检索结果-南通市图书馆

Identification of fungal fossils and novel azaphilone pigments in ancient carbonised specimens of Hypoxylon fragiforme from forest soils of Chatillon-sur-Seine(Burgundy)

引用

Fungal Diversity 2018年第5期92卷 345-356页

作者： Frank Surup Abolfazl Narmani Lucile Wendt Sebastian Pfutze Robin Kretz Kevin becker Cle ment Menbrives Alain Giosa Michelle Elliott Christophe Petit Manfred Rohde Marc Stadler Dept.Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany German Centre for Infection Research(DZIF) Partner Site Hannover-Braunschweig38124 BraunschweigGermany Department of Plant Protection Faculty of AgricultureUniversity of TabrizTabrizIran University of Paris 1 Panthéon-Sorbonne UMR 7041Archéologies EnvironnementalesParisFrance Helmholtz-Zentrum für Infektionsforschung GmbH Central Facility for MicroscopyInhoffenstrasse 738124 BraunschweigGermany

Fungal stromata were recently discovered in association with charcoal and burnt soil aggregates during an archaeological survey in the Chaˆtillon-sur-Seine forest *** wood and soil in the samples were dated to the medieval period(between 738 and 1411 AD).Light microscopy and scanning electron microscopy revealed that a few of the stromatal fragments still contained *** macromorphological characters were described and secondary metabolite profiles were generated using high performance liquid chromatography with diode array and mass spectrometric detection(HPLC–DAD/MS).The combination of these two data lines then allowed species *** of the fragments were assigned to Hypoxylon fragiforme,the type species of the Hypoxylaceae(Xylariales).Two further species whose stromata grew on the fossil charcoal could be tentatively identified as Jackrogersella cohaerens and(more tentatively)as Hypoxylon *** three species are still commonly encountered in the forests of Central Europe ***,the HPLC-HRMS data of *** suggested the presence of unknown azaphilone dimers and of further new *** archaeological compounds were compared to fresh stromata of *** collected in Germany and subjected to the same analytical *** the major components in both samples were identified as the known mitorubrin type azaphilones and orsellinic acid,the chemical structures of seven novel complex azaphilone pigments,for which we propose the trivial names rutilins C-D and fragirubrins A-E,were elucidated using spectral methods(NMR and CD spectroscopy,high resolution mass spectrometry).It appears that these pigments had indeed persisted for millennia in the fossil stromata.

关键词： Biodiversity Chemotaxonomy Phylogeny Sordariomycetes Xylariales Structure elucidation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

凝血酶拮抗剂和抗血小板药

引用

国外医学（心血管疾病分册） 1993年第1期20卷 28-29页

作者： becker RC 罗在明

急性心肌梗塞(AMI)溶栓疗法的临床价值已得到广泛认可。但仍有20～25％冠脉血栓不能溶解,10～15％病人发生冠脉再闭塞。本文介绍AMI溶栓治疗时合用凝血酶拮抗剂和抗血小板药的利弊。

关键词：凝血酶拮抗剂抗血小板药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人Ha-ras基因中蛋白质特异结合DNA位点的鉴定

引用

生物化学杂志 1989年第6期5卷 497-502页

作者：王智 F.F.becker 中国医学科学院基础医学研究所德州大学 M.D.Anderson肿庙研究所分子病理系

利用迁移率改变法和DNaseⅠ足纹法观察了Ha-ras癌基因5’端上游序列与特异结合蛋白的相互作用。用限制性内切酶XmaⅠ消化6.6kb Ha-ras基因得到约10个片段,进行3’-末端标记,与T24细胞核提取液反应,经低离子强度聚丙烯酰胺凝胶电泳,发现... 详细信息

利用迁移率改变法和DNaseⅠ足纹法观察了Ha-ras癌基因5’端上游序列与特异结合蛋白的相互作用。用限制性内切酶XmaⅠ消化6.6kb Ha-ras基因得到约10个片段,进行3’-末端标记,与T24细胞核提取液反应,经低离子强度聚丙烯酰胺凝胶电泳,发现与蛋白质特异结合的416bp片段,位于Ha-ras基因5’-端上游1230—1646区域内,靠近转录起始点1660bp处(CAP位置)。另一个与蛋白质特异结合的389bp片段,位于转录起始点上游162—551处。

关键词： DNA结合蛋白 Ha-ras癌基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

冠状动脉溶栓治疗的辅助措施:应用β阻滞剂,钙离子拮抗剂等

引用

国外医学（心血管疾病分册） 1991年第6期18卷 328-329页

作者： becker RC 张志根

在急性心梗时,有效地应用血栓溶解药物是十分重要的一步。再加用β阻滞剂、钙离子拮抗剂、硝酸酯类、镁、血管紧张素转换酶抑制剂等,常常可以得到更好的效果。

关键词：心肌梗塞溶栓疗法 β阻滞剂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antioxidants,inflammation and cardiovascular disease

引用

World Journal of Cardiology 2014年第6期6卷 462-477页

作者： Harald Mangge Kathrin becker Dietmar Fuchs Johanna M Gostner Research Unit on Lifestyle and Inflammation associated Risk Biomarkers Clinical Institute of Medical and Chemical Laboratory DiagnosisMedical University of Graz8036 Grazand BioTechMed-GrazAustria Division of Biological Chemistry BiocenterInnsbruck Medical University6020 InnsbruckAustria Division of Medical Biochemistry BiocenterInnsbruck Medical University6020 InnsbruckAustria

Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibrob

关键词： Atherogenesis Cardiovascular disease Neopterin Nitric oxide Tetrahydrobiopterin Tryptophan Oxidative stress Homocysteine Vitamins Antioxidative therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

引用

World Journal of Gastroenterology 2018年第7期24卷 810-818页

作者： Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M becker Illawarra Health and Medical Research Institute University of WollongongWollongong 2500Australia School of Biological Sciences University of WollongongWollongong 2500Australia Illawarra Cancer Centre Wollongong HospitalWollongong 2500Australia CONCERT-Translational Cancer Research Centre New South Wales 2000Australia Centre for Circulating Tumor Cell Diagnostics and Research Ingham Institute for Applied Medical ResearchLiverpool HospitalSydney 2170Australia School of Medicine University of Western SydneySydney 2170Australia South Western Medical School University of New South WalesSydney 2170Australia

AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal *** Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival *** While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

关键词： Cryopreservation Circulating tumor cells Liquid biopsy Gastroesophageal cancer Gastric cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Action of Essential Oils Obtained from Baccharis coridifolia D.C.(Asteraceae-Astereae)on the Activity of Antibiotics

引用

Advances in Microbiology 2013年第2期3卷 166-170页

作者： Sideney becker Onofre Marilde Canton Paula Andressa Pires Department of Biological Sciences and Pharmacy FAED—Faculty of Educational of Dois Vizinhos—Uniao de Ensino do Sudoeste do Paraná—UNISEP—Bairro Nossa Senhora AparecidaDois VizinhosParanáBrazil

The aim of this study was to investigate the effects of Baccharis coridifolia essential oil on the Activity of Antibiotics. Assays were performed with ampicillin (10 μg), cephalothin (30 μg), chloramphenicol (30 μg), gentamicin (10 μg) and tetracycline (30 μg) alone and in combination with the essential oil (4% v/v) through the disk diffusion susceptibility test. The results showed the effects of essential oil on the activity of the antibiotics tested. Zones of inhibition of bacterial growth with different diameters were observed surrounding the antibiotic disks, whether or not they were impregnated with the essential oil. The occurrence of the synergistic or antagonistic effect was observed in both bacterial strains assessed—Staphylococcus aureus (ATCC-25923) and Escherichia coli (ATCC-25922). These results show that the use of products derived from plants can, in some cases, interfere with the effectiveness of antibiotics during clinical therapy.

关键词： Medicinal Plants Essential Oils Antibiotic Associated Use Interference

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自动驾驶改变未来 1版

引用

2017年

作者：柴占祥聂天心 JAN becker

本书以通俗易懂的语言，对自动驾驶相关的技术、社会、经济、法规、道德伦理等方面的内容做了一个全景式的描述，对自动驾驶涉及到的众多技术、现状及趋势进行了阐述、其对环保、交通安全等带来的益处做了说明、对人们在观念、习惯上将... 详细信息

ISBN: (数字)9787111581871

ISBN: (纸本)9787111581871

本书以通俗易懂的语言，对自动驾驶相关的技术、社会、经济、法规、道德伦理等方面的内容做了一个全景式的描述，对自动驾驶涉及到的众多技术、现状及趋势进行了阐述、其对环保、交通安全等带来的益处做了说明、对人们在观念、习惯上将面临什么样的改变，在全球、国家、社区、家庭等方面面临哪些新的挑战进行了讨论，同时本书也对自动驾驶汽车引起的新旧体系的碰撞、倒逼法规的改变，新情况导致的道德的纠结、变革的可能付出的代价也有所涉猎，本书也花费相当的篇幅记录了汽车企业的努力。本书后畅想了自动驾驶的崭新未来。本书适合于汽车行业从业人员、汽车发烧友、汽车用户及对汽车行业感兴趣的大中学校的学生等阅读。本书以通俗易懂的语言，对自动驾驶相关的技术、社会、经济、法规、道德伦理等方面的内容做了一个全景式的描述，对自动驾驶涉及到的众多技术、现状及趋势进行了阐述、其对环保、交通安全等带来的益处做了说明、对人们在观念、习惯上将面临什么样的改变，在全球、国家、社区、家庭等方面面临哪些新的挑战进行了讨论，同时本书也对自动驾驶汽车引起的新旧体系的碰撞、倒逼法规的改变，新情况导致的道德的纠结、变革的可能付出的代价也有所涉猎，本书也花费相当的篇幅记录了汽车企业的努力。本书后畅想了自动驾驶的崭新未来。本书适合于汽车行业从业人员、汽车发烧友、汽车用户及对汽车行业感兴趣的大中学校的学生等阅读。

关键词：汽车驾驶自动驾驶系统

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams

引用

World Journal of Hepatology 2016年第16期8卷 685-690页

作者： David becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell Department of Radiology Thomas Jefferson University Division of Gastroenterology and Hepatology Department of MedicineThomas Jefferson University

AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are ***:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional *** selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or ***,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging *** explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum ***’s exact test was firs performed to identify significant imaging ***:Inclusion criteria selected for 42 patients with 65 treated *** of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant *** o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable ***:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable *** such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable *** possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Tumor recurrence Locoregional therapy Imaging surveillance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Superior biocompatibility and comparable osteoinductive properties: Sodium-reduced fluoride-containing bioactive glass belonging to the CaO–MgO–SiO2 system as a promising alternative to 45S5 bioactive glass

引用

Bioactive Materials 2020年第1期5卷 55-65页

作者： S.I.Schmitz B.Widholz C.Essers M.becker D.U.Tulyaganov A.Moghaddam I.Gonzalo de Juan F.Westhauser Center of Orthopedics Traumatology and Spinal Cord InjuryHeidelberg University HospitalSchlierbacher Landstraße 200a69118HeidelbergGermany Disperse Solid Materials Technical University DarmstadtOtto-Berndt-Straße 364287DarmstadtGermany Department of Natural-Mathematical Sciences Turin Polytechnic University in Tashkent17 Small Ring Street100095TashkentUzbekistan ATORG-Aschaffenburg Trauma and Orthopedic Research Group Center for Trauma SurgeryOrthopedicsand Sports MedicineKlinikum Aschaffenburg-AlzenauAm Hasenkopf 163739AschaffenburgGermany

Bioactive glasses(BGs)are promising bone substitute ***,under certain circumstances BGs such as the well-known 45S5 Bioglass®(composition in wt%:45.0 SiO2,24.5 Na2O,24.5 CaO,6.0 P2O5)act cytotoxic due to a strong increase in pH caused by a burst release of sodium ions.A potential alternative is a sodiumreduced fluoride-containing BG belonging to the CaO–MgO–SiO2 system,namely BG1d-BG(composition in wt%:46.1 SiO2,28.7 CaO,8.8 MgO,6.2 P2O5,5.7 CaF2,4.5 Na2O),that has already been evaluated in-vitro,in-vivo and in preliminary clinical *** further application,however,BG1d-BG should be compared to the benchmark amongst BGs,the 45S5 Bioglass®composition,to classify its effect on cell viability,proliferation and osteogenic differentiation of human mesenchymal stem cells(MSCs).Therefore,in this study,the biocompatibility and osteogenic potential of both BGs were investigated in an indirect and direct culture setting to assess the effect of the ionic dissolution products and the BGs’physical presence on the *** results indicated an advantage of BG1d-BG over 45S5 Bioglass®regarding cell viability and *** BGs induced an earlier onset of osteogenic differentiation and accelerated the expression of late osteoblast marker genes compared to the control *** conclusion,BG1d-BG is an attractive candidate for further experimental *** basic mechanisms behind the different impact on cell behavior should be assessed in further detail,*** further alteration of the BG compositions.

关键词： 45S5 Bioglass® Sodium-reduced bioactive glass Fluoride-containing bioactive glass Bone tissue engineering Human mesenchymal stromal cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：