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Journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly J Rivenbark timothy D Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis timothy M Pawlik Daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinoma(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor survival if *** sources:A systematic search of MEDLINE(PubMed),Embase,Cochrane Library and Database for Systematic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until December 2022 was conducted using free text and MeSH terms:hepatocellular carcinoma,portal vein tumor thrombus,portal vein thrombosis,vascular invasion,liver and/or hepatic resection,liver transplantation,and systematic ***:Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization or systemic *** elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus,accurate identification of the subgroups of patients who may benefit from resection,as well as meticulous surgical *** review addressed five specific areas:(a)formation of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatments versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.

关键词： Hepatectomy Liver surgery Liver neoplasms Portal vein tumor thrombus

Mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-David M.Gothié timothy E.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

Cultural Exclusion and the Transformation of the Cultural Landscape: The Origins of Anti-Chinese Racism in Canada

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Social Sciences in China 2024年第3期45卷 181-202页

作者： timothy J.Stanley Faculty of Education University of Ottawa

Anti-Chinese racism in Canada is a social structure of racialized exclusion that over time came to be built into the settler colonialism that continues to shape the *** of European,and especially of British and French origins,have consequently created the cultural landscapes that constitute the country(i.e.,its material constructions and dominant cultural overlays).When read against these landscapes,people of Chinese origins and members of other racialized groups continue to be positioned as aliens who do not belong in the country in way in which people racialized as white are *** on British Columbia(BC),Canada's westernmost province,and the historical activity of people of Chinese origins,this paper traces the history of anti-Chinese racism and its links to Anglo-Canadian settler *** has long been linked to China,and the Chinese entered BC at the same time as Europeans before the country *** this,Chinese people have repeatedly been positioned as threats to Anglo-Canadian dominance,and especially to control over the land and its *** Canadian resistance to racist exclusions,along with that of other groups,has led to the elimination of legislated ***,historic exclusions continue to shape cultural landscapes and popular understandings of who belongs and who does *** these landscapes requires an antiracist project of pursuing common projects that cross over racialized differences to remake the territory in ways that affirm the presence of all the peoples of Canada.

关键词： Chinese Canadians cultural exclusion white supremacy racism

Laser-based bionic manufacturing

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International Journal of Extreme Manufacturing 2024年第4期6卷 62-84页

作者： Xingran Li Baoyu Zhang timothy Jakobi Zhenglei Yu Luquan Ren Zhihui Zhang Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunPeople's Republic of China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyangPeople's Republic of China The University of New South Wales CanberraNorthcott DrCampbellACT 2612Australia

Over millions of years of natural evolution,organisms have developed nearly perfect structures and *** self-fabrication of organisms serves as a valuable source of inspiration for designing the next-generation of structural materials,and is driving the future paradigm shift of modern materials science and ***,the complex structures and multifunctional integrated optimization of organisms far exceed the capability of artificial design and fabrication technology,and new manufacturing methods are urgently needed to achieve efficient reproduction of biological *** one of the most valuable advanced manufacturing technologies of the 21st century,laser processing technology provides an efficient solution to the critical challenges of bionic *** review outlines the processing principles,manufacturing strategies,potential applications,challenges,and future development outlook of laser processing in bionic manufacturing *** primary manufacturing strategies for laser-based bionic manufacturing are elucidated:subtractive manufacturing,equivalent manufacturing,and additive *** progress and trends in bionic subtractive manufacturing applied to micro/nano structural surfaces,bionic equivalent manufacturing for surface strengthening,and bionic additive manufacturing aiming to achieve bionic spatial structures,are ***,the key problems faced by laser-based bionic manufacturing,its limitations,and the development trends of its existing technologies are discussed.

关键词： bionic manufacturing laser processing bionic micro/nano structural surface bionic strengthening surface bionic spatial structure

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK(Barrett T Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Partitioning Anatolian Kinematics into Tectonic Escape and Slab Rollback Dominated Domains

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Journal of Earth Science 2024年第3期35卷 758-768页

作者： Jiannan Meng timothy M.Kusky Erdin Bozkurt Hao Deng Ozan Sinoplu State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan 430074China Department of Geological Engineering Middle East Technical University06800 AnkaraTurkey Department of Geosciences Auburn UniversityAuburn AL 36849USA

Anatolia is the global archetype of tectonic escape,as witnessed by the devastating 2023 Kahramanmaraş Earthquake sequence,and the 2020 Samos Earthquake,which show different kinematics related to the framework of the escape *** Positioning System(GPS)motions of the wedge-shaped plate differ regionally from northwestwards to southwestwards(from east to west).Anatolia was extruded westward from the Arabian-Eurasian collision along the North and East Anatolian fault systems,rotating counterclockwise into the oceanic free-faces of the Mediterranean and Aegean,with dramatic extension of western Anatolia in traditional ***,which is the dominant mechanism for this change in kinematics,extrusion related to the Arabia/Eurasia collision or rollback of the African slab beneath western Anatolia is still *** assess the dominant driving mechanisms across Anatolia,we analyze recent GPS velocity datasets,and decomposed them into N-S and E-W components,revealing that westward motion is essentially constant across the whole plate and consistent with the slip rates of the North and East Anatolia fault zones,while southward components increase dramatically in the transition area between central and western Anatolia,where a slab tear is *** phenomenon is related to different tectonic driving *** ArabiaEurasia collision drives the Anatolian Plate uniformly westwards while western Anatolia is progressively more affected by the southward retreating African subducting slab west of the Aegean/Cypriot slab tear,which significantly increases the southward component of the velocity field and causes the apparent curve of the whole modern velocity *** 2020 and 2023 earthquake focal mechanisms also confirm that the northward colliding Arabian Plate forced Anatolia to the west,and the retreating African slab is pulling the upper plate of western Anatolian apart in *** propose that the Anatolian Plate is moving westwards as

关键词： tectonics neotectonics tectonic escape slab rollback Anatolian Plate GPS velocity field geodynamics.

ChatGPT and exercise prescription:Human *** or human plus machine?

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Journal of Sport and Health Science 2024年第5期13卷 661-662页

作者： timothy Gustavo Cavazzotto Diego Bessa Dantas Marcos Roberto Queiroga Department of Physical Education Midwestern Parana State UniversityParana 85040-167Brazil Postgraduate Program in Physical Education UEM-UEL State University of LondrinaParana 86057-970Brazil

The power of artificial intelligence(AI)to create stories,music,art,and other creative projects has been demonstrated and criticized over recent decades in media,mainly because of the idea that AI will replace human *** recently,in November 2022,reactions to Chat Generative Pre-training Transformer(ChatGPT)release for public use reverberated in news and social media headlines,while its users exceeded100 million in just a few *** is a natural language processing program created by AI non-profit OpenAI Inc.

关键词： prescription replace Human

The burden and psychosocial impact on immediate caregivers of patients with spinal cord injury in a tertiary health facility,Edo State,Nigeria

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Journal of Integrative Nursing 2024年第2期6卷 103-110页

作者： timothy Aghoghko EHWARIEME Uzezi JOSIAH Auwuli EMINA Department of Nursing Science School of Basic Medical SciencesUniversity of BeninBenin CityEdo StateNigeria Department of Nursing Science Delta State University AbrakaDelta StateNigeria Department of Nursing Science Faculty of Basic Medical and Health SciencesBenson Idahosa UniversityBenin CityEdo StateNigeria

Objective:This study aimed to assess the burden and psychosocial impact of spinal cord injury on the immediate caregivers at a tertiary health facility in Benin City,Edo *** and Methods:A descriptive cross-sectional survey design was adopted among 73 family caregivers in the neurological ward of a tertiary health facility using a structured questionnaire as instrument of data *** collected were analyzed using descriptive statistics and multiple logistic ***:Findings revealed that an overall mean of 2.73 indicates that the burden on the caregivers was moderate with a moderate psychological impact(m=2.88)and a high sociological impact(m=3.12).Factors affecting the caregiving provided by immediate caregivers include social and household responsibilities(94.5%),financial situation(89.0%),family support(83.6%),and health status of the caregiver(80.8%).Age(odds ratio[OR]=5.67,95%confidence interval[CI]:1.23-27.17,P=0.027),education(OR=3.75,95%CI:1.05-13.39,P=0.041),and“others”(spouses,siblings,friends,or extended family members)(OR=3.167,95%CI:1.583-6.337,P=0.001)were predictors for high psychological impact while education(OR=0.074;95%CI:0.015-0.370,P=0.001)and caregiving role(OR=3.167;95%CI:0.1.583-6.337,P=0.001)high sociological ***:Majority of the caregivers experience moderate burden,moderate psychological impact,and high sociological *** these factors is essential for developing targeted interventions and support services to address the unique needs of caregivers and mitigate the burden of caregiving on their psychosocial health.

关键词： Burden caregivers predictors of psychosocial impact psychological impact sociological impact spinal cord injury

Epidemiology of tuberculosis in Sabah, Malaysia, 2012–2018

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Infectious Diseases of Poverty 2020年第4期9卷 165-165页

作者： Michelle May D.Goroh Giri Shan Rajahram Richard Avoi Christel H.A.Van Den Boogaard timothy william Anna P.Ralph Christopher Lowbridge TB/Leprosy Control Unit Sabah State Health DepartmentKota KinabaluMalaysia Faculty of Medicine and Health Sciences Universiti Malaysia SabahKota KinabaluMalaysia Queen Elizabeth Hospital Kota KinabaluMalaysia Menzies School of Health Research Charles Darwin UniversityDarwinAustralia Infectious Diseases Society of Kota Kinabalu Kota KinabaluMalaysia Gleneagles Hospital Kota KinabaluMalaysia Division of Medicine Royal Darwin HospitalDarwinAustralia

Background Tuberculosis(TB)is of high public health importance in *** State,located on the island of Borneo,has previously reported a particularly high burden of disease and faces unique contextual challenges compared with peninsular *** aim of this study is to describe the epidemiology of TB in Sabah to identify risk groups and hotspots of TB *** We conducted a retrospective review of TB cases notified in Sabah,Malaysia,between 2012 and *** data from the state’s‘myTB’notification database,we calculated the case notification rate and described trends in the epidemiology,diagnostic practices and treatment outcomes of TB in Sabah within this *** Chi-squared test was used for determining the difference between two *** Between 2012 and 2018 there were 33193 cases of TB reported in Sabah(128 cases per 100000 population).We identified several geographic hotspots,including districts with>200 cases per 100000 population per *** rates increased with age and were highest in older ***<15 years accounted for only 4.6%of *** or advanced disease on chest X-ray and sputum smear positivity was high(58 and 81%of cases respectively),suggesting frequent late ***-drug resistant(MDR)TB prevalence was low(0.3%of TB cases),however,rapid diagnostic test coverage was low(1.2%)and only 18%of all cases had a positive culture *** success was 83%(range:81–85%)in those with drug-sensitive TB and 36%(range:25–45%)in cases of *** Between 2012 and 2018,TB notifications in Sabah State equated to 20%of Malaysia’s total TB notifications,despite Sabah representing only 10%of Malaysia’s *** found hotspots of TB in urbanised population hubs and points of migration,as well as evidence of late presentation and *** universal health coverage and expansion of GeneXpert®coverage is recommended to reduce barriers to care and early diagnosis and treatment fo

关键词： Tuberculosis Epidemiology Surveillance Sabah Malaysia