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Nano Research 2015年第3期8卷 774-789页

作者： Mohammed j.mshad Vinciane Grimard Ilaria Idini tim j. knowles Miriam R. Dowle Naomi Schofield Pooj. Sridhart Yupin Lin Rachael Finka Mark Wheatley Owen R. T. Thomas Richard E. Palmerr Michael Overduin Cedric Govaerts j.an-Marie Ruysschaert Karen j. Edler tim R. Dafforn School of Biosciences University of Birmingham Edgbaston Birmingham B 15 2TT UK Universite Libre de Bruxelles SFMB - CP206/2 Bd. du Triomphe Acces 2 1050 Bruxelles Belgium Department of Chemistry University of Bath Claverton Down Bath BA2 7AY UK School of Cancer Studies University of Birmingham Edgbaston Birmingham B 15 2 TT UK Nanoscale Physics Research Laboratory and PSIBS School of Physics and Astronomy University of Birmingham Edgbaston Birmingham B 15 2TT UK School of Chemical Engineering University of Birmingham Edgbaston Birmingham B 15 2TT UK

在过去几年里，在为稳定包含嵌入的蛋白质的类脂化合物膜的 nanoparticles 的使用有生长。这些 bionanoparticles 由维持类脂化合物 bilayer 必需品到蛋白质完整和活动提供一个解决方案给膜蛋白质隔离的挑战性的问题。我们以前描述了 am... 详细信息

在过去几年里，在为稳定包含嵌入的蛋白质的类脂化合物膜的 nanoparticles 的使用有生长。这些 bionanoparticles 由维持类脂化合物 bilayer 必需品到蛋白质完整和活动提供一个解决方案给膜蛋白质隔离的挑战性的问题。我们以前描述了 amphipathic 聚合物的使用(poly (styrene-co-maleic 酸) ， SMA ) 与包含嵌入的蛋白质的一个类脂化合物 bilayer 核心生产 discoidal nanoparticles。然而， nanoparticle 本身的结构还没是坚定的。这在理解 SMA 怎么稳定包含的 bilayer 并且 bilayer 怎么身体上联系和在结构上到 unencapsulated 类脂化合物 bilayer 离开主要差距。在这份报纸，我们由描述从小角度中子散布使用数据的 SMA 类脂化合物粒子( SMALP )(圣)的结构处理这个问题，电子显微镜学(他们)，稀释全部的思考 Fourier 变换红外线的光谱学( ATR-FTIR )，微分扫描热量测定( DSC )和原子磁性的回声光谱学( NMR )。我们证明粒子是塑造的圆盘包含环绕的一只聚合物手镯类脂化合物 bilayer。在 bilayer 和聚合物以内的单个部件的结构和取向是坚定的证明在 SMA 以内的苯乙烯一半在类脂化合物酰链之间设置。包含的 bilayer 的尺寸也被决定并且匹配为自然的膜测量的那些。一起拿，对 SMALP 的结构的描述在膜蛋白质生产和分析为未来开发和 SMALP 的应用形成基础。

关键词：纳米颗粒结构分析膜蛋白脂质洗涤剂两亲性聚合物 ATR-FTIR 提取

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura j.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan j.ang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge j.lian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David j.Beech Frank timo Beil Michael Amling j.hannes Keller Anita Ignatius timur A.Yorgan tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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湿型砂铸铝:打开新的视角

铸造 2024年第1期73卷 135-138页

作者： Per Larsen tim j.Baron 陈之伟(译) 刘溢(译) DISA Industries A/S 迪砂中国

许多汽车零部件已经用铸铝件替代以前的铸铁件。铸铝件在电动汽车的过渡中至关重要。随着汽车行业的成功转型,大批量的新型电动汽车传动系统铝部件应运而生,如电机壳和机盖。众所周知,湿型砂工艺能高效,可低成本生产出高质量的铸铁件。... 详细信息

许多汽车零部件已经用铸铝件替代以前的铸铁件。铸铝件在电动汽车的过渡中至关重要。随着汽车行业的成功转型,大批量的新型电动汽车传动系统铝部件应运而生,如电机壳和机盖。众所周知,湿型砂工艺能高效,可低成本生产出高质量的铸铁件。随着全球对铸铝件的需求不断上升,降低成本的压力不断加大,越来越多的铸造厂和制造商开始探索湿型砂生产铸铝件的运用。铸铁厂用湿型砂生产的优势成功转移到铸铝件,带来低成本、快速成形和灵活性等优点。

关键词：铸铝件湿型砂铸铁件低成本生产快速成形汽车零部件汽车传动系统电机壳

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Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International j.urnal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benj.min j.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail Tayfur j.nathan Abrahams Sanj.ya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura j.remy P.Novak Maria Opazo Kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

Non-invasive Angiographic-based Fractional Flow Reserve:Technical Development,Clinical Implications,and Future Perspectives

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当代医学科学(英文) 2023年第3期43卷 423-433页

作者： j.yce Peper Michiel L.Bots tim Leiner Martin j.Swaans Department of Cardiology St.Antonius HospitalNieuwegein 3435 CMThe Netherlands Department of Radiology University Medical Center UtrechtUtrecht 3508 GAThe Netherlands j.lius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3584 CGThe Netherlands

New non-and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve(FFR)for the assessment of potentially significant stenosis in the coronary *** FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR *** review provides an overview of the developments and validation of the virtual FFR-algorithms,states the challenges,discusses the upcoming clinical trials,and postulates the future role of virtual FFR in the clinical practice.

关键词： coronary artery disease quantitative flow ratio fractional flow reserve diagnostic accuracy physiology guided percutaneous coronary intervention

Dominant species of mid-elevation grasslands of the uKhahlamba-Drakensberg Park are predicted to be largely immune to climate change

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山地科学学报(英文) 2023年第9期20卷 2468-2486页

作者： Debbie j.WITT Craig D.MORRIS tim G.O’CONNOR Michelle j.TEDDER Ezemvelo KZN Wildlife Scientific ServicesPO Box 13053Cascades 3202South Africa School of Animal Plant and Environmental SciencesUniversity of the WitwatersrandJohannesburgPrivate Bag X3WITS 2050South Africa Agricultural Research Council-Animal Production(ARC-AP) ℅School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa

Anticipating global change impact on natural vegetation,especially in poorly researched systems,requires an understanding of the environmental factors that most strongly influence the organisation of plant communities at different *** environmental relations of plant communities in the Drakensberg mountains of South Africa remain poorly *** study investigated the influence of selected environmental determinants on the dominant species of plant community organisation in this *** order to provide an overview of the influence of the environment on botanical composition and plant diversity,this study,conducted as four discrete exercises,investigated the interplay of altitude,aspect and slope on the abundance of selected species,and to examine the influence of latitude,geological substrate and local topography on species *** diversity showed no pattern of response to investigated environmental *** composition was related to temperature and solarradiation *** altitude sites facing east were distinct for non-graminoid *** and latitude exerted a pronounced effect on species composition,confounded by longitude and precipitation *** substrate,in concert with slope steepness and orientation,influenced composition,restricting the abundance but not distribution of some *** individualistic responses were found for C_3,C_4,and non-graminoid species in relation to altitude,slope and *** and aspect mediate the effects of altitude and hence temperature for some *** study has demonstrated the complexity of drivers influencing species and compositional distribution in the Drakensberg and permits a preliminary consideration of potential changes in the composition and dominance structure of mid-elevation grasslands in response to climate *** dominant grass species were widespread across environmental gradients,occupying currently warm,cool,moist and dry habitats

关键词： Drakensberg Environmental gradients Grasslands Mountain biodiversity Vegetation

Understorey species distinguish late successional and ancient forests after decades of minimum human intervention: A case study from Slovenia

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Forest Ecosystems 2023年第1期10卷 92-101页

作者： Mirj.na Sipek tim Ravnj.k Nina Saj.a University of Maribor Faculty of Natural Sciences and MathematicsKoroska c.1602000MariborSlovenia

The main species composition drivers in temperate deciduous forests are environmental conditions, a stand?s age and the site history, e.g., the succession stage and past land use, as well as disturbance regime and current management. We compared plant species diversity and composition in late successional and ancient forests, cooccurring on the same small river island applying species accumulation curves and nonmetric multidimensional scaling, respectively. Given the island?s geomorphological characteristics, we expected these to be very similar before human intervention in the past. The forests experienced differing disturbance regimes in the past, while over the last 30 years, human intervention has been the same and reduced to a minimum. The ancient forest in this study had two maj.r characteristics defining it as old, mature forest: continuity of presence for more than 200years and specific composition. The late successional forest experienced maj.r disturbance in the 20th century and was allowed natural regeneration by bordering on the ancient forest, representing a potential species pool,and by decades of minimum human intervention. Our results showed that, even though there was no difference in species richness, we could still detect differences between the forests, particularly in the abundance and species composition of the understorey, among which geophytes had the most indicative importance. To make our results useful on a broader scale, we composed from the literature a species list of plants indicative for ancient forest and tested its application. These results are important for distinguishing between old and mature secondary stands and particularly for identifying old forest stands, which should be conserved and, in the case of fragmented landscapes, included in a network connecting forest fragments.

关键词： Forest community Successional forest Indicator plants Plant diversity Understorey Geophytes

A review of the resistome within the digestive tract of livestock

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j.urnal of Animal Science and Biotechnology 2022年第3期13卷 642-661页

作者： Tao Ma tim A.McAllister Le Luo Guan Key laboratory of Feed Biotechnology of the Ministry of Agriculture Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaT6G2P5EdmontonABCanada Lethbridge Research and Development Centre LethbridgeAB T1J 4P4Canada

Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production ***,the occurrence of antimicrobial resistance poses a huge threat to public and animal health,especial y in less developed countries where food-producing animals often intermingle with *** limit the spread of antimicrobial resistance from food-production animals to humans and the environment,it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance(AMR),The resistome refers to the col ection of al antimicrobial resistance genes associated with microbiota in a given *** dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in *** of the resistome in the digestive tract of humans and animals are increasing exponential y as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the *** this review,we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine,poultry,and *** then propose future research directions including analysis of resistome using long-read sequencing,investigation in the role of mobile genetic elements in the expression,function and transmission of *** review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems.

关键词： Antimicrobial resistance Antimicrobial resistance gene Digestive tract Food-producing animal Metagenomic sequencing Resistome

Heavy Precipitation over the j.ng–j.n–j. Region in Early October: What Controls Its Interannual Variability?

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j.urnal of Meteorological Research 2022年第4期36卷 586-600页

作者： j.ng FENG tim LI j. WANG Linna ZHANG Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate andEnvironmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC–FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Beij.ng Meteorological Information Center China Meteorological AdministrationBeijing 100089China International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of Hawaii at ManoaHonoluluHawaii 96822USA Beij.ng Municipal Climate Center Beijing 100089China Beij.ng Meteorological Observatory Beijing 100089China

Heavy regional precipitation(HRP)over Beij.ng,Tianj.n,and Hebei Province(the j.ng–j.n–j. region or j.j.in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational *** is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North *** latter connects the SNWP anticyclone through a Rossby wave *** ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the j.j.region in early October.

关键词： heavy regional precipitation(HRP)in j.ng–j.n–j.(j.j. Beij.ng Tianj.n and Hebei Province water vapor(WV)transport Rossby wave train diabatic heating anomalies La Niña-like SST anomaly

Morphodynamic signatures derived from daily surface elevation dynamics can explain the morphodynamic development of tidal flats

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Water Science and Engineering 2023年第1期16卷 14-25页

作者： tim j.Grandj.an j.co C.de Smit j.m van Belzen Gregory S.Fivash j.roen van Dalen Tom Ysebaert Tj.erd j.Bouma Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research(NIOZ)4401 NT YersekeThe Netherlands Faculty of Geosciences Department of Physical GeographyUtrecht University3508 TC UtrechtThe Netherlands

Understanding the sensitivity of tidal flats to environmental changes is ***,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal *** this study,we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation *** elevation dynamic(SED)indices focus on the magnitude and period of surface elevation changes,while morphodynamic signature(MDS)indices relate sediment dynamics to environmental *** statistical analyses were applied to an intervention site in the Netherlands to determine the effect of recently constructed groynes on the tidal *** these analyses,we were able to(1)detect a reduction in the daily SED and(2)determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal ***,the presented results showed that the combination of novel statistical indices provides new insights into the traj.ctories of tidal flats,ecosystem functioning,and sensitivity to physical drivers(wind and tides).Finally,we suggested how the SED and MDS indices may help to explore the future traj.ctories and climate resilience of intertidal habitats.

关键词： Surface elevation dynamics Tidal flat traj.ctories Morphodynamic development Morphodynamic signature Bed level dynamics