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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Light(science & Applications) 2020年第1期9卷 346-357页

作者： Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin Ekaterina N.Lazareva sergei V.German sergey s.Kosolobov timofei s.za.sepin Olga V.sergeeva Julia s.skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin skolkovo Institute of science and Technology 3 Nobelya str.Moscow 121205Russia Department of Electrical Engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel saratov state University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk state University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow state University Leninskie Gory1-3Moscow 119992Russia sPE LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOs).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

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Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides,anti-OX40,anti-PD1 antibodies,and aptamers

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The Journal of Biomedical Research 2023年第3期37卷 194-212页

作者： Anastasia s.Proskurina Vera s.Ruzanova Genrikh s.Ritter Yaroslav R.Efremov zakhar s.Mustafin sergey A.Lashin Ekaterina A.Burakova Alesya A.Fokina timofei s.za.sepin Dmitry A.stetsenko Olga Y.Leplina Alexandr A.Ostanin Elena R.Chernykh sergey s.Bogachev Institute of Cytology and Genetics Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Department of Natural sciences Novosibirsk State UniversityNovosibirsk 630090Russia Department of Physics Novosibirsk State UniversityNovosibirsk 630090Russia Department of Chemistry Moscow State UniversityMoscow 119991Russia Research Institute of Fundamental and Clinical Immunology Novosibirsk630099Russia

To overcome immune tolerance to cancer,the immune system needs to be exposed to a multi-target action ***,we investigated the activating effect of CpG oligodeoxynucleotides(ODNs),mesyl phosphoramidate CpG ODNs,anti-OX40 antibodies,and OX40 RNA aptamers on major populations of immunocompetent cells ex *** analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies,as well as several other combinations,such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers,was *** against programmed death 1(PD1)checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical *** scenarios were considered:a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice;a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice;and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c *** anti-PD1 antibodies(CpG+αOX40+αPD1)to in situ vaccinations boosts the antitumor *** to be used instead of antibodies,aptamers also possess antitumor activity,although this effect was less *** strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma.

关键词： immunogenicity Krebs-2 carcinoma Lewis carcinoma Ehrlich carcinoma A20 B cell lymphoma mesyl phosphoramidate

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Thymidine Glycol: The Effect on DNA structure and DNA Binding by site-specific Proteins

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Natural science 2015年第11期7卷 491-509页

作者： Elena A. Kubareva Fan Yang Alexandra Yu. Ryazanova Nina G. Dolinnaya Andrei V. Golovin Nikolai V. Molochkov Elena A. Romanova Elizaveta A. Karpova timofei s. zatsepin Tatiana s. Oretskaya Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State University Moscow Russia Chemistry Department Lomonosov Moscow State University Moscow Russia Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Moscow Russia Institute of Theoretical and Experimental Biophysics Russian Academy of Science Moscow Region Pushchino Russia

Thymidine glycol (5,6-dihydroxy-5,6-dihydrothymidine, Tg) is a major type of oxidative damage in DNA. During chemical oligonucleotide synthesis, Tg residue was incorporated in the different positions of 17 b.p. DNA duplexes, which differ in one base pair in the internal part. According to UV-melting curves, Tg destabilizes the double helix in a sequence independent manner. In contrast, the localized alterations in duplex structure were shown by CD spectroscopy to depend on the type of base pairs flanking the Tg lesion. Molecular dynamics simulations demonstrate that Tg is partially out of the double helix. For the first time, Tg impact on several site-specific DNA-binding proteins is studied, namely p50 and p65 subunits of nuclear factor kappa-B (NF-κB) and DNA methyltransferase ssoII (***). Our results show that p50/p50 and p65/p65 homodimers of NF-κB can tolerate a single Tg residue in the binding site quite well. Nevertheless the homodimers have different affinities to the oxidized κB site depending on the Tg position. *** can act as a transcription repressor when bound to the regulatory site. *** demonstrates decreased affinity and lowered methylation efficiency when its methylation site contains Tg in the central position. single Tg in one half of the regulatory site decreases *** affinity to the oxidized DNA, whereas Tg presence in both half-sites prevents *** binding to such ligand.

关键词： Thymidine Glycol Oxidative Damage Molecular Dynamics simulations Nuclear Factor Kappa-B DNA Methyltransferase ssoII

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战略轻率还是新的均势?

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全球秩序 2018年第1期 47-62页

作者：〔俄〕季莫菲·博尔达切夫刘传平(译) 张翔(校) 傅瑜(校) 俄罗斯国立高等经济大学欧洲和国际综合研究中心俄罗斯智库瓦尔代欧亚俱乐部项目部不详

毫无疑问,当前是二战以来国际环境变化最为显著的时期。被普遍承认的准则和居于主导地位的国家的缺失成为当前国际局势最重要的特征之一。相互尊重可能是大国,甚至主要大国关系中最为稀缺的东西。中国和美国都将俄罗斯视为潜在盟友,他... 详细信息

毫无疑问,当前是二战以来国际环境变化最为显著的时期。被普遍承认的准则和居于主导地位的国家的缺失成为当前国际局势最重要的特征之一。相互尊重可能是大国,甚至主要大国关系中最为稀缺的东西。中国和美国都将俄罗斯视为潜在盟友,他们正为此而努力。欧洲政治将进入新时期,届时欧洲和作为整体的西方将不再具有影响国际事务的垄断性地位。西方自由主义全球秩序的终结并没有带来一个新的、对所有国家更公正的秩序安排。相反,世界显然已经进入了一个漫长的外交和混合型军事对抗的时代。由西方全能力量相对衰弱导致的相对不确定的时期正在结束,一场争夺全球主导权的新的斗争正在上演。

关键词：均势战略轻率全球主导权西方自由世界秩序

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