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A new mixed agent-based network and compartmental simulation framework for joint modeling of related infectious diseases-application to sexually transmitted infections

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Infectious Disease Modelling 2023年第1期8卷 84-100页

作者： Chaitra Gopalappa Hari Balasubramanian Peter j.Haas University of Massachusetts Amherst 160 Governors DriveAmherstMA01003USA

Background:A model that jointly simulates infectious diseases with common modes of transmission can serve as a decision-analytic tool to identify optimal intervention combinations for overall disease *** the United States,sexually transmitted infections(STIs)are a huge economic burden,with a large fraction of the burden attributed to *** also show interactions between HIV and other sexually transmitted infections(STIs),such as higher risk of acquisition and progression of co-infections among persons with HIV compared to persons ***,given the wide range in prevalence and incidence burdens of STIs,current compartmental or agent-based network simulation methods alone are insufficient or computationally burdensome for joint disease ***,causal factors for higher risk of coinfection could be both behavioral(i.e.,compounding effects of individual behaviors,network structures,and care behaviors)and biological(i.e.,presence of one disease can biologically increase the risk of another).However,the data on the fraction attributed to each are ***:We present a new mixed agent-based compartmental(MAC)framework for jointly modeling *** uses a combination of a new agent-based evolving network modeling(ABENM)technique for lower-prevalence diseases and compartmental modeling for higher-prevalence *** a demonstration,we applied MAC to simulate lower-prevalence HIV in the United States and a higher-prevalence hypothetical Disease 2,using a range of transmission and progression rates to generate burdens replicative of the wide range of *** simulated sexual transmissions among heterosexual males,heterosexual females,and men who have sex with men(men only and men and women).Setting the biological risk of co-infection to zero,we conducted numerical analyses to evaluate the influence of behavioral factors alone on disease ***:The contribution of behavioral factors to risk of coinfection was sensitive to disease

关键词： joint-modeling diseases Multi-disease modeling Simulation modeling HIV and STIs Diseases and social determinants SDOH

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Organic micro-pollutant removal in liquid-phase using carbonized silk cotton hull

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journal of Environmental Sciences 2008年第9期20卷 1046-1054页

作者： M Sathishkumar A R Binupriya D Kavitha R Selvakumar K K Sheema j G Choi Department of Food Science and Technology Institute of Agricultural Science and Technology Chonbuk National University Department of Chemical Engineering Yonsei University Department of Biotechnology Bharathiar University Department of Plant biology and Biotechnology Government Arts College National Agricultural Products Quality Management Services

Phenolic compounds constitute one of the major pollutants in the modern world. Although many physical and chemical treatment technologies for their removal exist, most of them are economically not feasible. The present study was aimed at using silk cotton hull, a potent agricultural waste as an adsobent for removal of 2,4-dichlorophenol (2,4-DCP), which was used as a model phenolic compound. The process parameters were investigated and optimized conditions were determined. The equilibrium time was found to ...

关键词： silk cotton hull carbon adsorption 2 4-DCP temperature kinetic study

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Do specific ultrasonography features identified at the time of early pregnancy loss predict fetal chromosomal abnormality? e A systematic review and meta-analysis

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Genes & Diseases 2019年第2期6卷 129-137页

作者： j.Huang W.Zhu j.Tang S.H.Saravelos L.C.Y.Poon T.C.Li Department of Obstetrics and Gynaecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina IVF Unit Hammersmith HospitalImperial College Healthcare NHS TrustLondonUK

To investigate the association of specific ultrasonography features identified during the diagnosis of early pregnancy loss(EPL)and abnormal *** was a systematic review and meta-analysis conducted in accordance with PRISMA *** searched PubMed,Cochrane and Ovid MEDLINE from 1977 to jan 2017 to identify the articles that described EPL with karyotype and ultrasonography *** differences were pooled to estimate the chromosomal abnormality rates in ultrasonography features,including pre-embryonic,enlarged yolk sac(YS),short crown rump length(CRL),small gestational sac(GS),symmetrical arrested growth embryo,or gestational sac with only a *** assessment of included studies was performed using Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)checklists for Observational Studies(2007 version).Thirteen studies were included in the *** abnormality was more likely to occur in embryonic EPL and enlarged *** the other hand,short CRL,small GS,symmetrical arrested growth embryo,or gestational sac with only a YS,were not associated with an increased risk of fetal chromosomal *** features at the time of diagnosis of EPL have limited predictive value of fetal chromosomal abnormality.

关键词： Ultrasonography Early pregnancy loss Chromosomal abnormality Predictive value

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Designing Hardware for the Boundary Condition Round Robin Challenge

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Sound & Vibration 2018年第1期52卷 9-12页

作者： David E.Soine Richard j.jones julie M.Harvie Troy j.Skousen Tyler F.Schoenherr Kansas City National Security Campus* 14520 Botts RoadKansas CityMissouriUSA Sandia National Laboratories P.O.Box 5800-MS 0840AlbuquerqueNM 87185

Qualification of products to their vibration and shock requirements in a laboratory setting consists of two basic *** first is the quantification of the product’s mechanical environment in the *** second is the process of testing the product in the laboratory to ensure it is robust enough to survive the field *** latter part is the subject of the“Boundary Condition for Component Qualification”challenge *** paper describes the challenges in determining the appropriate boundary conditions and input stimulus required to qualify the *** paper also describes the step sand analyses that were taken to design a set of hardware that demonstrates the issue and can be used by round robin challenge participants to investigate the problem.

关键词： field. Boundary Robin

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Seismic performance evaluation of innovative balloon type CLT rocking shear walls

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Resilient Cities and Structures 2022年第1期1卷 44-52页

作者： T.Y.Yang S.Lepine-Lacroix j.A.Ramos Guerrero j.B.W.McFadden M.A.Q.Al-janabi Department of Civil Engineering The University of British ColumbiaVancouverCanada Canadian Construction Materials Center National Research Council CanadaOttawaCanada Department of Civil Engineering Al-Nahrain UniversityBaghdadIraq

Balloon type cross laminated timber(CLT)rocking shear walls are a novel seismic force resisting *** this paper,the seismic performance of four 12-story balloon type CLT rocking shear walls,designed by a structural engineering firm located in Vancouver(Canada)using the performance-based design procedure outlined in the technical guideline published by the Canadian Construction Materials center(CCMC)/National Research Council Canada(NRC),is *** seismic performance of the prototype CLT rocking shear walls was investigated using nonlinear time history *** nonlinear finite element models were developed using OpenSees and the nonlinear behavior of the displacement-controlled components was calibrated using available experimental data.A detailed site-specific hazard analysis was conducted and sets of ground motions suitable for the prototype buildings were *** ground motions were used in a series of incremental dynamic analyses(IDAs)to quantify the adjustable collapse margin ratio(ACMR)of the prototype balloon type CLT rocking shear *** results show that the prototype balloon type CLT rocking shear walls designed using the performance-based design procedure outlined in the CCMC/NRC technical guideline have sufficient ACMR when compared to the acceptable limits recommended by FEMA P695.

关键词： Cross-laminated timber Rocking shear walls Seismic performance CLT shear walls

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Calculation and interpretation of classical turning surfaces in solids

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npj Computational Materials 2021年第1期7卷 229-238页

作者： Aaron D.Kaplan Stewart j.Clark Kieron Burke john P.Perdew Department of Physics Temple UniversityPhiladelphiaPA 19122USA Centre for Materials Physics Durham UniversityDurham DH13LEUK Departments of Chemistry and Physics University of CaliforniaIrvineCA 92697USA Departments of Physics and Chemistry Temple UniversityPhiladelphiaPA 19122USA

Classical turning surfaces of Kohn–Sham potentials separate classically allowed regions(CARs)from classically forbidden regions(CFRs).They are useful for understanding many chemical properties of molecules but need not exist in solids,where the density never decays to *** equilibrium geometries,we find that CFRs are absent in perfect metals,rare in covalent semiconductors at equilibrium,but common in ionic and molecular *** all materials,CFRs appear or grow as the internuclear distances are uniformly *** can also appear at a monovacancy in a *** with several approximate density functionals and codes confirm these behaviors.A classical picture of conduction suggests that CARs should be connected in metals,and disconnected in wide-gap insulators,and is confirmed in the limits of extreme compression and ***,many semiconductors have no CFR at equilibrium,a key finding for density functional ***,a strong correlation with insulating behavior can still be ***,equilibrium bond lengths for all cases can be estimated from the bond type and the sum of the classical turning radii of the free atoms or ions.

关键词： turning solids expanded

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Complex courtship success and plasticity environments displays facilitate in signaling across male reproductive variable

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Current Zoology 2011年第2期57卷 175-186页

作者： Dustin j. WILGERS Eileen A. HEBETS School of Biological Sciences University of Nebraska-Lincoln Lincoln NE USA

Effective signal transmission is essential for communication. In environments where signal transmission is highly variable, signalers may utilize complex signals, which incorporate multiple components and modalities, to maintain effective communication. Male Rabidosa rabida wolf spiders produce complex courtship signals, consisting of both visual and seismic components. We test the hypothesis that the complex signaling of R. rabida contributes to male reproductive success in variable signaling environments. We first examine the condition-dependence of foreleg ornamentation （a presumed visual signal） and seismic signal components and find that both may provide potentially redundant information on foraging history. Next, we assessed reproductive success across manipulated signaling environments that varied in the effectiveness of visual and/or seismic signal transmission. In environments where only one signal could be successfully transmitted （e.g., visual or seismic）, pairs were still able to successfully copulate. Additionally, we found that males altered their courtship display depending on the current signaling environment. Specifically, males reduced their use of a visual display component in signaling environments where visual signal transmission was ablated. Incorporating signals in multiple modalities not only enables R. rabida males to maintain copulation success across variable signaling environments, but it also enables males to adjust their composite courtship display to current signaling conditions .

关键词： Communication Multimodal Signal evolution Condition-dependent Lycosidae Rabidosa rabida Efficacy back-up Redundant signals

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Precipitation on stacking faults in Mg–9.8wt%Sn alloy

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journal of Materials Science & Technology 2020年第10期42卷 230-240页

作者： C.Q.Liu C.He H.W.Chen j.F.Nie International joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringChongqing UniversityChongqing400044China Department of Materials Science and Engineering Monash UniversityVictoria3800Australia Electron Microscopy Center Chongqing UniversityChongqing400044PR China

In this work,we have systematically investigated precipitation ofβ’-Mg3Sn phase on intrinsic stacking faults I1 and I2 in a Mg-9.8 wt%Sn alloy using aberration-corrected scanning transmission electron *** observed I1 faults are generated by the dissociation of c+a perfect dislocations and bounded by Frank partial dislocations having a Shockley *** ofβ’on I1 involves a shear of 1/3α,similar to its formation directly from theα-Mg ***β’phase often nucleates at one end of an I1 fault due to the interaction between shear strain fields ofβ’and the Shockley component of the Frank partial at that end,and subsequently grows towards the other end of the *** theβ’reaches to the other end,the Shockley partial bounding the lengthening end of theβ’reacts with the Frank partial bounding the fault,generating an a perfect dislocation that can glide away from the precipitate and the *** observed I2 faults are generated by the dissociation of a perfect dislocations and bounded by Shockley *** ofβ’on I2 does not need a shear of 1/3α,since the pre-existing I2 fault already provides an ABCA four-layer structure ofβ’.Thickening of theβ’that has already formed on the I2 involves the successive occurrence of three crystallographically equivalent shears of 1/3αon every second(0002)αplane of theα-Mg *** this thickening mechanism is similar to that of theβ’formed directly from theα-Mg matrix,an a perfect dislocation will be produced when theβ’is thickened to eight layers,and it can again glide away from the precipitate and the fault.

关键词： Heterogeneous precipitation HAADF-STEM Shockley partial dislocation Frank partial dislocation Dislocation reaction

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Monolithic ultrasound fingerprint sensor

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Microsystems & Nanoengineering 2017年第1期3卷 37-44页

作者： Xiaoyue jiang Yipeng Lu Hao-Yen Tang julius M.Tsai Eldwin j.Ng Michael j.Daneman Bernhard E.Boser David A.Horsley Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA Department of Mechanical and Aerospace Engineering University of CaliforniaDavisCA 95616USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA Invensense Inc. San JoseCA 95110USA

This paper presents a 591×438-DPI ultrasonic fingerprint *** sensor is based on a piezoelectric micromachined ultrasonic transducer(PMUT)array that is bonded at wafer-level to complementary metal oxide semiconductor(CMOS)signal processing electronics to produce a pulse-echo ultrasonic imager on a *** meet the 500-DPI standard for consumer fingerprint sensors,the PMUT pitch was reduced by approximately a factor of two relative to an earlier *** conducted a systematic design study of the individual PMUT and array to achieve this scaling while maintaining a high *** resulting 110×56-PMUT array,composed of 30×43-μm^(2) rectangular PMUTs,achieved a 51.7% fill-factor,three times greater than that of the previous *** with the custom CMOS ASIC,the sensor achieves 2 mV kPa^(−1) sensitivity,15 kPa pressure output,75μm lateral resolution,and 150μm axial resolution in a 4.6 mm×3.2 mm *** the best of our knowledge,we have demonstrated the first MEMS ultrasonic fingerprint sensor capable of imaging epidermis and sub-surface layer fingerprints.

关键词： piezoelectric micromachined ultrasonic transducer(PMUT) fingerprint sensors ultrasound

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Themis regulates metabolic signaling and effector functions in CD4^(+) T cells by controlling NFAT nuclear translocation

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Cellular & Molecular Immunology 2021年第9期18卷 2249-2261页

作者： Mukul Prasad joanna Brzostek Namrata Gautam Renu Balyan Vasily Rybakin Nicholas R.j.Gascoigne Translational Immunology Programme Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore H.Lee Moffitt Cancer Center and Research Institute TampaFLUSA Torque Therapeutics CambridgeMAUSA

Themis is a T cell lineage-specific molecule that is involved in TCR signal *** effects of germline Themis deletion on peripheral CD4^(+)T cell function have not been described *** this study,we found that Themis-deficient CD4^(+)T cells had poor proliferative responses,reduced cytokine production in vitro and weaker inflammatory potential,as measured by their ability to cause colitis in *** T cells are quiescent,whereas activated T cells have high metabolic *** of these metabolic demands depends upon nutrient availability and upregulation of nutrient intake channels after efficient TCR signal transduction,which leads to metabolic reprogramming in T *** tested whether defects in effector functions were caused by impaired metabolic shifts in Themis-deficient CD4^(+)T cells due to inefficient TCR signal transduction,in turn caused by the lack of *** found that upon TCR stimulation,Themis-deficient CD4^(+)T cells were unable to upregulate the expression of insulin receptor(IR),glucose transporter(GLUT1),the neutral amino acid transporter CD98 and the mTOR pathway,as measured by c-Myc and pS6 *** analysis of activated Themis-deficient CD4^(+)T cells showed more oxidative phosphorylation(OXPHOS)than aerobic glycolysis,indicating defective metabolic ***,we found reduced NFAT translocation in Themis-deficient CD4^(+)T cells upon TCR *** previously reported ChIP-seq and RNA-seq data,we found that NFAT nuclear translocation controls IR gene ***,our results describe an internal circuit between TCR signal transduction,NFAT nuclear translocation,and metabolic signaling in CD4^(+)T cells.

关键词： Immunometabolism NFAT nuclear translocation Insulin receptor mTOR Mitochondria

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