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Convergence in leaf phenology traits of two understorey ferns in the northwestern Iberian peninsula

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Journal of plant Ecology 2018年第1期11卷 92-102页

作者： Luis G.Quintanilla Beatriz pías Department of Biology and Geology Physics and Inorganic ChemistrySchool of Environmental Sciences and TechnologyRey Juan Carlos Universityc/Tulipán s/n28933 MóstolesMóstolesSpain Department of plant Sciences Faculty of BiologyComplutense of Madrid UniversityMadridSpain

Aims plants control leaf phenology to maximize annual photosynthetic *** ferns play an important ecological role in many habitats,especially forests,their phenology traits have been poorly ***,we investigate the leaf phenology of two ferns of the forest understorey and analyse the relationship between the timing of leaf emergence and spore dispersal and the effect of between-year climatic *** We compared the leafing and sporing phenologies of two ferns with very large(>2 m),overwintering leaves:Culcita macrocarpa and Woodwardia *** regularly monitored individuals of six popu-lations in the northwestern Iberian peninsula during a 3-year *** studied eight phenology variables:leafing start date,leafing end date,leaf expansion time,number of new leaves per individual,between-individual synchrony,within-individual synchrony,percentage of fertile leaves and spore release *** also determined leaf mass per area(LMA)and gathered data on air temperature and *** findings Both *** and *** produce few leaves(~2 leaves individual−1 year−1),which expand simultaneously for a very long period(from midwinter to early summer),are retained for more than 1 year(37 and 19 months,respectively)and have relatively high *** traits,together with large leaf size,have also been found in seed plants from the forest understorey and represent adap-tations to this light-limited *** of both study ferns are simultaneously released in late winter,with little between-year variation caused by differences in air *** remarkable similarity between species suggests that the convergence in tim-ing of leaf emergence favours the convergence in timing of spore dispersal.

关键词： Culcita macrocarpa leaf phenology spore dispersal temperate forest Woodwardia radicans

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大鼠慢性高眼压诱导视神经损伤的研究

上海交通大学学报（医学版） 2008年第6期28卷 622-625页

作者：汪建涛许迅 Alfredo A.Sadun tim T.Lam 葛坚上海交通大学第一人民医院眼科上海200080 南加州大学 Keck医学院Doheny眼科研究所洛杉矶90033 中山大学中山眼科中心广州510060

目的建立大鼠慢性高眼压模型,对其眼压、视网膜节细胞(RGCs)和视神经轴突损伤进行研究。方法对40只大鼠行慢性高眼压模型手术,分为4组:术后即刻、5 d、2周和4周,每组10只,分别测定眼压。采用全视网膜-RGCs Cresyl Violet染色,术后2周和... 详细信息

目的建立大鼠慢性高眼压模型,对其眼压、视网膜节细胞(RGCs)和视神经轴突损伤进行研究。方法对40只大鼠行慢性高眼压模型手术,分为4组:术后即刻、5 d、2周和4周,每组10只,分别测定眼压。采用全视网膜-RGCs Cresyl Violet染色,术后2周和4周对大鼠视网膜进行RGCs计数,并对视神经进行对位苯二胺(ppD)染色。对照组20只大鼠,分为2组,每组10只。结果31只大鼠眼压升高,眼压升高率为77.5%,且4周内眼压维持稳定。眼压升高2周时中心和周边RGCs分别减少11.0%和11.3%,眼压升高4周时中心和周边视网膜分别丢失RGCs达17%和24.6%,与正常对照组比较差异均有统计学意义(pp>0.05)。高眼压组大鼠视神经轴突在颞上方有大约5.3%损伤,球后1 mm的视神经在光镜下可以看到视神经轴突水肿和髓鞘碎屑。结论慢性高眼压动物模型是一种可以重复且有效的青光眼模型,它模拟了人类慢性眼压升高所导致的RGCs丢失和视神经的损伤。

关键词：高眼压动物模型视网膜节细胞视神经损伤

Slow Growing pre-Weaning piglets Have Altered Adipokine Gene Expression

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Open Journal of Animal Sciences 2014年第4期4卷 187-195页

作者： tim G. Ramsay M. J. Stoll T. J. Caperna Animal Biosciences and Biotechnology Laboratory Beltsville Agricultural Research Center USDA/ARS Beltsville USA

Growth rate affects adipose tissue development and variations in growth rate may potentially impact adipokine expression. Samples of subcutaneous (SQ) and perirenal (pR) adipose tissues and longissimus muscle were collected at day 21 of age from the fastest and slowest growing piglets within seven litters. Reverse transcription and real-time pCR were used to quantify adipokine mRNA abundance. Leptin, adiponectin, tumor necrosis factor α (TNFα ) and lipoprotein lipase (LpL) mRNA abundance were lower in SQ from slow growing piglets (SGp) than in fast growing piglets (FGp, p α gene expression were reduced in pR from SGp in comparison to FGp (p β (IL1β), IL15 and LpL were increased in the longissimus of SGp relative to FGp (p pokines within adipose tissue at day 21 of age demonstrated that the effect of growth rate on adipokine expression varies among different adipokines and the internal and external sites of adipose tissue deposition (pR versus SQ). The increase in longissimus expression of LpL and IL15 suggests that nutrient partitioning for energy use may be greater in the skeletal muscle of the SGp.

关键词： Adipose Tissue Adipokines Neonate Growth Rate

The Effects of Anma (Traditional Japanese Massage)—Randomised Trial

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Health 2022年第7期14卷 775-787页

作者： Hiroshi Kuge Hidetoshi Mori Tsunehiko Wada Mayumi Watanabe tim Hideaki Tanaka Eiichi Taniwaki Tateyuki Morisawa Department of Anesthesiology pain Clinic Osaka Medical and Pharmaceutical University Hospital Osaka Japan Department of Health Faculty of Health Science National University Corporation Tsukuba University of Technology Tsukuba Japan Information Science Center for Humanities and Sciences School of Health Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan Acupuncture and physical Therapy Teacher Training School National University Corporation University of Tsukuba Tsukuba Japan Sakura Acupuncture Massage Center Tsukuba Japan

Background and Objective: Anma is a traditional Japanese bodywork therapy that has not been widely known and used in the West. There have been only a few Anma studies published in English journals. To study the effect of Anma (traditional Japanese massage) among participants who have neck and shoulder stiffness symptoms (so-called Katakori, in Japanese). Methods: The study participants consisted of seventy-seven (Study 1), thirteen (Study 2), and twenty (Study 3) adults with “Katakori” symptoms. The research design is as follows: (Study1) Randomized, parallel-Group, Controlled Trial. (Study 2) Crossover Clinical Trial. (Study 3) Randomized, parallel-Group, Controlled Trial. And we conducted Anma treatment for 45 minutes (Treatment) or rest in lying position for 45 minutes (Control). Results: In study 1, the symptom of “Katakori” was relieved after Anma treatment in Anma group (p d: 2.2). There was a significant interaction between the Anma group and the control group (p p and the control group (p = 0.022). In study 3, the symptom of “Katakori” was relieved after Anma treatment in the treatment group. There were no significant interactions between the groups in VAS and MBV values. Discussion and Conclusions: The study demonstrated that Anma therapy decreases “Katakori” symptoms while increasing MBV in the shoulder region.

关键词： Massage Therapy Acupressure Musculoskeletal pain Visual Analog Scale (VAS) Muscle Blood Volume (MBV) Near-Infrared Spectroscopy (NIRS) Anma Katakori

Association Between Maternal Thyroid Hormones and Birth Weight at Early and Late pregnancy

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Association Between Maternal Thyroid Hormones and Birth Weig...

Characterization of the plasma mirror system at the J-KAREN-p facility

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Chen Zhang Xi Yang Yong Zhang Fei Guo Shuai Yang Robin p.peeters tim I.M.Korevaar He-Feng Huang Jianxia Fan

Context: previous studies suggest that maternal thyroid function affects fetal growth, while the association between combined thyroid hormones from early to late pregnancy and newborn birth weight remains ***: To explore the association of maternal thyroid function during early and late pregnancy with birth ***: A large prospective cohort study of a Chinese ***: This study recruited pregnant women who underwent first trimester prenatal screenings at the International peace Maternity and Child Health Hospital between January 2013 and December ***: This study enrolled 46,186 mothers in whom thyroid stimulating hormone(TSH), free thyroxine(FT4), triiodothyronine(T3) and TpOAbs concentrations were measured in the first and third trimester and in whom data on birth weight were *** Outcome Measures: Birth weight, small for gestation age(SGA), large for gestation age(LGA).Results: A higher TSH or FT4 concentration, as well as a lower T3 concentration, during the 1 st or 3 rd trimester was associated with a lower birth weight. The lowest percentiles of maternal FT4(FT4 percentile) in both trimesters were associated with a 0.34 SD higher birth weight. The effect estimates were greater in those only in 1 st trimester(0.23 SD) or in 3 rd trimester(0.17 SD). The association of maternal TSH and FT4 with birth weight differed according to fetal ***: persistently low FT4 concentrations throughout pregnancy were associated with higher birth weight and an increased risk of LGA. Based on these findings we recommend monitoring of mildly altered concentrations of thyroid hormone throughout ***: Our results indicate that low maternal FT4 and high maternal T3 concentrations are associated with a higher risk of LGA newborns, with additive effects for persistency of high FT4 from early to late pregnancy.

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High power Laser Science and Engineering 2022年第4期10卷 26-35页

作者： Akira Kon Mamiko Nishiuchi Yuji Fukuda Kotaro Kondo Koichi Ogura Akito Sagisaka Yasuhiro Miyasaka Nicholas p.Dover Masaki Kando Alexander S.pirozhkov Izuru Daito Liu Chang Il Woo Choi Chang Hee Nam tim Ziegler Hans-peter Schlenvoigt Karl Zeil Ulrich Schramm Hiromitsu Kiriyama Kansai photon Science Institute National Institutes for Quantum Science and TechnologyKyoto 619-0215Japan Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea Advanced photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of physics and photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Helmholtz-ZentrumDresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We report on the design and characterization of the plasma mirror system installed on the J-KAREN-p laser at the Kansai photon Science Institute,National Institutes for Quantum Science and *** reflectivity of the single plasma mirror system exceeded 80%.In addition,the temporal contrast was improved by two orders of magnitude at 1 ps before the main ***,the laser near-field spatial distribution after the plasma mirror was kept constant at plasma mirror fluence of less than 100 kJ/cm^(2).We also present the results of investigating the difference and the fluctuation in energy,pulse width and pointing stability with and without the plasma mirror system.

关键词： high-powerlasers laser plasma plasma mirror

Bioactive Low Molecular Weight Compounds in Two Traditional Spanish products

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Food and Nutrition Sciences 2013年第9期4卷 14-22页

作者： María Luisa timón Emilio José Galea Ana Isabel Andrés María Jesús petrón Department of Animal production and Food Science School of Agricultural Engineering University of Extremadura Badajoz Spain

The aim of this work focuses on the study of low molecular weight (LMW) compounds with antioxidant and antihy-pertensive effect in Iberian ham and La Serena cheese, two traditional products in Spain, in comparison to cured ham and matured Ewe’s milk cheese. proteolysis parameters were studied, LMW compounds were isolated and their antioxidant and antihypertensive activity was analyzed. Results showed that a more intense proteolysis, expressed as peptidic nitrogen (pN), in Iberian ham (p product for both DppH radical scavenging (p p proteolysis in La Serena cheese, expressed as non protein nitrogen (NpN) (p pN (p promote higher antioxidant activity in this cheese. On the other hand, no differences were found for antihypertensive activity, expressed as angiotensin I-converting enzyme (ACE) inhibitory activity, in both type of hams or cheese.

关键词： Bioactive Compound proteolysis Traditional Food Antioxidant Activity Antihypertensive Activity

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肝细胞癌的免疫治疗（上）

传染病网络动态 2007年第1期 16-17页

作者： tim F.Greten Michael p.Manns Firouzeh Korangy 姚勤伟（编译）杨月（审校）

肝细胞癌（HCC）是世界第五大常见肿瘤，5年生存率低于5％，每年至少100万新发病例。其中一小部分病人可能适合外科切除或者局部消融治疗。但是，这些治疗受到肿瘤大小、肝脏储备功能和肝内转移的限制。因此，对于绝大多数晚期HCC患者... 详细信息

肝细胞癌（HCC）是世界第五大常见肿瘤，5年生存率低于5％，每年至少100万新发病例。其中一小部分病人可能适合外科切除或者局部消融治疗。但是，这些治疗受到肿瘤大小、肝脏储备功能和肝内转移的限制。因此，对于绝大多数晚期HCC患者来说，这些有望治愈的治疗手段都是不可能的。肝动脉化疗栓塞术（TACE）延长了已无条件行外科手术切除、肝移植或肿瘤消融治疗的患者的生存期，但是只有那些肝功能适当的患者才能够进行此项治疗。因为HCC患者基本上都有肝硬化基础，全身化疗耐受性较差，并且效果不佳。因此，根据全球性的指南（EASL或AASLD），像免疫治疗一类的备选方案最近正在晚期HCC患者中进行评估。

关键词：免疫治疗肝细胞癌肝动脉化疗栓塞术局部消融治疗肿瘤大小肝脏储备功能外科手术切除 5年生存率

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

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World Journal of Gastroenterology 2013年第48期19卷 9282-9293页

作者： Fergus Noble Luke Nolan Adrian C Bateman James p Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees timothy J Iveson tim J Underwood Andrew R Bateman Cancer Sciences Unit Faculty of Medicine University of Southampton Southampton SO16 6YD United Kingdom Department of Surgery University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Department of Cellular pathology University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Cancer Care University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom

AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant ***:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were *** neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 *** to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et *** addition lymph node downstaging was also *** node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery *** were followed up for 5 years post *** was defined radiologically,with or without pathological *** association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological ***:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality *** hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological *** four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(pponse to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,

关键词： Esophageal cancer Gastro-esophageal cancer Neoadjuvant Regression