检索结果-南通市图书馆

Hepatobiliary & pancreatic Diseases International 2018年第6期17卷 524-530页

作者： Charing Ching-Ning Chong Siu tim Cheung Yue-Sun Cheung Anthony Wing-Hung Chan Stephen Lam Chan Simon Chun-Ho Yu paul Bo-San Lai Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong4/F Clinical Science Building30-32 Ngan Shing StreetShatinHong KongChina Department of Anatomical and Cellular pathology State Key Laboratory in Oncology in South ChinaPrince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Imaging and Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina

Background: Transarterial chemoembolization(TACE) is the most commonly used adjuvant therapy for hepatocellular carcinoma(HCC) after curative resection. Responses to TACE are variable due to tumor and patient heterogeneity. We had previously demonstrated that expression of Granulin-epithelin precursor(GEp) and ATp-dependent binding cassette(ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEp/ABCB5 expression and response to adjuvant TACE after curative resection for HCC. Methods: patients received adjuvant TACE after curative resection for HCC and patients received curative resection alone were identified from a prospectively collected database. Clinical samples were retrieved for biomarker analysis. patients were categorized into 3 risk groups according to their GEp/ABCB5 status for survival analysis: low(GEp-/ABCB5-), intermediate(either GEp +/ABCB5-or GEp-/ABCB5 +) and high(GEp +/ABCB5 +). Early recurrence(recurrence within 2 years after resection) and disease-free survival were analyzed. Results: Clinical samples from 44 patients who had followed-up for more than 2 years were retrieved for further biomarker analysis. Among them, 18 received adjuvant TACE and 26 received surgery alone. patients with adjuvant TACE in the intermediate risk group was associated with significantly better overall survival and 2-year disease-free survival than those who had surgery alone( p = 0.036 and p = 0.011, respectively). Adjuvant TACE did not offer any significant differences in the early recurrence rate, 2-year disease-free survival and overall survival for patients in low and high risk groups. Conclusions: Adjuvant TACE can only provide survival benefits for patients in the intermediate risk group(either GEp +/ABCB5-or GEp-/ABCB5 +). A larger clinical study is warranted to confirm its role in patient selection for adjuvant TACE.

关键词： Adjuvant therapy Hepatocellular carcinoma Drug transporter Transarterial chemoembolisation Granulin-epithelin precursor

Newly-discovered ultra-high temperature granulites from the East Hebei terrane,North China Craton

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2022年第7期67卷 670-673页

作者： Ting Liu Chunjing Wei tim E.Johnson Elena Sizova College of Earth Sciences Chengdu University of TechnologyChengdu 610059China School of Earth and Space Sciences Peking UniversityBeijing 100871China School of Earth and planetary Sciences the Institute for Geoscience ResearchCurtin UniversityPerthWA 6845Australia Institute of Earth Sciences University of GrazGraz 8010Austria

Archean crustal terranes are commonly featured with the dome–and–keel structures,in which supracrustal rocks occur as belts(greenstones)between,and rafts within,dome-like bodies of tonalite–trondhjemite–granodiorite(TTG).Supracrustal rafts within TTG gneisses generally record metamorphic grades ranging from amphibolite-to ultra-high temperature(UHT)granulitefacies of low-to moderate-pressure conditions[1].Notably,granulite-facies rafts commonly show counterclockwise p±T paths involving a significant increase in pressure at high temperatures[2,3].However,the tectonothermal drivers behind such metamorphism are still debated.

关键词： crustal 超高温麻粒岩 facies

Undercover Economist:For better or worth

在线全文

学校读者我要写书评

暂无评论

国际经济合作 2007年第5期 1-1页

作者： tim Harford

The price of the first serving of Co-ca-Cola was five cents in 1886, which is about a dollar (50p) in today’s *** no longer sells for a nickel, and that is not terribly surprising. What is surpris-ing is that it took... 详细信息

关键词：可口可乐公司产品价格市场价格镍币价格变迁

在线全文

学校读者我要写书评

暂无评论

美国加州活动断层探测及其成果应用

城市与减灾 2018年第1期 72-76页

作者：陈睿 tim E.Dawson tim p.McCrink 美国加州地质调查局

引言本文简要介绍美国,特别是加利福尼亚州,活动断层探测填图及其成果在抗震减灾中的应用。为避免由地震产生的地表破裂对建筑物造成的直接破坏,加州州政府在1972年颁布了《Alquistpriolo地震断层区划法》（以下简称＂Ap法＂）。此后开... 详细信息

引言本文简要介绍美国,特别是加利福尼亚州,活动断层探测填图及其成果在抗震减灾中的应用。为避免由地震产生的地表破裂对建筑物造成的直接破坏,加州州政府在1972年颁布了《Alquistpriolo地震断层区划法》（以下简称＂Ap法＂）。此后开始对活动断层系统探测并填制大比例尺活动断层分布图。

关键词：断层探测美国加州成果应用加利福尼亚州地震断层抗震减灾地表破裂活动断层

Electrocatalytic hydrogen peroxide formation on mesoporous non-metal nitrogen-doped carbon catalyst

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2016年第2期25卷 249-255页

作者： Frédéric Hasché Mehtap Oezaslan peter Strasser tim-patrick Fellinger Technische Universitat Berlin Department of Chemistry10623 BerlinGermany Max planck Institut fur Kolloid-und Grenzfliichenforschung Department of Colloids14424 PoadamGermany Carl von Ossietzky University of Oldenburg Department of ChemistryElectrocatalysis26111 OldenburgGermany

Direct electrochemical formation of hydrogen peroxide（H2O2） from pure O2 and H2on cheap metal-free earth abundant catalysts has emerged as the highest atom-efficient and environmentally friendly reaction pathway and is therefore of great interest from an academic and industrial point of view. Very recently,novel metal-free mesoporous nitrogen-doped carbon catalysts have attracted large attention due to the unique reactivity and selectivity for the electrochemical hydrogen peroxide formation [1–3]. In this work,we provide deeper insights into the electrocatalytic activity, selectivity and durability of novel metal-free mesoporous nitrogen-doped carbon catalyst for the peroxide formation with a particular emphasis on the influence of experimental reaction parameters such as p H value and electrode potential for three different electrolytes. We used two independent approaches for the investigation of electrochemical hydrogen peroxide formation, namely rotating ring-disk electrode（RRDE） technique and photometric UV–VIS technique. Our electrochemical and photometric results clearly revealed a considerable peroxide formation activity as well as high catalyst durability for the metal-free nitrogen-doped carbon catalyst material in both acidic as well as neutral medium at the same electrode potential under ambient temperature and pressure. In addition, the obtained electrochemical reactivity and selectivity indicate that the mechanisms for the electrochemical formation and decomposition of peroxide are strongly dependent on the p H value and electrode potential.

关键词： Electrochemical hydrogen peroxide formation Selectivity Mesoporous nitrogen-doped carbon Green synthesis Electrocatalysis Metal-free catalysis

Aberrant calcium signalling downstream of mutations in Tp53 and the pI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2022年第3期5卷 560-576页

作者： Alex J.Eustace Min Jie Lee Grace Colley Jack Roban tim Downing paul J.Buchanan DCU Cancer Research Dublin City UniversityDublin D9Ireland National Institute Cellular Biotechnology Dublin City UniversityDublin D9Ireland School of Biotechnology Dublin City UniversityDublin D9Ireland School of Nursing Psychotherapyand Community HealthDublin City UniversityDublin D9Ireland

Triple-negative breast cancer(TNBC)is characterized as an aggressive form of breast cancer(BC)associated with poor patient *** the majority of patients,there is a lack of approved targeted ***,chemotherapy remains a key treatment option for these patients,but significant issues around acquired resistance limit its ***,TNBC has an unmet need for new targeted personalized medicine ***(Ca^(2+))is a ubiquitous second messenger that is known to control a range of key cellular processes by mediating signalling transduction and gene *** in Ca^(2+)through altered calcium channel expression or activity are known to promote tumorigenesis and treatment resistance in a range of cancers including *** evidence shows that this is mediated by Ca^(2+)modulation,supporting the function of tumour suppressor genes(TSGs)and *** review provides insight into the underlying alterations in calcium signalling and how itplays a key role in promoting disease progression and therapy resistance in TNBC which harbours mutations intumour protein p53(Tp53)and the pI3K/AKT pathway.

关键词： Triple-negative breast cancer Tp53 pI3K/AKT pathway calcium

The Efficiency of the Energy Saving Stoves in Amboseli Ecosystem-Analysis of time, Energy and Carbon Emissions Savings

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Energy Efficiency 2017年第3期6卷 87-96页

作者： David Owino Manoa tim Oloo Simon Kasaine Born Free Foundation Nairobi Kenya

It is estimated that more than 2.5 billion people worldwide use biomass for cooking. Burning biomass is one of the major contributors to carbon dioxide (CO2) emission—a principle gas in global warming and climate change. One way of cutting down the CO2 emissions is adaptation of efficient and clean energy technologies. This study examined the efficiency of the energy saving stoves in Amboseli ecosystem by comparing the cooking time, energy use, wood fuel and carbon emissions to the traditional three stone open fire set ups. The result indicates a statistical difference in the time spent cooking on energy stoves and three stone open fire (t = 5.3055;n = 60;p = 0.00117). Energy saving stoves saved 12.7% - 33.3% of wood fuel compared to the traditional three stones set ups. Water boiling tests to determine the energy savings, revealed that energy saving stoves saved between 25.74% and 26.16% energy/joule per session in-house and outdoor settings respectively. Based on the two meals prepared per day by each household, the total Carbon Emission Savings for the 1000 local beneficiaries of energy saving stoves varied from 102,200 kg CO2 (indoor cooking) to 357,700 kg CO2 (outdoor cooking) per year. It is therefore concluded that energy saving stoves saves time, fuel wood and energy, and reduces carbon emissions. The study findings refute the claims that open fire when carefully operated can be fuel efficient and clean burning to rival energy saving stoves. To improve the performance of the energy saving stoves, it is recommended that a design modification be done to include a chimney to emit excess smoke during indoor cooking;and the stove should be fixed to the floor with mortar to minimise heat loss and breakages.

关键词： Energy-Saving Stoves time Carbon Dioxide Fuel Wood Efficiency Amboseli

Seed Germination of Five poa Species at Negative Water potentials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of plant Sciences 2016年第3期7卷 601-611页

作者： tim L. Springer Jason J. Goldman Southern plains Range Research Station USDA-Agricultural Research Service Woodward OK USA

Under field conditions water is often inadequate for satisfactory seed germination. An experiment was conducted to determine the effects of simulated dry conditions on germination and seedling growth of five bluegrass (poa) species, including: Texas, p. arachnifera Torr.;annual, p. annua L.;mutton, p. fendleriana Vasey;Kentucky, p. pratensis L., and Sandberg, p. secunda J. presl. bluegrasses. Fifty-seed samples of each species were germinated at water potentials of -1.6, -0.8, -0.4, -0.2, and 0 Mpa for a 42-d period. Annual and Sandberg bluegrass tolerated moisture stress at germination better than the other species, requiring 14 d to reach 40% germination in water of -0.8 Mpa potential. Kentucky bluegrass required 21 d to reach 40% germination under similar conditions. Mutton and Texas bluegrass were the least tolerant of low water potentials, requiring 42 d to reach 20% germination. Selection for increased seed germination at low water potentials should be possible in poa species assuming the trait has moderate heritability.

关键词： Negative Water potential poa Seed Germination

MDR1基因在睫状体色素上皮细胞容积激活性氯电流中的作用(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生理学报 2002年第1期54卷 1-6页

作者：陈丽新王立伟 tim JACOB3 广东医学院细胞生物学研究室广东医学院生理教研室湛江524023 Cardiff School of Biosciences

用膜片钳、反义寡核苷酸、免疫荧光及激光共聚焦显微镜等技术 ,研究MDR1基因在牛睫状体色素上皮(pigmentedciliaryepithelial,pCE)细胞容积激活性氯电流中的作用。pCE细胞表达MDR1基因产物 p糖蛋白 (p gp)。反义MDR1寡核苷酸抑制MDR1基... 详细信息

用膜片钳、反义寡核苷酸、免疫荧光及激光共聚焦显微镜等技术 ,研究MDR1基因在牛睫状体色素上皮(pigmentedciliaryepithelial,pCE)细胞容积激活性氯电流中的作用。pCE细胞表达MDR1基因产物 p糖蛋白 (p gp)。反义MDR1寡核苷酸抑制MDR1基因的表达 (p gp免疫荧光减少 93 % ) ,延缓容积激活性氯电流的出现 (潜伏期延长10 9% ) ,并导致激活率降低 62 %及电流峰值减小 5 6%。而核酸转染剂阳离子脂质体和非配对性的寡核苷酸对电流没有显著性影响。上述观察结果表明。

关键词：睫状体色素上皮细胞氯通道寡核苷酸反义基因表达 MDR1 容积激活性氯电流