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应用优化建模法构建红松人工林单木直径生长模型

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东北林业大学学报 2024年第5期52卷 63-69,74页

作者：吕洁童茜坪金星姬 timo Pukkala 东北林业大学哈尔滨150040 东芬兰大学

为了提高不完备数据集下红松人工林直径生长模型的预测精度,以1980—2022年黑龙江省75块红松林不同复测间隔期的样地数据(林木胸径、竞争因子和立地等),利用优化建模法构建红松人工林单木直径生长模型,采用单纯形优化算法寻求模拟和实... 详细信息

为了提高不完备数据集下红松人工林直径生长模型的预测精度,以1980—2022年黑龙江省75块红松林不同复测间隔期的样地数据(林木胸径、竞争因子和立地等),利用优化建模法构建红松人工林单木直径生长模型,采用单纯形优化算法寻求模拟和实测直径分布差异最小下的模型参数,并利用自举法对模型进行检验。结果表明:优化建模法损失函数的初始参数a=1、b=0.003、c1=c2=1.5时,预测期末林分断面积偏差为0.02 m^(2)·hm^(-2),显著优于由传统归回建模法的精度(林分断面积偏差为0.44 m^(2)·hm^(-2));结合实测数据与视图分析,验证了优化建模法的优势和可靠性,揭示了优化法损失函数与传统回归法构建的直径生长模型之间的差异。因此,优化法损失函数构建的红松人工林生长模型在模拟自然生长中表现优越,为制定科学的森林经营方案提供了技术支持。

关键词：红松人工林单木生长模型单纯形优化方法自举法

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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

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Bone research 2020年第2期8卷 157-168页

作者： Tobias Schwerd Freia Krause Stephen r.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer Miryam Müller Santiago Manrique Neele Schumacher Steven A.Wall Jonathan Jung timo Damm Claus-Christian Glüer Jürgen Scheller Stefan rose-John E.Yvonne Jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Holm H.Uhlig Translational Gastroenterology Unit John Radcliffe HospitalUniversity of OxfordOxfordUK Department of Pediatrics Dr von Hauner Children’s HospitalLMU MunichMunichGermany Christian-Albrechts-University Kiel Institute of BiochemistryKielGermany Clinical Genetics Group MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordUK Center for Molecular Neurobiology Hamburg(ZMNH) University Medical Center Hamburg-EppendorfHamburgGermany Division of Structural Biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK Craniofacial Unit Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK Section Biomedical Imaging Department of Radiology and NeuroradiologyUniversity Medical Center Schleswig-HolsteinKielGermany Institute of Biochemistry and Molecular Biology Ⅱ Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Department of Paediatrics University of OxfordOxfordUK NIHr Oxford Biomedical research Centre OxfordUK The Beatson Institute for Cancer research GlasgowUK School of Medicine University of GlasgowGlasgowUK

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.r281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.r279 Q. We show that human GP130 p.r281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSM, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.r279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 rA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects.

关键词： IL11 cytokine facial

Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages

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Bioactive Materials 2024年第11期41卷 657-671页

作者： Kamila Iskhakova Hanna Cwieka Svenja Meers Heike Helmholz Anton Davydok Malte Storm Ivo Matteo Baltruschat Silvia Galli Daniel Pröfrock Olga Will Mirko Gerle timo Damm Sandra Sefa Weilue He Keith Macrenaris Malte Soujon Felix Beckmann Julian Moosmann Thomas O'Hallaran roger J.Guillory II D.C.Florian Wieland Berit Zeller-Plumhoff regine Willumeit-römer florian wieland berit zeller-plumhoffregine willumeit-römer1institute of metallic biomaterialshelmholtz zentrum hereongeesthachtgermany institute of materials physiscs helmholtz zentrum hereongeesthachtgermany deutsches elektronen-synchrotron desy hamburggermany department of prosthodontics faculty of odontologyuniversity of malmömalmösweden institute of coastal environmental chemistry helmholtz zentrum hereongeesthachtgermany molecular imaging north competence center kiel universitykielgermany the department of oral and maxillofacial surgery campus kiel ukshkielgermany department of biomedical engineering michigan technological universityusa department of microbiology and biochemistry michigan state universityusa joint department of biomedical engineering medical college of wisconsinusa institute of materials mechanics helmholtz zentrum hereongeesthachtgermany

Magnesium(Mg)–based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing,*** a suture *** to their mechanical properties and biocompatibility,they may replace titanium or stainless-steel implants,commonly used in orthopedic ***,patient safety has to be assured by finding a long-term balance between metal degradation,osseointegration,bone ultrastructure adaptation and element distribution in *** order to determine the implant behavior and its influence on bone and tissues,we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to permanent materials titanium and polyether ether *** implants were present in rat tibia for 10,20 and 32 weeks before sacrifice of the *** radiation-based micro computed tomography enables the distinction of features like residual metal,degradation layer and bone ***,X-ray diffraction and X-ray fluorescence yield information on parameters describing the bone ultrastructure and elemental composition at the bone-to-implant ***,with element specific mass spectrometry,the elements and their accumulation in the main organs and tissues are *** results show that Mg-xGd implants degrade in vivo under the formation of a stable degradation layer with bone remodeling similar to that of Ti after 10 *** accumulation of Mg and Gd was observed in selected organs,except for the interfacial bone after 8 months of ***,we confirm that Mg-5Gd and Mg-10Gd are suitable material choices for bone implants.

关键词： Biodegradable implants Bone ultrastructure Degradation Mg-based alloys

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生产准备时间缩短一半

现代制造 2024年第8期 30-30,32页

作者： Lars rödel Jonas Krebs Gregor Müller timo Denner 不详

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充... 详细信息

在生产准备工作实现自动化之后,才能实现节约生产成本的目标。而利用弗劳恩霍夫IPA生产技术和自动化研究所开发的“设计链(Designchain)”系统可实现生产准备的自动化。当前,虽然经济形势不容乐观,但Ceratizit公司的订单合同依然比较充足。究其原因,是由于此前受全球疫情影响,Ceratizit公司忘记了如何快速高效地处理客户合同订单,还是因为供应链受到干扰而出现订单积压?

关键词：自动化研究所供应链设计链生产准备时间合同订单生产准备工作节约生产订单合同

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–rANKL signaling

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Bone research 2018年第1期6卷 50-59页

作者： Alexander Bartelt Friederike Behler-Janbeck F.timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier Department of Orthopaedics University Medical Center Hamburg-EppendorfMartinistr.5220246 HamburgGermany Department of Biochemistry and Molecular Cell Biology University Medical Center Hamburg-EppendorfMartinistr.5220246 HamburgGermany Department of Osteology and Biomechanics University Medical Center Hamburg-EppendorfMartinistr5220246 HamburgGermany Department of Orthodontics University Medical Center Hamburg-EppendorfMartinistr52 20246 HamburgGermany Department of Anatomy and Experimental Morphology University Medical Center Hamburg-EppendorfMartinistr.5220246 HamburgGermany Department of Molecular Genetics University of Texas Southwestern Medical CenterDallasTX 75390USA Institute for Comparative Molecular Endocrinology University of UlmUlmGermany Correspondence:Andreas Niemeier Department of Genetics and Complex Diseases&Sabriülker Center Harvard T.H.Chan School of Public Health665 Huntington AvenueBostonMA 02115USA

Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone *** lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(rANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFrβ-dependent manner and in vivo treatment with the PDGFr tyrosine kinase inhibitor imatinib mesylate limited rANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–rANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LrP1 gene variants in the control of bone mass in humans.

关键词： PDGFrβ rANKL activator receptor imatinib axis gene vivo

将健康融入所有政策:构建“健康城市”健康促进能力的途径——2018年健康城市国际研讨会暨健康嘉定论坛演讲实录

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健康教育与健康促进 2019年第1期14卷 22-26页

作者： timo St?hl 芬兰国家卫生和福利研究所

“将健康融入所有政策”这一理念并不是一个新名词,几十年来,我们一直在讨论将健康融入所有政策,将健康融入其他部门的政策,并认识到其他多部门的需求。然而,我们还没有获得令人满意的成果。这是芬兰在2006年担任欧盟轮值主席国期间提... 详细信息

“将健康融入所有政策”这一理念并不是一个新名词,几十年来,我们一直在讨论将健康融入所有政策,将健康融入其他部门的政策,并认识到其他多部门的需求。然而,我们还没有获得令人满意的成果。这是芬兰在2006年担任欧盟轮值主席国期间提出“将健康融入所有政策”这一理念的主要原因,我们认为这将成为健康行动实施的指南。

关键词：健康城市国际研讨会论坛能力

Challenges in the use of stainless steel slag

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Baosteel Technical research 2010年第S1期4卷 138-页

作者： Juha YLIMAUNU timo PArVIAINEN Outi JrVINEN Outokumpu Oyi.Corporate Management riihitontuntie 7 A P.O.Box 140FI-02201 EspooFinland r & D Engineer Outokumpu Stainless Oy Outokumpu Tornio WorksFI-95490 TornioFinland Aalto University School of Science and Technology HelsinkiFinland

Stainless steel melting shops of Outokumpu Group are located in Finland,Sweden and England(UK). In all of the countries the European Union legislation is the same,but in practice the plants face different technical,economical and administrative challenges in developing sustainable treatments and use of by-products. Due to availability of good natural construction materials,the use of slag and other industrial by-products has been quite small in Northern *** furnace slag has been completely utilized,while slag from stainless steel processes has earlier been regarded as *** of the metallurgical melt phase,slag cooling,treatment and metal recovery processes are the main technical challenges for increasing the sustainable use of stainless steel slag. Moreover,product properties have to fulfill standards and customer *** or water-cooled EAF slag aggregates are typically used in road *** has developed light mineral slag aggregates which are cooled in rapid water *** this process,a specific structure and mineralogy is formed in the slag and leaching from the material *** many regulatory discussions,it seems that there is not enough relevant scientific data from harmful *** values are based only on laboratory tests and model estimations,not on the material use itself or real nature.A risk-based approach is needed when environmental acceptance is not *** values based on content are not applicable because environmental or health risks depend on the release or leaching of substances from the *** is the case especially with metals.

关键词： stainless steel slag slag aggregate environmental acceptance leaching

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淡水沉积物中的生物多样性和生态系统过程

人类环境杂志 1997年第8期26卷 563-569页

作者： Margaret A.Palmer Alan P.Covich Bland J.Finlay Janine Gibert Kevin D.Hyde richard K.Johnson timo Kairesalo Sam Lake Charles r.Lovell robert J.Naiman Claudia ricci Francese Sabater David Strayer 习晓环马里兰大学自科罗拉多州立大学淡水生态研究所微生物室里昂大学香港大学真菌学瑞典农业科学大学赫尔辛基大学 Monash大学南卡罗来纳大学华盛顿大学渔业学校国立米兰大学巴塞罗那大学生态系统研究所

所有的淡水在穿过或经过沉积物生境后最终流入海洋或进入大气圈。在这些淡水沉积物带中含有大量制造和加工有机碳化合物的生物种。有的物种担负着特定的功能,如氮的固定和循环,其它物种则分解污染物或将沉积物混匀以改变生态系统过程的... 详细信息

所有的淡水在穿过或经过沉积物生境后最终流入海洋或进入大气圈。在这些淡水沉积物带中含有大量制造和加工有机碳化合物的生物种。有的物种担负着特定的功能,如氮的固定和循环,其它物种则分解污染物或将沉积物混匀以改变生态系统过程的速率。现在已描述了大约175000个物种,但新的物种仍不断被发现。它们的多样性及分布随深度梯度、溶解氧、所在纬度和湿地、湖泊、河流及地下水高度的不同而不同。独特的特有种,特别是那些分散能力有限的物种,多分布在深度大且隔离的生境。应该在全球范围培养合格的科学家,以促进物种丰富的生物群和生态系统基本关系方面的研究。

关键词：淡水沉积物生物多样性生态系统过程

ULTrASONIC INPUT OUTPUT CHArACTErISTICS FOr TrANSMITTING AND rECEIVING CONTACT TYPE TrANSDUCErS COUPLED TO A timoSHENKO BEAM

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Transactions of Nanjing University of Aeronautics and Astronautics 1996年第1期13卷 49-56页

作者： Liu Tierang Department of Aircraft Engineering,NUAA29 Yudao Street, Nanjing 210016, P. r. China)

Acousto ultrasonic input output characteristics for transmitting and receiving contact type transducers coupled to a timoshenko beam waveguide are considered. By means of a multiple integral transform method and contour integration technique, the spectral response of the normal contact force between the receiving transducer and the wave guide, due to an arbitrary input pulse excited by the transmitting transducer, is expressed as a form of explicitly physical interpretations. Time histories of the response are then obtained through the inversion of the spectra by a fast Fourier transform (FFT) method. Finally, some numerical results are presented in diagrams, from which the effects on the mass of the receiver, the distance between the two transducers, and the input pulse width on the output are discussed. From the numerical calculation and the nature of the whole analysis it is shown that the analytical method presented in this paper is not only effective but also extendible to the more general cases.

关键词： stress wave ultrasonic transducers stress wave factor material evaluation