检索结果-南通市图书馆

Cytokines in the BALB/c mouse testis in various conditions

在线全文

学校读者我要写书评

暂无评论

Asian journal of Andrology 2001年第1期3卷 9-19页

作者： E.Verjnkorva M.Martikainen P.Pllnen Department of Anatomy University of Turku FIN-20520 Turku FinlandDepartment of Anatomy University of Turku FIN-20520 Turku FinlandDepartment of Anatomy and Department of Obstetrics and Gynecology University of Turku FIN-20520 Turku Finland

Aim: To investigate whether testosterone, estrogens, vasectomy, experimental cryptorchidism, varicocele or agingwould induce changes in the cytokine environment of the mouse testis. Methods: In adult male BALB/c mice,testosterone implants, estradiol benzoate, vasectomy, unilateral cryptorchidism, unilateral varicocele were adminis-tered/performed. The mice were followed up for different periods of time and were then sacrificed with testes incisedfor examination. The control mice received the vehicle or sham-operation. Results: IL-10 was present in Leydigcells of nearly every testis and IL-10 + macrophages in 39% of testes. IL-6 was found in the testes of intact adultmice, mice treated with testosterone for 70 days, cryptorchid testes and sham-operated testes. Conclusion: Resultssuggest that IL-10 might be involved in the generation of the immunologically privileged microenvironment in the testis.(Asian j Androl 2001 Mar; 3: 9-19)

关键词： testosterone vasectomy estrogens cryptorchidism abdominal testis varicocele cyokines IL-10 macrophages clonal anergy

CD99and CD 106(VCAM-1)in human testis

在线全文

学校读者我要写书评

暂无评论

Asian journal of Andrology 2002年第4期4卷 243-248页

作者： E. Verjnkorva M. Laato P. Pllnen Department of Anatomy Turku Graduate School of Clinical SciencesDepartment of Medical Molecular Biology and Biochemistry Department of SurgeryDepartment of Anatomy Department of Obstetrics and Gynaecology University of Turku

Aim: The expression of the cytokines IL-2, IL-6, IL-10, IFN-γ and TNF-α and the adhesion proteins CD99 and CD106 was studied in the human testis at the protein level. Methods: The expression of the cytokines and the adhesion proteins was assessed using immunohistochemistry and immunoblotting. Results: None of the cytokines studied was present in the human testis, but CD99 and CD106 (VCAM-1) strongly were expressed in all the testes investigated. CD99 was present in the interstitial tissue of the human testis as well as in the Sertoli cells. The identity of the CD99+ interstitial cells is unclear. CD106 (VCAM-1) was present in Leydig cells as well as the basal parts of the Sertoli cells in the seminiferous tubules. In immunoblotting, CD99 was demonstrated at molecular ratios of 46-57 (kD). This is a novel isoform of the molecule. Conclusion: The human testis produces both CD99 and CD106 and as CD106 mediates cell binding to lymphocytes, it is possible that the human Leydig cells adhere to lymphocytes like the rodent Leydig cells. (Asian j Androl 2002 Dec; 4: 243-248)

关键词： testis prostate carcinoma hydrocele cytokines adhesion proteins CD99 CD106 IL-2 IL-6 IL-10 IFN-γ TNF-α

THE　RISE　AND　DECLINE　OF　THE　UNITED　STATES　SHIPPING　AND　SHIPBUILDING　INDUSTRIES

在线全文

学校读者我要写书评

暂无评论

上海交通大学学报 1994年第6期 1-10页

作者： (Captain james S.C.Chao,DCS,ll.D.john j.Clark,Ph.D.)

ＴＨＥＲＩＳＥＡＮＤＤＥＣＬＩＮＥＯＦＴＨＥＵＮＩＴＥＤＳＴＡＴＥＳＳＨＩＰＰＩＮＧＡＮＤＳＨＩＰＢＵＩＬＤＩＮＧＩＮＤＵＳＴＲＩＥＳ￥（ＣａｐｔａｉｎＪａｍｅｓＳ．Ｃ．Ｃｈａｏ，ＤＣＳ，ＬＬ．Ｄ．ＪｏｈｎＪ．Ｃｌａ... 详细信息

ＴＨＥＲＩＳＥＡＮＤＤＥＣＬＩＮＥＯＦＴＨＥＵＮＩＴＥＤＳＴＡＴＥＳＳＨＩＰＰＩＮＧＡＮＤＳＨＩＰＢＵＩＬＤＩＮＧＩＮＤＵＳＴＲＩＥＳ￥（ＣａｐｔａｉｎＪａｍｅｓＳ．Ｃ．Ｃｈａｏ，ＤＣＳ，ＬＬ．Ｄ．ＪｏｈｎＪ．Ｃｌａｒｋ，Ｐｈ．Ｄ．）Ａｂｓｔｒａｃｔ...

关键词： shipping industry shipbuilding industry management

“When you’re down, stay down”:A lesson for all competitive alpine skiers supported by an ACL rupture measured in vivo

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2022年第1期11卷 14-20页

作者： jörg Spöorri Erich Müller josef Kröoll Sports Medical Research Group Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland University Centre for Prevention and Sports Medicine Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland Department of Sport Science and Kinesiology University of SalzburgHallein-Ri 5400Austria

Background:During an experiment,a ski racer equipped with various measurement devices suffered an anterior cruciate ligament(ACL)rupture in his right *** aim of this study was to describe the underlying injury mechanism from a functional ***:Eight giant slalom turns(i.e.,4 left turns),followed by 1 left turn at which the ACL injury occurred,were recorded by 2 video cameras,electromyography of 4 relevant muscle groups,inertial measurement units to measure knee and hip angles,and pressure insoles to determine ground reaction ***:Due to a loss of balance,the ski racer began to slide sideways at the apex of a left *** sliding,his right(outside)leg was actively abducted upward without touching the *** ski racer then attempted to stand up again by dropping his leg back towards the snow *** end of this dropping was accompanied by a decrease in electromyographic activity in the knee stabilizing *** the inside edge of the outer ski caught the snow surface,a rapidly increasing peak force,knee flexion,and an aggressive sudden activation of the vastus medialis muscle were observed,while biceps femoris and rectus femoris further decreased their activation *** likely resulted in excessive anterior translation of the tibia relative to the femur,causing damage to the ***:Our example emphasizes that ski racers should not get up until they stop ***:“When you’re down,stay down.”

关键词： Alpine skiing Athletes Injury mechanism Injury prevention Knee injuries

在线全文

学校读者我要写书评

暂无评论

负温度系数热敏电阻对半导体桥电爆性能影响

含能材料 2014年第6期22卷 808-812页

作者：李勇李凯刘恩良周彬南京理工大学江苏南京210094 航天科工六院41所内蒙古呼和浩特010010

温度是影响火工品电磁防护其防护效果的主要因素,负温度系数(NTC)热敏电阻用于半导体桥(SCB)能有效提高其射频感度。采用恒流激励和电容放电两种实验,对不同环境温度下NTC热敏电阻对SCB性能的影响规律进行了研究。通过1 A 5 min恒流激... 详细信息

温度是影响火工品电磁防护其防护效果的主要因素,负温度系数(NTC)热敏电阻用于半导体桥(SCB)能有效提高其射频感度。采用恒流激励和电容放电两种实验,对不同环境温度下NTC热敏电阻对SCB性能的影响规律进行了研究。通过1 A 5 min恒流激励实验,分析了室温(25℃)和高温(70℃)时NTC热敏电阻的并联分流情况;25℃时NTC热敏电阻分走59%回路电流,70℃时,对小尺寸SCB(S-SCB)的分流率最大达到63%。在电容放电激励下,探讨了并联NTC热敏电阻SCB在25℃和70℃时电爆性能的变化情况。结果表明,并联NTC热敏电阻前后,典型尺寸(L-SCB)在25℃和70℃下的爆发时间和爆发消耗能量均无显著性变化。而S-SCB并联NTC热敏电阻后,当温度从25℃升至70℃,爆发时间从5.94μs增长到7.18μs,爆发消耗积分能量从0.388 m j降低到0.178 m j。

关键词：军事化学与烟火技术半导体桥(SCB) 负温度系数(NTC)热敏电阻电爆性能电磁防护

Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2017年第1期6卷 585-592页

作者： Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz j Antosiewicz Mikael Käll Department of Physics Chalmers University of Technology41296 GöteborgSweden Department of Chemistry and Chemical Engineering Chalmers University of Technology41296 GöteborgSweden Centre of New Technologies University of WarsawBanacha 2c02-097 WarsawPoland

Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic ***,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device *** address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized *** resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation *** demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption.

关键词： biosensing hyperspectral lab-on-a-chip LSPR nonspecific adsorption

In vitroactivity of cationic peptides against Neisseria gonorrhoeaeand vaginal Lactobacillusspecies: The effect of divalent cations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2012年第3期3卷 249-255页

作者： Bernard j. Moncla timothy A. Mietzner Sharon Louise Hillier Department of Molecular Genetics and Biochemistry University of Pittsburgh School of Medicine Biomedical Sciences Tower Pittsburgh USA Department of Obstetrics Gynecology and Reproductive Sciences University of Pittsburgh Pittsburgh USA

One of the new strategies for the prevention of HIV acquisition is the use of microbicides such as topical microbicides including antimicrobial and antiviral peptides. Ideally, new drug candidates should kill pathogens without determent to the normal bacterial flora considered important in health;such as hydrogen peroxide producing Lactobacillus species. The antimicrobial peptides ll-37 and LSA-5 were studied to determine their spectrum of activity against bacterial pathogens and normal flora organisms. The effects of divalent cations at biologically relevant concentrations were determined. We show the synthetic lytic peptide LSA-5 and the naturally occurring peptides ll-37 inactivate Neisseria gonorrhoeae but are less active against many normal flora members such as Lactobacillus species. Biologically relevant concentrations of calcium and magnesium prevented killing of sensitive strains. LSA-5 is more potent than ll-37, both are inhibited from killing sensitive strains by calcium and magnesium. Strains of Lactobacillus iners were killed by both microbicides even in the presence of the divalent cations. Antimicrobial peptides, such as LSA-5, have good potential for use in prevention of sexually transmitted disease, if formulated to sequester calcium and magnesium present in biological fluids.

关键词： Microbicides HIV Lactobacillus Antimicrobial Peptides Cations Neisseria gonorrhoeae

3,3'-二(氟偕二硝基)二呋咱基醚(FOF-13)新法合成(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

含能材料 2014年第6期22卷 884-886页

作者：王伯周翟连杰廉鹏李亚南李辉霍欢李祥志西安近代化学研究所陕西西安710065

自行设计了3,3'-二(氟偕二硝基)二呋咱基醚(FOF-13)新的合成路线,采用3,3'-二氰基二呋咱醚(FOF-2)为原料,经氰基加成、重氮化、硝化、还原、氟化5步反应合成了FOF-13,总收率为8.5%,并通过IR、13C NMR、1 9F NMR、元素分析等分析手段进... 详细信息

自行设计了3,3'-二(氟偕二硝基)二呋咱基醚(FOF-13)新的合成路线,采用3,3'-二氰基二呋咱醚(FOF-2)为原料,经氰基加成、重氮化、硝化、还原、氟化5步反应合成了FOF-13,总收率为8.5%,并通过IR、13C NMR、1 9F NMR、元素分析等分析手段进行了结构表征。开展了FOF-13物化与爆轰性能研究,实验结果为:结晶密度1.92 g·cm-3,熔点43.5℃(DSC),撞击感度大于14 j,摩擦感度为64%,爆速为8497(ρ=1.69 g·cm-3),表明FOF-13为一种性能优异的增塑剂。

关键词：有机化学 3,3′-二(氟偕二硝基)二呋咱基醚(FOF-13) 新法合成性能

Identification of human herpesvirus-8 in Kaposi＆#39;s sarcoma with bullous pemphigoid

在线全文

学校读者我要写书评

暂无评论

Chinese Medical journal 2014年第4期127卷 786-788页

作者： Wang T Li CT Yang C Cui HZ Fu XH Wen ll Cui Y Yang S Zhang X j Institute of Dermatology & Department of Dermatology First Hospital of Anhui Medical University Hefei Anhui 230032 China epartment of Dermatology Second Hospital of Anhui MedicalUniversity Hefei Anhui 230032 China

Kaposi＆#39;s sarcoma （KS） is a rare,malignant *** of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive *** to the clinical characteristics and the affected population,four clinical types of KS have been described successively：classic,endemic to Africa,acquired immunodeficiency syndrome （AIDS）-associated,and immunosuppression associated *** pemphigoid （BP） is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G （IgG） deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with ***,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for *** also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 （HHV-8） in the pathogenic mechanism.

关键词： Kaposi's sarcoma bullous pemphigoid human herpesvirus-8 immunosuppressive agents