mercury ion

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Journal of Environmental Sciences 2025年第2期148卷 1-12页

作者： Yongli Liu Xiaoyan Su Huanjia Liu Guifen Zhu Guobei Ge Yuxin Wang Penghui zhou Qingxiang zhou School of Environment Henan Key Laboratory for Environmental Pollution ControlKey Laboratory for Yellow River and Huai River Water Environmental and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiang 453007China College of Chemical Engineering and Environment China University of Petroleum-BeijingBeijing 102249China

In present work,blue carbon dots(b-CDs)were derived from ammonium citrate and guanidine hydrochloride,and red carbon dots(r-CDs)were stemmed from malonate,ethylenediamine and meso-tetra(4-carboxyphenyl)porphin based on facile hydrothermal ***-friendly ratiometric fluorescence probe was innovatively constructed to effectively measure Hg2+utilizing b-CDs and *** developed probe displayed two typical emission peaks at 450 nm from b-CDs and 650 nm from r-CDs under the excitation at 360 *** ion has strong quenching effect on the fluorescence intensity at 450 nm due to the electron transfer process and the fluorescence change at 450 nm was used as the response signal,whereas the fluorescence intensity at 650 nm kept unchangeable which resulted from the chemical inertness between Hg^(2+)and r-CDs,serving as the reference signal in the sensing *** optimal circumstances,this probe exhibited an excellent linearity between the fluorescence response values of F450/F650 and Hg^(2+)concentrations over range of 0.01-10μmol/L,and the limit of detectionwas down to 5.3 nmol/***,this probe was successfully employed for sensing Hg^(2+)in practical environmental water samples with satisfied recoveries of 98.5%-105.0%.The constructed ratiometric fluorescent probe provided a rapid,environmental-friendly,reliable,and efficient platform for measuring trace Hg^(2+)in environmental field.

关键词： Blue carbon dots Red carbon dots Electron transfer Hg^(2+) Eco-friendliness

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Development of a coupled model to simulate and assess arsenic contamination and impact factors in the Jinsha River Basin,China

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Journal of Environmental Sciences 2025年第1期147卷 50-61页

作者： Yidian Sun Xu Zhang Hong Peng Wenting zhou Anna Jiang Feng zhou Hao Wang Wanshun Zhang School of Resource and Environmental Sciences Wuhan UniversityWuhan 430079China School of Water Conservancy and Hydropower Engineering Wuhan UniversityWuhan 430072China China Institute of Water Resources and Hydropower Research Beijing 100038China School of Water Resources and Hydropower State Key Laboratory of Water Resources and Hydropower Engineering ScienceWuhan UniversityWuhan 430072China

With the increasing severity of arsenic(As)pollution,quantifying the environmental behavior of pollutant based on numerical model has become an important approach to determine the potential impacts and finalize the precise control *** the industrialintensive Jinsha River Basin as typical area,a two-dimensional hydrodynamic water quality model coupled with Soil andWater Assessment Tool(SWAT)model was developed to accurately simulate the watershed-scale distribution and transport of As in the terrestrial and aquatic environment at high spatial and temporal *** effects of hydro-climate change,hydropower station construction and non-point source emissions on Aswere quantified based on the coupled *** result indicated that higher As concentration areas mainly centralized in urban districts and concentration slowly decreased from upstream to *** to the enhanced rainfall,the As concentration was significantly higher during the rainy season than the dry ***-climate change and the construction of hydropower station not only affected the dissolved As concentration,but also affected the adsorption and desorption of As in ***,As concentration increased with the input of non-point source pollution,with the maximum increase about 30%,resulting that non-point sources contributed important pollutant impacts to *** coupled model used in pollutant behavior analysis is generalwith high potential application to predict and mitigate water pollution.

关键词： Watershed system Arsenic Modeling Distribution Hydro-climate change Non-point source pollution

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Edge-aware Feature Aggregation Network for Polyp Segmentation

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Machine Intelligence Research 2025年第1期22卷 101-116页

作者： Tao zhou Yizhe Zhang Geng Chen Yi zhou Ye Wu Deng-Ping Fan PCA Lab Key Laboratory of Intelligent Perception and Systems for High-dimensional Information of Ministry of EducationSchool of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing210094China School of Computer Science and Engineering Northwestern Polytechnical University(NPU)Xi’an710129China School of Computer Science and Engineering Southeast UniversityNanjing211189China Computer Vision Lab ETH ZürichZürich8092Switzerland

Precise polyp segmentation is vital for the early diagnosis and prevention of colorectal cancer(CRC)in clinical ***,due to scale variation and blurry polyp boundaries,it is still a challenging task to achieve satisfactory segmentation performance with different scales and *** this study,we present a novel edge-aware feature aggregation network(EFA-Net)for polyp segmentation,which can fully make use of cross-level and multi-scale features to enhance the performance of polyp ***,we first present an edge-aware guidance module(EGM)to combine the low-level features with the high-level features to learn an edge-enhanced feature,which is incorporated into each decoder unit using a layer-by-layer ***,a scale-aware convolution module(SCM)is proposed to learn scale-aware features by using dilated convolutions with different ratios,in order to effectively deal with scale ***,a cross-level fusion module(CFM)is proposed to effectively integrate the cross-level features,which can exploit the local and global contextual ***,the outputs of CFMs are adaptively weighted by using the learned edge-aware feature,which are then used to produce multiple side-out segmentation *** results on five widely adopted colonoscopy datasets show that our EFA-Net outperforms state-of-the-art polyp segmentation methods in terms of generalization and *** implementation code and segmentation maps will be publicly at https://***/taozh2017/EFANet.

关键词： Colorectal cancer polyp segmentation edge-aware guidance module scale-aware convolution module cross-level fusion module

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Advancing gravitational theory through the tetrahedral constellation gravitational wave observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 197-198页

作者： Yun-Yong Wang zhou-Jian Cao Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing102206China

The Tetrahedral Constellation Gravitational Wave Observatory(TEGO)[1]represents a significant leap forward in gravitational wave detection,advancing our understanding of gravitational *** introducing a fourth spacecraft to form a tetrahedral configuration,TEGO enhances traditional triangular setups,enabling the simultaneous sensitivity to all six gravitational wave polarization modes,including those not predicted by general relativity.

关键词： wave polarization theory

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