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Another Year of Record Heat for the Oceans

Advances in Atmospheric Sciences 2023年第6期40卷 963-974页

作者： Lijing chenG John ABRAHAM Kevin ETRENBERTH John FASULLO tim BOYER Michael EMANN Jiang ZHU Fan WANG Ricardo LOCARNINI Yuanlong LI Bin ZHANG Fujiang YU Liying WAN Xingrong chen Licheng Feng Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin chen Alexey MISHONOV Jim REAGAN Guancheng LI International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of St.Thomas School of EngineeringMinnesota 55105USA National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland AucklandNew Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMDCollege ParkMaryland 20740USA Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China

Changes in ocean heat content(OHC), salinity, and stratification provide critical indicators for changes in Earth’s energy and water cycles. These cycles have been profoundly altered due to the emission of greenhouse gasses and other anthropogenic substances by human activities, driving pervasive changes in Earth’s climate system. In 2022, the world’s oceans, as given by OHC, were again the hottest in the historical record and exceeded the previous 2021 record *** to IAP/CAS data, the 0–2000 m OHC in 2022 exceeded that of 2021 by 10.9 ± 8.3 ZJ(1 Zetta Joules = 1021Joules);and according to NCEI/NOAA data, by 9.1 ± 8.7 ZJ. Among seven regions, four basins(the North Pacific, North Atlantic, the Mediterranean Sea, and southern oceans) recorded their highest OHC since the 1950s. The salinity-contrast index, a quantification of the “salty gets saltier–fresh gets fresher” pattern, also reached its highest level on record in 2022,implying continued amplification of the global hydrological cycle. Regional OHC and salinity changes in 2022 were dominated by a strong La Ni?a event. Global upper-ocean stratification continued its increasing trend and was among the top seven in 2022.

关键词： ocean heat content salinity stratification global warming climate

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需要层次理论指导下集束化护理对腹腔镜胆囊切除术患者麻醉复苏期并发症的影响

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中国临床研究 2024年第10期37卷 1629-1634页

作者：张磊谢晨王浩李玉李建立河北医科大学临床医学院、河北省人民医院麻醉科河北石家庄050000

目的探讨马斯洛需要层次理论指导下集束化护理对腹腔镜胆囊切除术(LC)患者麻醉复苏期并发症的影响。方法选取2023年6月至10月于河北省人民医院进行LC治疗的200例患者为研究对象,按照随机数字表法分为试验组(需要层次理论指导下集束化护... 详细信息

目的探讨马斯洛需要层次理论指导下集束化护理对腹腔镜胆囊切除术(LC)患者麻醉复苏期并发症的影响。方法选取2023年6月至10月于河北省人民医院进行LC治疗的200例患者为研究对象,按照随机数字表法分为试验组(需要层次理论指导下集束化护理方法)和对照组(常规护理方法),每组100例,对比两组患者下床活动时间、排气时间、住院时间、焦虑评分(SAS)、抑郁评分(SDS)、视觉模拟评分(VAS)。应用Kaplan-Meier方法分析麻醉复苏期并发症发生率,应用Cox比例风险模型分析影响LC患者麻醉复苏期并发症的临床风险因素。结果试验组患者下床活动时间、排气时间、住院时间均早于对照组(P<0.01)。两组患者干预后SAS、SDS、VAS评分低于干预前(P<0.05),且试验组低于对照组(P<0.05)。试验组患者麻醉复苏期并发症发生率为8.00%,对照组患者麻醉复苏期并发症发生率为21.00%(Log-rank=6.970,P=0.008)。不同麻醉复苏期并发症发生情况患者的年龄、BMI、手术时间、术中出血量、护理方式对比差异具有统计学意义(P<0.05)。单因素Cox回归分析结果显示,年龄(OR=1.063,P=0.009)、BMI(OR=1.202,P=0.031)、手术时间(OR=1.088,P<0.01)、护理方式(OR=4.563,P<0.01)是LC患者麻醉复苏期并发症的影响因素。多因素Cox回归分析结果显示,手术时间长(OR=1.061,P=0.002)、常规护理方法(OR=2.822,P=0.020)是LC患者麻醉复苏期并发症的危险因素。结论需要层次理论指导下集束化护理用于LC患者,能够缩短其下床活动时间、排气时间、住院时间,改善负面情绪,减轻疼痛,对减少LC患者麻醉复苏期并发症的发生具有临床意义。

关键词：需要层次理论集束化护理腹腔镜胆囊切除术麻醉复苏期并发症

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Involvement of regulatory volume decrease in the migration of nasopharyn-geal carcinoma cells

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Cell Research 2005年第5期15卷 371-378页

作者： tim JACOB Cardiff School of Biosciences Cardiff University Biomedical Sciences Building Museum Avenue Cardiff CF10 3US UK

The transwell chamber migration assay and CCD digital camera imaging techniques were used to investigate the relationship between regulatory volume decrease (RVD) and cell migration in nasopharyngeal carcinoma cells (CNE-2Z cells). Both migrated and non-migrated CNE-2Z cells, when swollen by 47% hypotonic solution, exhibited RVD which was inhibited by extracellular application of chloride channel blockers adenosine 5’-triphosphate (ATP), 5-nitro-2-(3- phenylpropylamino) benzoic acid (NPPB) and tamoxifen. However, RVD rate in migrated CNE-2Z cells was bigger than that of non-migrated cells and the sensitivity of migrated cells to NPPB and tamoxifen was higher than that of non- migrated cells. ATP, NPPB and tamoxifen also inhibited migration of CNE-2Z cells. The inhibition of migration was positively correlated to the blockage of RVD, with a correlation coefficient (r) = 0.99, suggesting a functional relation- ship between RVD and cell migration. We conclude that RVD is involved in cell migration and RVD may play an important role in migratory process in CNE-2Z cells.

关键词： tumor cells chloride channel blockers cell volume cell migration transwell chamber.

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Fresh fruit consumption and diabetes: a prospective cohort study of 0.5 million adults in the China Kadoorie Biobank

Fresh fruit consumption and diabetes: a prospective cohort s...

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第十二届全国营养科学大会

作者： Huaidong Du Liming Li Derrick A.Bennett Yu Guo Zheng Bian Junshi chen tim Key Rory Collins Richard Peto Zhengming chen CTSU Nuffield Department of Population HealthUniversity of Oxford Chinese Academy of Medical Sciences School of Public Health Peking University

Background:Several studies in Western populations have observed that a higher consumption of fruit could help to prevent diabetes incidence,but no such beneficial effect has been reported from *** importantly,to date there is little direct evidence about the associations of fruit consumption with mortality and incidence of

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Emerging landscapes of nanosystems based on pre-metastatic microenvironment for cancer theranostics

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Chinese Chemical Letters 2022年第9期33卷 4157-4168页

作者： Yongchao Chu Tao Sun chen Jiang Key Laboratory of Smart Drug Delivery(Ministry of Education) Minhang HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceDepartment of PharmaceuticsSchool of PharmacyResearch Center on Aging and MedicineFudan UniversityShanghai 201203China

The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant *** pre-metastatic microenvironment,including the primary tumor-derived components,pre-metastatic niche(PMN),circulating tumor cells(CTCs),micro-metastases,and tumor immune microenvironment(tim),are the crucial factors to initiate metastasis and form *** may be a more promising strategy for directly targeting pre-metastatic microenvironment-interrelated factors and cells before they have the chance to form secondary tumors to prevent *** recent years,a variety of nanosystems,with specific microstructures and functional properties,have been devised to selectively target pre-metastatic cells components and interrelated molecular,and exhibited strong potential on anti-metastatic therapy by absorbing and neutralizing primary tumor-derived components,preventing establishment of the PMN,eliminating the CTCs,eradicating the micro-metastases and modulating the *** this review,we comprehensively review the emerging nanosystems based on the pre-metastatic ***,this review can cast new lights for early preventing and attenuating metastatic progression.

关键词： Circulating tumor cells Pre-metastatic niche Cancer metastasis Tumor immune microenvironment Micro-metastasis

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Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber

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Light(Science & Applications) 2016年第1期5卷 671-676页

作者： Rishi N Patel tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H chen Dirk R Englund Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology77 Massachusetts AveCambridgeMA 02139USA Department of Applied Physics Stanford University348 Via Pueblo MallStanfordCA 94305USA

A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum ***,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical *** this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica *** optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two ***,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 *** integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids.

关键词： diamond nanophotonics fiber optics nitrogen vacancy center quantum optics single photon source

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Dependence of the Relationship between the Tropical Cyclone Track and Western Pacific Subtropical High Intensity on Initial Storm Size: A Numerical Investigation

Dependence of the Relationship between the Tropical Cyclone ...

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第33届中国气象学会年会

作者： Yuan Sun Zhong Zhong Lan Yi tim Li Ming chen Hongchao Wan Yuxing Wang Kai Zhong International Laboratory on Climate and Environment Change and Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science and Technology College of Meteorology and Oceanography PLA University of Science and Technology IPRC/AORC and Department of Atmospheric Sciences University of Hawaii at Manoa Jiangsu Collaborative Innovation Center for Climate Change and School of Atmospheric Sciences Nanjing University National Climate Center and Chinese Academy of Meteorological Sciences National Center for Atmospheric Research

A suite of numerical experiments were conducted to investigate the sensitivity of the tropical cyclone（TC）motion-western Pacific subtropical high（WPSH）intensity relationship to initial storm *** TC cases,Songda（2004）and Megi（2010）,were *** was found that with the increase of initial storm size,the main body of the WPSH tends to withdraw eastward and the TC tends to turn northward *** involved physical mechanism was *** than the change of the beta effect due to storm size change,it is the change of the geopotential height in the TC outer region that is critical for the different TC tracks between the sensitivity *** to increase of the initial storm size,the inflow mass flux entering the TC region increases,leading to a significant decrease in 500-h Pa geopotential height in the TC outer region after 2-3-day *** a result,the simulated intensity of the WPSH over its fringe close to the TC decreases notably when the WPSH edge is within the TC outer *** a decrease leads to a break of ***,the TC turns northward towards the break of the subtropical *** further weakens the intensity of the WPSH over the region close to the *** result helps us better understand the relationship between the TC track and WPSH *** also indicates that a proper representation of initial storm size is important for realistic prediction of TC track and the change of the WPSH.

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time-dependent density functional theory for quantum transport

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Frontiers of physics 2014年第6期9卷 698-710页

作者： Yanho Kwok Yu Zhang GuanHua chen Department of Chemistry The University of Hong Kong Hong Kong China

The rapid miniaturization of elect, ronic devices motivates research interests in quantum *** time-dependent quantum transport has become an important research topic. Here we re- view recent progresses in the development of time-dependent density-functional theory for quantum transport including the theoretical foundation and numerical algorithms. In particular, the reducedsingle electron density matrix based hierarchical equation of motion, which can be derived from Liouville---von Neumann equation, is reviewed in details. The numerical implementation is discussed and simulation results of realistic devices will be given.

关键词： tim-dependent density functional theory (TDDFT) quantum transports nonequilibrium Green's function

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腺苷诱导耗竭型CD8^(+)T细胞影响肾癌细胞迁移及凋亡

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中国医学工程 2024年第7期32卷 15-23页

作者：陈明明刁建伟王俊霖李昊王黎姚启盛陈从波锦州医科大学辽宁锦州121000 湖北医药学院附属太和医院泌尿外科湖北十堰442000 朝阳市第二医院泌尿外科辽宁朝阳122000

目的探索腺苷是否诱导耗竭型T细胞生成以及对肾透明细胞癌细胞迁移和凋亡的影响。方法流式细胞术检测肾透明细胞癌及癌旁组织中CD8^(+)T细胞及耗竭表型分子3(tim-3)的表达。生物信息学分析肾透明细胞癌及癌旁组织中基因表达差异,寻找影... 详细信息

目的探索腺苷是否诱导耗竭型T细胞生成以及对肾透明细胞癌细胞迁移和凋亡的影响。方法流式细胞术检测肾透明细胞癌及癌旁组织中CD8^(+)T细胞及耗竭表型分子3(tim-3)的表达。生物信息学分析肾透明细胞癌及癌旁组织中基因表达差异,寻找影响T细胞耗竭基因。利用shRNA技术构建稳定敲除该基因的肾透明细胞癌786-O细胞株,检测细胞的迁移、凋亡等生物学行为。制备不同肿瘤条件培养基,培养CD8^(+)T细胞,研究敲除基因后的肾透明细胞癌细胞对耗竭型T细胞的影响。结果肾透明细胞癌与癌旁组织相比高表达CD8^(+)T细胞及tim-3。生物信息学分析发现腺苷合成限速酶NT5E(CD73)在肾透明细胞癌中的表达高于癌旁组织。检测临床标本发现肾透明细胞癌组织中腺苷及CD73的表达高于癌旁组织。与对照组比较,敲除NT5E组的786-O细胞迁移能力下降及凋亡增加。敲除NT5E的肿瘤条件培养基培养的CD8^(+)T细胞中程序性死亡蛋白1表达减少,抑制T细胞增殖能力下降。结论肾透明细胞癌组织存在耗竭型CD8^(+)T细胞、腺苷及CD73的高表达。敲除NT5E的肾透明细胞癌786-O细胞迁移能力下降、凋亡增加。敲除NT5E可减少腺苷合成,减少耗竭型T细胞的生成。

关键词：肾透明细胞癌腺苷耗竭型CD8^(+)T细胞 NT5E(CD73) CD8^(+)T细胞肿瘤微环境

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内脏脂肪指数对瘦型人群中非酒精性脂肪性肝病的预测价值:一项横断面研究

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西安交通大学学报（医学版） 2024年第5期45卷 776-781页

作者：马维冬巩红肖静高希羽张岩张春艳陈方尧韩拓西安交通大学第二附属医院心血管内科陕西西安710004 西安交通大学第二附属医院健康管理部陕西西安710004 西安交通大学医学部公共卫生学院流行病与卫生统计学系陕西西安710061

目的探究内脏脂肪指数(visceral adiposity index,VAI)与瘦型人群中非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的相关性及其预测价值。方法随机纳入2020年6月-2021年5月西安交通大学第二附属医院2576名健康体检者,身... 详细信息

目的探究内脏脂肪指数(visceral adiposity index,VAI)与瘦型人群中非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的相关性及其预测价值。方法随机纳入2020年6月-2021年5月西安交通大学第二附属医院2576名健康体检者,身体质量指数(BMI)正常(即<24 kg/m^(2)),分为瘦型NAFLD组(n=213)与健康对照组(n=2363),根据VAI四分位数由低到高分为Q 1~Q 4组,比较组间生化指标差异与NAFLD患病情况。采用限制性立方样条分析VAI与瘦型NAFLD之间关系,Logistic回归与受试者工作特征(ROC)曲线探究VAI对瘦型NAFLD的预测价值。结果共纳入2576名体检者,瘦型NAFLD患病率为8.3%(213例)。Q 1~Q 4组平均年龄、男性占比、BMI与腰围(waist circumference,WC)显著增加,且呈明显剂量反应关系(均P<0.001)。与Q 1组相比,Q 2~Q 4组收缩压、舒张压、白细胞计数、血红蛋白浓度、谷丙转氨酶、谷草转氨酶、γ氨基转肽酶、碱性磷酸酶、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血尿酸与空腹血糖水平均明显增加,直接胆红素与高密度脂蛋白胆固醇水平则逐渐降低,组间差异均具有统计学意义(P<0.001)。Q 1~Q 4组NAFLD的患病率分别为0.6%、3.3%、7.0%、22.2%,呈显著递增(P<0.001)。限制性立方样条图显示随着VAI增加,瘦型人群中NAFLD的患病风险显著增加(P<0.001),两者之间存在非线性关系(P for nonlinear<0.001)。Logistic回归结果显示,在调整各混杂因素后,Q 2、Q 3、Q 4组瘦型NAFLD的患病风险仍分别为Q 1组的2.926倍(95%CI:0.971~8.811)、3.435倍(95%CI:1.154~10.230)与5.920倍(95%CI:1.873~18.719)。ROC曲线显示,VAI对于瘦型NAFLD具有较好的预测价值,曲线下面积为0.815,临界值为1.532,诊断敏感性为77.9%,特异性为72.8%,均优于BMI与WC。结论瘦型体检人群中VAI升高与NAFLD发病风险显著相关,具有良好预测价值,可用于瘦型NAFLD早期筛查与诊断。

关键词：非酒精性脂肪性肝病(NAFLD) 瘦型人群内脏脂肪指数(VAI) 胰岛素抵抗

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