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中国和英国子宫内膜异位症患者的发病相关因素分析

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南方医科大学学报 2022年第1期42卷 137-142页

作者：聂伟哲李舒婷 Krina T.Zondervan Christian M.becker 郭逸男宗利丽广州中医药大学第一临床医学院广东广州510405 广州中医药大学第一附属医院国家区域(华南区)中医妇科诊疗中心广东广州510405 Oxford Endometriosis CaRe Centre Nuffield Department of Women's and Reproductive HealthUniversity of OxfordOxford UK OX39DU Wellcome Centre for Human Genetics University of OxfordOxford UK OX39DU 西安市中医院妇科陕西西安710021

目的研究子宫内膜异位症发病的相关因素及其在中国和英国患者之间可能的差异。方法采用病例对照研究方法,选取英国牛津John Radcliffe Hospital收治的子宫内膜异位症患者387例和非子宫内膜异位症患者199例、广州中医药大学第一附属医院... 详细信息

目的研究子宫内膜异位症发病的相关因素及其在中国和英国患者之间可能的差异。方法采用病例对照研究方法,选取英国牛津John Radcliffe Hospital收治的子宫内膜异位症患者387例和非子宫内膜异位症患者199例、广州中医药大学第一附属医院收治的子宫内膜异位症患者101例和非子宫内膜异位症患者50例分别为病例组和对照组。通过标准化的WERF EPHect调查问卷,收集4组人群的身高、体质量、体质量指数、婚姻状况、工作状况、月经情况、生育情况、手术原因等临床资料并进行统计分析。结果多因素Logistic回归分析结果显示,英国患者中体质量指数、因痛经进行手术、怀孕史、既往子宫内膜异位症手术次数、工作情况等均与子宫内膜异位症的发生相关(P<0.05),而中国患者中痛经史与子宫内膜异位症的发生相关(P<0.05)。结论痛经可能是中国和英国子宫内膜异位症患者最主要的相关因素;同时,子宫内膜异位症发生的相关因素在中国和英国患者之间可能存在差异。

关键词：子宫内膜异位症中国人群英国人群相关因素差异性

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细胞型DNA特异结合蛋白的快速分离

中国医学科学院学报 1990年第2期12卷 105-109页

作者：王智 F.F.becker 中国医学科学院基础医学研究所美国德州大学肿瘤研究所

本文建立了一个改良的凝胶洗脱法,用以分离细胞型DNA特异结合蛋白质。采用小型平板SDS凝胶电泳分离和银染鉴定,用硝酸纤维素滤膜结合法和迁移率改变法检测DNA活性。此法具有快速、经济和保留DNA活性等优点,适用于分离纯化象细胞型DNA特... 详细信息

本文建立了一个改良的凝胶洗脱法,用以分离细胞型DNA特异结合蛋白质。采用小型平板SDS凝胶电泳分离和银染鉴定,用硝酸纤维素滤膜结合法和迁移率改变法检测DNA活性。此法具有快速、经济和保留DNA活性等优点,适用于分离纯化象细胞型DNA特异结合这样含量极微的蛋白质。

关键词：凝胶洗脱分离结合蛋白质 DNA

Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

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Microsystems & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC27708USA Department of Neurology Duke UniversityDurhamNC27708USA Department of Biomedical Engineering Duke UniversityDurhamNC27708USA Department of Geriatrics Duke UniversityDurhamNC27708USA Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTX77840USA

Traumatic brain injury(TBI)is a global cause of morbidity and *** management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic *** particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue *** applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after *** isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow *** cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of *** levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma *** finding demonstrated the necessity of sample purification prior to exosomal biomarker *** acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

关键词： diagnosis separation injury

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Molecular Modeling of Cell Adhesion Peptides on Hydroxyapatite and TiO<sub>2</sub>Surfaces: Implication in Biomedical Implant Devices

2012年

作者： (德) Angelika becker-Kavan Jeffrey Lloyd Jochen Timm

本书以四位职员的有趣故事为线索贯穿于10个单元。第一单元是启蒙动力期, 帮助学生迈入英语学习的第一步。在其他单元中精选案例教学, 寓教于乐, 将工作和社会交际轻松相结合, 教会学生使用恰当的专业技术语言。每个单元包含语言部分、... 详细信息

ISBN: (纸本)9787894335951;9787111391616

本书以四位职员的有趣故事为线索贯穿于10个单元。第一单元是启蒙动力期, 帮助学生迈入英语学习的第一步。在其他单元中精选案例教学, 寓教于乐, 将工作和社会交际轻松相结合, 教会学生使用恰当的专业技术语言。每个单元包含语言部分、网络资源、词汇部分、语法部分和学习建议五个部分。

关键词：机械工程

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 351-356页

作者： Subhashis Biswas Udo becker Department of Chemistry Narula Institute of Technology Westbengal University of Technology Kolkata India Department of Earth and Environmental Sciences University of Michigan Ann Arbor USA.

Molecular modeling as a tool in studying peptide-substrate interactions provides insight on peptide adsorption conformation, adsorption energy, and stability of the peptide-inorganic interface. This work investigates the hydration and interaction of cell-adhesion peptides, specifically RGD and YIGSR, with the hydroxyapatite surface and TiO2 surface in cluster and periodic boundary condition approaches. The comparison of adsorption energies of RGD and YIGSR on both Hydroxyapatite (HA) and TiO2 surfaces reveals the similarities in adsorption energy and orientation pattern of peptides on both surfaces. The models demonstrate that initial peptide orientation affects adsorption energy for both. YIGSR is consistently more strongly adsorbed to HA-(001) surfaces and steps than RGD for both the surfaces. In addition, RGD maintained its “hairpin”-like structure during adsorption on a flat HA-(001) surface, and a slightly “relaxed hairpin” structure on TiO2 (110) surface. Adsorption energies of RGD on TiO2 (110) surface are significantly more favorable compared to HA-(001) surface, suggesting potential role of TiO2 as biomedical implants when tissue regeneration occurs via cell signaling.

关键词： Hydroxyapatite Nanobiomaterial Bone-Tissue Engineering RGD TiO2

The Properties and Applications of MoS_2/Ti Composite Coatings in Dry Cutting and Forming

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材料热处理学报 2004年第5B期25卷 894-898页

作者： XiaolingZhang HailinSun D.becker S.Wagner D.G.Teer TeerCoatingsLtd. WestStineHouseBerryHillIndustrialEstateDroitwichWorcestershireUK InstituteforMetalFormingTechnology stuttgartUniversityStuttgartGermany

MoSi/Ti composite coatings (MoST?), have been deposited by a closed-field unbalanced magnetron sputter ion-plating system. The high ion-current densities at low substrate bias voltage of the system ensures that the MoST? coatings are characteristic of dense coherent structures, with high adhesion (critical scratch load above 120 N), high load bearing capacity up to 5 GPa., low friction (0.02-0.1), high wear resistance (less than 4xlO"17 m3/N m) even at a relative humidity of 40%, and high temperature resistance up to 350 °C. The successful applications of MoST? coatings in large- scale productions for dry cutting and forming, with increasing lifetime and productivity are presented.

关键词： MoS2/Ti复合涂层干切割低摩擦力磁控管溅射

Pay or Nature？ The Relative Weights of Pecuniary Incentives and Course Conditions in IRONMAN Races

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Economics World 2018年第2期6卷 108-120页

作者： Joachim Prinz Phillip becker University of Duisburg-Essen Duisburg Germany University of Paderbom Paderbom Germany

FSI晶圆表面处理技术的专家——访FSI半导体设备有限公司市场营销副总裁*** becker

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中国集成电路 2006年第3期15卷 82-82,58页

作者：陈宏 Scott becker FSI半导体设备有限公司

Scott becker现任FSI公司市场营销副总裁.becker博士从1983年到1985年在FSI担任工艺开发工程师.1992年,他再次加入FSI并担任单晶圆产品经理,1999年兼任FSI首席技术专家.

关键词：表面处理技术 Scott 半导体设备市场营销有限公司技术专家 FSI 单晶圆总裁 Dr

A New Rectangular Finite Element Formulation Based on Higher Order Displacement Theory for Thick and Thin Composite and Sandwich Plates

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World Journal of Mechanics 2013年第3期3卷 194-201页

作者： Sanjib Goswami Wilfried becker Department of Mechanical Engineering Institute of Structural Mechanics Technical University of Darmstadt Darmstadt Germany Shaktibad Apartment Phase-2 Ground Floor Garia Station Road Calcutta India

A new displacement based higher order element has been formulated that is ideally suitable for shear deformable composite and sandwich plates. Suitable functions for displacements and rotations for each node have been selected so that the element shows rapid convergence, an excellent response against transverse shear loading and requires no shear correction factors. It is completely lock-free and behaves extremely well for thin to thick plates. To make the element rapidly convergent and to capture warping effects for composites, higher order displacement terms in the displacement kinematics have been considered for each node. The element has eleven degrees of freedom per node. Shear deformation has also been considered in the formulation by taking into account shear strains ( rxz and ryz) as nodal unknowns. The element is very simple to formulate and could be coded up in research software. A small Fortran code has been developed to implement the element and various examples of isotropic and composite plates have been analyzed to show the effectiveness of the element.

关键词： Finite Element Displacement Approach Plate Bending Composite Shear Deformation Higher Order Theory Lock-Free