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体力活动与衰老

体力活动与衰老

Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting

作者： R.j.·谢泼德(R.j. shephard)

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World j.urnal of Gastroenterology 2006年第28期12卷 4504-4510页

作者： Schalk W van der Merwe Maria M Conradie Robert Bond Brenda j.Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G shephard Maritha j.Kotze Nico P de Villiers Stephen Hough Department of Internal Medicine and Gastroenterology ImmunologyHepatology and GI- research laboratoryUniversity of PretoriaSouth Africa Department of Internal Medicine and Endocrinology University of StellenboschSouth Africa Department of Internal Medicine and Gastroenterology1 Hepatology and GI- research laboratoryUniversity of PretoriaSouth Africa Department of Hepatology and GI- research laboratory University of PretoriaSouth Africa Department of Chemical Pathology University of PretoriaSouth Africa Department of Ampath pathology PretoriaSouth Africa Department of Surgery Grootte Schuur HospitalUniversity of Cape TownSouth Africa MRC Liver Research Centre Grootte Schuur HospitalUniversity of Cape TownSouth Africa Department of Genecare Molecular Genetics Christiaan Barnard Memorial HospitalCape TownSouth Africa

AIM： TO study if T-cell activation related to portasystemic shunting causes osteoclast-mediated bone loss through RANKL-dependent pathways. We also investigated if T-cell inhibition using rapamycin would protect against bone loss in rats. METHODS： Portasystemic shunting was performed in male Sprague-Dawley rats and rapamycin 0.1 mg/kg was administered for 15 wk by gavage. Rats received powderized chow and supplemental feeds to prevent the effects of malnutrition on bone composition. Weight gain and growth was restored after surgery in shunted animals. At termination, biochemical parameters of bone turnover and quantitative bone histology were assessed. Markers of T-cell activation, inflammatory cytokine production, and RANKL-dependent pathways were measured. In addition, the roles of IGF-1 and hypogonadism were investigated. RESULTS： Portasystemic shunting caused low turnover osteoporosis that was RANKL independent. Bone resorbing cytokine levels, including IL-1, IL-6 and TNFα, were not increased in serum and TNFα and RANKL expression were not upregulated in PBMC. Portasystemic shunting increased the circulating CD8＋ T-cell population. Rapamycin decreased the circulating CD8＋ T-cell population, increased CD8＋ CD25＋ T-regulatory cell population and improved all parameters of bone turnover. CONCLUSION： Osteoporosis caused by portasystemic shunting may be partially ameliorated by rapamycin in the rat model of hepatic osteodystrophy.

关键词： Osteopenia Liver disease Portasystemic shunting T-lymphocyte Rapamycin

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体力活动与衰老

1987年

作者：（加拿大）谢泼德（shephard R.j.）陶心铭等译

本书对体力活动与衰老的知识作了介绍。

ISBN: (纸本)7015·2376

本书对体力活动与衰老的知识作了介绍。

关键词：体育活动关系衰老

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练习太极拳时心血管呼吸和代谢功能的改变

中山大学学报(医学科学版) 1987年第3期 22-25页

作者：卓大宏,Roy j.shephard,Michael j.Plyley,Glen M.Davis 中山医科大学加拿大多伦多大学加拿大多伦多大学加拿大多伦多大学

太极拳是中国传统的武术健身运动。近二、三十年来,北美和西方其他国家许多医学界和武术界人士对太极拳的健身作用越来越感兴趣。太极拳被认为是一种柔和的、放松的运动,可作为对慢性病者的一种放松性的康复性体操,同时,也是一种对一般... 详细信息

太极拳是中国传统的武术健身运动。近二、三十年来,北美和西方其他国家许多医学界和武术界人士对太极拳的健身作用越来越感兴趣。太极拳被认为是一种柔和的、放松的运动,可作为对慢性病者的一种放松性的康复性体操,同时,也是一种对一般中老年和青年人的健身运动。

关键词：太极拳运动心率简化太极拳练习

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练太极拳时心血管呼吸和代谢功能的改变

中国康复医学杂志 1987年第6期 241-244页

作者：卓大宏 Roy j.shephard Michael j.Plyley Glen M.Davis 中山医科大学加拿大多伦多大学加拿大多伦多大学加拿大多伦多大学

有关太极拳代谢及生理强度的研究报道极少见。本研究旨在通过实验以了解太极拳的生理强度。受试者为11名健康男青年,平均年龄28.4岁。练习太极拳运动史平均5年,动作娴熟。观察受试者在练习杨家老式太极拳时摄氧量和有关代谢指标,以及心... 详细信息

有关太极拳代谢及生理强度的研究报道极少见。本研究旨在通过实验以了解太极拳的生理强度。受试者为11名健康男青年,平均年龄28.4岁。练习太极拳运动史平均5年,动作娴熟。观察受试者在练习杨家老式太极拳时摄氧量和有关代谢指标,以及心率、血压的改变。用自动呼吸气体分析装置(j.eger Ergcoxyscreen)及心电遥测装置测量打一套太极拳(历时17～25分钟,平均22分钟)时上述指标的变化。老式太极拳平均能量消耗为4.1METS,相当于1.03升/分或14.5毫升/分/公斤体重的摄氧量,运动时平均最高心率为134次/分。这些数值提示老式太极拳可列为柔和运动,其生理强度不超过最大摄氧量的50％。

关键词：太极拳运动平均练习血压受试者简化太极拳心率

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体质评价

体质评价

Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

作者： R.j.·谢泼德(R.j. shephard) H.·赖伐尔(H. Lavallee)

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j.urnal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie Ella Miller Claire Lawrence Rebecca j.Beeken Abigail Fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adj.sting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAEnd

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