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Fungal diversity 2019年第5期 77-160页

作者： Ruvishika S.Jayawardena Kevin d.Hyde Eric H.C.McKenzie Rajesh Jeewon Alan J.L.phillips Rekhani H.Perera Nimali I.de Silva Sajeewa S.N.Maharachchikumburua Milan C.Samarakoon Anusha H.Ekanayake danushka S.Tennakoon Asha J.dissanayake Chada Norphanphoun Chuangen Lin Ishara S.Manawasinghe Qian Tian Rashika Brahmanage Putarak Chomnunti Sinang Hongsanan Subashini C.Jayasiri F.Halleen Chitrabhanu S.Bhunjun Anuruddha Karunarathna Yong Wang department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025GuizhouChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Landcare Research-Manaaki Whenua Private Bag 92170AucklandNew Zealand department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Faculdade de Ciéncias Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of ShuguanghuayuanzhongluHaidian DistrictBeijing 100097People’s Republic of China College of Life Science and Oceanography Shenzhen University1068Nanhai AvenueNanshanShenzhen 518055China Plant Protection division ARC Infruitec-NietvoorbijPrivate Bag X5026Stellenbosch 7599South Africa department of Plant Pathology University of StellenboschPrivate Bag X1Matieland 7602South Africa

This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and *** paper focuses on 25 phytopathogenic genera:Alternaria,Capnodium,Chaetothyrina,Cytospora,Cyphellophora,Cyttaria,dactylonectria,diplodia,dothiorella,Entoleuca,Eutiarosporella,Fusarium,Ilyonectria,Lasiodiplodia,Macrophomina,Medeolaria,Neonectria,Neopestalotiopsis,Pestalotiopsis,Plasmopara,Pseudopestalotiopsis,Rosellinia,Sphaeropsis,Stagonosporopsis and *** genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.A new database(Onestopshopfungi)is established to enhance the current understanding of plant pathogenic genera among plant pathologists.

关键词： Classification database Plant pathology Phylogeny Taxonomy Symptoms Systematics

Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal diversity 2021年第6期111卷 1-335页

作者： Saranyaphat Boonmee dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh deepak K.Maurya Ajay C.Lagashetti deepika Choudhary Yu-Cheng dai Chang-Lin Zhao Yan-Hong Mu Hai-Sheng Yuan Shuang-Hui He Rungtiwa Phookamsak Hong-Bo Jiang María P.Martín Margarita dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen diana S.Pereira Alan J.L.phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Guo-Jie Li Wen-Fei Lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.Rajeshkumar Nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi Zhang Phongeun Sysouphanthong Naritsada Thongklang dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco dovana Muhammad Usman Abdul Nasir Khalid Asha J.dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning Jiang Cheng-Ming Tian Esmaeil Shams Farzaneh dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.denchev Cvetomir M.denchev Martin Kemler dominik Begerow Chun-Ying deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova Yusufjon Gafforov Aziz Abdurazakov Jian-Chu Xu Peter E.Mortimer Guang-Cong Ren Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin d.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China CIFOR-ICRAF China Program World Agroforestry(ICRAF)Kunming 650201YunnanPeople’s Republic of China Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe CountyKunming 654400YunnanPeople’s Republic of China department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Section Environmental Sciences Department MeSVAUniversity of L’Aquila67100 CoppitoAQItaly National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.Agarkar RoadPune 411004India Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083People’s Republic of China College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China department of Mycology Real Jardín Botánico-CSICPlaza de Murillo 228014 MadridSpain department of Algology and Mycology Faculty of Biology and Environmental ProtectionUniversity of LodzBanacha 12/1690-237ŁódźPoland Institute of dendrology Polish Academy of SciencesParkowa 562-035 KórnikPoland Jodrell Laboratory Royal Botanic GardensKewRichmond TW93DSSurreyUK Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal dep

This article is the 13th contribution in the Fungal diversity Notes series,wherein 125 taxa from four phyla,ten classes,31 orders,69 families,92 genera and three genera incertae sedis are treated,demonstrating worldwide and geographic *** taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical *** new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(Lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique *** described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,***-latus,***,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,diaporthe chamaeropicola,didymella azollae,diplodia alanphillipsii,dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,***,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,***,***,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,***,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema

关键词： 72 new taxa One new combination One reference specimen 51 new records Agaricomycetes Ascomycota Bartheletiomycetes Basidiomycota dothideomycetes Eurotiomycetes Exobasidiomycetes Laboulbeniomycetes Leotiomycetes Mortierellomycetes Mortierellomycota Mucoromycetes Mucoromycota Phylogeny Sordariomycetes Taxonomy

One stop shop Ⅱ:taxonomic update with molecular phylogeny for important phytopathogenic genera:26–50(2019)

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Fungal diversity 2019年第1期 41-129页

作者： Ruvishika S.Jayawardena Kevin d.Hyde Rajesh Jeewon Masoomeh Ghobad-Nejhad dhanushka N.Wanasinghe NingGuo Liu Alan J.L.phillips Jose Ribamar COliveira-Filho Gladstone Ada Silva Tatiana B.Gibertoni P.Abeywikrama L.M.Carris K.W.T.Chethana A.J.dissanayake S.Hongsanan S.C.Jayasiri A.R.McTaggart R.H.Perera K.Phutthacharoen K.G.Savchenko R.G.Shivas Naritsada Thongklang Wei dong dePing Wei Nalin NWijayawardena Ji-Chuan Kang The Engineering Research Center of Southwest Biopharmaceutical Resources Ministry of EducationGuizhou UniversityGuiyang 550025People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius department of Biotechnology Iranian Research Organization for Science and Technology(IROST)P.O.Box 15815-3538Tehran 15819Iran World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Universidade de Lisboa Faculdade de CienciasBiosystems and Integrative Sciences Institute(BioISI)Campo Grande1749-016 LisbonPortugal departamento de Micologia Universidade Federal de PernambucoAvenida da EngenhariaS/N-Cidade UniversitariaRecifePE 50740-600Brazil Beijing Key Laboratory of Environmet Friendly Management on Fruit disease and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China department of Plant Pathology Washington State UniversityPullmanWA 99164USA College of Life Science and Oceanography ShenZhen University1068Nanhai AvenueNanshanShenzhen 518055China Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLD 4001Australia department of Biological Sciences Butler UniversityIndianapolisIN 46208USA Centre for Crop Health University of Southern QueenslandToowoombaQLD 4350Australia department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Faculty of Agriculture National Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand

This paper is the second in a series focused on providing a stable platform for the taxonomy of phytopathogenic *** focuses on 25 phytopathogenic genera:Alternaria,Bipolaris,Boeremia,Botryosphaeria,Calonectria,Coniella,Corticiaceae,Curvularia,Elsinoe,Entyloma,Erythricium,Fomitiporia,Fulviformes,Laetisaria,Limonomyces,Neofabraea,Neofusicoccum,Phaeoacremonium,Phellinotus,Phyllosticta,Plenodomus,Pseudopyricularia,Tilletia,Venturia and Waitea,using recent molecular data,up to date names and the latest taxonomic *** each genus a taxonomic background,diversity aspects,species identification and classification based on molecular phylogeny and recommended genetic markers are *** this study,varieties of the genus Boeremia have been elevated to species ***,Bipolaris,Curvularia,Neofusicoccum and Phyllosticta that were included in the One Stop Shop 1 paper are provided with updated entries,as many new species have been introduced to these genera.

关键词： Boeremia dNA barcodes Endophytes Plant pathology Systematics Taxonomy

Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa

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Fungal diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin d.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug d.Jayarama Bhat dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui dong Qin dai Yu Cheng dai dinushani A.daranagama Kanad das Monika C.dayarathne Eske de Crop Rafael J.V.de Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.dentinger Asha J.dissanayake Mingkwan doilom E.Ricardo drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144Bagnacavallo

Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,diatrype thailandica,dothiorella rhamni,durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,***,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species

Rolapitant预防术后恶心呕吐：一项前瞻性、双盲、安慰剂对照的随机试验

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麻醉与镇痛 2012年第4期8卷 23-30页

作者： Tong J. Gan Jiezhun Gu Neil Singla Frances Chung Michael H. Pearman Sergio d. Bergese Ashraf S. Habib Keith A. Candiotti Yi Mo Susan Huyck Mary R. Creed Marc Cantillon Rolapitant Investigation group 黄礼兵(译) 崔苏扬(校) department of Anesthesiology Duke University Medical Center Durham North Carolina department of Clinical Trials Statistics Duke Clinical Research Institute Durham North Carolina Lotus Clinical Research Inc. Arcadia California department of Anesthesia University Health Network University of Toronto Toronto Ontario Canada department of Anesthesia Jane Phillips Medical Center Bartlesville Oldahoma department of Anesthesiology and Neurological Surgery Ohio State University Columbus Ohio department of Anesthesiology Duke University Medical Center Durham North Carolina University of Miami Miami Florida tt Schering-Plough Research Institute Kenilworth New Jersey duke Clinical Research Institute Durham North Carolina See the Appendix for a full listing of Rolapitant Investigation group participating investigators 不详

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相... 详细信息

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相当长（达180小时）的强效选择性NK、受体拮抗剂，潜在的药物相互作用低。我们对Rolapitant用于预防PONV高危人群的量效关系以及术后5天的预防迟发性IK）NV的效果进行了研究。方法这项关于Rolapitant的随机、多中心、双盲、有效剂量范围的研究设有安慰剂组和阳性对照组。纳入619例行开腹手术的成年妇女，基于PONV或晕动病史进行分层，分为6个研究组：Rolapitant口服剂量5mg组、20mg组、70nag组或200mg组；静注昂丹司琼4mg组或安慰剂组。主要研究终点：不考虑补救用药，拔管后24小时的无呕吐发生率。结果Rolapitant20mg、70mg或200mg组患者的术后24小时无呕吐发生率高于安慰剂组。Rolapitant剂量与主要转归呈线性相关。与安慰剂组相比，Rolapitant70mg和200mg组的呕吐次数明显更低（P≤0．001，对数秩和检验）。尽管术后24小时无呕吐次数在Rolapitant组和昂丹司琼对照组没有明显差异，但Rolapitant200mg组和70mg组的术后72小时和120小时无呕吐发生率更高（不考虑补救用药）。结论Rolapitant降低术后呕吐的疗效优于安慰剂，呈剂量依赖性地降低呕吐发生率。而且Rolapitant与安慰剂在不良反应方面没有差异。

关键词：术后恶心呕吐安慰剂对照随机试验预防双盲受体拮抗剂阳性对照组 PONV

胶质母细胞瘤的基因测绘和生存期预测:血流动力学成像生物标志物强化的分子亚型

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国际医学放射学杂志 2013年第3期 279-279页

作者： R.Jain L.Poisson J.Narang d.Gutman L.Scarpace S.N.Hwang 陈超 division of Neuroradiology Department of RadiologyDepartment of Neurosurgeryand Department of Public Health SciencesHenry Ford Health System

目的使用动态磁敏感T2*加权增强MR成像序列进行脑灌注检查,研究胶质母细胞瘤(GBM)肿瘤血容量和病人生存率的关系,并确定其分子亚类。材料与方法此研究遵从HIPAA回顾性研究的要求并获得机构审查委员会的批准。50例病人进行动态磁敏感对... 详细信息

目的使用动态磁敏感T2*加权增强MR成像序列进行脑灌注检查,研究胶质母细胞瘤(GBM)肿瘤血容量和病人生存率的关系,并确定其分子亚类。材料与方法此研究遵从HIPAA回顾性研究的要求并获得机构审查委员会的批准。50例病人进行动态磁敏感对比增强T2*加权MR灌注成像检查,并从癌症基因组图谱中找到基因表达数据。测定强化病灶的相对脑血容量(rCBV)[最大rCBV(rCBVmax),平均rCBV(rCBVmean)]和非强化灶的相对脑血容量(rCBVNEL)。病人通过Verhaak和phillips分类模式进行分类,这是基于相似性来定义基因表达信号。通过Cox回归分析rCBV测量数据及分子亚类与病人的总体生存时间的关系。结果 4个Verhaak亚类和3个phillips亚类,对比增强病变的rCBVmax、rCBVmean或无强化灶的rCBVNEL均无显著的统计学差异。然而rCBV增加与GMS较差的生存期有相关性。无论潜在的混杂因素或分子亚类,rCBVmax(P=0.0131)是最强的生存期预测因子。尤其是作为预测因素,GBMVerhaak分子分类中的rCBVmean与单独的rCBVmean(危险比:1.25,P=0.1918)比较,前者与病人总生存期相关(危险比:1.46,P=0.0212)。phillips分子亚类既不能作为预测总生存期的因素,也不对rCBV的预测生存期的能力产生影响。结论 rCBVmax可作为独立预测病人总生存期的因素使用,与GBM分子的亚类无关。但是,Verhaak分类提供了额外的信息,表明在未来分子标记物可以和血流动力学成像的生物标志物联合使用。

关键词：生存期病人分子亚类胶质母细胞瘤血流动力生物标志物