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东亚大槽和西伯利亚高压的季节内变率对冬季东亚气温的影响

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大气科学学报 2024年第2期47卷 184-200页

作者：李天明丁柳丹南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际联合实验室/气象灾害预报预警与评估协同创新中心江苏南京210044 夏威夷大学马诺阿分校大气科学系夏威夷檀香山96822

基于气候态定义了西伯利亚高压指数(SH index)、东亚大槽指数(ET index)和高低压系统间的东亚经向风指数(V index),使用回归分析探究西伯利亚高压和东亚大槽在季节内尺度上对东亚地区冬季温度的影响机理,构建线性模型对冬季华南地区季... 详细信息

基于气候态定义了西伯利亚高压指数(SH index)、东亚大槽指数(ET index)和高低压系统间的东亚经向风指数(V index),使用回归分析探究西伯利亚高压和东亚大槽在季节内尺度上对东亚地区冬季温度的影响机理,构建线性模型对冬季华南地区季节内尺度温度进行延伸期预报。结果表明:西伯利亚高压和东亚大槽系统变化中最显著的是季节内尺度信号;季节内尺度SH index和ET index对V index的贡献分别为82.6%和42.2%;3个指数的回归模态在对流层中层对应西北-东南向低频罗斯贝波列缓慢东南传播,低层水汽、近地面层环流、降水及2 m温度场配置良好,当西伯利亚高压深厚或东亚大槽发展时,经向风关键区北风强盛,有利于冬季高纬度地区干冷空气向东亚输送;V index对华南地区冬季季节内尺度2 m气温的有效预报时效达25 d。

关键词：西伯利亚高压东亚大槽季节内尺度变率冬季东亚气温延伸期预报

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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets tim Vanmierlo Rudy Schreiber BIOmEd Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&d ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Intraoperative application of three-dimensional printed guides in total hip arthroplasty: A systematic review

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World Journal of Orthopedics 2024年第7期15卷 660-667页

作者： tim P Crone Bart m W Cornelissen Jakob Van Oldenrijk Pieter Koen Bos Ewout S Veltman department of Orthopedic Surgery and Sports medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands department of Oral and maxillofacial Surgery Erasmus Medical CenterRotterdam 3015 GDNetherlands

BACKGROUNd Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of *** majority of acetabular components are aligned freehand,without the use of navigation *** specific instruments(PSI)and three-dimensional(3d)printing of THA placement guides are increasingly used in primary THA to ensure optimal *** To summarize the literature on 3d printing in THA and how they improve acetabular component *** Pubmed was used to identify and access scientific studies reporting on different 3d printing methods used in *** studies with 236 hips in 228 patients were *** studies could be divided into two main categories;3d printed models and 3d printed *** 3d printing in THA helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to *** overarching consensus between the studies is that the use of 3d guidance tools can assist in improving THA cup positioning and reduce the need for revision THA and the associated *** The implementation of 3d printing and PSI for primary THA can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.

关键词： Total hip arthroplasty Three-dimensional printing Hip replacement surgery Three-dimensional planning Surgical guides

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.marshall david Hancock tim Wallis Julian downward Rob m.Ewing donna E.davies mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EmT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EmT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3d co-cultures of ATIl cells and mRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EmT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EmT LKB1 Pulmonary fibrosis

detection of TmPRSS2：ERG fusion gene in circulating prostate cancer cells

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Asian Journal of Andrology 2008年第3期10卷 467-473页

作者： Xueying mao Greg Shaw sharon Y. James Patricia Purkis Sakunthala C. Kudahetti Theodora Tsigani Saname Kia Bryan d. Young R. tim d. Oliver dan Berney david m. Prowse Yong-Jie Lu medical Oncology University of London Charterhouse SquareLondon EC1M 6BQ UK molecular Oncology Centres Institute of Cancer University of London Charterhouse SquareLondon EC1M 6BQ UK department of Histopathology and morbid Anatomy Barts and London School of Medicine and Dentistry Queen Mary University of London Charterhouse SquareLondon EC1M 6BQ UK

Aim： To investigate the existence of TmPRSS2：ERG fusion gene in circulating tumor cells （CTC） from prostate cancer patients and its potential in monitoring tumor metastasis. methods- We analyzed the frequency of TmPRSS2： ERG and TmPRSS2：ETV1 transcripts in 27 prostate cancer biopsies from prostatectomies, and TmPRSS2：ERG transcripts in CTC isolated from 15 patients with advanced androgen independent disease using reverse transcription polymerase chain reaction （RT-PCR）. Fluorescence in situ hybridization （FISH） was applied to analyze the genomic truncation of ERG, which is the result of TmPRSS2：ERG fusion in 10 of the 15 CTC samples. Results： TmPRSS2： ERG transcripts were found in 44% of our samples, but we did not detect expression of TmPRSS2：ETV1. Using FISH analysis we detected chromosomal rearrangements affecting the ERG gene in 6 of 10 CTC samples, including 1 case with associated TmPRSS2：ERG fusion at the primary site. However, TmPRSS2：ERG transcripts were not detected in any of the 15 CTC samples, including the 10 cases analyzed by FISH. Conclusion： Although further study is required to address the association between TmPRSS2：ERG fusion and prostate cancer metastasis, detection of genomic truncation of the ERG gene by FISH analysis could be useful for monitoring the appearance of CTC and the potential for prostate cancer metastasis.

关键词： TmPRSS2:ERG fusion gene prostate cancer metastasis circulating tumor cells fluorescence in situ hybridization polymerase chain reaction

Reappraising the P-T evolution of the Rogaland-Vest Agder Sector,southwestern Norway

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Geoscience Frontiers 2017年第1期8卷 1-14页

作者： Eleanore Blereau tim E.Johnson Chris Clark richard J.m.Taylor Peter d.Kinny martin Hand department of Applied Geology The Institute for Geoscience Research(TIGeR)Curtin University Centre for Tectonics Resources and Exploration(TRaX)School of Earth and Environmental SciencesUniversity of Adelaide

The Rogaland-Vest Agder Sector of southwestern Norway comprises high-grade metamorphic rocks intruded by voluminous plutonic bodies that include the ~1000 km^2 Rogaland Igneous Complex（RIC）.New petrographic observations and thermodynamic phase equilibria modelling of three metapelitic samples collected at various distances（30 km,10 km and ~ 10 m） from one of the main bodies of RIC anorthosite were undertaken to assess two alternative P-T-t models for the metamorphic evolution of the *** results are consistent with a revised two-phase *** metamorphism followed a clockwise P-T path reaching peak conditions of ~ 850-950 ℃ and ~7-8 kbar at ~1035 ma followed by high-temperature decompression to ~5 kbar at ~950 ma,and resulted in extensive anatexis and melt loss to produce highly residual *** emplacement of the RIC at ~930 ma caused regional-scale contact metamorphism that affected country rocks 10 km or more from their contact with the *** thermal overprint is expressed in the sample proximal to the anorthosite by replacement of sillimanite by coarse intergrowths of cordierite plus spinel and growth of a second generation of garnet,and in the intermediate（10 km） sample by replacement of sapphirine by coarse intergrowths of cordierite,spinel and *** formation of late biotite in the intermediate sample may suggest the rocks retained small quantities of melt produced by regional metamorphism and remained at temperatures above the solidus for up to 100 *** results are more consistent with an accretionary rather than a collisional model for the Sveconorwegian Orogen.

关键词： UHTPhase equilibria modellingRogaland Igneous ComplexTHERmOCALCSveconorwegian Orogen

development of a CO_2 Tolerant Fischer-Tropsch Catalyst:from Laboratory to Commercial-Sca1e demonstration in Alaska

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Journal of Natural Gas Chemistry 2004年第1期13卷 1-9页

作者： Joep J H m Font Freide tim d Gamlin J richard Hensman Barry Nay Christopher Sharp BP Exploration Operating Company Chertsey RoadSunbury on ThamesMiddlesexTWl6 7LNEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEngland

This article describes the development of BP's Fischer-Tropsch catalyst, used for the conversion of carbon monoxide and hydrogen into liquid hydrocarbons. It covers the 18 year period from the early eighties, when laboratory scale preparations and micro-reactors were heavily used, right through to the present day with the commercial scale manufacture and proving of the finished catalyst in BP's new ＄86 million gas to liquids demonstration facility in Nikiski, Alaska. Extensive performance testing and scale-up experiments have been successfully carried out, all proof that a laboratory preparation can indeed be translated into a commercial manufacturing process. In addition, the resulting catalyst does not only meet the process design targets, but also exhibits enhanced stability and is tolerant to carbon dioxide. Above all, a commercial scale, fixed bed Fischer-Tropsch catalyst is now available and ready for licensing. manufacturing procedures and quality control have all been successfully detailed and transferred to the commercial manufacturer.

关键词： carbon dioxide Fisher-Tropsch development syngas commercial catalyst

mJO与北半球高纬地区冬季地表气温异常的联系

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气象 2021年第1期47卷 49-59页

作者：崔静杨双艳 LI tim 南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心南京210044 夏威夷大学国际太平洋研究中心美国夏威夷

基于1979—2016年NCEP-NCAR逐日再分析资料研究了热带季节内振荡(mJO)和北半球冬季高纬地区地表气温(SAT)之间的联系。利用实时多变量mJO(Rmm)指数,将mJO分为8个位相,其中位相2(位相6)对应于位于印度洋地区的正(负)对流。不同mJO位相下... 详细信息

基于1979—2016年NCEP-NCAR逐日再分析资料研究了热带季节内振荡(mJO)和北半球冬季高纬地区地表气温(SAT)之间的联系。利用实时多变量mJO(Rmm)指数,将mJO分为8个位相,其中位相2(位相6)对应于位于印度洋地区的正(负)对流。不同mJO位相下的SAT合成结果显示mJO第二位相后的5~15 d,北半球高纬地区(60°~90°N、180°~60°W)有明显的负SAT异常;由于热带异常加热信号的改变,在mJO第六位相后的5~15 d该地区则对应于显著的正SAT异常。该地区温度的垂直结构在各个位相下也表现出类似的分布特征。合成的500 hPa位势高度异常场显示,在温度负(正)异常的位相对应有明显的位势高度负(正)异常,这种环流异常主要是由与热带对流异常相联系的向东北方向传播的罗斯贝波列所引起的。通过对波活动通量的计算,推断该东北方向传播的罗斯贝波列很可能是罗斯贝波能量频散的结果。合成的700 hPa比湿异常场和SAT之间在存在着较好的对应关系,考虑到对流层中层的比湿与向下长波辐射之间存在着正相关关系,说明该温度异常也可能与辐射过程相关。上述分析表明与mJO对流相关的大尺度环流异常对高纬地区季节内SAT变率有重要影响,该异常SAT信号可能来自平流输送和辐射过程等。准确把握mJO位相与SAT异常信号的联系也可以为北半球高纬地区SAT的延伸期预报提供一些可靠线索。

关键词： mJO 地表气温罗斯贝波列波活动通量

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交直流系统发电机故障电压稳定评估快速算法

电力系统保护与控制 2010年第16期38卷 35-38,43页

作者：赵周芳李华强叶晓峻张希猛四川大学电气信息学院四川成都610065

高压直流输电给电力系统电压稳定的研究带来了新的挑战,适合于在线电压稳定评估的快速算法的开发显得尤为重要。针对发电机故障情况下采用线性灵敏度快速算法进行交直流系统电压稳定评估。在直流系统典型控制方式下,应用内点法求取故障... 详细信息

高压直流输电给电力系统电压稳定的研究带来了新的挑战,适合于在线电压稳定评估的快速算法的开发显得尤为重要。针对发电机故障情况下采用线性灵敏度快速算法进行交直流系统电压稳定评估。在直流系统典型控制方式下,应用内点法求取故障前崩溃点处的负荷裕度,在崩溃点处将潮流方程线性化,快速求取除平衡节点发电机以外所有可能发电机故障情况时的负荷裕度。通过对IEEE30节点系统进行仿真证明该算法的可行性。

关键词：交直流系统发电机故障线性灵敏度负荷裕度内点法