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Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第20期12卷 3275-3282页

作者： Lars A Ormandy Anatol frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning frank Lehner Michael P Manns firouzeh Korangy tim f greten Department of Gastroenterology Hepatology and Endocrinology Hannover Medical SchoolGermany Departments of Visceral and Transplantation Surgery Hannover Medical School Germany

瞄准：与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法：骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80， CD83， CD86 和 HLA... 详细信息

瞄准：与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法：骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80， CD83， CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立，他们的功能被测试。吞噬作用用 fITC 葡聚糖祷告被分析，肽特殊刺激，在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果：骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80， CD83， CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论：在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。

关键词：树状细胞肝细胞癌骨髓细胞外周血

Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause Sub-synchronous Oscillations in Series-compensated Power System

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang H.f.Wang Tao Zhao tim Littler College of Electrical Engineering Sichuan UniversityChengduChina School of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

The induction generator effect(IGE)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(SSOs)in a series-compensated power system(SCPS)may *** IGE attributes the growing SSOs to negative resistance,while the OLMP explains the SSO mechanism from the standpoint of modal *** this paper,we investigate the connections between the IGE and the OLMP through equivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DfIG is connected at the sending *** investigation reveals the conditions,in which the IGE and the OLMP may jointly cause the growing SSOs,i.e.,both the IGE and the OLMP can explain why the growing SSOs ***,the investigation indicates that the IGE and the OLMP may be totally irrelevant and lead to growing SSOs *** implies that it is possible that in a SCPS,the growing SSOs are only due to the IGE,and the OLMP is non-existent,and vice ***,when the growing SSOs occurs in a SCPS,examination based on both the IGE and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGE,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival

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Hepatobiliary & Pancreatic Diseases International 2007年第3期6卷 259-266页

作者： timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd frericks Lars Zender Nisar P Malek tim f greten Stefan Kubicka Michael P Manns Michael Galanski Department of Diagnostic Radiology Hannover Medical School Germany Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Germany Department of Diagnostic and Interventional Radiology Klinikum Oldenburg Germany Division of Rheumatology Hannover Medical School Germany Department of Radiology and Nuclear Medicine Campus B.F-Charité-University Medicine Berlin Germany

BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (ficantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major

关键词： carcinoma, hepatocellular transarterial chemoembolization degradable starch microspheres Lipiodol tumor response survival

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： tim Aberle Michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Development of CAR T cell therapy targeting glypican-3 in liver cancer

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Cancer Biology & Medicine 2018年第S1期15卷 17-17页

作者： Dan Li Nan Li Yifan Zhang Haiying fu Madeline B.Torres tim f.greten Mitchell Ho Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA

Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,***,we engineered human T cells ... 详细信息

关键词： Development CAR liver cancer

Effect of vertical overturning circulation scale and moist static energy tendency on MJO phase speed

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Atmospheric and Oceanic Science Letters 2022年第1期15卷 68-75页

作者： feng Hu tim Li School of Geographic Information and Tourism Chuzhou UniversityChuzhouChina Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjingChina International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of Hawaii at ManoaHonoluluHawaiiUSA

本文通过对1979-2019年ERA-I再分析资料进行诊断分析,研究了MJO垂直环流(VOC)纬向尺度和湿静力能(MSE)趋势纬向不对称性对MJO传播速度的综合影响.研究结果表明,MJO传播速度与VOC的纬向尺度和MSE趋势纬向梯度之间存在显著的正相关关系.... 详细信息

本文通过对1979-2019年ERA-I再分析资料进行诊断分析,研究了MJO垂直环流(VOC)纬向尺度和湿静力能(MSE)趋势纬向不对称性对MJO传播速度的综合影响.研究结果表明,MJO传播速度与VOC的纬向尺度和MSE趋势纬向梯度之间存在显著的正相关关系.基于上述两个参数,本文建立了线性回归模型,该模型可以较好的估计MJO的传播速度.本文对上述结果在不同的地理区域(120°-140°E)进行了敏感性测试.MJO传播速度仍然与这两个参数之间有显著的正相关关系.

关键词：垂直环流 MJO传播速度湿静力能趋势简单线性回归模型

A review of the resistome within the digestive tract of livestock

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Journal of Animal Science and Biotechnology 2022年第3期13卷 642-661页

作者： Tao Ma tim A.McAllister Le Luo Guan Key laboratory of feed Biotechnology of the Ministry of Agriculture Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaT6G2P5EdmontonABCanada Lethbridge Research and Development Centre LethbridgeAB T1J 4P4Canada

Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production ***,the occurrence of antimicrobial resistance poses a huge threat to public and animal health,especial y in less developed countries where food-producing animals often intermingle with *** limit the spread of antimicrobial resistance from food-production animals to humans and the environment,it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance(AMR),The resistome refers to the col ection of al antimicrobial resistance genes associated with microbiota in a given *** dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in *** of the resistome in the digestive tract of humans and animals are increasing exponential y as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the *** this review,we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine,poultry,and *** then propose future research directions including analysis of resistome using long-read sequencing,investigation in the role of mobile genetic elements in the expression,function and transmission of *** review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems.

关键词： Antimicrobial resistance Antimicrobial resistance gene Digestive tract food-producing animal Metagenomic sequencing Resistome

Acupuncture Effects on Heart failure: How to Create Objective Study Designs

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 307-308页

作者： HJ greten A Kick E Scholz J fischer T greten f Brazkiewicz f Schroder S Sertel Wendt M Goncalves O Karrer A Remppis German Society of Traditional Chinese Medicine Heidelberg Germany Porto University ICBAS Portugal Dept. of Endocrinology and Metabolism University of Heidelberg Germany Dept. of Cardiology University of Heidelberg Germany Dept. of Otorhinolaryngology Head & Neck Surgery University of Heidelberg Germany

根据对针刺机制的现代理解,针刺可以引起植物神经反射,可能是影响与心力衰竭(其特征之一是6分钟步行实验得分较低)症状有关的系统植物神经调节异常。笔者进行了一个初步的前瞻性随机、单盲、交叉临床试验,比较符合海德尔堡中医模型诊断(... 详细信息

根据对针刺机制的现代理解,针刺可以引起植物神经反射,可能是影响与心力衰竭(其特征之一是6分钟步行实验得分较低)症状有关的系统植物神经调节异常。笔者进行了一个初步的前瞻性随机、单盲、交叉临床试验,比较符合海德尔堡中医模型诊断(i-ACU)和不符合这一模型(u-ACU)的两种针刺治疗。重复测量分析提示:与不符合海德尔堡中医模型的针灸治疗相比,符合这一模型的针灸治疗更有效(f=7.2,df=1.37,P=0.011)。这一研究结果表明针刺可延长6分钟行走距离这一心力衰竭的重要指标。

关键词：针刺疗法心力衰竭随机对照试验人类

Associations between meeting 24-hour movement guidelines and academic achievement in Australian primary school-aged children

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Journal of Sport and Health Science 2022年第4期11卷 521-529页

作者： Amanda Watson Dorothea Dumuid Carol Maher tim Olds Alliance for Research in Exercise Nutrition and Activity(ARENA)Allied Health and Human PerformanceUniversity of South AustraliaAdelaideSA5001Australia

Background:few studies have investigated associations between academic achievement and meeting recommendations from the 24-hour(24-h)movement *** specific guidelines associated with the most benefit academic achievement are *** both self-report and objective movement data,this study examined associations between academic achievement and meeting individual recommendations and combinations of recommendations from the 24-h movement guidelines(sleep,physical activity,and screen time).Methods:Data from CheckPoint,a cross-sectional study nested between Waves 6 and 7 of the Longitudinal Study of Australian Children,were *** behaviors were measured using 24-h wrist-worn accelerometry(GENEActiv(Activinsights,Kimbolton,UK))and were selfreported by children using the Multimedia Activity Recall for Children and *** achievement was measured using a nationally administered standardized test in literacy and *** of covariance,with t tests with sequential Bonferroni adjustments,was used to compare academic achievement with all possible combinations of meeting recommendations,adjusting for demographic *** models were considered:guideline compliance assessed by self-report(n=1270,mean age=11.99 years,52%males)and by accelerometry(for moderate-to-vigorous intensity physical activity(MVPA)and sleep))and self-report(screen time)in combination(n=927,mean age=11.97 years,52%males).Results:Literacy achievement significantly differed based on self-report(f_((7,1258))=3.08,p=0.003)and accelerometer derived(f_((7,915))=2.40,p=0.02)guideline *** achievement significantly differed based on self-report(f_((7,1258))=2.92,p=0.005)but not accelerometer derived guideline compliance(f_((7,915))=0.80,p=0.58).When assessed by self-report,children who met all guidelines(t_((334))=-4.05,p=0.0001)or met the screen time and sleep guidelines in combination(t_((125))=-5.02,p<0.001)had superior literacy ***

关键词： Academic achievement Physical activity Sedentary behavior Sleep