检索结果-南通市图书馆

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok timothy G.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Hymenopteran-specific TRPA channel from the Texas leaf cutter ant(Atta texana)is heat and cold activated and expression correlates with environmental temperature

在线全文

学校读者我要写书评

暂无评论

Insect Science 2025年第1期32卷 301-320页

作者： Julia M.York timothy N.Taylor Sarah LaPotin Ying Lu Ulrich Mueller Department of Evolution Ecologyand BehaviorUniversity of Illinois Urbana-ChampaignUrbanaUSA Department of Integrative Biology University of Texas at AustinAustinUSA Institute for Neuroscience University of Texas at AustinAustinUSA Department of Human Genetics University of UtahSalt Lake CityUSA

Leaf cutting ants of the genus Atta cultivate fungal gardens,carefully modifying environmental conditions to maintain optimal temperature for fungal *** nerves from Atta are highly temperature sensitive,but the underlying molecular sensor is ***,we utilize Atta texana(Texas leaf cutter ant)to investigate the molecular basis of ant temperature sensation and how it might have evolved as the range expanded northeast across Texas from ancestral populations in *** focus on transient receptor potential(TRP)channel genes,the best characterized temperature sensor proteins in *** texana antennae express 6 of 13 Hymenopteran TRP channel genes and sequences are under a mix of relaxed and intensified *** a behavioral assay,we find *** workers prefer 24℃(range 21−26℃)for fungal *** was no evidence of regulatory evolution across a temperature transect in Texas,but instead Hymenoptera-specific TRPA(HsTRPA)expression highly correlated with ambient *** expressed in vitro,HsTRPA from *** is temperature activated with Q10 values exceeding 100 on initial exposure to temperatures above 33℃.Surprisingly,HsTRPA also appears to be activated by cooling,and therefore to our knowledge,the first non-TRPA1 ortholog to be described with dual heat/cold activation and the first in any invertebrate.

关键词： electrophysiology evolution invertebrate leaf cutter ants temperature TRPchannels

Perspectives on the M 7.1 2025 Southern Tibetan Plateau (Xizang) Earthquake

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2025年

作者： timothy M.Kusky Jiannan Meng State Key Lab for Geological Processes and Mineral Resources and Center for Global TectonicsSchool of Earth SciencesChina University of Geosciences(Wuhan) Badong National Observatory and Research Station for Geohazards China University of Geosciences

On January 7,2025,01:05:15 UTC （9:05 *** time） southern Tibet was rocked by a Mw7.1 earthquake （Mw=moment magnitude,USGS） centered（28.639°N 87.361°E） in the Lhasa Block north of the India/Eurasia Plate boundary,in a remote area about 180km SW of Xigaze,in Dingri County of Shigatse of the Xizang Autonomous Region （Figure 1）.The China Earthquake Networks Center measured the magnitude differently,using surface wave magnitude,Ms,at *** of Jan.10,a total of 126 people were confirmed dead,another 188 injured,and about 61 500 people displaced from their *** region is currently being shaken by thousands of aftershocks,which are likely to continue for weeks or *** than 14 000 search and rescue personnel have been deployed to the epicentral region.

关键词：

Large-scale laboratory investigation of pillar-support interaction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 71-93页

作者： Akash Chaurasia Gabriel Walton Sankhaneel Sinha timothy J.Batchler Kieran Moore Nicholas Vlachopoulos Bradley Forbes Colorado School of Mines GoldenCOUSA Equilibrium Mining KolkataWest BengalIndia National Institute of Occupational and Safety Hazard(NIOSH) PittsburghPAUSA Royal Military College of Canada(RMC) KingstonOntarioCanada BGC Engineering Inc. KingstonOntarioCanada

Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and *** prior research has been conducted to understand pillar failure mechanics and design safe pillar ***,limited studies(mostly based on empirical field observation and small-scale laboratory tests)have considered pillar-support interactions under monotonic loading conditions for the design of pillar-support *** study used a series of large-scale laboratory compression tests on porous limestone blocks to analyze rock and support behavior at a sufficiently large scale(specimens with edge length of 0.5 m)for incorporation of actual support elements,with consideration of different w/h *** unsupported and supported(grouted rebar rockbolt and wire mesh)tests were conducted,and the surface deformations of the specimens were monitored using three-dimensional(3D)digital image correlation(DIC).Rockbolts instrumented with distributed fiber optic strain sensors were used to study rockbolt strain distribution,load mobilization,and localized deformation at different w/h *** axial and bending strains were observed in the rockbolts,which became more prominent in the post-peak region of the stress-strain curve.

关键词： Grouted rockbolt Welded wire mesh Porous limestone Digital image correlation Distributed fiber optic sensing Large-scale laboratory tests

Plate tectonics in relation to mantle temperatures and metamorphic properties

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2020年第5期63卷 634-642页

作者： timothy KUSKY State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Three Gorges Research Center for Geohazards China University of GeosciencesWuhan 430074China

When plate tectonics emerged and how it has evolved over Earth history are two of the most fundamental challenges in Earth *** questions are tackled using a holistic approach to analyze tectonic styles in the history of Earth,giving rise to the interpretation of two styles of plate tectonics since the *** these interpretations,there are different styles of deformation and metamorphism between early times dominated by warm subduction,and later times preferring cold *** two styles of plate tectonics are recorded by different properties of regional metamorphism at convergent plate boundaries,which are linked to the differences in mantle temperature between the Archean and Phanerozoic.A transition to modern plate tectonics is recorded by the signature of blueschist facies metamorphism developed in the *** is consistent with geological evidence for the operation of ancient plate tectonics since the early *** temporal cooling of the mantle explains the geochemical trends of mantle-derived melts,the likely change from numerous small plates to fewer but larger plates,changes in thickness and preservation of oceanic crust and lithosphere in accretionary and collisional orogens,and led to the oxygenation of the surface environment providing the environments needed to foster life.

关键词： Plate tectonics Precambrian Accretionary orogen Mantle temperature Metamorphic facies series

Analysis of the design and performance characteristics of pumpable roof supports

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2017年第1期27卷 91-99页

作者： Batchler timothy NIOSH Office of Mine Safety and Health ResearchPittsburghPA 15236USA

Pumpable roof supports are currently being used to provide a safe working environment for longwall mining. Because different pumpable supports are visually similar and installed fundamentally in the same manner as other supports, there is a tendency to believe they all perform the same way. However, there are several design parameters that can affect their performance, including the cementitious material properties and the bag construction practices that influence the degree of confinement provided. A full understanding of the impact of these design parameters is necessary to optimize the support application and to provide a foundation for making further improvements in the support performance. This paper evaluates the impact of various support design parameters by examining full-scale performance tests conducted using the National Institute for Occupational Safety and Health(NIOSH) Mine Roof Simulator(MRS) as part of manufacturers' developmental and quality control testing. These tests were analyzed to identify correlations between the support design parameters and the resulting performance. Based on more than 160 tests over 7 years, quantifiable patterns were examined to assess the correlation between the support dimensions, cementitious material type, wire pitch, and single-wall vs. dualwalled bag designs to the support capacity, stiffness, load shedding events, and yield characteristics.

关键词： Pumpable Roofsuppo Performance characteristics Secondary support

Growth of continental crust in intra-oceanic and continental-margin arc systems: Analogs for Archean systems

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2022年第9期65卷 1615-1645页

作者： timothy KUSKY Lu WANG State Key Lab for Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan 430074China

Earth’s continental crust has grown and been recycled throughout geologic history along convergent plate *** main locus of continental crustal growth is in intra-oceanic and continental-margin arc systems in Archean time. In arc systems, oceanic lithosphere is subducted to the deeper mantle, and together with its overlying sedimentary sequence is in some cases off-scraped to form accretionary prisms. Fluids are released from the subducting slab to chemically react with the mantle wedge, forming mafic-ultramafic metasomatites, whose partial melting generates mafic melts that rise up to form arcs. In intraoceanic arcs, they produce dominantly basaltic lavas, with a mid-crust that includes variably-developed vertically-walled intermediate plutons and higher-level dikes and sills. In continental-margin arcs, different petrogenetic processes cause assimilation and fractionation of basaltic magmas, partial melting/reworking of juvenile basaltic rocks, and mixing of mantle-and crust-derived melts, so they produce andesitic calc-alkaline melts but still have a mid-crust dominated by vertically-walled felsic plutons, which form 3-D dome-and-basin structures, akin to those in some Archean terranes such as parts of the Pilbara and Zimbabwe cratons. Notably, the continental crust of Archean times is dominated by tonalite-trondhjemite-granodiorite(TTG)plutons, similar to that of the mid-crust of these arc systems, suggesting that early continental crust may have formed largely by the amalgamation of multiple arc systems. The patterns of magmatism, in terms of petrogenesis, rock types, duration of magmatic and accretionary events, and the spatial scales of deformation and magmatism have remained essentially the same throughout geological history, demonstrating that plate tectonic processes characterized by subduction and arc magmatism have been in operation at least as long as recorded by the preserved geologic record, since the Eoarchean. However, the early Earth was dom

关键词： Oceanic arc Continental arc Accretionary orogen Archean Crustal growth

Performance-based seismic design of nonstructural building components:The next frontier of earthquake engineering

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 17-46页

作者： Andre Filiatrault timothy Sullivan Dept.of Civil Structural and Environmental Engineering University at BuffaloState University of New York Dept.of Civil Engineering & Architecture University of Pavia Assistant Professor

With the development and implementation of performance-based earthquake engineering,harmonization of performance levels between structural and nonstructural components becomes vital. Even if the structural components of a building achieve a continuous or immediate occupancy performance level after a seismic event,failure of architectural,mechanical or electrical components can lower the performance level of the entire building system. This reduction in performance caused by the vulnerability of nonstructural components has been observed during recent earthquakes worldwide. Moreover,nonstructural damage has limited the functionality of critical facilities,such as hospitals,following major seismic events. The investment in nonstructural components and building contents is far greater than that of structural components and framing. Therefore,it is not surprising that in many past earthquakes,losses from damage to nonstructural components have exceeded losses from structural damage. Furthermore,the failure of nonstructural components can become a safety hazard or can hamper the safe movement of occupants evacuating buildings,or of rescue workers entering buildings. In comparison to structural components and systems,there is relatively limited information on the seismic design of nonstructural components. Basic research work in this area has been sparse,and the available codes and guidelines are usually,for the most part,based on past experiences,engineering judgment and intuition,rather than on objective experimental and analytical results. Often,design engineers are forced to start almost from square one after each earthquake event: to observe what went wrong and to try to prevent repetitions. This is a consequence of the empirical nature of current seismic regulations and guidelines for nonstructural components. This review paper summarizes current knowledge on the seismic design and analysis of nonstructural building components,identifying major knowledge gaps that w

关键词： nonstructural building components performance-based earthquake engineering seismic design and analysis