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Metastatic recurrence to a solitary lymph node four years after hepatic lobectomy for primary hepatocellular carcinoma

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World Journal of Hepatology 2016年第23期8卷 994-998页

作者： Michael L Caparelli Nathan J Roberts timothy S braverman Robert M Stevens Edward R Broun Shyam Allamaneni Department of Surgery the Jewish Hospital Department of Pathology the Jewish Hospital Department of Radiology the Jewish Hospital Department of Oncology Hematology Care Inc.

This report describes a patient that developed recurrent metastatic hepatocellular carcinoma(HCC) to a suprapancreatic lymph node four years after being treated for primary HCC via complete left hepatectomy. Metastatic HCC was proven by pathologic confirmation. The report addresses the role of surgical resection as a treatment modality for recurrent HCC to solitary lymph nodes. The role of biological chemotherapy as adjuvant treatment is also addressed.

关键词： Hepatocellular carcinoma Lymph node Recurrence Metastatic Extrahepatic

The Healthcare of the Final Frontier- Comprehensive Epidemiological Approach to the Future of Human Space Exploration and Travel

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Space(Science & Technology) 2023年第1期3卷 256-258页

作者： Ariel braverman Clalit Health Services Tel AvivIsrael Ben Gurion University of The Negev BeershebaIsrael

Today,the discussion about colonizing different planets has shifted from the"IF"mode to the"WHEN"mode,and the substantial large group of humans living for a long time in an isolated,hostile,and enclosed environment is about to become a ***,the space-related healthcare methodologies should shift as well from a small number of selected persons to much more extensive groups with much less health ***,the development of human colonies,first on the Moon and later on Mars,will be a game changer in allthat we know and use to see in space travel and eventually in space *** will leave Earth but will carry human society's health patterns,adjusted to the *** foundation for space epidemiology modeling can be set today and should attract the attention of the epidemiological and space research communities.

关键词： eventually Human planet

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Clinical Photograph: “A Third Arythenoid?”

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第1期3卷 54-55页

作者： Itzhak braverman Yuri Pastuhov Otolaryngology—Head and Neck Surgery Unit Hillel Yaffe Medical Center Hadera Israel The Technion—The Israel Institute of Technology Haifa Israel

A case of anatomical variation of the hyoid bone in a girl is presented. Over-extended bending of the elongated and curved right side of the hyoid bone, may project to the lumen of the supraglottic area as the patient presented. She had a foreign body sensation in her throat, and on fiber optic laryngeal examination, a bulge’s appearance as a “third arythenoid” was seen. We present the clinical finding and the picture of a “third arythenoid” with literature review.

关键词： Arythenoid Hyoid Bone Anatomic Variation Larynx

Circular smooth muscle contributes to esophageal shortening during peristalsis

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World Journal of Gastroenterology 2012年第32期18卷 4317-4322页

作者： Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips Alan S braverman Mary F Barbe Michael R Ruggieri Larry S Miller Department of Medicine Section of GastroenterologyHofstra Northshore Long Island Jewish HospitalHofstra University School of MedicineManhassetNY 11030United States Department of Medicine Section of GastroenterologyTemple University School of MedicinePhiladelphiaPA 19140United States Department of Anatomy and Cell Biology Temple University School of MedicinePhiladelphiaPA 19140United States Department of Urology Temple University School of MedicinePhiladelphiaPA 19140United States Department of Anatomy and Cell Biology and Department of Urology Temple University School of MedicinePhiladelphiaPA 19140United States

AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal ***:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 *** outer longitudinal layer of the muscularis propria was exposed after stripping the outer *** inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis *** of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle *** were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent *** human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J ***:All data are presented as mean ± *** CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = *** CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 *** CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 *** CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P =

关键词： Esophageal shortening Gastroesophageal junction Circular smooth muscle Gastroesophageal reflux disease Esophageal contraction

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拍摄者

2016年

作者： (美)Barry braverman

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劳动与垄断资本

劳动与垄断资本

Coblation Intracapsular Tonsillectomy and Coblation Complete Tonsillectomy for Obstructive Sleep Apnea

作者： H.·布雷弗曼(H. braverman)

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 350-355页

作者： Itzhak braverman Alex Nemirovsky Adi Klein Miriam Sarid Galit Avior Unit of Otolaryngology-Head & Neck Surgery Hadera Israel Pediatric Department Hillel Yaffe Medical Center Hadera and The Faculty of Medicine The Technion Haifa Israel Western Galilee College Acco Israel

Objective: Total tonsillectomy and intracapsular tonsillectomy are common procedures for the treatment of obstructive sleep apnea (OSA) in children. The objective of this study was to compare the effectiveness of coblation intracapsular tonsillectomy (ICT) and coblation complete tonsillectomy (CT) as treatments for OSA. Study design: A retrospective study of all the children ages 2 - 18 years with OSA who underwent coblation intracapsular tonsillectomy (ICT) or coblation complete tonsillectomy (CT) from January 2007 to August 2010 by the same surgeons at one institution. Methods: Data were retrieved from children’s charts and from telephone interviews with children’s parents, regarding pre and postoperative OSA-18 scores, postoperative pain, postoperative complications, use of analgesic drugs, and time to return to a solid food diet. Results: All 43 children who underwent ICT and 37 children who underwent CT suffered from OSA before surgery, and none did postoperatively. There were no minor complications in the ICT group, compared to 13.5% in the CT group (p = 0.01). According to parental report, 72% and 21% suffered a low level of postoperative pain, and 9% and 33% severe pain in the ICT and CT groups, respectively. For these respective groups, 49% and 73% needed analgesic drugs (p < 0.05);and 65% and 35% ate solid food during the first 3 days post surgery. Conclusions: Both ICT and CT were safe, with few complications;however recovery was faster in the ICT group, as demonstrated by less pain, and more rapid return to a solid food diet.

关键词： Obstructive Sleep Apnea Tonsillectomy Coblation Intracapsular Tonsillectomy Pain Adenotonsillectomy Tonsillotomy

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未来主义的交通工具设计,让人眼前一亮

工业设计 2024年第5期 22-22页

作者： Maks Chaschin Alexey Blinkov Blinkova Design Alex braverman Vladimir Plekhanov Roman Mishchenko Vladislav Chikin Alexey Zalata Эдуард Тян Irina Ivanova Nikita Pavlov 2050 Lab

来源:https://***/galleries/4b3aca9bfeeca513e932e2a1c0eb92a5?favorite=true这款未来主义交通工具从乘客体验出发,遵循人机工程学设计理念,让乘客即使在城市运营的高峰时段也能感到愉快。与上一代的设计相比,该交通工具重新布置了入... 详细信息

来源:https://***/galleries/4b3aca9bfeeca513e932e2a1c0eb92a5?favorite=true这款未来主义交通工具从乘客体验出发,遵循人机工程学设计理念,让乘客即使在城市运营的高峰时段也能感到愉快。与上一代的设计相比,该交通工具重新布置了入口处的柱子,将过道增加了100毫米,座椅加宽了30毫米,使乘坐舱变得更加宽敞。对乘客来说,即便穿着厚厚的冬装,也能获得舒适的乘坐体验。设计团队考虑了不同乘客的旅行场景,例如有孩子的乘客、行李很多的旅客或者残疾人等,在设计中兼顾每一类人群的便利性。导航系统基于人性化理念设计,让视障人士可以感知入口照明的线条。乘坐舱内的材料亲近自然,改进后的座椅面料也变得更加耐用和舒适。

关键词：人性化理念视障人士人机工程学城市运营未来主义交通工具设计导航系统亲近自然