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prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases

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World Journal of Gastroenterology 2023年第18期29卷 2850-2863页

作者： Heinrich Steinhoff Miklos Acs Sebastian Blaj Magdolna Dank Magdolna Herold Zoltan Herold Jonas Herzberg patricia Sanchez-Velazquez tim Strate Attila Marcell Szasz pompiliu piso Department of General and Visceral Surgery Hospital Barmherzige BrüderRegensburg 93049Germany Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary Department of Surgery Krankenhaus Reinbek St.Adolf-StiftReinbek 21465Germany Department of General Surgery Hospital del MarBarcelona 08003Spain

BACKGROUND Advanced gastric cancer with synchronous peritoneal metastases(GC-pM)is associated with a poor *** cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS-HIpEC)is a promising approach,only a limited number of Western studies *** To investigate the clinicopathological outcomes of patients who underwent CRSHIpEC for *** A retrospective analysis of patients with GC-pM was *** patients were seen at the Department of General and Visceral Surgery,Hospital Barmherzige Brüder,Regensburg,Germany between January 2011 and July 2021 and underwent *** laboratory results,the use of neoadjuvant trastuzumab,and the details of CRS-HIpEC,including peritoneal carcinomatosis index,completeness of cytoreduction,and surgical procedures were ***-specific(DSS),and overall survival(OS)of patients were *** A total of 73 patients were included in the *** treated with neoadjuvant trastuzumab(n=5)showed longer DSS(p=0.0482).Higher white blood cell counts(DSS:p=0.0433)and carcinoembryonic antigen levels(OS and DSS:ppprotein(OS:p=0.0368)levels were associated with shorter *** HIpEC duration was associated with more advantageous median survival times[60-min(n=59):12.86 mo;90-min(n=14):27.30 mo],but without statistical *** obtain additional data from this observation,further separation of the study population was ***,propensity score-matched patient pairs(n=14 in each group)were *** different DSS was found between patient pairs(hazard ratio=0.2843;95%confidence interval:0.1119-0.7222;p=0.0082).Second,those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity(median survival:12.68 mo vs 24.02 mo),or had to undergo the procedure before 2016(median survival:12.68 mo vs 27.30 mo;p=0.0493)were removed from the orig

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy peritoneal metastasis Stomach neoplasms Gastric cancer

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Acceptance and Commitment Therapy for Adults with ADHD during COVID-19: An Open Trial

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Open Journal of psychiatry 2020年第4期10卷 205-215页

作者： tim Fullen Nazmeen Galab Karl A. Abbott Marios Adamou Adult ADHD and Autism Service South West Yorkshire Partnership Foundation Trust NHS Manygates Clinic Wakefield UK School of Human and Health Sciences University of Huddersfield Huddersfield UK

This exploratory study reports the outcomes of a remotely delivered manualised form of Acceptance and Commitment Therapy (ACT) to adults with Attention Deficit Hyperactivity Disorder (ADHD) during the COVID-19 imposed “lockdown”. Adults completing this intervention (N = 12) reported statistically and clinically significant improvements on outcomes relating to self-reported mood F(1.356, 14.917) = 21.64, p ηp>2p> = 0.66), anxiety F(2, 22) = 22.93, p ηp>2p> = 0.68), psychosocial adjustment (χp>2p>(4) = 26.51, p ptability was good. preliminary findings suggest this cost effective and remotely delivered psychotherapeutic approach might be one appropriate method for supporting the well-being and adjustment of adults with ADHD during future COVID-19 or other pandemic related lockdowns. Further research is urgently required to establish efficacy using larger sample sizes and the implementation of wait list and treatment comparison groups. Future research might also explore the use of this manualised approach in other clinical subgroups and the general population.

关键词： ADHD COVID-19 Coronavirus ACT Adjustment psychotherapy

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Effects of Continuous Vertical Soil pores on Root and Shoot Growth of Winter Wheat: A Microcosm Study

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Agricultural Sciences 2018年第6期9卷 750-764页

作者： tim Dresemann Miriam Athmann Lukas Heringer timo Kautz INRES-Agroecology and Organic Farming University of Bonn Bonn Germany Experimental Farm Wiesengut Hennef Germany INRES Soil Science University of Bonn Bonn Germany

Round shaped, continuous vertical pores (CVps) in the soil are typically created by roots and earthworms. CVps with diameters > 2 mm are abundant in many agricultural soils. We hypothesized that potential effects of CVps on shoot growth of winter wheat (Triticum aestivum L.) increase with: 1) decreasing availability of water and 2) decreasing availability of nutrients in the topsoil. We conducted a microcosm experiment with different irrigation regimes (Irr+/Irr-) and p concentrations (p+/p-), with or without artificially created continuous vertical pores (CVp+/CVp-). Winter wheat was cultivated for 16 weeks. In the bulk soil, presence of CVps resulted in decreased root length in 20 - 40 cm but increased root length in 40 - 60 cm soil depth. In general, total root length of winter wheat in 20 - 60 cm soil depth was higher when CVps were present or when p concentrations in the topsoil were elevated. presence of CVps generally had a positive effect on shoot dry matter and N uptake of wheat. In columns with high phosphorous concentrations but low soil moisture in the topsoil, presence of CVps increased shoot dry matter by 66%;in contrast, the beneficial effect of CVps on shoot dry matter was only 39% in columns with high nutrient concentrations and high soil moisture in the topsoil. In total numbers, however, the effect of CVps on p uptake into the shoot was more pronounced when p concentrations in the topsoil were elevated. We conclude that CVps can promote the exploration of the solid soil phase by high root-length densities, but adequate nutrient supply in the topsoil is essential.

关键词： Subsoil Mechanical Resistance Drought Stress p Supply Nutrient Acquisition

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Getting to know ArcGIS desktop : basics of ArcView, ArcEditor, and ArcInfo /

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2004年

作者： Ormsby tim.

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从新手到能手在工作中活到老学到老

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英国医学杂志中文版 2008年第3期11卷 185-187页

作者： p W Teunissen tim Dornan 卢杰(译) Institute for Medical Education VU University Medical Centre Van der Boechorststraat 7 1081 BT Amsterdam Netherlands University of Manchester Medical School Manchester M13 9PT 不详

终生学习的重要性早已在医学界达成共识。

关键词：终生学习学习策略青年医师

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Comparable efficacy of 100 mg aspirin twice daily and rivaroxaban for venous thromboembolism prophylaxis following primary total hip arthroplasty:a randomized controlled trial

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Chinese Medical Journal 2021年第2期134卷 164-172页

作者： Yi Ren Shi-Liang Cao Zeng Li tim Luo Bin Feng Xi-Sheng Weng Department ot Orthopedic Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Orthopaedic Surgery Peking University Third HospitalPeking UniversityBeijing 100191China Doctor of Medicine program University of AlbertaEdmontonAB T6G 2R3Canada.

Background:Aspirin has demonstrated safety and efficacy for venous thromboembolism(VTE)prophylaxis following total hip arthroplasty(THA);however,inconsistent dose regimens have been reported in the *** study aimed to evaluate and compare the safety and efficacy of 100 mg aspirin twice daily with rivaroxaban in VTE prophylaxis following ***:patients undergoing elective unilateral primary THA between January 2019 and January 2020 were prospectively enrolled in the study and randomly allocated to receive 5 weeks of VTE prophylaxis with either oral enteric-coated aspirin(100 mg twice daily)or rivaroxaban(10 mg once daily).Medication safety and efficacy were comprehensively evaluated through symptomatic VTE incidence,deep vein thrombosis(DVT)on Doppler ultrasonography,total blood loss(TBL),laboratory bloodwork,Harris hip score(HHS),post-operative recovery,and the incidence of other ***:We included 70 patients in this study;34 and 36 were allocated to receive aspirin and rivaroxaban prophylaxis,*** cases of symptomatic VTE occurred in this *** DVT rate on Doppler ultrasonography in the aspirin group was not significantly different from that in the rivaroxaban group(8.8%vs.8.3%,χ^(2)=0.01,p=0.91),confirming the non-inferiority of aspirin for DVT prophylaxis(χ^(2)=2.29,p=0.01).The calculated TBL in the aspirin group(944.9 mL[658.5-1137.8 mL])was similar to that in the rivaroxaban group(978.3 mL[747.4-1740.6mL])(χ^(2)=1.55,p=0.12).However,there were no significant inter-group differences in HHS at post-operative day(pOD)30(Aspirin:81.0[78.8-83.0],Rivaroxaban:81.0[79.3-83.0],χ^(2)=0.43,p=0.67)and pOD 90(Aspirin:90.0[89.0-92.0],Rivaroxaban:91.5[88.3-92.8],χ^(2)=0.77,p=0.44),the incidence of bleeding events(2.9%vs.8.3%,χ^(2)=0.96,p=0.33),or gastrointestinal complications(2.9%vs.5.6%,χ^(2)=1.13,p=0.29).Conclusion:In terms of safety and efficacy,the prophylactic use of 100 mg aspirin twice daily was not statistically differe

关键词： Total hip arthroplasty Aspirin Rivaroxaban Venous thromboembolism Blood loss Complication

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木材

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丛书名：商品国际工贸指南译丛

2002年

作者：（英）tim peck 党英杰王庆等译

本书着重对木产品的生产、消费和贸易类型及其作为一大类商品对国家经济和世界贸易的重要性作了详细论述，阐明了全球地区间及地区内贸易的主要方式和趋势。

ISBN: (纸本)7801650565

关键词：木材学科:国际贸易学科:基本知识国际贸易

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Quenching of the red Mn^(4+) luminescence in Mn^(4+)-doped fluoride LED phosphors

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Light(Science & Applications) 2018年第1期7卷 973-985页

作者： tim Senden Relinde J.A.van Dijk-Moes Andries Meijerink Condensed Matter and Interfaces Debye Institute for Nanomaterials ScienceUtrecht UniversityP.O.Box 800003508 TA UtrechtThe Netherlands Soft Condensed Matter Debye Institute for Nanomaterials ScienceUtrecht UniversityP.O.Box 800003508 TA UtrechtThe Netherlands

Red-emitting Mn^(4+)-doped fluorides are a promising class of materials to improve the color rendering and luminous efficacy of white light-emitting diodes(w-LEDs).For w-LEDs,the luminescence quenching temperature is very important,but surprisingly no systematic research has been conducted to understand the mechanism for thermal quenching in Mn^(4+)-doped ***,concentration quenching of the Mn^(4+) luminescence can be an issue but detailed investigations are *** this work,we study thermal quenching and concentration quenching in Mn^(4+)-doped fluorides by measuring luminescence spectra and decay curves of K2TiF6:Mn^(4+) between 4 and 600 K and for Mn^(4+) concentrations from 0.01%to 15.7%.Temperature-dependent measurements on K2TiF6:Mn^(4+) and other Mn^(4+)-doped phosphors show that quenching occurs through thermally activated crossover between the ^(4)T_(2) excited state and ^(4)A_(2) ground *** quenching temperature can be optimized by designing host lattices in which Mn^(4+) has a high 4T2 state ***-dependent studies reveal that concentration quenching effects are limited in K_(2)TiF_(6):Mn^(4+)up to 5%Mn^(4+).This is important,as high Mn^(4+)concentrations are required for sufficient absorption of blue LED light in the parity-forbidden Mn^(4+)d–d *** even higher Mn^(4+) concentrations(>10%),the quantum efficiency decreases,mostly due to direct energy transfer to quenching sites(defects and impurity ions).Optimization of the synthesis to reduce quenchers is crucial for developing more efficient highly absorbing Mn^(4+) *** present systematic study provides detailed insights into temperature and concentration quenching of Mn^(4+) emission and can be used to realize superior narrow-band red Mn^(4+) phosphors for w-LEDs.

关键词： luminescence quenching fluoride

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CCNp Switching认证考试指南

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丛书名：专业认证考试丛书

2001年

作者：（美）tim Boyles （美）David Hucaby 王崧等译

本书共分四部分。概述了CCNp和CCDp资格认证的有关内容，讲述了校园网的设计模型、交换机与端口的配置方法，以及应用于交换式网络的各种技术，提供了许多案例。

ISBN: (纸本)750536961X

关键词：互连网络考核通信设备

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Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesis

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Bioactive Materials 2023年第2期20卷 306-317页

作者： Tianyu Yao Honglin Chen Rong Wang Rebeca Rivero Fengyu Wang Lilian Kessels Stijn M.Agten Tilman M.Hackeng tim G.A.M.Wolfs Daidi Fan Matthew B.Baker Lorenzo Moroni Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi710069China Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineMaastricht UniversityMaastricht6229 ERthe Netherlands Guangdong provincial people’s Hospital Guangdong Academy of Medical SciencesGuangzhou510080China Radboudumc Department of Dentistry-Regenerative BiomaterialsRadboud University Medical CenterPhilips van Leydenlaan 256525 EXNijmegenthe Netherlands School of Medicine South China University of TechnologyGuangzhou510006China Maastricht University Medical Center MUMC+ P.Debyelaan 256229 HXMaastrichtthe Netherlands Research School for Cardiovascular Diseases(CARIM) Maastricht UniversityUniversiteitssingel 506229ER Maastrichtthe Netherlands School for Oncology and Developmental Biology(GROW) Maastricht UniversityUniversiteitssingel 406229ER Maastrichtthe Netherlands

Vascular endothelial growth factor(VEGF)plays a vital role in promoting attachment and proliferation of endothelial cells,and induces *** recent years,much research has been conducted on the functionalization of tissue engineering scaffolds with VEGF or a VEGF-mimetic peptide to promote ***,most chemical reactions are nonspecific and require organic solvents,which can compromise control over functionalization and alter peptide/protein *** attractive alternative is the fabrication of functionalizable electrospun fibers,which can overcome these *** this study,we used thiol-ene chemistry for the conjugation of a VEGF-mimetic peptide to the surface of poly(ε-caprolactone)(pCL)fibrous scaffolds with varying amounts of a functional pCL-diacrylate(pCL-DA)polymer.30%pCL-DA was selected due to homogeneous fiber morphology.A VEGF-mimetic peptide was then immobilized on pCL-DA fibrous scaffolds by a light-initiated thiol-ene reaction.7-Mercapto-4-methylcoumarin,RGD-FITC peptide and VEGF-TAMRA mimetic peptide were used to validate the thiol-ene reaction on the fibrous *** strength and elastic modulus of the 30%pCL-DA fibrous scaffolds were significantly increased after the *** of the 30%pCL-DA fibrous scaffolds with the VEGF peptide increased the surface water wettability of the *** structures could be obtained after using a photomask on the fibrous ***,in vitro studies indicated that scaffolds functionalized with the VEGF-mimetic peptide were able to induce phosphorylation of the VEGF receptor and enhanced HUVECs survival,proliferation and adhesion.A chick chorioallantoic membrane(CAM)assay further indicated that the VEGF peptide functionalized scaffolds were able to promote angiogenesis in *** results show that scaffold functionalization can be controlled via a simple polymer mixing approach,and that the functionalized VEGF peptide-scaffolds have potential for vascular

关键词： Electrospinning Fibrous scaffolds Thiol-ene reaction VEGF peptide

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