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Horticulture Research 2020年第1期7卷 449-458页

作者： Kiflu Gebramicael Tesfamicael Endale Gebre timothy j.march Beata Sznajder Diane E.Mather Carlos Marcelino Rodríguez López Environmental Epigenetics and Genetics Group Department of HorticultureCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKY 40546USA Policy Study Institute P.O.Box:2479Addis AbabaEthiopia School of Agriculture Food&WineThe University of AdelaideWaite CampusGlen OsmondSAAustralia

Enset(Ensete ventricosum(Welw.)Cheesman)is a drought tolerant,vegetatively propagated crop that was domesticated in *** is a staple food for more than 20 million people in *** its current importance and immense potential,enset is among the most genetically understudied and underexploited food *** collected 230 enset wild and cultivated accessions across the main enset producing regions in Ethiopia and applied amplified fragment length polymorphism(AFLP)and genotype by sequencing(GBS)analyses to these *** and cultivated accessions were clearly separated from each other,with 89 genes found to harbour SNPs that separated wild from cultivated *** these,17 genes are thought to be involved in flower initiation and seed *** cultivated accessions,differentiation was mostly associated with geographical location and with proximity to wild *** results indicate that vegetative propagation of elite clones has favoured capacity for vegetative growth at the expense of capacity for sexual *** is consistent with previous reports that cultivated enset tends to produce non-viable seeds and flowers less frequently than wild enset.

关键词： cultivated elite flowers

Déjàvu:Might Future Eruptions of Hunga Tonga-Hunga Ha'apai Volcano be a Repeat of the Devastating Eruption of Santorini,Greece(1650 BC)?

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journal of Earth Science 2022年第2期33卷 229-235页

作者： timothy M.Kusky Center for Global Tectonics Three Gorges Research Center for Geo-HazardsChina University of GeosciencesWuhan 430074China

The remote Pacific islands nation of Tonga(about 170 islands,with a population of 105000),and surrounding countries,are suffering from the damage from one of the largest,most explosive volcanic eruptions in at least several decades,at least since the 1991 eruption of Pinatubo in the *** data is still coming in from the jan.15,2022 *** reports show(remarkably)few casualties,but the islands are still(as of this writing)inaccessible because of thick volcanic ash coverings。

关键词： volcanic eruption thick

CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies

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Cellular & Molecular Immunology 2022年第1期19卷 14-22页

作者： timothy N.j.Bullock Department of Pathology University of VirginiaCharlottesvilleVAUSA

The substantial advances attained by checkpoint blockade immunotherapies have driven an expansion in the approaches used to promote T cell access to the tumor microenvironment to provide targets for checkpoint *** in any T cell response to a tumor antigen is the capacity of dendritic cells to initiate and support such ***,the rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed,with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.

关键词： CD40 vaccine CD40L T cell dendritic cell

Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly j Rivenbark timothy D Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

Making the link between ADF and 4D STEM:Resolution,transfer and coherence

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Chinese Physics B 2024年第11期33卷 26-33页

作者： Peter D.Nellist timothy j.Pennycook Department of Materials University of OxfordOxfordUK EMAT University of AntwerpGroenenborgerlaan 1712020 AntwerpBelgium

Steve Pennycook is a pioneer in the application of high-resolution scanning transmission electron microscopy(STEM)and in particular the use of annular dark-field(ADF)*** we show how a general framework for 4D STEM allows clear links to be made between ADF imaging and the emerging methods for reconstructing images from 4D STEM data *** show that both ADF imaging and ptychographical reconstruction can be thought of in terms of integrating over the overlap regions of diffracted discs in the detector *** approach allows the similarities in parts of their transfer functions to be understood,though we note that the transfer functions for ptychographic imaging cannot be used as a measure of information *** also show that conditions of partial spatial and temporal coherence affect ADF imaging and ptychography similarly,showing that achromatic interference can always contribute to the image in both cases,leading to a robustness to partial temporal coherence that has enabled high-resolution imaging.

关键词： image forming and processing phase retrieval electron microscopy scanning transmission electron microscope(STEM)

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Adapting the botanical landscape of Melbourne Gardens(Royal Botanic Gardens Victoria)in response to climate change

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Plant Diversity 2017年第6期39卷 338-347页

作者： timothy j.Entwisle Chris Cole Peter Symes Royal Botanic Gardens Victoria

Botanic gardens around the world maintain collections of living plants for science, conservation, education, beauty and more. These collections change over time-in scope and content-but the predicted impacts of climate change will require a more strategic approach to the succession of plant species and their landscapes. Royal Botanic Gardens Victoria has recently published a 'Landscape Succession Strategy'for its Melbourne Gardens, a spectacular botanical landscape established in 1846. The strategy recognizes that with 1.6 million visitors each year, responsibility for a heritage-listed landscape and the need to care for a collection of 8500 plant species of conservation and scientific importance, planting and planning must take into account anticipated changes to rainfall and temperature. The trees we plant today must be suitable for the climate of the twenty-second century. Specifically, the Strategy sets out the steps needed over the next twenty years to transition the botanic garden to one resilient to the climate modelled for2090. The document includes a range of practical measures and achievable(and at times somewhat aspirational) targets. Climate analogues will be used to identify places in Australia and elsewhere with conditions today similar to those predicted for Melbourne in 2090, to help select new species for the collection. Modelling of the natural and cultivated distribution of species will be used to help select suitable growth forms to replace existing species of high value or interest. Improved understanding of temperature gradients within the botanic garden, water holding capacity of soils and plant water use behaviour is already resulting in better targeted planting and irrigation. The goal is to retain a similar diversity of species but transition the collection so that by 2036 at least 75% of the species are suitable for the climate in 2090. Over the next few years we hope to provide 100% of irrigation water from sustainable water sources, and

关键词： Climate change Landscape succession Botanic garden Uving collection

Organization of future training in bariatric gastroenterology

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World journal of Gastroenterology 2017年第35期23卷 6371-6378页

作者： timothy R Koch timothy R Shope Christopher j Gostout Center for Advanced Laparoscopic General and Bariatric Surgery Med Star Washington Hospital Center and Georgetown University School of Medicine Division of Gastroenterology and Hepatology Mayo Clinic

A world-wide rise in the prevalence of obesity continues. This rise increases the occurrence of, risks of, and costs of treating obesity-related medical conditions. Diet and activity programs are largely inadequate for the long-term treatment of medically-complicated obesity. Physicians who deliver gastrointestinal care after completing traditional training programs, including gastroenterologists and general surgeons, are not uniformly trained in or familiar with available bariatric care. It is certain that gastrointestinal physicians will incorporate new endoscopic methods into their practice for the treatment of individuals with medically-complicated obesity, although the longterm impact of these endoscopic techniques remains under investigation. It is presently unclear whether gastrointestinal physicians will be able to provide or coordinate important allied services in bariatric surgery, endocrinology, nutrition, psychological evaluation and support, and social work. Obtaining longitudinal results examining the effectiveness of this ad hoc approach will likely be difficult, based on prior experience with other endoscopic measures, such as the adenoma detection rates from screening colonoscopy. As a longterm approach, development of a specific curriculum incorporating one year of subspecialty training in bariatrics to the present training of gastrointestinal fellows needs to be reconsidered. This approach should be facilitated by gastrointestinal trainees' prior residency training in subspecialties that provide care for individuals with medical complications of obesity, including endocrinology, cardiology, nephrology, and neurology. Such training could incorporate additional rotations with collaborating providers in bariatric surgery, nutrition, and psychiatry. Since such training would be provided in accredited programs, longitudinal studies could be developed to examine the potential impact on accepted measures of care, such as complication rates, outcomes, and

关键词： Obesity Bariatrics Bariatric surgery Intragastric balloon Endoscopic sleeve gastroplasty Nutrition Endoscopy Training

CityGML goes mobile: application of large 3D CityGML models on smartphones

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International journal of Digital Earth 2019年第1期12卷 25-42页

作者： Christoph Blut timothy Blut jörg Blankenbach Department of Computing in Civil Engineering and Geo Information Systems Geodetic InstituteRWTH Aachen UniversityAachenGermany

CityGML,a semantic information model for digital/virtual city models has become quite popular in various *** the data format is still actively under development,it is already supported by different software solutions,especially GIS-based desktop *** systems on the other hand are still neglected,even though the georeferenced objects of CityGML have many application fields,for example,in the currently popular area of location-based Augmented *** this paper we present an independent multi-platform CityGML viewer,its architecture and specific implementation techniques that we use to realize and optimize the process of visualizing CityGML data for use in Augmented *** main focus lies in improving the implementation on mobile devices,such as smartphones,and assessing its usability and performance in comparison to web-based *** to the constrained hardware resources of smartphones,it is a particular challenge to handle complex 3D objects and large virtual worlds as provided by CityGML,not only in terms of memory and storage space,but also with respect to mobile processing units and display sizes.

关键词： CityGML city model android 3D visualization real-time rendering

Ribozymes and the mechanisms that underlie RNA catalysis

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： timothy j. Wilson Yijin Liu David M. j. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism