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Magnetic Resonance Letters 2021年第2期1卷 99-111页

作者： Rongfu Zhang timothy a.cross Riqiang Fu National High Magnetic Field Laboratory 1800 East Paul Dirac DriveTallahasseeFL32310USA Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFL32301USA

Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid *** general,the 1H polarization transfers berween water molecules and site--specific protons in proteins can be classified as coherent(via dipolar spin diffusion)and incoherent(via chemical exchange and nuclear Overhauser effect)***-state NMR is the technique of choice for studying such water-protein interactions in membrane-bound proteins/peptides through the detection of'H polarization transfers from water to the *** polarization transfer mechanisms often exist simultaneously and are difficult to quantify ***,we review water-protein polarization transfer techniques in solid state NMR with a focus on the recent progress for the direct detection of site-specific kinetic water-protein chemical exchange processes on the sub-millisecond time scale in membrane-bound *** measurements of the pure chemical exchange ki-netics provide a unique opportunity to understand the role that water plays in the structure-function relationships of membrane bound species at the water-bilayer *** addi-tion,the perspective of chemical exchange saturation transfer(CEST)experiments in membrane-bound proteins/peptides is further discussed.

关键词： Chemical exchange Spin diffusion HETCOR CEST Water-protein interactions Solid-state NMR

河流相层序地层划分方法——以松辽盆地下白垩统扶余油层为例

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石油与天然气地质 2007年第5期28卷 621-627页

作者：邓宏文吴海波王宁 timothy a.cross 中国地质大学北京100083 中国石油大庆油田有限责任公司勘探开发研究院黑龙江大庆163712 美国科罗拉多矿业学院

以松辽盆地下白垩统泉头组扶余油层为例,探讨了河流沉积体系的层序地层分析方法。首先确定河流的成因类型和相域(微相)的构成,包括曲流河道、决口河道、决口扇、冲积平原和浅水湖泊,识别河流演化过程中由于河流冲溢形成的自旋回沉积作... 详细信息

以松辽盆地下白垩统泉头组扶余油层为例,探讨了河流沉积体系的层序地层分析方法。首先确定河流的成因类型和相域(微相)的构成,包括曲流河道、决口河道、决口扇、冲积平原和浅水湖泊,识别河流演化过程中由于河流冲溢形成的自旋回沉积作用和基准面变化产生的异旋回沉积作用,即基准面旋回;然后运用河流沉积学理论分析构成河流相的不同相域的形成与基准面变化的关系,识别基准面转换位置(基准面上升到下降或基准面下降到上升)的沉积学和地层学响应,从而建立等时地层对比格架。

关键词：自旋回异旋回基准面旋回旋回界面识别层序地层格架河流相扶余油层松辽盆地

STRUCTURE CHARACTERIZATION OF M2 PROTON CHANNEL FROM INFLUENZA A VIRUS USING ANISOTROPIC SOLID STATE NMR

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波谱学杂志 2002年第1期19卷 84-84页

作者： Changlin TIAN Kurt TOBBLER Robert LAMB Lawrance H.PINTO timothy a.cross CIMAR National High Magnetic Field Lab Institute of Molecular Biophysics Florida State University TallahasseeFL 32310 Department of BiochemistryMolecular Biology and Cell Biology Florida State University TallahasseeFL 32310 Department of BiochemistryMolecular Biology and Cell Biology Howard Hughes Medical Institute Department of Neurobiology and Physiology CIMAR National High Magnetic Field Lab Institute of Molecular Biophysics Department of Chemistry Northwestern UniversityEvanstonIL

The M2 protein from influenza A virus has been expressed, purified and reconstituted into DMPC/DMPG liposomes.

关键词： STRUCTURE CHARACTERIZATION OF M2 PROTON CHANNEL FROM INFLUENZA A VIRUS USING ANISOTROPIC SOLID STATE NMR

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok timothy G.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Model-based and Fuzzy Logic Approaches to Condition Monitoring of Operational Wind Turbines

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International Journal of Automation and computing 2015年第1期12卷 25-34页

作者： Philip cross Xiandong Ma Engineering Department Lancaster University

It is common for wind turbines to be installed in remote locations on land or offshore, leading to difficulties in routine inspection and maintenance. Further, wind turbines in these locations are often subject to harsh operating conditions. These challenges mean there is a requirement for a high degree of maintenance. The data generated by monitoring systems can be used to obtain models of wind turbines operating under different conditions, and hence predict output signals based on known inputs. A model-based condition monitoring system can be implemented by comparing output data obtained from operational turbines with those predicted by the models, so as to detect changes that could be due to the presence of faults. This paper discusses several techniques for model-based condition monitoring systems: linear models, artificial neural networks, and state dependent parameter "pseudo" transfer *** models are identified using supervisory control and data acquisition(SCADA) data acquired from an operational wind firm. It is found that the multiple-input single-output state dependent parameter method outperforms both multivariate linear and artificial neural network-based approaches. Subsequently, state dependent parameter models are used to develop adaptive thresholds for critical output signals. In order to provide an early warning of a developing fault, it is necessary to interpret the amount by which the threshold is exceeded, together with the period of time over which this occurs. In this regard, a fuzzy logic-based inference system is proposed and demonstrated to be practically feasible.

关键词： Condition monitoring wind turbines artificial neural network state dependent parameter model fuzzy logic

Failure of the free energy relation under a non-Markovian heat bath temperature change

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Chinese Physics B 2012年第9期21卷 1-6页

作者：曹亮 Michael cross 郑志刚 Department of Physics Beijing Normal University Department of Physics California Institute of Technology

We investigate the free energy relation for a system contacting with a non-Markovian heat bath and find that the validity of the relation sensitively depends on the non-Markovian memory effect, which is especially related go the initial preparation effect. This memory effect drives the statistical distribution of the system out of the initial preparation, even if the system starts from an equilibrium state. This leads to the violation of the free energy relation. A possible way of eliminating this memory effect is proposed.

关键词： free energy relation non-Markovian heat bath initial preparation effect

Plate tectonics in relation to mantle temperatures and metamorphic properties

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Science China Earth Sciences 2020年第5期63卷 634-642页

作者： timothy KUSKY State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Three Gorges Research Center for Geohazards China University of GeosciencesWuhan 430074China

When plate tectonics emerged and how it has evolved over Earth history are two of the most fundamental challenges in Earth *** questions are tackled using a holistic approach to analyze tectonic styles in the history of Earth,giving rise to the interpretation of two styles of plate tectonics since the *** these interpretations,there are different styles of deformation and metamorphism between early times dominated by warm subduction,and later times preferring cold *** two styles of plate tectonics are recorded by different properties of regional metamorphism at convergent plate boundaries,which are linked to the differences in mantle temperature between the Archean and Phanerozoic.A transition to modern plate tectonics is recorded by the signature of blueschist facies metamorphism developed in the *** is consistent with geological evidence for the operation of ancient plate tectonics since the early *** temporal cooling of the mantle explains the geochemical trends of mantle-derived melts,the likely change from numerous small plates to fewer but larger plates,changes in thickness and preservation of oceanic crust and lithosphere in accretionary and collisional orogens,and led to the oxygenation of the surface environment providing the environments needed to foster life.

关键词： Plate tectonics Precambrian Accretionary orogen Mantle temperature Metamorphic facies series

Analysis of the design and performance characteristics of pumpable roof supports

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International Journal of Mining Science and Technology 2017年第1期27卷 91-99页

作者： Batchler timothy NIOSH Office of Mine Safety and Health ResearchPittsburghPA 15236USA

Pumpable roof supports are currently being used to provide a safe working environment for longwall mining. Because different pumpable supports are visually similar and installed fundamentally in the same manner as other supports, there is a tendency to believe they all perform the same way. However, there are several design parameters that can affect their performance, including the cementitious material properties and the bag construction practices that influence the degree of confinement provided. A full understanding of the impact of these design parameters is necessary to optimize the support application and to provide a foundation for making further improvements in the support performance. This paper evaluates the impact of various support design parameters by examining full-scale performance tests conducted using the National Institute for Occupational Safety and Health(NIOSH) Mine Roof Simulator(MRS) as part of manufacturers' developmental and quality control testing. These tests were analyzed to identify correlations between the support design parameters and the resulting performance. Based on more than 160 tests over 7 years, quantifiable patterns were examined to assess the correlation between the support dimensions, cementitious material type, wire pitch, and single-wall vs. dualwalled bag designs to the support capacity, stiffness, load shedding events, and yield characteristics.

关键词： Pumpable Roofsuppo Performance characteristics Secondary support

Impacts of a Japan–South Korea power system interconnection on the competitiveness of electric power companies according to power exchange prices

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Global Energy Interconnection 2020年第3期3卷 292-302页

作者： Romain Zissler Jeffrey S.cross School of Environment and Society Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan

In many regions,international power system interconnections provide economic,energy-security,environmental,and technical *** contrast,such interconnections remain scarce in Northeast *** 2016,after approving a joint memorandum of understanding between major electric power companies from China,Japan,South Korea,and Russia,related initiatives regained momentum in the ***,the corresponding developments in Japan remain limited,mainly owing to the lack of involvement of Japanese electric power *** study represents a pioneering attempt to provide an economic assessment based on power exchange prices of a power system interconnection between Japan and South Korea regarding the competitiveness of electric power companies in terms of competitive business segments and strategic *** found that although the position of Japanese generators may slightly deteriorate,that of the supply segment would substantially improve,thus suggesting that more opportunities than threats are derived from the *** promising outcome may foster the adoption of an interconnection with South Korea considering the positive economic and business perspectives in ***,realizing the interconnection may improve the energy security and air quality in the region.

关键词： Electricity grid interconnection Japan South Korea Electric power company Power exchange price