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a.socia.ions between Hea.th-Rela.ed Fitness a.d Ca.dio-Meta.olic Blood Profiles in Low-Income Children

Open Journa. of Preventive Medicine 2015年第9期5卷 370-376页

作者： Rya. D. Burns timothy a. brusseau You Fu Ja.es C. Ha.non Depa.tment of Exercise a.d Sport Science University of Utah Salt Lake City USA Kinesiology a.d Sport Science Depa.tment University of Nebraska Kearney Kearney USA College of Physica. a.tivity a.d Sport Sciences West Virginia University Morgantown USA

Children from low-income fa.ilies ha.e a.higher incidence for developing ea.ly onset ca.dio-meta.olic disea.e risk fa.tors. Optima. levels of hea.th-rela.ed fitness ma. a.tenua.e risk, but little resea.ch ha. exa.ined its rela.ionships with individua. ca.dio-meta.olic blood ma.kers in low-income children. The purpose of this study wa. to exa.ine the preva.ence a.d correla.es of unfa.ora.le ca.dio-meta.olic blood profiles in children from low-income fa.ilies. Da.a.were collected a.d a.a.yzed on 124 children (mea. a.e = 10.4 ± 0.9 yea.s;57 girls, 67 boys;97% Hispa.ic) recruited from three urba. Title I schools from the sta.e of Uta. in the US Hea.th-rela.ed fitness. Mea.ures were collected using the va.ida.ed FITNESSGRa. fitness test ba.tery. The Cholestech LDX system wa. used to a.a.yze students’ tota. cholesterol (TC), LDL cholesterol, HDL cholesterol, triglycerides (TRI), a.d blood glucose (BG). Ca.illa.y blood sa.ples via.finger sticks were collected while ea.h student wa. in a.fa.ted sta.e before school hours. Unfa.ora.le mea.urements were defined a. TC ≥ 200 mg/dL, LDL ≥ 130 mg/dL, HDL 150 mg/dL, a.d BG ≥ 100 mg/dL (pre-dia.etes). a.proxima.ely 5.3% of the tota. sa.ple ha. unfa.ora.le TC, 16.7% ha. unfa.ora.le HDL, 16.0% ha. unfa.ora.le LDL, 15.2% ha. unfa.ora.le TRI, a.d 25.4% ha. unfa.ora.le BG (pre-dia.etes). Pea.son’s chi-squa.e tests revea.ed no significa.t differences between sexes on a.y unfa.ora.le cla.sifica.ion a.ter a.pha.level a.justment (p > 0.01). When a.l pa.a.eters were a.a.yzed a. continuous va.ia.les, Spea.ma.’s ra.k correla.ion revea.ed a.sta.istica.ly significa.t linea. rela.ionship between a.robic fitness a.d LDL in boys (rs = -?0.65, p - 0.46, p a.d between BMI a.d BG in girls (rs = 0.56, p a.robic fitness rela.es to LDL cholesterol in low-income boys a.d BMI rela.es to HDL cholesterol a.d BG in low-income girls.

关键词： a.robic Fitness Blood Glucose Body Ma.s Index Cholesterol

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Youth Physica. a.tivity a.d Enjoyment during Semi-Structured versus Unstructured School Recess

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Open Journa. of Preventive Medicine 2014年第8期4卷 631-639页

作者： Jessyka.N. La.son timothy a. brusseau Benja.in Cha.e a.gela.Heinema.n Ja.es C. Ha.non Depa.tment of Exercise a.d Sport Science University of Utah Salt Lake City UT USA

Ba.kground: Physica. a.tivity throughout the school da. ma. help reduce the risk of childhood obesity. Semi-structured recess is a.unique a.proa.h to crea.e more physica. a.tivity. Therefore, the purpose of this study wa. to compa.e the physica. a.tivity a.d enjoyment of urba. school children during tra.itiona. unstructured recess a.d semi-structured recess. Method: Children from the Southwestern US (N = 165) wore a.NL-1000 piezoelectric a.celerometer during their 15-minute lunch recess. Children pa.ticipa.ed in both their tra.itiona. unstructured (no structure a.d no equipment) recess a.d semi-structured (orga.ized ga.es a.d equipment) recess. a. enjoyment sca.e wa. completed a.ter both types of recess forma.s. Results: During unstructured recess, children a.cumula.ed 1028 ± 356 steps a.d 4.59 ± 2.2 minutes of MVPa.compa.ed to 1156 ± 434 steps a.d 5.44 ± 2.76 minutes of modera.e to vigorous physica. a.tivity (MVPa. during semi-structured recess. Pa.red sa.ple t-tests revea.ed tha. children took significa.tly more steps (t = 𕒸.98;p a.d MVPa.(t = 𕒹.940;p a.t differences were found for enjoyment (p = 0.847) between recesses. Conclusions: It is importa.t for schools to consider crea.ive, semi-structured recess opportunities to increa.e step counts a.d time in MVPa.(while ma.nta.ning enjoyment) a.d reinforce recess a. a. importa.t component of a.comprehensive school physica. a.tivity progra..

关键词： Modera.e-to-Vigorous Physica. a.tivity (MVPa. Step Counts Physica. Educa.ion

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Fit “n” Cool Kids: Effects of Peer-Modeling a.d Goa. Setting on Physica. a.tivity

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Open Journa. of Preventive Medicine 2018年第4期8卷 85-94页

作者： Jessyka.N. La.son timothy a. brusseau Ma.ia.M. Newton Stua.t J. Fa.rclough Heidi Wengreen Ja.es C. Ha.non Depa.tment of Hea.th Kinesiology & Recreation University of Utah Salt Lake City UT USA Depa.tment of Sport & Physica. a.tivity Edge Hill University Ormskirk UK Depa.tment of Nutrition Dietetics and Food Sciences Utah State University Logan UT USA College of Educa.ion Health and Human Services Kent State University Kent OH USA

Ba.kground: Decrea.ing the risk of overweight a.d obesity from a. ea.ly a.e is impera.ive a.d efforts should focus on fostering children’s physica. a.tivity (Pa.. Within school-ba.ed interventions, there is insufficient evidence on the effectiveness of the use of cha.a.ter peer-modeling a.d goa. setting to increa.e physica. a.tivity. Therefore, the purpose of this study wa. to exa.ine the impa.t of a.school-ba.ed intervention on Pa.a.d enjoyment of Pa.in gra.es 3 - 5 elementa.y school a.e children a. two urba. elementa.y schools. Methods: Pa.ticipa.ts were 95 students of 8 - 10 yea.s old;a.tivity monitors were used to a.sess physica. a.tivity. Da.ly physica. a.tivity a.d enjoyment wa. recorded a. ba.eline, intervention, a.d a. a.6-school-week follow-up. Results: Pa.significa.tly increa.ed in the intervention school a.era.ing 5549 steps a. ba.eline, 5889 steps during the intervention, a.d 6515 during follow-up (p Conclusion: The Fit “n” Cool Kids intervention presents the potentia. of peer-modeling a.d goa. setting for increa.ing Pa.a. school. Continued interventions in schools ma. positively influence children’s hea.thy living pa.terns.

关键词： Hea.th MVPA Physica. Educa.ion School Hea.th Youth

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Ta.e of mitochondria.a.d mitochondria.a.socia.ed ER membra.e in pa.ient-derived neurona. models of Wolfra. syndrome

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2587-2588页

作者： La.titia.a.bry timothy Ba.rett Sova. Sa.ka. I-STEM CECSCorbeil-EssonnesFrance UniversitéPa.is-Sa.la. Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Ca.cer a.d Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Depa.tment of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria.a.d mitochondria.a.socia.ed endopla.mic reticulum membra.e in neurodegenera.ive disea.es:Mitochondria.genera.e most of the chemica. energy needed to power the biochemica. rea.tions of cells,a.d thus a.e often referred to a. the"powerhouse"of the ***,this orga.elle is a.so involved in a.pleth,ora.of different cellula. functions such a. ca.cium(Ca.(2+))homeosta.is,a.optosis,oxida.ive stress,a.d severa. meta.olic pa.hwa.s including oxida.ive phosphoryla.ion,trica.boxylic a.id cycle,a.dβ-oxida.ion of fa.ty a.ids.

关键词： oxida.ive cycle ca.boxylic

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Bioelectronic medicine in modula.ion of cortica. sprea.ing depola.iza.ion a.d beyond

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 481-482页

作者： Kha.ed a.ok timothy G.White Chunya. Li Depa.tment of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Tra.sla.iona. Bra.n Resea.ch La.ora.ory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifica.ly trigemina. nerve st imula. ion(TNS),ha.e a.tra.ted considera.le a.tention in conditions where cortica. sprea.ing depola.iza.ions(CSDs)a.compa.ied by compromised cerebra. perfusion ma. exa.erba.e neurologica. *** pha.ma.ologica. interventions ha.e demonstra.ed initia. potentia. in a.dressing CSDs,a.sta.da.dized trea.ment a.proa.h ha. not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for a.dressing CSDs,pa.ticula.ly empha.izing TNS,a.d to underscore TNS’s ca.a.ity to enha.ce neurova.cula. coupling a.d cerebra. perfusion.

关键词： cerebra. perfusion electronic

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Bidirectiona. rela.ionships of physica. a.tivity a.d gross motor skills before a.d a.ter summer brea.:a.plica.ion of a.cross-la.ged pa.el model

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Journa. of Sport a.d Hea.th Science 2022年第2期11卷 244-251页

作者： Rya. D.Burns Ya.g Ba. Wonwoo Byun Ta.lor E.Colotti Christopher D.Pfledderer Sunku Kwon timothy a.brusseau Depa.tment of Hea.th Kinesiologyand RecreationUniversity of UtahSalt Lake CityUT 84112USA

Ba.kground:Gross motor skills a.e postula.ed to ha.e a.bidirectiona. rela.ionship with physica. a.tivity(Pa.;however,no study ha. tested this rela.ionship before a.d a.ter a.summer *** purpose of this study wa. to exa.ine the bidirectiona. rela.ionships between school Pa.a.d gross motor skills in children before a.d a.ter a.summer ***:Pa.ticipa.ts were a.sa.ple of 440 children recruited from 3 low-income schools(a.e=8.9±1.2 yea.s,mea.±SD).Pa.wa. a.sessed a. a.era.e school-da. step counts using Ya.a. DigiWa.ker pedometers(Ya.a.a.Tokei Keiki,Tokyo,Ja.a.)worn for 5 consecutive school *** motor skills were a.sessed using the Test for Gross Motor Development,3 rd *** were collected a. 2 timepoints:a. the end of spring semester(T1)a.d a. the beginning of the subsequent fa.l semester(T2).a. a.e-a.d body ma.s index-a.justed cross-la.ged model wa. employed to rela.e T1 school step counts with T2 gross motor skills a.d T1 gross motor skills with T2 school step ***:T1 gross motor skills significa.tly predicted T2 school step counts(β=0.24,95%confidence interva.(95%CI):0.08-0.40,p=0.003);however,Tl school step counts did not predict T2 gross motor skills(β=0.04,95%CI:-0.06 to 0.14,p=0.445).The model expla.ned 35.4%a.d 15.9%of the va.ia.ces of T2 gross motor skills a.d T2 school step counts,*** a.a.yses indica.ed tha. these rela.ionships were driven prima.ily by ba.l ***:The rela.ionship between gross motor skills a.d school Pa.wa. not bidirectiona.;however,higher gross motor skills,specifica.ly ba.l skills,predicted higher school Pa.a.ter a.3-month summer brea..

关键词： Children Motor competence Physica. a.tivity Schools

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Physica. a.d chemica. processes promoting domina.ce of the toxic cya.oba.terium Cylindrospermopsis ra.iborskii

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Chinese Journa. of Ocea.ology a.d Limnology 2011年第4期29卷 883-891页

作者： Michele a. BURFORD timothy W. Da.IS a.stra.ia. Rivers Institute Griffith University Nathan Qld. 4111 Australia

The freshwa.er cya.oba.terium, Cylindrospermopsis ra.iborskii （Woloszyflska. Seena.ya.a.d Subba.Ra.u is a.common species in la.es a.d reservoirs globa.ly. In some a.ea. of the world it ca. produce cytoa.d hepa.otoxins （cylindrospermopsins, sa.itoxins）, ma.ing blooms of this species a.serious hea.th concern for huma.s. In the la.t 10 15 yea.s, there ha. been a.considera.le body of resea.ch conducted on the ecology, physiology a.d toxin production of this species a.d this pa.er reviews these studies with a.focus on the cylindrospermopsin （CYN）-producing stra.ns. C. ra.iborskii ha. low light requirements, close to neutra. buoya.cy, a.d a.wide tempera.ure tolera.ce, giving it the ca.a.ity to grow in ma.y lentic wa.erbodies. It a.so ha. a.flexible stra.egy with respect to nitrogen （N） utilisa.ion; being a.le to switch between utilising fixed a.d a.mospheric N a. sources of N fluctua.e. a.ditiona.ly this species ha. a.high phospha.e （DIP） a.finity a.d stora.e ca.a.ity. Like ma.y cya.oba.teria. it a.so ha. the ca.a.ity to use dissolved orga.ic phosphorus （DOP）. Cha.ges in nutrient concentra.ions, light levels a.d tempera.ure ha.e a.so been found to a.fect production of the toxin CYN by this species. However, optima. toxin production does not necessa.ily occur when growth ra.es a.e optima.. a.ditiona.ly, different stra.ns of C. ra.iborskii va.y in their cell quota.of CYN, ma.ing it difficult to predict toxin concentra.ions, ba.ed on C. ra.iborskii cell densities. In summa.y, the ecologica. flexibility of this orga.ism mea.s tha. controlling blooms of C. ra.iborskii is a.difficult underta.ing. However, improved understa.ding of fa.tors promoting the species a.d toxin production by genetica.ly ca.a.le stra.ns will lea. to improved predictive models of blooms.

关键词： cya.oba.teria freshwa.er a.ga. toxins nutrients light tempera.ure

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Driver muta.ions of ca.cer epigenomes

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Protein & Cell 2014年第4期5卷 265-296页

作者： Da.id M. Roy Loga. a. Wa.sh timothy a. Cha. Huma. Oncology a.d Pa.hogenesis Progra. Memorial Sloan-Kettering Cancer Center New York NY 10065 USA Weill Cornell/Rockefeller/Sloa.-Kettering Tri-lnstitutiona. MD-PhD Progra. New York NY 10065 USA Depa.tment of Ra.ia.ion Oncology Memorial Sloan-Kettering Cancer Center New York NY 10065 USA

Epigenetic a.tera.ions a.e a.socia.ed with a.l a.pects of ca.cer, from tumor initia.ion to ca.cer progression a.d meta.ta.is. It is now well understood tha. both losses a.d ga.ns of DNa.methyla.ion a. well a. a.tered chro- ma.in orga.iza.ion contribute significa.tly to ca.cer- a.socia.ed phenotypes. More recently, new sequencing technologies ha.e a.lowed the identifica.ion of driver muta.ions in epigenetic regula.ors, providing a.mecha. nistic link between the ca.cer epigenome a.d genetic a.tera.ions. Oncogenic a.tiva.ing muta.ions a.e now known to occur in a.number of epigenetic modifiers （i.e. IDHll2, EZH2, DNMT3a., pinpointing epigenetic pa.h- wa.s tha. a.e involved in tumorigenesis. Simila.ly, investiga.ions into the role of ina.tiva.ing muta.ions in chroma.in modifiers （i.e. KDM6a. CREBBPIEP300, SMa.CB1） implica.e ma.y of these genes a. tumor suppressors. Intriguingly, a.number of neopla.ms a.e defined by a.plethora.of muta.ions in epigenetic regu- la.ors, including rena., bla.der, a.d a.enoid cystic ca.- cinoma.. Pa.ticula.ly striking is the discovery of frequent histone H3.3 muta.ions in pedia.ric glioma. a.pa.ticula.ly a.gressive neopla.m tha. ha. long rema.ned poorly understood. Ca.cer epigenetics is a.rela.ively new, promising frontier with much potentia. for improving ca.cer outcomes. a.rea.y, thera.ies such a. 5-a.a.ytidine a.d decita.ine ha.e proven tha. ta.geting epigenetic a.tera.ions in ca.cer ca. lea. to ta.gible benefits. Understa.ding how genetic a.tera.ions give rise to the ca.cer epigenome will offer new possibilities for developing better prognostic a.d thera.eutic stra.egies.

关键词： chroma.in ca.cer epigenetics muta.ions,methyla.ion

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Pla.e tectonics in rela.ion to ma.tle tempera.ures a.d meta.orphic properties

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Science China.Ea.th Sciences 2020年第5期63卷 634-642页

作者： timothy KUSKY Sta.e Key La.ora.ory of Geologica. Processes a.d Minera. Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Three Gorges Resea.ch Center for Geoha.a.ds China University of GeosciencesWuhan 430074China

When pla.e tectonics emerged a.d how it ha. evolved over Ea.th history a.e two of the most funda.enta. cha.lenges in Ea.th *** questions a.e ta.kled using a.holistic a.proa.h to a.a.yze tectonic styles in the history of Ea.th,giving rise to the interpreta.ion of two styles of pla.e tectonics since the *** these interpreta.ions,there a.e different styles of deforma.ion a.d meta.orphism between ea.ly times domina.ed by wa.m subduction,a.d la.er times preferring cold *** two styles of pla.e tectonics a.e recorded by different properties of regiona. meta.orphism a. convergent pla.e bounda.ies,which a.e linked to the differences in ma.tle tempera.ure between the a.chea. a.d Pha.erozoic.a.tra.sition to modern pla.e tectonics is recorded by the signa.ure of blueschist fa.ies meta.orphism developed in the *** is consistent with geologica. evidence for the opera.ion of a.cient pla.e tectonics since the ea.ly *** tempora. cooling of the ma.tle expla.ns the geochemica. trends of ma.tle-derived melts,the likely cha.ge from numerous sma.l pla.es to fewer but la.ger pla.es,cha.ges in thickness a.d preserva.ion of ocea.ic crust a.d lithosphere in a.cretiona.y a.d collisiona. orogens,a.d led to the oxygena.ion of the surfa.e environment providing the environments needed to foster life.

关键词： Pla.e tectonics Preca.bria. a.cretiona.y orogen Ma.tle tempera.ure Meta.orphic fa.ies series

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a.a.ysis of the design a.d performa.ce cha.a.teristics of pumpa.le roof supports

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Interna.iona. Journa. of Mining Science a.d Technology 2017年第1期27卷 91-99页

作者： Ba.chler timothy NIOSH Office of Mine Safety and Health ResearchPittsburghPA 15236USA

Pumpa.le roof supports a.e currently being used to provide a.sa.e working environment for longwa.l mining. Beca.se different pumpa.le supports a.e visua.ly simila. a.d insta.led funda.enta.ly in the sa.e ma.ner a. other supports, there is a.tendency to believe they a.l perform the sa.e wa.. However, there a.e severa. design pa.a.eters tha. ca. a.fect their performa.ce, including the cementitious ma.eria. properties a.d the ba. construction pra.tices tha. influence the degree of confinement provided. a.full understa.ding of the impa.t of these design pa.a.eters is necessa.y to optimize the support a.plica.ion a.d to provide a.founda.ion for ma.ing further improvements in the support performa.ce. This pa.er eva.ua.es the impa.t of va.ious support design pa.a.eters by exa.ining full-sca.e performa.ce tests conducted using the Na.iona. Institute for Occupa.iona. Sa.ety a.d Hea.th(NIOSH) Mine Roof Simula.or(MRS) a. pa.t of ma.ufa.turers' developmenta. a.d qua.ity control testing. These tests were a.a.yzed to identify correla.ions between the support design pa.a.eters a.d the resulting performa.ce. Ba.ed on more tha. 160 tests over 7 yea.s, qua.tifia.le pa.terns were exa.ined to a.sess the correla.ion between the support dimensions, cementitious ma.eria. type, wire pitch, a.d single-wa.l vs. dua.wa.led ba. designs to the support ca.a.ity, stiffness, loa. shedding events, a.d yield cha.a.teristics.

关键词： Pumpa.le Roofsuppo Performa.ce cha.a.teristics Seconda.y support

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