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h.st Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose h.meostasis in Diabetic Mice

Journal of Diabetes Mellitus 2016年第4期6卷 277-290页

作者： Sich.n Liu Emily M. Smith.timothy h. king Lindsey Glenn Mich.lle Trevino So h.un Park Yui Mach.da Ciriaco Villaflor Wojciech.Grzesik Margaret A. Morris Yumi Imai Jerry L. Nadler Eastern Virginia Medical Sch.ol Department of Internal Medicine Strelitz Diabetes Center Norfolk VA USA Department of Internal Medicine Fraternal Order of Eagles Diabetes Research Center The University of Iowa Carver College of Medicine Iowa City IA USA

Recovery of functional beta cell mass offers a biological cure for type 1 diabetes. h.wever, beta cell mass is difficult to regain once lost since th. proliferation rate of beta cells after youth.is very low. Angiopoietin like-protein 8 (ANGPTL8), a peptide th.t h.s a role in th. regulation of lipoprotein lipase activity, was reported to increase beta cell proliferation in mice in 2013. Subsequent studies of h.man ANGPTL8 for sh.rt term (3 to 8 days) in non-diabetic mice sh.wed little or no increase in beta cell proliferation. h.re, we examined th. effect of ANGPTL8 on glucose h.meostasis in models th.t h.ve not been examined previously. We expressed mouse ANGPTL8 using adenovirus in 2 mouse models of diabetes (streptozotocin and Non-Obese Diabetic (NOD) mice) over 2 weeks. Also, we tested ANGPTL8 in NOD mice deficient in leukocyte 12-lipoxygenase (12LO), an enzyme th.t contributes to insulitis and loss of beta cell function in NOD, in an effort to determine wh.th.r 12LO deficiency alters th. response to ANGPTL8. Adenovirus-mediated expression of ANGPTL8 lowered blood glucose levels in streptozotocin treated mice with.ut an increase in beta cell proliferation or serum insulin concentration. Wh.le ANGPTL8 did not reverse h.perglycemia in overtly h.perglycemic NOD mice or alter glucose h.meostasis of non-diabetic NOD mice, ANGPTL8 reduced blood glucose levels in 12LOKO NOD mice. h.wever, th. lower glucose levels in 12LOKO NOD were not associated with.h.gh.r serum insulin levels or beta cell proliferation. In summary, wh.le mouse ANGPTL8 does not increase beta cell proliferation in NOD mice or streptozotocin treated mice in agreement with.studies in non-diabetic mice, it lowers blood glucose levels in multiple low-dose streptozotocin induced diabetes and 12LO deficiency indicating th.t h.st factors influence th. impact of ANGPTL8 on glucose h.meostasis.

关键词： Angiopoietin-Like Protein 8 Type 1 Diabetes NOD 12-Lipoxygenase Beta Cells Glucose h.meostasis

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Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotroph.c lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： Peter h.king Department of Neurology and Center for Neurodegeneration and Experimental Th.rapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingh.m Veterans Affairs Medical Center BirminghamALUSA

Amyotroph.c lateral sclerosis is a fatal multisystemic neurodegenerative disease with.motor neurons being a primary *** progressive weakness is a h.llmark feature of amyotroph.c lateral sclerosis,th.re is considerable h.terogeneity,including clinical presentation,progression,and th. underlying triggers for disease *** on longitudinal studies with.families h.rboring amyotroph.c lateral sclerosis-associated gene mutations,it h.s become apparent th.t overt disease is preceded by a prodromal ph.se,possibly in years,wh.re compensatory mech.nisms delay symptom *** 85-90%of amyotroph.c lateral sclerosis is sporadic,th.re is a strong need for identifying biomarkers th.t can detect th.s prodromal ph.se as motor neurons h.ve limited capacity for *** Food and Drug Administration-approved th.rapies work by slowing th. degenerative process and are most effective early in th. *** muscle,including th. neuromuscular junction,manifests abnormalities at th. earliest stages of th. disease,before motor neuron loss,making it a promising source for identifying biomarkers of th. prodromal *** accessibility of muscle th.ough.biopsy provides a lens into th. distal motor system at earlier stages and in real *** advent of“omics”tech.ology h.s led to th. identification of numerous dysregulated molecules in amyotroph.c lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** tech.ology h.s opened th. door for identifying biomarkers of disease activity and providing insigh. into disease mech.nisms.A major ch.llenge is correlating th. myriad of dysregulated molecules with.clinical or h.stological progression and understanding th.ir relevance to presymptomatic ph.ses of *** are two major goals of th.s *** first is to summarize some of th. biomarkers identified in h.man amyotroph.c lateral sclerosis muscle th.t h.ve a clinicopath.logical correlation with.disease activi

关键词： amyotroph.c lateral sclerosis biomarkers clinicopath.logical correlation disease progression muscle biomarkers neurogenic atroph. neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

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行人膝关节韧带的建模及验证研究

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汽车工程 2012年第1期34卷 57-61,75页

作者：张冠军曹立波官凤娇张勇 Yang king h. 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 华侨大学机电及自动化学院厦门361021 Bioengineering Center Wayne State Universitydetroitus48201

基于人体模型Th.MS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较... 详细信息

基于人体模型Th.MS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较好,说明模型具有较好的生物逼真度,能较准确地模拟韧带的损伤和拉伸响应。

关键词：汽车与行人碰撞膝关节韧带有限元模型验证

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Numerical Algorith. for Solving Multi-Pantograph.Delay Equations on th. h.lf-line Using Jacobi Rational Functions with.Convergence Analysis

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Acta Math.maticae Applicatae Sinica 2017年第2期33卷 297-310页

作者： Eid h. DOh. Ali h. Bh.AWY Ramy M. h.FEZ Department of Math.matics Faculty of Science Cairo University Giza Egypt Department of Math.matics Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Department of Math.matics Faculty of Science Beni-Suef University Beni-Suef Egypt Department of Math.matics Alwagjh University College University of Tabuk Tabuk Saudi Arabia Department of Basic Science Institute of Information Technology Modern Academy Cairo Egypt

A new spectral Jacobi rational-Gauss collocation （JRC） meth.d is proposed for solving th. multi- pantograph.delay differential equations on th. h.lf-line. Th. meth.d is based on Jacobi rational functions and Gauss quadrature integration formula. Th. main idea for obtaining a semi-analytical solution for th.se equations is essentially developed by reducing th. pantograph.equations with.th.ir initial conditions to systems of algebraic equations in th. unknown expansion coefficients. Th. convergence analysis of th. meth.d is analyzed. Th. meth.d possesses th. spectral accuracy. Numerical results indicating th. h.gh.accuracy and effectiveness of th.s algorith. are presented. Indeed, th. present meth.d is compared favorably with.oth.r meth.ds.

关键词： multi-pantograph.equation delay equation collocation meth.d Jacobi-Gauss quadrature Jacobirational functions convergence analysis

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Oscillation of th.rd-order functional dynamic equations on time scales

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Science Ch.na Math.matics 2011年第12期54卷 2597-2614页

作者： SAKER Samir h. College of Science Research.Centre King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia

We consider th. nonlinear functional dynamic equation （p（t）[（r（t）x^△（t））^△]γ）^△＋q（t）f（x（τ（t））） =0, for t≥t0,on a time scale T, wh.re γ〉 0 is th. quotient of odd positive integers, p, r, τ- and q are positive rd-continuous functions defined on th. time scale 1F, and lirut→∞ τ（t） = ∞. Th. main aim of th.s paper is to establish.some new sufficient conditions wh.ch.guarantee th.t th. equation h.s oscillatory solutions or th. solutions tend to zero as →∞ τ. Th. main investigation depends on th. Riccati substitution and th. analysis of th. associated Riccati dynamic inequality. Our results extend, complement and improve some previously obtained ones. In particular, th. results provided substantial improvement for th.se obtained by Yu and Wang [J Comput Appl Math. 225 （2009）, 531-540]. Some examples illustrating th. main results are given.

关键词： oscillation th.rd-order dynamic equations time scales

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GPS monitoring of th. crustal motion in south.estern Ch.na

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Ch.nese Science Bulletin 1999年第19期44卷 1804-1807页

作者： B.Clark Burch.iel Robert W.king Leigh.h.Royden Massach.setts Institute of Tech.ology CambridgeMA 02139USAMassachusetts Institute of TechnologyCambridgeMA 02139USAMassachusetts Institute of TechnologyCambridgeMA 02139USA

Th.ough.GPS carrier ph.ses observation in south.estern Ch.na during 1991-1997,th. velocity field with.n eastern Qingh.i-Xizang (Tibet) and its neigh.our regions h.s been es-’tablish.d. Th. velocity of th.se sites in and west of Ch.an-Dian block is mostly 5-10 mm·a-1relative to th. fiduciary station Ch.U (Ch.ngdu), and th. motion in Ch.an-Qing and

关键词： eastern Tibetan Plateau global positioning system (GPS) crustal motion and deformation.

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3D Printing of Polylactic Acid Bioplastic–Carbon Fibres and Twisted Kevlar Composites Th.ough.Coextrusion Using Fused Deposition Modeling

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Journal of Renewable Materials 2020年第12期8卷 1671-1680页

作者： J.Y.Tey W.h.Yeo Y.J.king W.O.Ding Department of Mech.nical and Material Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanJalan Sungai LongBandar Sungai LongCheras43000 KajangSelangorMalaysia

Polylactic acid(PLA)bioplastic is a common material used in Fused Deposition Modeling(FDM)3D *** is biodegradable and environmentally friendly biopolymer wh.ch.made out of ***,it exh.bits weak mech.nical properties wh.ch.reduced its usability as a functional prototype in a real-world *** th. present study,two PLA composites are created th.ough.coextruded with.3K carbon fibres and twisted Kevlar string(as core fibre)to form a fibre reinforced parts(FRP).Th. mech.nical strength.of printed parts was examined using ASTM D638 standard with.a strain rate of 1 mm/*** h.s been demonstrated th.t th. FRPs coextruded with.3K carbon fibres h.d ach.eved significant improvement in Young’s modulus(+180.6%,9.205 GPa),ultimate tensile strength.+175.3%,103 MPa)and maximum tensile strain(+21.6%,1.833%).Alth.ugh.th. Young’s modulus of Kevlar FRP was found to be similar to as compared to unreinforced PLA(~3.29 GPa),it h.s gained significant increment in terms of maximum tensile strain(+179.7%,104.64 MPa),and maximum tensile strain(+257%,5.384%).Th.s,th.s study revealed two unique composite materials,in wh.ch.th. 3K carbon FRP can offer stiff and h.gh.strength.structure wh.le Kevlar FRP offers similar strength.but at a h.gh.r elasticity.

关键词： 3D printing Kevlar fibre 3K carbon fibre coextruded reinforced plastic polylactic acid bioplastic

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行人下肢有限元模型的建立与验证研究

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湖南大学学报（自然科学版） 2015年第2期42卷 48-54页

作者：张冠军魏嵬曹立波官凤娇 YANG king h 湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082 国防科学技术大学机电工程与自动化学院湖南长沙410073 Bioengineering Center Wayne State Universitydetroitus48201

下肢损伤是行人与车辆碰撞事故中的主要损伤形式之一,建立具有较高生物逼真度的行人下肢有限元模型,可以为下肢保护提供有效的研究手段.在下肢长骨(股骨、胫骨、腓骨)、韧带(ACL,PCL,MCL,LCL)及膝关节得到全面验证的基础上,建立了包含... 详细信息

下肢损伤是行人与车辆碰撞事故中的主要损伤形式之一,建立具有较高生物逼真度的行人下肢有限元模型,可以为下肢保护提供有效的研究手段.在下肢长骨(股骨、胫骨、腓骨)、韧带(ACL,PCL,MCL,LCL)及膝关节得到全面验证的基础上,建立了包含骨骼、韧带、肌肉及皮肤等详细解剖学结构的行人下肢有限元模型,并定义了各组织间的接触.利用行人下肢弯曲的生物力学实验,对下肢有限元模型进行了整体弯曲验证.结果显示,下肢有限元模型的损伤形式、损伤发生时刻、膝关节弯矩和弯曲角度均与实验结果吻合较好,能够较真实地反映行人下肢的损伤和生物力学响应,具有较好的生物逼真度.

关键词：下肢行人与车辆碰撞有限元模型验证

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Development of a new biomech.nical indicator for primary blast-induced brain injury

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Ch.nese Journal of Traumatology 2015年第1期18卷 10-12页

作者： Feng Zh. Cliff C. Ch.u king h. Yang Albert I. king Bioengineering Center Wayne State University 818 W. Hancock Detroit M148201 USA

Primary blast-induced traumatic brain injury （bTBI） h.s been observed at th. boundary of brain tissue and cerebrospinal fluid （CSF）. Such.injury can h.rdly be explained by using th. th.ory of compressive wave propagation, since both.th. solid and fluid materials h.ve similar compressibility and th.s th. intracranial pressure （ICP） h.s a continuous distribution across th. boundary. Since th.y h.ve completely different sh.ar properties, it is h.poth.sized th. injury at th. interface is caused by sh.ar wave. In th. present study, a preliminary combined numerical and th.oretical analysis was conducted based on th. th.ory of sh.ar wave propagation]reflection. Simulation results sh.w th.t h.gh.r lateral acceleration of brain tissue particles is concentrated in th. boundary region. Based on th.s finding, a new biomech.nical vector, termed as strain gradient, was suggested for primary bTBI. Th. subsequent simple th.oretical analysis reveals th.t th.s parameter is proportional to th. value of lateral acceleration. At th. boundary of lateral ventricles, h.gh.spatial strain gradient implies th.t th. brain tissue in th.s area （wh.re neuron cells may be contained） undergo significantly different strains and large velocity discontinuity, wh.ch.may result in mech.nical damage of th. neuron cells.

关键词： Traumatic brain injury Sh.ck wave Sh.ar wave Analytical model Numerical simulation

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Commutativity of Near-rings with.Derivations

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Algebra Colloquium 2014年第2期21卷 215-230页

作者： Ah.ed A.M. Kamal Kh.lid h. AI-Sh.alan Department of Math.matics College of Science King Saud University P.O. Box 2455 Riyadh 11451 Kingdom of Saudi Arabia

In th.s paper we first prove th.t a near-ring admits a derivation if and only if it is zero-symmetric. Also, we prove some commutativity th.orems for a non-necessarily 3-prime near-ring R with.a suitably-constrained derivation d satisfying th. condition th.t d（a） is not a left zero-divisor in R for some a ∈ R. As consequences, we generalize several commutativity th.orems for 3-prime near-rings admitting derivations.

关键词： near-rings derivations 3-prime near-ring non-left zero-divisors commuta-tivity of near-rings

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