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对马和马驹兔疫系统衰竭的评价

西南民族大学学报(自然科学版) 1981年第2期 52-53页

作者： LanceE.Perryman TrajisC.mcguire 穆安斌

本文对2092匹马和马驹进行了免疫学紊乱的评价。在2092匹试验马中,未满1周岁的马驹有1881匹,其中1155匹都为未满1月龄的小驹,一周岁以上的马有133匹,未统计年龄的马78匹。实验方法是:用单相放射免疫扩散来测定血清中的 ***.(T)和 IgA ... 详细信息

本文对2092匹马和马驹进行了免疫学紊乱的评价。在2092匹试验马中,未满1周岁的马驹有1881匹,其中1155匹都为未满1月龄的小驹,一周岁以上的马有133匹,未统计年龄的马78匹。实验方法是:用单相放射免疫扩散来测定血清中的 ***.(T)和 IgA 的浓度。以检测淋巴细胞表面 Ig 和激活的补体第三成分的受体来定量 B 淋巴细胞。在活体内和活

关键词：马驹月龄淋巴细胞白细胞免疫球蛋白

Sequencing a Juglans regia×*** hybrid yields high-quality genome assemblies of parental species

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Horticulture Research 2019年第1期6卷 1271-1286页

作者： Tingting Zhu Le Wang Frank M.You Juan C.Rodriguez Karin R.Deal Limin Chen Jie Li Sandeep Chakraborty Bipin Balan Cai-Zhong Jiang Patrick J.Brown Charles ALeslie Mallikarjuna KAradhya Abhaya M.Dandekar Patrick E.mcguire Daniel Kluepfel Jan Dvorak Ming-Cheng Luo Department of Plant Sciences University of CaliforniaDavisCA 95616USA Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawaON K1A 0C6Canada Genome Center University of CaliforniaDavisCA 95616USA Crops Pathology and Genetics Research Unit USDA-ARSDavisCA 95616USA National Clonal Germplasm Repository USDA-ARSDavisCA 95616USA

Members of the genus Juglans are monecious wind-pollinated trees in the family Juglandaceae with highly heterozygous genomes,which greatly complicates genome sequence *** genomes of interspecific hybrids are usually comprised of haploid genomes of parental *** exploited this attribute of interspecific hybrids to avoid heterozygosity and sequenced an interspecific hybrid Juglans microcarpa×*** using a novel combination of single-molecule sequencing and optical genome mapping *** resulting assemblies of both genomes were remarkably complete including chromosome termini and centromere *** termini consisted of arrays of telomeric repeats about 8 kb long and heterochromatic subtelomeric regions about 10 kb *** centromeres consisted of arrays of a centromere-specific Gypsy retrotransposon and most contained genes,many of them *** genomes evolved by a whole-genome-duplication dating back to the Cretaceous-Paleogene boundary and consist of two subgenomes,which were fractionated by numerous short gene deletions evenly distributed along the length of the *** was shown to be asymmetric with one subgenome exhibiting greater gene loss than the *** asymmetry of the process is ongoing and mirrors an asymmetry in gene expression between the *** the importance of ***×*** hybrids as potential walnut rootstocks,we catalogued disease resistance genes in the parental genomes and studied their chromosomal *** also estimated the molecular clock rates for woody perennials and deployed them in estimating divergence times of Juglans genomes and those of other woody perennials.

关键词： Juglans parental evenly

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拿破仑

作者： (美)李丝莉·麦圭尔(Leslie mcguire)

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麦芽浸出物的近红外线反射比测定法

大麦与谷类科学 1989年第2期19卷 48-52页

作者： C.F.mcguire 徐大勇孙承军

摘录传统的大麦品质分析方法对于早期世代品系的快速选拔已明显地不适应。知道测出物的含量有助于选择具有测出物含量较高趋势的品系,避免全部在实验室内进行昂贵的、耗时的,不必要的实验。近红外线反射比（缩写为NIR）技术的应用提供了... 详细信息

摘录传统的大麦品质分析方法对于早期世代品系的快速选拔已明显地不适应。知道测出物的含量有助于选择具有测出物含量较高趋势的品系,避免全部在实验室内进行昂贵的、耗时的,不必要的实验。近红外线反射比（缩写为NIR）技术的应用提供了在F3代进行早期淘汰不良系统的可能性,而相应地加快了啤酒大麦品种的改良。因此传统的实验方法可以用于更有希望的品系选择上。我们选择了54个已知道麦芽测出率含量的基因类型。

关键词：近红外线麦芽质量浸出物反射比基因类型啤酒大麦品质分析实验方法制麦麦汁

Predictors of Malignant Pathology and the Role of Trans-Thoracic Needle Biopsy in Management of Solitary Fibrous Tumors of the Pleura: A 30-Year Review of a Tertiary Care Center Patient Cohort

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Open Journal of Thoracic Surgery 2016年第4期6卷 57-69页

作者： Anna mcguire Patrick J. Villeneuve Harman Sekhon Sebastien Gilbert Sudhir Sundaresan Donna E. Maziak Andrew E. J. Seely Farid M. Shamji Faculty of Medicine University of British Columbia Vancouver Canada Division of Thoracic Surgery Vancouver Coastal Health Vancouver Canada Division of Thoracic Surgery Department of Surgery The Ottawa Hospital General Campus University of Ottawa Ottawa Canada Division of Thoracic Pathology Department of Anatomic Pathology The Ottawa Hospital General Campus University of Ottawa Ottawa Canada

Background: Solitary fibrous tumors of the pleura (SFTP) are rare neoplasms with unpredictable behavior. Lack of unifying criteria for benign or malignant SFTP has resulted in reports of SFTP exhibiting malignant behavior years after complete surgical resection (despite benign initial diagnosis). Additionally, the role of trans-thoracic needle biopsy in initial management of SFTP is unclear. Understanding predictors of malignancy identifies patients at unacceptably high risk for non-surgical primary therapy, and for recurrence despite complete surgical resection. Objectives: The primary objectives were to identify clinicopathological predictors of malignancy & recurrence in SFTP. The secondary aim was to determine the role of trans-thoracic needle biopsy in the management decision algorithm of SFTP. Methods: Retrospective chart review was conducted (Jan. 1983-Dec. 2013) at the Ottawa Hospital for pathologically confirmed SFTP. Data were collected on biopsy-related, clinical, histopathological & immunohistochemistry (IHC) variables. Appropriate tests of statistical inference were conducted for all variables. Results: Pathologically confirmed SFTP was identified in 26 cases. Transthoracic needle biopsy was conducted in 22 (84.6%);with 16 (72.7%) biopsies diagnostic of SFTP with IHC;3 (13.6%) being malignant. Primary management was surveillance in 3 and complete surgical resection in 23. Surgical pathology reported 15 (65.2%) benign and 8 (34.8%) malignant cases. Local recurrence occurred in 3 and distant recurrence in 1. Initial pathology was benign in 3 (75%) with recurrence. Clinicopathologic variables analyzed did not predict recurrent disease. IHC features did not differ between malignant & benign pathology significantly. Predictors of malignant pathology included: infiltrative cellular pattern (p = 0.042), nuclear crowding (p = 0.006), tumour necrosis (p 4 mitoses/ 10 high power field (p Conclusion: Because numerous variables analyzed did not predict recurrent di

关键词： Solitary Fibrous Tumour of the Pleura Thoracic Surgery Thoracic Oncology

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体质量和脂肪分布与高血压发病的相关性

中华高血压杂志 2014年第10期22卷 985-986页

作者： Chandra A Neeland IJ Berry JD Ayers CR Rohatgi A Das S Khera A mcguire DK de Lemos JA Turer AT 练桂丽叶鹏 The unit is not available

流行病学已经充分证实了肥胖与高血压发生的相关性,然而许多肥胖患者血压却是正常的。脂肪组织的分布差异可能解释肥胖在临床和生物学上表现的异质性[1]。在过量的皮下脂肪存在时,可导致三酰甘油在其他部位如内脏脂肪组织（visceral adi... 详细信息

流行病学已经充分证实了肥胖与高血压发生的相关性,然而许多肥胖患者血压却是正常的。脂肪组织的分布差异可能解释肥胖在临床和生物学上表现的异质性[1]。在过量的皮下脂肪存在时,可导致三酰甘油在其他部位如内脏脂肪组织（visceral adipose tissue,VAT）、肌肉和肝脏中储存。皮下脂肪组织（subcutaneous adipose tissue,SAT）的代谢相对缓慢,

关键词：高血压相关性脂肪分布体质量内脏脂肪组织皮下脂肪组织发病肥胖患者

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激光辅助的非翻瓣冠延长术：病例研究

中国口腔医学继续教育杂志 2012年第3期15卷 129-134页

作者： Michael K. mcguire E. Todd Scheyer 李熠(译) 徐莉(审) 不详北京大学口腔医学院牙周科北京市中关村南大街22号100081

由于现阶段对手术操作的要求趋向于微创，越来越多的关于非翻瓣而采用激光辅助冠延长术（Laser—mediated Flapless Crown Lengthening）的文章出现在各种期刊中。但是，大多数的文章都是病例报告或者是操作技术方面的探讨。关于科学地... 详细信息

由于现阶段对手术操作的要求趋向于微创，越来越多的关于非翻瓣而采用激光辅助冠延长术（Laser—mediated Flapless Crown Lengthening）的文章出现在各种期刊中。但是，大多数的文章都是病例报告或者是操作技术方面的探讨。关于科学地评价激光冠延长术（非翻瓣）的安全性和有效性的前瞻性、随机和对照研究却很少。本文对于微创不翻瓣手术所产生的临床问题进行了初步分析和研究。事实上，只有严格设计、随机、对照的试验才可以为循证医学提供数据，才可将非翻瓣的冠延长术归为标准冠延长术的治疗方法中。

关键词：冠延长术翻瓣手术病例研究激光手术操作操作技术病例报告临床问题

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中国和美国强直性脊柱炎的临床比较

广东医学 1991年第3期12卷 8-12页

作者：曾庆馀叶士圻 James mcguire Elaine Lambert 汕头大学医学院内科辽宁汤岗子理疗医院美国斯坦福大学医学院内科

强直性脊柱炎（As）是一种常见的风湿性疾病,20多年来,尤其是发现本病与HLAB（?）7强相关以后,对本病的认识日渐深刻。既往认为本病在我国属于少见。

关键词：强直性脊柱炎中国美国

血浆单核细胞趋化蛋白-1水平、传统的心血管危险因子和亚临床动脉粥样硬化之间的关系

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 55-56页

作者： Deo R. Khera A. mcguire D.K. 尚福军

We sought to evaluate the association between plasma levels of monocyte chemoattractant protein(MCP)-1 and the risk for subclinical atherosclerosis. Monocyte chemoattractant protein is a chemokine that recruits monocytes into the developing atheroma and may contribute to atherosclerotic disease development and progression. Plasma levels of MCP-1 are independently associated with prognosis in patients with acute coronary syndromes, but few population-based data are available from subjects in earlier stages of atherosclerosis. In the Dallas Heart Study, a population-based probability sample of adults in Dallas County ≤65 years old, plasma levels of MCP-1 were measured in 3,499 subjects and correlated with traditional cardiovascular risk factors, high-sensitivity C-reactive protein(hs-CRP), and coronary artery calcium(CAC) measured by electron beam computed tomography. Higher MCP-1 levels were associated with older age, white race, family history of premature coronary disease, smoking, hypertension, diabetes, hypercholesterolemia,and higher levels of hs-CRP (p< 0.01 for each). Similar associations were observed between MCP-1 and risk factors in the subgroup of participants without detectable CAC. Compared with the subjects in the lowest quartile of MCP-1, the odds of prevalent CAC (CAC score ≥10) for subjects in the second, third, and fourth quartiles were 1.30 (95%confidence interval 0.99 to 1.73), 1.60 (95%CI 1.22 to 2.11), and 2.02 (95%CI 1.54 to 2.63), respectively. The association between MCP-1 and CAC remained significant when adjusted for traditional cardiovascular risk factors, but not when further adjusted for age. In a large population-based sample, plasma levels of MCP-1 were associated with traditional risk factors for atherosclerosis, supporting the hypothesis that MCP-1 may mediate some of the atherogenic effects of these risk factors. These findings support the potential role of MCP-1 as a biomarker target for drug development.

关键词：亚临床冠状动脉钙化粥样斑块冠心病家族史断层显像相关性分析心血管病大样本研究亚组白色人种