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Amyloid,tau,pathogen infection and antimicrobial protection in Alzheimer’s disease-conformist,nonconformist,and realistic prospects for AD pathogenesis

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Translational Neurodegeneration 2018年第1期7卷 362-377页

作者： Hongmei Li Chia-Chen Liu Hui Zheng timothy y.huang Department of Neuroscience Mayo ClinicJacksonvilleFLUSA Huffington Center on Aging Baylor College of MedicineHoustonTXUSA Neuroscience Initiative Sanford Burnham Prebys Medical Discovery InstituteSan DiegoCAUSA

Background:Alzheimer’s disease(AD)is a fatal disease that threatens the quality of life of an aging population at a global *** hypotheses on the etiology of AD have been developed over the years to guide efforts in search of therapeutic *** body:In this review,we focus on four AD hypotheses currently relevant to AD onset:the prevailing amyloid cascade hypothesis,the well-recognized tau hypothesis,the increasingly popular pathogen(viral infection)hypothesis,and the infection-related antimicrobial protection *** briefly reviewing the main evidence supporting each hypothesis and discussing the questions that need to be addressed,we hope to gain a better understanding of the complicated multi-layered interactions in potential causal and/or risk factors in AD *** a defining feature of AD,the existence of amyloid deposits is likely fundamental to AD onset but is insufficient to wholly reproduce many complexities of the disorder.A similar belief is currently also applied to hyperphosphorylated tau aggregates within neurons,where tau has been postulated to drive neurodegeneration in the presence of pre-existing Aβplaques in the *** infection of the central nerve system by pathogens such as viruses may increase AD risk,it is yet to be determined whether this phenomenon is applicable to all cases of sporadic AD and whether it is a primary trigger for AD ***,the antimicrobial protection hypothesis provides insight into a potential physiological role for Aβpeptides,but how Aβ/microbial interactions affect AD pathogenesis during aging awaits further ***,this hypothesis cautions potential adverse effects in Aβ-targeting therapies by hindering potential roles for Aβin anti-viral ***:AD is a multi-factor complex disorder,which likely requires a combinatorial therapeutic approach to successfully slow or reduce symptomatic memory decline.A better understanding of how various causal a

关键词： Amyloid-beta Alzheimer’s disease Amyloid hypothesis Tau hypothesis Pathogen hypothesis Viral infection Antimicrobial protection

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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INFLUENCE OF ALLOyING ELEMENTS ON HyDROGEN DIFFUSION USING SCM-DV-X_α

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Acta Metallurgica Sinica(English Letters) 2004年第1期17卷 71-76页

作者： y.huang D.M.Xing School of Materials Science and Engineering Tianjin University Tianjin 300072 ChinaSchool of Physics Tianjin Normal UniversityTianjin 300071China

The influence of alloy composition (Ti, Mn, TiN) on hydrogen diffusion in Fe was studied in detail using SCM-DV-Xα method. The voltage barriers were obtained via calculation on Fe clusters containing the alloy elements such as Ti, Mn as well as the chemical compound TiN respectively. The results showed that Ti element produced deep trap in Fe, decreasing the diffusion coefficient of hydrogen elements, Mn element did not produce deep trap in Fe, decreasing the diffusion coefficient slightly and TiN in Fe produced very deep "trap" decreasing the diffusion coefficient obviously. The calculation results were in agreement with experiment results.

关键词： hydrogen diffusion SCM-DV-Xα method cluster

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Genes important for survival or reproduction in Varroa destructor identified by RNAi

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Insect Science 2019年第1期26卷 68-75页

作者： Zachary y.huang Guowu Bian Zhiyong Xi Xianbing Xie Department of Laboratory Animal Science Nanchang UniversityNanchangJiangxiChina Department of Entomology Michigan State UniversityEast LansingMIUSA Department of Microbiology and Molecular Genetics Michigan State UniversityEast LansingMI USA Ecology Evolutionary Biology and BehaviorMichigan State UniversityEast LansingMIUSA BEACON Center for the Study of Evolution in Action Michigan State UniversityEast LansingMIUSA

The Varroa mite,(Varroa destructor),is the worst threat to honey bee health *** explore the possibility of using RNA interference to control this pest, we determined the effects of knocking down various genes on Varroa mite survival and ***-stranded RNA (dsRNA)of six candidate genes (Da,Pros26S,RpL8, RpL11,RpPO and RpS13)were synthesized and each injected into Varroa mites,then mite survival and reproduction were *** of dsRNA for Da (Daughterless)and Pros26S (Gene for proteasome 26S subunit adenosine triphosphatase)caused a significant reduction in mite survival,with 3.57%±1.94% and 30.03%±11.43% mites surviving at 72 h post-inj ection (hpi),*** mites injected with green fluorescent protein (GFP)-dsRNA showed survival rates of 81.95%±5.03% and 82.36 ±2.81%,respectively. Injections of dsRNA for four other genes (RpL8,RpL11,RpPO and RpS13)did not affect survival significantly,enabling us to assess their effect on Varroa mite *** number of female offspring per mite was significantly reduced for mites injected with dsRNA of each of these four genes compared to their GFP-dsRNA *** of the target genes was verified by real-time polymerase chain reaction for two genes important for reproduction (RpL8,RpL11)and one gene important for survival (Pros26S). In conclusion,through RNA interference,we have discovered two genes important for mite survival and four genes important for mite *** genes could be explored as possible targets for the control of Varroa destructor in the future.

关键词： Apis mellijera reproduction RNAi survival Varroa destructor

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The Role of TNF Related Apoptosis-Inducing Ligand in Neurodegenerative Diseases

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Cellular & Molecular Immunology 2005年第2期2卷 113-122页

作者： y.huang N.Erdmann H.Peng y.Zhao ThelaboratoryofNeurotoxicologyattheCenterforNeurovirology＆NeurodegenerativeDisorders ／／Dept.Pharmacology Dept.ofSurgery UniversityofNebraskaMedicalCenterOmahaNE68198-5880USA／／InstituteofAnimalResearchChineseAcademyofScienceChina

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions,and in many cases neuronal cell *** the etiology of neurodegenerative diseases may be distinct,different diseases display a similar pathogenesis,for example abnormal immunity within the central nervous system(CNS),activation of macrophage/microglia and the involvement of proinflammatory *** studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death,also called ***-related apoptosis-inducing ligand(TRAIL),a member of the TNF family,has been shown to be involved in apoptosis during many *** one member of a death ligand family,TRAIL was originally thought to target only tumor cells and was not present in ***,recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages,a major disease inducing cell during HIV-1-assoeiated dementia(HAD).TRAIL is also induced on neuron by β-amyloid protein,an important pathogen for Alzheimer's *** this review,we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases,TRAIL induced apoptosis signaling in the CNS cells,and specific role of TRAIL in individual *** & Molecular Immunology.2005;2(2):113-122.

关键词： Alzheimer's disease HⅣ-1 associated dementia multiple sclerosis apoptosis TRAIL macrophage

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Leveraging generative adversarial networks to create realistic scanning transmission electron microscopy images

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npj Computational Materials 2023年第1期9卷 1492-1500页

作者： Abid Khan Chia-Hao Lee Pinshane y.huang Bryan K.Clark Department of Physics University of Illinois Urbana-ChampaignUrbanaIL 61801USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIL 61801USA Materials Research Laboratory University of Illinois Urbana-ChampaignUrbanaIL 61801USA Institute for Condensed Matter Theory and IQUIST and NCSA Center for Artificial Intelligence Innovation University of Illinois Urbana-ChampaignUrbanaIL 61801USA

The rise of automation and machine learning(ML)in electron microscopy has the potential to revolutionize materials research through autonomous data collection and processing.A significant challenge lies in developing ML models that rapidly generalize to large data sets under varying experimental *** address this by employing a cycle generative adversarial network(CycleGAN)with a reciprocal space discriminator,which augments simulated data with realistic spatial frequency *** allows the CycleGAN to generate images nearly indistinguishable from real data and provide labels for ML *** showcase our approach by training a fully convolutional network(FCN)to identify single atom defects in a 4.5 million atom data set,collected using automated acquisition in an aberration-corrected scanning transmission electron microscope(STEM).Our method produces adaptable FCNs that can adjust to dynamically changing experimental variables with minimal intervention,marking a crucial step towards fully autonomous harnessing of microscopy big data.

关键词： autonomous adjust network

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Material and structural instabilities of single-wall carbon nanotubes

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Acta Mechanica Sinica 2008年第3期24卷 285-288页

作者： J.Wu K.C.Hwang J.Song y.huang FML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Department of Mechanical Science and Engineering University of Illinois1206 W.Green StreetUrbanaIL 61801USA Department of Civil and Environmental Engineering and Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA

The nonlinear atomistic interactions usually involve softening behavior. Instability resulting directly from this softening are called the material instability, while those unrelated to this softening are called the structural instability. We use the finite-deformation shell theory based on the interatomic potential to show that the tension instability of single-wall carbon nanotubes is the material instability, while the compression and torsion instabilities are structural instability.

关键词： Carbon nanotubes Instability

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Proton transport in unsintered BaCe_(0.8)y_(0.2)O_(3-α) for easily prepared electrochemical devices

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Journal of Rare Earths 2025年第1期43卷 133-145,I0006页

作者： Xi Wang yushi Ding ying Li Gaopeng Zhou Wenlong huang Liaoning Key Laboratory for Metallurgical Sensor Material and Technology School of MetallurgyNortheastern UniversityShenyang110819China

BaCe_(0.8)y_(0.2)O_(3)-αceramics exhibit superior conductivity among related ***,the hightemperature sintering makes it difficult to prepare electrochemical devices with a BaCe_(0.8)y_(0.2)O_(3)-αmultilayer film,and very few studies have examined the conductivity and transport properties of unsintered BaCe_(0.8)y_(0.2)O_(3)-α.In nominally dry conditions,the instability of this material in a watercontaining atmosphere can be minimized,allowing the unsintered BaCe_(0.8)y_(0.2)O_(3)-αto be applied in some particular test environment as a component of electrochemical ***,the conductivity of unsintered BaCe_(0.8)y_(0.2)O_(3)-αin dry conditions was measured via AC impedance spectroscopy in the temperature range of 500-800℃.The unsintered BaCe_(0.8)y_(0.2)O_(3)-αexhibits high conductivity and hydration ability,as well as low proton activation *** addition,it shows high oxygen vacancy and low proton transport numbers at high temperature,limited by its grain *** work provides insights into the conductivity and proton transport of unsintered BaCe_(0.8)y_(0.2)O_(3)-αand demonstrates its potential as a proton-conducting electrolyte.

关键词： Protonic conductor Unsintered material BaCe_(0.8)y_(0.2)0^(3-α) Conductivity Transport number Rare earths

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Mblk-1 regulates sugar responsiveness in honey bee(Apis mellifera)foragers

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Insect Science 2022年第3期29卷 683-690页

作者： Fang Liu Lixian Wu yuan Zhang Qiang Li Liangbin Li Zachary y.huang Hongxia Zhao Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesChina yunnan Academy of Biodiversity Southwest Forestry UniversityKunmingYunnan650224China Department of Entomology Michigan State UniversityEast LansingMichiganUSA

Brain transcriptional regulatory network for behavior demonstrates that brain gene expression in the honey bee can be accurately predicted from the expression transcription factors(TFs),but roles for specific TFs are less *** bodies(MBs)are important for learning,memory and sensory integration in the honey bee brain.A TFs,Mblk-1,expressed preferentially in the large-type Kenyon cells of the honeybee MBs is predicted to be involved in brain function by regulating transcription of its target genes in honey ***,its function and the mechanism of regulation in behavior of honey bee is still *** we show that Mblk-1 had significantly higher expression in the brains of forager bees relative to nurse ***-1 was significantly inhibited in bees fed small interfering *** addition,inhibition of Mblk-1 decreased sucrose responsiveness in ***,we determined that Mblk-1 regulated the messenger RNA of *** findings suggest that Mblk-1 may target AmGRl to regulate the sucrose responsiveness of foragers.

关键词： division of labor GRs honey bee Mblk-1 sucrose responsiveness

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Tomographic reconstruction of the Earth’s magnetosheath from multiple spacecraft:a theoretical study

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Earth and Planetary Physics 2024年第1期8卷 204-214页

作者： A.M.Jorgensen TianRan Sun y.huang L.Li R.Xu L.Dai Chi Wang New Mexico Institute of Mining and Technology SocorroNMUSA National Space Science Center Chinese Academy of SciencesBeijing 100190China Tsinghua University Beijing 100084China

Following our earlier work on tomographic reconstruction of the magnetosheath soft X-ray emissions with superposed epoch analysis of many images recorded from a single spacecraft we now explore the instantaneous reconstruction of the magnetosheath and magnetopause using a few images recorded simultaneously from a few *** work is motivated by the prospect of possibly having two or three soft X-ray imagers in space in the coming years,and that many phenomena which occur at the magnetopause boundary,such as reconnection events and pressure pulse responses,do not lend themselves as well to superposed epoch *** the reconstruction is successful-which we demonstrate in this paper that it can be-this collection of imagers can be used to reconstruct the magnetosheath and magnetopause from a single image from each spacecraft,allowing for high time resolution *** this paper we explore the reconstruction using,two,three,and four *** show that the location of the subsolar point of the magnetopause can be determined with just two satellites,and that volume emissions of soft X-rays,and the shape of the boundary,can be reconstructed using three or more satellites.

关键词： magnetosheath tomography soft X-ray imaging SMILE

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