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Two haplotype-resolved genomes reveal important flower traits in bigleaf hydrangea(Hydrangea macrophylla)and insights into Asterid evolution

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Horticulture Research 2023年第12期10卷 45-57页

作者： Xingbo Wu Sheron A.Simpson Ramey C.Youngblood Xiaofen FLiu Brian E.Scheffler timothy a.rinehart Lisa W.Alexander Amanda M.Hulse-Kemp Department of Environmental Horticulture Tropical Research and Education CenterUniversity of FloridaHomesteadFL 33031United States Genomics and Bioinformatics Research Unit USDA-ARSRaleighNC 27695United States Genomics and Bioinformatics Research Unit USDA-ARSStonevilleMS 38776United States Institute for Genomics Biocomputing and BiotechnologyMississippi State UniversityStarkvilleMS 39762United States Crop Production and Protection USDA-ARSBeltsvilleMD 20705United States Floral and Nursery Plants Research Unit U.S.National ArboretumUSDA-ARSMcMinnvilleTN 37110United States Department of Crop and Soil Sciences North Carolina State UniversityRaleighNC 27695United States

The Hydrangea genus belongs to the Hydrangeaceae family,in the Cornales order of flowering plants,which early diverged among the Asterids,and includes several species that are commonly used ornamental plants.Of them,Hydrangea macrophylla is one of the most valuable species in the nursery trade,yet few genomic resources are available for this crop or closely related Asterid species.Two high-quality haplotype-resolved reference genomes of hydrangea cultivars‘Veitchii’and‘Endless Summer’[highest quality at 2.22 gigabase pairs(Gb),396 contigs,N5022.8 megabase pairs(Mb)]were assembled and scaffolded into the expected 18 pseudochromosomes.Utilizing the newly developed high-quality reference genomes along with high-quality genomes of other related flowering plants,nuclear data were found to support a single divergence point in the Asterids clade where both the Cornales and Ericales diverged from the euasterids.Genetic mapping with an F1 hybrid population demonstrated the power of linkage mapping combined with the new genomic resources to identify the gene for inflorescence shape,CYP78A5 located on chromosome 4,and a novel gene,BAM3 located on chromosome 17,for causing double flower.Resources developed in this study will not only help to accelerate hydrangea genetic improvement but also contribute to understanding the largest group of flowering plants,the Asterids.

关键词： Hydra traits resolved

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Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline Edwards Sarah Jeffrey Tamara May Nicole J.rinehart Lisa M.Barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar age.Feasibility was a secondary aim.Methods: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was feasible.Conclusion: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

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Strengthening nanocomposite magnetism through microemulsion synthesis

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Nano Research 2018年第8期11卷 4133-4141页

作者： Yijun xie Alexandre H. Vincent Haeun Chang Jeffrey D. rinehart Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Department of Chemistry and Biochemistry University of Cafifomia San Diego 9500 Gilman Drive La Jolla CA 92093 USA

The magnetic strength and versatility of heterostructures generated via a simple microemulsion cluster-formation technique is demonstrated. This approach allows optimization of individual component magnetic nanoparticles prior to heterostructuring, expediting the discovery and optimization of hybrid magnetic materials. The efficacy of this method is validated through a magnetic study of nanoparticle clusters combining antiferromagnetic CoO and superparamagnetic CoFe204 nanoparticles with tunable particle ratio and size. An enhancement of coercivity compared with pure CoFe204 nanoparticles indicates that close interparticle contacts are achieved. Upon annealing, an exchange bias field of 0.32 T was observed--over twice that achieved in any other colloidally-synthesized system. Additionally, the unique microstructure is defined during cluster formation and thus protects magnetic coercivity during the annealing process. Overall, this work demonstrates a general approach for quickly exploring magnetic parameter space, designing interparticle functionality, and working towards the construction of high-value bulk magnets with low materials and processing cost.

关键词： nanoparticle cluster microemulsion exchange bias exchange interaction coercivity

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Can tranexamic acid change preoperative anemia management during total joint arthroplasty?

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World Journal of Orthopedics 2015年第7期6卷 521-527页

作者： Duy L Phan Joseph B rinehart Ran Schwarzkopf Department of Orthopaedic Surgery University of California Department of Anesthesiology University of California

AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of pa

关键词： Total knee replacement Tranexamic acid Total hip replacement Preoperative anemia

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YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse rinehart Perry L.Miller Kenneth R.Williams W.M.Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（LC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

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Joint arthroplasty Perioperative Surgical Home:Impact of patient characteristics on postoperative outcomes

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World Journal of Orthopedics 2016年第6期7卷 376-382页

作者： Duy L Phan Kyle Ahn Joseph B rinehart Michael-David Calderon Wei-Der Wu Ran Schwarzkopf Department of Orthopaedic Surgery Universityof California Irvine Medical Center Department of Anesthesiology University of CaliforniaIrvine Medical Center Division of Adult Reconstruction Departmentof Orthopaedic Surgery New York University Langone Medical Center

AIM:To determine the impact of different characteristics on postoperative outcomes for patients in a joint arthroplasty Perioperative Surgical Home(PSH) program.METHODS:A retrospective review was performed for patients enrolled in a joint arthroplasty PSH program who had undergone primary total hip arthroplasty(THA) and total knee arthroplasty(TKA).Patients were preoperatively stratified based on specific procedure performed,age,gender,body mass index(BMI),American Society of Anesthesiologists Physical Classification System(ASA) score,and Charleston Comorbidity Index(CCI) score.The primary outcome criterion was hospital length of stay(LOS).Secondary criteria including operative room(OR) duration,trans-fusion rate,Post-Anesthesia Care Unit(PACU) stay,readmission rate,post-operative complications,and discharge disposition.For each outcome,the predictor variables were entered into a generalized linear model with appropriate response and assessed for predictive relationship to the dependent variable.Significance level was set to 0.05.RESULTS:A total of 337 patients,200 in the TKA cohort and 137 in the THA cohort,were eligible for the study.Nearly two-third of patients were female.Patient age averaged 64 years and preoperative BMI averaged 29 kg/m2.The majority of patients were ASA score Ⅲ and CCI score 0.After analysis,ASA score was the only variable predictive for LOS(P = 0.0011) and each increase in ASA score above 2 increased LOS by approximately 0.5 d.ASA score was also the only variable predictive for readmission rate(P = 0.0332).BMI was the only variable predictive for PACU duration(P = 0.0136).Specific procedure performed,age,gender,and CCI score were not predictive for any of the outcome criteria.OR duration,transfusion rate,postoperative complications or discharge disposition were not significantly associated with any of the predictor variables.CONCLUSION:The joint arthroplasty PSH model reduces postoperative outcome variability for patients with different preoperative characteristics and medical comorbiditi

关键词： Perioperative Surgical Home Arthroplasty Length of stay American Society of Anesthesiologists Physical Classification System Body mass index

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行善的快乐

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英语学习 2009年第6期 36-39页

作者： Mary Roberts rinehart

股票和信贷经纪人埃弗里特在一笔交易中赚了2，000美元，不禁欣喜异常；可贷出去的300美元却无法收回，他又懊恼不已。不过一瞬间，这一切似乎都变得不再重要：真正让他体会到快乐的，是他慷慨掏出的20美元。

关键词：快乐经纪人美元交易信贷股票

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Peroxidase-Like Reactivity at Iron-Chelation Sites in a Mesoporous Synthetic Melanin

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CCS Chemistry 2021年第3期3卷 1483-1490页

作者： Yijun Xie Kelsey A.Krug Kristine S.Cay Mark Kalaj Naneki C.McCallum Zofia E.Siwicka Zhao Wang Nathan C.Gianneschi Michael D.Burkart Jeffrey D.rinehart Materials Science and Engineering Program University of CaliforniaSan DiegoLa JollaCA 92093 Department of Chemistry and Biochemistry University of CaliforniaSan DiegoLa JollaCA 92093 Department of Chemistry Northwestern UniversityEvanstonIL 60208 International Institute of Nanotechnology Simpson-Querrey InstituteChemistry of Life Processes InstituteNorthwestern UniversityEvanstonIL 60208 Pritzker School of Molecular Engineering University of ChicagoChicagoIL 60637 Lurie Cancer Center Northwestern UniversityEvanstonIL 60208 Department of Materials Sciences and Engineering Northwestern UniversityEvanstonIL 60208 Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208

High catalytic activity and substrate specificity make enzymes a rich source of inspiration for catalyst development.Co-opting the advantages of natural materials while tuning them to a modified form and purpose,however,is not a straightforward synthetic task.Polymerization of L-3,4-dihydroxyphenylalanine(L-DOPA)results in amorphous polymer nanoparticles that are similar in many ways to natural eumelanin.Herein,the authors introduce mesoporosity and iron ion chelation to synthesize a variant of the L-DOPA polymer with high peroxidase-like activity.Our results indicate catalytic reaction with peroxide under mildly acidic conditions(pH 5.4 and 6)with a greater maximum reaction velocity(Vmax)than horseradish peroxidase(HRP)at optimal pH 3.5–4.5.Comparison between Fe(Ⅲ)and Fe(Ⅱ)loading indicates that either can be used as a starting point to trigger reactivity,though Fe(Ⅱ)loading leads to materials with twice the Vmax of the Fe(Ⅲ)-loaded sample.The lack of catalyst degradation despite the redox changes and presence of radical species is consistent with the robust nature and redox versatility of polydopamine-based materials and demonstrates strong potential as a versatile redox-catalysis platform.

关键词： L-DOPA mesoporosity peroxidase-like reactivity iron ion chelation catalysis

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抗生素生物合成进展

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国际药学研究杂志 1982年第2期 107-113页

作者： rinehart K L ,张海澜

作者近年研究了一些很重要的氨基环醇(Aminocyclitol)类抗生素的生物合成。如:庆大霉素,新霉素,链霉素和奇放线菌素(Spec-tinomycin)等,同时并研究了许多其它抗生素的生源。本文讨论了新近研究的三个抗生素即:约霉素(Pactamycin)、伯尔... 详细信息

作者近年研究了一些很重要的氨基环醇(Aminocyclitol)类抗生素的生物合成。如:庆大霉素,新霉素,链霉素和奇放线菌素(Spec-tinomycin)等,同时并研究了许多其它抗生素的生源。本文讨论了新近研究的三个抗生素即:约霉素(Pactamycin)、伯尔尼霉素(Ber-ninamycin)和链霉溶菌素(Streptolydigin)。约霉素

关键词：伯尔尼掺入生物合成瑞士生化反应脱氢丙氨酸氨基己二酸抗生素

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海洋天然产物的检测筛选

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国际药学研究杂志 1988年第6期 354-357页

作者： rinehart KL ,林绮

海洋天然产物在人类医学上的应用或更确切地说其潜在的用途已引起人们广泛关注.80年代以来对来源于海洋的药物筛选无论在工业或学术上均引起人们极大兴趣.涌现了一类专业公司——海洋药学公司,完全致力于源于海洋的药物筛选研究.

关键词：细胞毒性提取物化合物初筛方法小鼠小家鼠生物活性海洋天然产物活性物质

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