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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

First-Principles Investigation of Charge Transfer Mechanism of B-Doped 3C-SiC Semiconductor Material

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World Journal of Condensed Matter Physics 2024年第2期14卷 35-44页

作者： Abdullahi Alkali Dauda Muhammad Yusuf Onimisi Adeyemi Joshua Owolabi Hameed Adeneyi Lawal Hassan Muhammad Gambo Bashir Mohammed Aliyu Surajo Bala Muhammad Lamido Madugu Muhammad Abdurrahman Nainna.johnson Akinade Bamikole Physics Department Faculty of Science Air Force Institute of Technology Kaduna Nigeria Physics Department Faculty of Science Nigeria Defence Academy Kaduna Nigeria Physics Department Umaru Musa Yar&#8217adua University Batagarawa Nigeria Physics Department Faculty of Science Gombe State University Gombe Nigeria Physics Department Federal University of Lafia Lafia Nigeria

This study delves into the charge transfer mechanism of boron (B)-doped 3C-SiC through first-principles investigations. We explore the effects of B doping on the electronic properties of 3C-SiC, focusing on a 12.5% impurity concentration. Our comprehensive analysis encompasses structural properties, electronic band structures, and charge density distributions. The optimized lattice constant and band gap energy of 3C-SiC were found to be 4.373 Å and 1.36 eV respectively, which is in agreement with previous research (Bui, 2012;Muchiri et al., 2018). Our results show that B doping narrows the band gap, enhances electrical conductivity, and influences charge transfer interactions. The charge density analysis reveals substantial interactions between B dopants and surrounding carbon atoms. This work not only enhances our understanding of the material’s electronic properties, but also highlights the importance of charge density analysis for characterizing charge transfer mechanisms and their implications in the 3C-SiC semiconductors.

关键词： First-Principles Calculations DFT Boron (B)-Doped 3C-SiC Charge Transfer

在人数多的外语教学班级中使用交际法来评估交际能力

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外语教学理论与实践 1991年第3期 14-16,49页

作者： Judith a.johnson 朱钟毅华东师大

很多国家中,一个把英语作为外语教学的口语班级里往往有三十到五十甚至更多的学生,他们是通过语法翻译法来学习外语的,因此,听和说的能力都很差。学习外语的传统方法——重复和记忆使这些学生有较大的词汇量,并且通晓不同程度的语法规... 详细信息

很多国家中,一个把英语作为外语教学的口语班级里往往有三十到五十甚至更多的学生,他们是通过语法翻译法来学习外语的,因此,听和说的能力都很差。学习外语的传统方法——重复和记忆使这些学生有较大的词汇量,并且通晓不同程度的语法规则。然而他们学到的词汇常常和实际生活中的情景脱节,也通常不会在语法正确的句子中使用那些即使是最基本的词汇。

关键词：外语教学语法翻译法流利程度考试结果 think something 语言内容语言水平语言知识小组讨论

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解释极限的一个实例

数学教学研究 1988年第3期 40-41页

作者： a.johnson 冯振杰

假如你的抽屉里有两双袜子,一双红的,一双蓝的。当你早晨醒来,在朦朦胧胧中,穿衣服准备上学时,从抽屉里随手拿出两只袜子,那么你拿到的恰好是一双的概率有多大呢? 我们可作一简单的分析:先拿了一只袜

关键词：袜子抽屉概率

Biodiversity and interactions of acidophiles:Key to understanding and optimizing microbial processing of ores and concentrates

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中国有色金属学会会刊：英文版 2008年第6期18卷 1367-1373页

作者： D.B.johnson School of Biological Sciences Bangor University

采矿公司为从低档矿石恢复贱、宝贵的金属，并且为重新调停变得逐渐地知道 microbiological 途径的潜力从操作和放弃的矿地点排干的酸的、充满金属的废水。生物系统出现很多环境并且(有时) 超越常规途径的节俭的优点尽管他们的申请是，... 详细信息

采矿公司为从低档矿石恢复贱、宝贵的金属，并且为重新调停变得逐渐地知道 microbiological 途径的潜力从操作和放弃的矿地点排干的酸的、充满金属的废水。生物系统出现很多环境并且(有时) 超越常规途径的节俭的优点尽管他们的申请是，例如热冶学，别处于每种状况拨出。矿物质用微生物处理为提取黄金，铜，铀和钴被利用了，并且当前的开发正在指向另外的贱金属。最近，我们 biomining 环境，并且微生物怎么与对方一起交往的微生物学的差异的知识和理解有大增加。从模仿了搅动的坦克和堆生物反应器系统的实验室实验的结果证明了微生物引起的协会比氧化矿物质的 acidophiles 的纯文化更柔韧，并且也趋于在 bioleaching 和氧化简历的矿石更有效并且专注。纸论述了性质的简明评论和涉及硫化物矿物质的氧化的微生物引起的协会的相互作用，并且这些怎么可能被改编在 biomining 操作遇见未来挑战。

关键词：嗜酸细胞生物采矿生物多样性微生物加工

Experimental Modelling of Transverse Oscillations in Aquaculture Netting Parallel to the Flow – Sounds Baffling

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China Ocean Engineering 2015年第3期29卷 391-400页

作者： Andrew johnson Cheslav BALASH National Centre for Maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of Tasmania Launceston

Numerous studies have been undertaken to improve the viability, durability and suitability of materials and methods used for aquaculture enclosures. While many of the previous studies considered macro-deformation of nets, there is a paucity of information on netting micro-deformation. When aquaculture pens are towed, industry operators have observed the motion described as ＂baffling＂ – the transverse oscillation of the net planes parallel and near parallel to the flow. The difficulty to observe and assess baffling motion in a controlled experimental environment is to sufficiently reproduce netting boundary conditions and the flow environment experienced at sea. The focus of the present study was to develop and assess experimental methods for visualisation and quantification of these transverse oscillations. Four netrig configurations with varied boundary conditions and model-netting properties were tested in a flume tank. While the Reynolds number was not equivalent to full-scale, usage of the pliable and fine mesh model netting that enabled baffling to develop at low flow velocities was deemed to be of a larger relevance to this initial study. Baffling was observed in the testing frame that constrained the net sheet on the leading edge, similarly to a flag attachment onto a pole. Baffling motion increased the hydrodynamic drag of the net by 35%–58% when compared to the previously developed formula for taut net sheets aligned parallel to the flow. Furthermore, it was found that the drag due to baffling decreased with the increasing velocity over the studied Reynolds numbers（below 200）; and the drag coefficient was non-linear for Reynolds numbers below 120. It is hypothesised that baffling motion is initially propagated by vortex shedding of the netting twine which causes the netting to oscillate; there after the restoring force causes unstable pressure differences on each side of the netting which excites the amplitude of the netting oscillations.

关键词： aquaculture pen baffling model net testing netting drag netting micro-deformation

Blockchain-Based System for Secure and Efficient Cross-Border Remittances: A Potential Alternative to SWIFT

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Journal of Software Engineering and Applications 2024年第8期17卷 664-712页

作者： Omoshola S. Owolabi Emmanuel Hinneh Prince C. Uche Nathaniel T. Adeniken Jennifer A. Ohaegbulem Samuel Attakorah Oluwabukola G. Emi-johnson Chinaza S. Belolisa Harold Nwariaku Department of Data Science Carolina University Winston Salem NC USA Patterson School of Business Carolina University Winston Salem NC USA Department of Statistical Sciences Wake Forest University Winston Salem NC USA Department of Computer Science Fisk University Nashville TN USA Harold & Co Procurement and Supply Chain Consulting Lagos Nigeria

This paper proposes a blockchain-based system as a secure, efficient, and cost-effective alternative to SWIFT for cross-border remittances. The current SWIFT system faces challenges, including slow settlement times, high transaction costs, and vulnerability to fraud. Leveraging blockchain technology’s decentralized, transparent, and immutable nature, the proposed system aims to address these limitations. Key features include modular architecture, implementation of microservices, and advanced cryptographic protocols. The system incorporates Proof of Stake consensus with BLS signatures, smart contract execution with dynamic pricing, and a decentralized oracle network for currency conversion. A sophisticated risk-based authentication system utilizes Bayesian networks and machine learning for enhanced security. Mathematical models are presented for critical components, including transaction validation, currency conversion, and regulatory compliance. Simulations demonstrate potential improvements in transaction speed and costs. However, challenges such as regulatory hurdles, user adoption, scalability, and integration with legacy systems must be addressed. The paper provides a comparative analysis between the proposed blockchain system and SWIFT, highlighting advantages in transaction speed, costs, and security. Mitigation strategies are proposed for key challenges. Recommendations are made for further research into scaling solutions, regulatory frameworks, and user-centric designs. The adoption of blockchain-based remittances could significantly impact the financial sector, potentially disrupting traditional models and promoting financial inclusion in underserved markets. However, successful implementation will require collaboration between blockchain innovators, financial institutions, and regulators to create an enabling environment for this transformative system.

关键词： Interoperability Tokens AML/KYC Compliance Peer-to-Peer Transfers Financial Inclusion

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世界猪人工授精技术研究和应用现状

国外畜牧学（猪与禽） 1991年第2期11卷 26-28页

作者：陶永辉 Beltsville Lawrence a.johnson 美国农业部农业研究服务部农业研究中心繁殖研究室农业研究中心繁殖研究室博士博士

1948年伊藤、丹羽等首先报道利用新鲜猪精液的实际应用技术,而后1956年 Polge 也作了报道。但是打开猪冷冻精液商品化利用之路乃是1971年的事。1971年 Graham 等、Crabro 和 Einarsson 以及 Pursel 和 johnson 同时报道,将冻精经子宫颈... 详细信息

1948年伊藤、丹羽等首先报道利用新鲜猪精液的实际应用技术,而后1956年 Polge 也作了报道。但是打开猪冷冻精液商品化利用之路乃是1971年的事。1971年 Graham 等、Crabro 和 Einarsson 以及 Pursel 和 johnson 同时报道,将冻精经子宫颈管道输入,成功产下仔猪。1975年发明了简便的冷冻及解冻方法后冷冻精液作为商品使用。

关键词：猪人工授精研究

Min-Max Theory for Cell Complexes

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Algebra Colloquium 2020年第3期27卷 447-454页

作者： Lacey johnson Kevin Knudson Department of Mathematics University of FloridaGainesvilleFL 32611USA

In the study of smooth functions on manifolds,min-max theory provides a mechanism for identifying critical values of a *** introduce a discretized version of this theory associated to a discrete Morse function on a(regular)cell *** applications we prove a discrete version of the mountain pass lemma and give an alternate proof of a discrete Lusternik-Schnirelmann theorem.

关键词： discrete Morse theory min-max theory