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中山医科大学学报 2001年第3期22卷 170-173,191页

作者：陈忠平 Anne MONKS timothy g.myers Edward A.SAUSVILLE Dominic A.SCUDIERO Lawrence C.PANASCI 中山医科大学肿瘤防治中心神经外科广东广州510060 Frederick Cancer Research and Development Center Information Technology Branch National Cancer Institute Developmental Therapeutics Programme National Cancer InstituteExecutive Plaza NorthSuite8436130ExecutiveBlvd

【目的】探讨切割修复交叉互补基因 2 (excisionrepaircross complementingrodentrepairdeficiencygene 2 ,ERCC2 )表达与人肿瘤对抗癌药耐药的关系。【方法】采用Westernblot检测美国国家癌症研究所 (NationalCancerInstitute,NCI)用于抗癌药筛选的 6 0株人肿瘤细胞的ERCC2表达 ,并与 170种抗癌药物的细胞毒试验结果进行相关性分析。【结果】肿瘤细胞ERCC2的蛋白表达水平高低不一 ,其中 6株细胞的ERCC2蛋白水平在可测定范围以下。 170种抗癌药物中有 2 8种化疗药物的耐药性与肿瘤细胞的ERCC2蛋白水平相关性显著或非常显著。根据药物作用机理分析 ,肿瘤细胞ERCC2表达与其对烷化剂和抗有丝分裂剂类抗癌药耐药相关性显著。【结论】肿瘤细胞具有DNA修复能力 ,如核苷酸切割修复。

关键词： DNA修复切割修复交叉互补基因2 抗肿瘤药烷化剂耐药性 ERCC2 基因表达

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人肿瘤细胞ERCC2基因表达与抗癌药耐药的相关性研究

人肿瘤细胞ERCC2基因表达与抗癌药耐药的相关性研究

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2000全国肿瘤学术大会

作者：陈忠平 Anne Monks timothy g.myers Edward A.Sausville Dominic A.Scudiero Lawrence C.Panasci

目的:探讨核苷酸切除修复（NER,nucleotide excision repair）系统的重要因子切除修复交叉互补基因2（excision repair cross-com- plementing rodent repair deficiency gene 2,ERCC2）表达与人肿瘤对抗癌药耐药的关系。方法:采用 western blot 检测美国国家癌症研究所（National Cancer Institute,NCI）用于抗癌药筛选的60株人肿瘤细胞的 ERCC2表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:肿瘤细胞 ERCC2的蛋白表达水平高低不一,其中6株细胞的 ERCC2蛋白水平在可测定范围以下。ERCC2蛋白水平与肿瘤细胞对化疗药物耐药的相关性在170种抗癌药物中有28种非常显著（p ＜0.05）。根据药物作用机理分析,肿瘤细胞 ERCC2表达与其对烷化剂和抗有丝分裂剂类抗癌药耐药相关性显著。结论:肿瘤细胞具有 DNA 修复能力,如核苷酸切除修复,更具体是具有 ERCC2基因表达将表现为对主要是烷化剂和抗有丝分裂剂类抗癌药的耐药。

关键词：核苷酸切除修复切除修复交叉互补基因2 化疗/耐药烷化剂类抗癌药

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社会心理学

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作者： (美)戴维·迈尔斯(David g.myers)

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Social psychology / David g. myers. 9th ed.

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2008年

作者： David g. myers.

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Exploring Psychology 4th ed. 4th ed.

Exploring Psychology 4th ed.

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1999年

作者： David g.myers

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Social Psychology David g. myers 7th ed.

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2002年

作者： David g. myers

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A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows

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Journal of Animal Science and Biotechnology 2021年第3期12卷 995-1007页

作者： Madison N.myers Maya Zachut Joseph Tam g.Andres Contreras Department of Large Animal Clinical Sciences College of Veterinary MedicineMichigan State UniversityEast LansingMI 48824USA Department of Ruminant Science Institute of Animal SciencesAgricultural Research Organization/Volcani Center7505101 Rishon LeZionIsrael Obesity and Metabolism Laboratory The Institute for Drug ResearchSchool of PharmacyFaculty of MedicineThe Hebrew University of Jerusalem9112001 JerusalemIsrael

To sustain the nutrient demands of rapid fetal growth,parturition,and milk synthesis,periparturient dairy cows mobilize adipose tissue fatty acid stores through *** process induces an inflammatory response within AT that is resolved as lactation progresses;however,excessive and protracted lipolysis compounds the risk for metabolic and inflammatory *** suppression of lipolytic action and inflammation,along with amplification of adipogenesis and lipogenesis,serve as prospective therapeutic targets for improving the health of periparturient dairy ***,the activation of cannabinoid receptors by endocannabinoids enhances adipogenesis and lipogenesis,suppresses lipolysis,and increases appetite in *** biological effects of activating the endocannabinoid system open the possibility of harnessing the endocannabinoid system through nutritional intervention in dairy herds as a potential tool to improve dairy cows’health,although much is still to be revealed in this *** review summarizes the current knowledge surrounding the components of the endocannabinoid system,elaborates on the metabolic effects of its activation,and explores the potential to modulate its activity in periparturient dairy cows.

关键词： Adipogenesis Adipose tissue Dairy cow health Endocannabinoids Endocannabinoid system Lipogenesis Lipolysis

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Proton-pump inhibitor use does not affect semen luality in subfertile men

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Asian Journal of Andrology 2018年第3期20卷 290-293页

作者： Sorena Keihani James R Craig Chong Zhang Angela P Presson Jeremy B myers William O Brant Kenneth I Aston Benjamin R Emery timothy g Jenkins Douglas T Carrell James M Hotaling Division of Urology Department of Surgery University of Utah Salt Lake City Utah 84132 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City Utah 84132 USA Andrology and IVF Laboratory Department of Surgery (Urology) University of Utah Salt Lake City Utah 84108 USA

Proton-pump inhibitors （PPIs） are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with detrimental effects on semen parameters in a large population of subfertile men. We retrospectively reviewed data from 12 257 subfertile men who had visited our fertility clinic from 2003 to 2013. Patients who reported using any PPIs for 〉3 months before semen sample collection were included; 7698 subfertile men taking no medication served as controls. Data were gathered on patient age, medication use, and conventional semen parameters; patients taking any known spermatotoxic medication were excluded. Linear mixed-effect regression models were used to test the effect of PPI use on semen parameters adjusting for age. A total of 248 patients （258 samples） used PPIs for at least 3 months before semen collection. In regression models, PPI use （either as the only medication or when used in combination with other nonspermatotoxic medications） was not associated with statistically significant changes in semen parameters. To our knowledge, this is the largest study to compare PPI use with semen parameters in subfertile men. Using PPIs was not associated with detrimental effects on semen quality in this retrospective study.

关键词： infertility proton-pump inhibitors semen analysis sperm quality spermatozoa

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A Review of Arctic-Subarctic Ocean Linkages: Past Changes, Mechanisms, and Future Projections

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Ocean-Land-Atmosphere Research 2023年第1期2卷 134-172页

作者： Qiang Wang Qi Shu Shizhu Wang Agnieszka Beszczynska-Moeller Sergey Danilov Laura de Steur Thomas W.N.Haine Michael Karcher Craig M.Lee Paul g.myers Igor V.Polyakov Christine Provost Øystein Skagseth gunnar Spreen Rebecca Woodgate Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI) BremerhavenGermany First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdaoPeople’s Republic of China Shandong Key Laboratory of Marine Science and Numerical Modeling QingdaoPeople’s Republic of China Institute of Oceanology Polish Academy of SciencesSopotPoland Department of Mathematics and Logistics Jacobs UniversityBremenGermany Norwegian Polar Institute Fram CentreTromsøNorway Earth&Planetary Sciences The Johns Hopkins UniversityBaltimoreMDUSA .8Ocean Atmosphere Systems gmbH HamburgGermany Applied Physics Laboratory University of WashingtonSeattleWAUSA. Department of Earth and Atmospheric Sciences University of AlbertaEdmontonABCanada. International Arctic Research Center and College of Natural Science and Mathematics University of Alaska FairbanksFairbanksAKUSA. Finnish Meteorological Institute HelsinkiFinland. Laboratoire LOCEAN-IPSL Sorbonne Université(UPMCUniversity Paris 6)CNRSIRDMNHNParisFrance. Institute of Marine Research and Bjerknes Centre of Climate Research BergenNorway. Institute of Environmental Physics University of BremenBremenGermany

Arctic Ocean gateway fluxes play a crucial role in linking the Arctic with the global ocean and affecting climate and marine *** reviewed past studies on Arctic-Subarctic ocean linkages and examined their changes and driving *** review highlights that radical changes occurred in the inflows and outflows of the Arctic Ocean during the ***,the Pacific inflow temperature in the Bering Strait and Atlantic inflow temperature in the Fram Strait hit record highs,while the Pacific inflow salinity in the Bering Strait and Arctic outflow salinity in the Davis and Fram straits hit record *** the ocean heat convergence from lower latitudes to the Arctic and the hydrological cycle connecting the Arctic with Subarctic seas were stronger in 2000-2020 than in ***6 models project a continuing increase in poleward ocean heat convergence in the 21st century,mainly due to warming of inflow *** also predict an increase in freshwater input to the Arctic Ocean,with the largest increase in freshwater export expected to occur in the Fram Strait due to both increased ocean volume export and decreased *** Strait sea ice volume export hit a record low in the 2010s and is projected to continue to decrease along with Arctic sea ice *** quantitatively attribute the variability of the volume,heat,and freshwater transports in the Arctic gateways to forcing within and outside the Arctic based on dedicated numerical simulations and emphasize the importance of both origins in driving the variability.

关键词： Arctic ocean Strait

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Surface plasma treatment effects on the molecular structure at polyimide/air and buried polyimide/epoxy interfaces

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Chinese Chemical Letters 2015年第4期26卷 449-454页

作者： John N.myers Zhan Chen Department of Chemistry University of Michigan

Polyimides are widely used as chip passivation layers and organic substrates in microelectronic packaging. Plasma treatment has been used to enhance the interfacial properties of polyimides, but its molecular mechanism is not clear. In this research, the effects of polyimide surface plasma treatment on the molecular structures at corresponding polyimide/air and buried polyimideJepoxy interfaces were investigated in situ using sum frequency generation （SFg） vibrational spectroscopy. SFg results show that the polyimide backbone molecular structure was different at polyimide/air and polyimideJepoxy interfaces before and after plasma treatment. The different molecular structures at each interface indicate that structural reordering of the polyimide backbone occurred as a result of plasma treatment and contact with the epoxy adhesive. Furthermore, quantitative orientation analysis indicated that plasma treatment of polyimide surfaces altered the twist angle of the polyimide backbone at corresponding buried polyimide/epoxy interfaces. These SFg results indicate that plasma treatment of polymer surfaces can alter the molecular structure at corresponding polymer/air and buried polymer interfaces.

关键词： Molecular structureVibrational spectroscopySum frequency generation spectroscopy

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