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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok timothy G.white Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Exercise and Cancer Prevention: Current Evidence and Future Directions

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Journal of Science in Sport and Exercise 2020年第3期2卷 190-200页

作者： Lee w.jones Department of Medicine Memorial Sloan Kettering Cancer Center1275 York AvenueNew YorkNY 10065USA weill Cornell Medical College New YorkNYUSA

Establishment of the strong putative relationship between exercise and risk of virtually all non-communicable diseases prompted several research groups over the past two decades to investigate a question of significant public health concern:whether exercise lowers the risk of certain forms of *** this Opinion review I first overview studies of exercise in cancer prevention summarizing evidence from observational studies and available clinical *** the final section,I consider the next steps in the continued development of exercise as a cancer prevention strategy.

关键词： Cancer Exercise Oncology Physical activity Primary prevention

Synchrotron micro-scale measurement of metal distributions in Phragmites australis and Typha latifolia root tissue from an urban brownfield site

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Journal of Environmental Sciences 2016年第3期28卷 172-182页

作者： Huan Feng Yu Qian Frank J.Gallagher weiguo Zhang Lizhong Yu Changjun Liu Keith w.jones Ryan Tappero Department of Earth and Environmental Studies Montclair State University Urban Forestry Program Department of EcologyEvolution and Natural ResourcesRutgersThe State University of New Jersey State Key Laboratory of Estuarine and Coastal Research East China Normal University Biological Environmental and Climate Sciences DepartmentBrookhaven National Laboratory Photon Sciences Directorate Brookhaven National Laboratory

Liberty State Park in New Jersey,USA,is a ＂brownfield＂ site containing various levels of *** investigate metal uptake and distributions in plants on the brownfield site,Phragmites australis and Typha latifolia were collected in Liberty State Park during the growing season（May–September）in 2011 at two sites with the high and low metal loads,*** objective of this study was to understand the metal（Fe,Mn,Cu,Pb and Zn）concentration and spatial distributions in *** and *** root systems with micro-meter scale resolution using synchrotron X-ray microfluorescence（μXRF）and synchrotron X-ray computed microtomography（μCMT）*** root structure measurement by synchrotron μCMT showed that high X-ray attenuation substance appeared in the *** μXRF measurement showed that metal concentrations and distributions in the root cross-section between epidermis and vascular tissue were statistically *** correlations were found between metals（Cu,Mn,Pb and Zn）and Fe in the epidermis,implying that metals were scavenged by Fe *** results from this study suggest that the expression of metal transport and accumulation within the root systems may be element *** information derived from this study can improve our current knowledge of the wetland plant ecological function in brownfield remediation.

关键词： Phragmites australis Typha latifolia Trace metals Synchrotron radiation technique Brownfield

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Surveys of rodent-borne disease in Thailand with a focus on scrub typhus assessment

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Integrative Zoology 2008年第4期3卷 267-273页

作者： Kriangkrai Lerdthusnee Joseph Nigro Taweesak Monkanna warisa Leepitakrat Surachai Leepitakrat Sucheera Insuan weerayut Charoensongsermkit Nittaya Khlaimanee wilasinee Akkagraisee Kwanta Chayapum James w.jones Department of Entomology United States Army Medical ComponentArmed Forces Research Institute of Medical SciencesBangkokThailand Science Systems and Applications National Aeronautics and Space Administration–Goddard Space Flight Center NASA-GSFCGreenbeltMarylandUSA

The epidemiology of many rodent-borne diseases in South-East Asia remains *** typhus and lep-tospirosis are common and medically significant,while other zoonotic diseases,such as spotted fever group Rickettsiae have been identified,but their overall medical significance is *** surveillance was con-ducted from June 2002 to July 2004 in 18 provinces from *** were set up for one to three *** and serum samples and animal tissue samples(liver,spleen,kidney and urinary bladder)were ***-mites,ticks and fleas were removed from captured *** of 4536 wild-caught rodents from 27 species were captured over two years of animal *** rattus was the dominant species,followed by Rattus exulans and Bandicota *** 43000 ectoparasites were removed from the captured *** 98%of the ectoparasites were chigger-mites,of which 46%belonged to the genus Leptotrombidium(scrub typhus vector).Other genera included Schoengastia and *** and flea specimens together comprised less than 1%of the *** the five species of ticks collected,Haemaphysalis bandicota was the predominant species caught,followed by Ixodes granulatus other Haemaphysalis spp.,Rhipicephalus *** Dermacentor *** two species of fleas were collected and Xenopsylla cheopis(rat flea)was the predominant *** both commercial diagnostic kits and in-house molecular assays,animal tissue samples were examined and screened for zoonotic *** zoonotic diseases were detected:scrub typhus,leptospirosis,murine typhus,tick typhus,bartonella,babesiosis and *** samples were positive for scrub *** zoonotic diseases still under investigation include borrelosis,ehrlichiosis,the plague,and other rickettsial *** geo-graphic information systems,global positioning systems and remote sensing technology,epidemiological and environmental data were combined to assess the re

关键词： GIS model rodent-borne diseases scrub typhus surveillance surveys.

Burn recidivism:a 10-year retrospective study characterizing patients with repeated burn injuries at a large tertiary referral burn center in the United States

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Burns & Trauma 2019年第1期7卷 75-84页

作者： Sarah L.Laughon Bradley N.Gaynes Lori P.Chrisco Samuel w.jones Felicia N.williams Bruce A.Cairns Gary J.Gala Department of Psychiatry 101 Manning DriveCB#7160Chapel HillNC 27599-7160USA Department of Surgery 4001 Burnett-Womack BuildingCB#7050Chapel HillNC 27599-7050USA North Carolina Jaycee Burn Center 101 Manning DriveCB#7206Chapel HillNC 27599-7600USA

Background:Psychiatric and substance use disorders are common among trauma and burn patients and are known risk factors for repeat episodes of trauma,known as trauma *** epidemiology of burn recidivism,specifically,has not been *** study aimed to characterize cases of burn recidivism at a large US tertiary care burn center and compare burn recidivists(RCs)with non-recidivists(NRCs).Methods:A 10-year retrospective descriptive cohort study of adult burn patients admitted to the North Carolina Jaycee Burn Center was conducted using data from an electronic burn registry and the medical *** variables were reported using medians and interquartile ranges(IQR).Chi-square and wilcoxon-Mann-whitney tests were used to compare demographic,burn,and hospitalization characteristics between NRCs and ***:A total of 7134 burn patients were admitted,among which 51(0.7%)were RCs and accounted for 129(1.8%)*** the 51 RCs,37 had two burn injuries each,totaling 74 admissions as a group,while the remaining 14 RCs had between three and eight burn injuries each,totaling 55 admissions as a *** to NRCs,RCs were younger(median age 36 years vs.42 years,p=0.02)and more likely to be white(75%vs.60%,p=0.03),uninsured(45%vs.30%,p=0.02),have chemical burns(16%vs.5%,pwere≤10%total body surface area(89%vs.76%,p=0.001).The mortality rate for RCs *** did not differ(0%vs.1.2%,p=0.41).Psychiatric and substance use disorders were approximately five times greater among RCs compared to NRCs(75%vs.15%,pwere nearly three times higher for RCs ***($85,736 vs.$32,023,pwith more severe injury or increased *** to trauma recidivists,but to a greater extent,burn RCs have high rates of comorbid psychiatric and medical conditions that contribute to increased health care u

关键词： Burn recidivism Consult psychiatry Substance use disorder Repeat burn injury