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北京PM_(10)中矿物颗粒的微观形貌及粒度分布

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环境科学学报 2005年第7期25卷 863-869页

作者：吕森林邵龙义 timj.nes 吴明红焦正上海大学环境与化学工程学院射线应用研究所上海218000 中国矿业大学(北京)资源与地球科学系北京100083 Department of Earth Ocean and Planetary SciencesCardiff UniversityCardiffCF103YEUK.

使用高分辨率环境扫描电镜和图像分析技术对北京PM10中矿物颗粒的微观形貌和粒度分布特征进行了研究.结果表明,北京PM10中的矿物颗粒按其形貌、组成特点可以分为单矿物和矿物集合体2类;矿物颗粒多以不规则的形态出现;形态规则的矿物主... 详细信息

使用高分辨率环境扫描电镜和图像分析技术对北京PM10中矿物颗粒的微观形貌和粒度分布特征进行了研究.结果表明,北京PM10中的矿物颗粒按其形貌、组成特点可以分为单矿物和矿物集合体2类;矿物颗粒多以不规则的形态出现;形态规则的矿物主要是硫酸盐类矿物,是大气化学反应的产物,形态不规则的矿物是来自扬尘的原生矿物.不同类型污染产生的PM10中矿物颗粒的粒度分布特征表现不同,在沙尘暴样品和道路扬尘样品中矿物颗粒的粒度峰值在1～2.5μm;在局地扬尘的样品中,矿物颗粒的粒度较粗,主要分布在1～2.5μm和2.5～10μm.

关键词：矿物颗粒微观形貌粒度分布可吸入颗粒物(PM10)

图雷特综合征患儿成年期的抽搐和强制性障碍症状严重程度的转归

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 25-26页

作者： Bl.ch M.H. Peterson B.S. Scahil. l. j.F. l.ckman 朱新菊 Chil. Study Center Yale University School of Medicine PO Box 207900 New Haven CT 06520-790 0 United States.Dr

Background: Tourette syndrome (TS) is a chil.hood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One hal. to two thirds of chil.ren with TS experience a reduction or compl.te resol.tion of tic sympto ms during adol.scence. At l.ast one third of adul.s with TS have comorbid obsess ive-compul.ive disorder (OCD). Obj.ctives: To cl.rify the cl.nical.course of ti c and OCD symptoms in chil.ren with TS and determine if basel.ne cl.nical.measurements in chil.hood are associated with future symptom severity in l.te adol.sce nce and earl. adul.hood. Design: Prospective cohort study. Setting: Yal. Chil. Study Center tic and OCD outpatient special.y cl.nic. Participants: Forty-six chil.ren with TS who received a structured cl.nical.eval.ation prior to age 14 years. Main Outcome Measures: Expert-rated tic and OCD symptom sever ity at fol.ow-up interview an average of 7.6 years l.ter (range, 3.8-12.8 year s). Resul.s: Eighty-five percent of subj.cts reported a reduction in tic sympto ms during adol.scence. Onl. increased tic severity in chil.hood was associated w ith increased tic severity at fol.ow-up. The average age at worst-ever tic sev erity was 10.6 years. Forty-one percent of patients with TS reported at one tim e experiencing at l.ast moderate OCD symptoms. Worst-ever OCD symptoms occurred approximatel. 2 years l.ter than worst-ever tic symptoms. Increased chil.hood IQ was strongl. associated with increased OCD severity at fol.owup. Concl.sion: Obsessive-compul.ive disorder symptoms in chil.ren with TS became more severe a t a l.ter age and were more l.kel. to persist than tic symptoms.

关键词：症状严重程度图雷特综合征成年期抽搐患儿强制性转归障碍神经精神疾病完全缓解

DPHl.A DIA Pan-human Protein Mass Spectrometry l.brary for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham tim Schel.horst Richard R.G.D.Haas Irene V.Bij.sdorp Rui Sun l.ang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan j.Van Houdt Tessa Y.S.l. l.rge j.cquel.ne Cl.os Anna Woj.uszkiewicz Danij.l. Koppers-l.l.c Franziska Bottger Chantal.Scheepbouwer Ruud H.Brakenhoff Geert j.l.H.van l.enders j.n N.M.Ij.ermans j.hn W.M.Martens Renske D.M.Steenbergen Nicol. C.Grieken Sathiyamoorthy Sel.araj.n Sangeeta Mantoo Sze S.l.e Serene j.Y.Yeow Syed M.F.Al.aff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei l.u Tian l. Zhicheng Wu Xiao l.ang Man Wang Yingkuan Shao Xi Zheng Kail.n Xu Qin Yang Yifan Meng Cong l. j.ang Zhu j.n'e Zheng Bo Wang Sai l.u Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.l.m j.anmin Wu Xiaofei Gao Zhongzhi l.an Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry l.m Ding Ma j.afu j. Oi l.Kon Shu Zheng Ruedi Aebersol. Connie R.j.menez Tiannan Guo Zhej.ang Provincial.l.boratory of l.fe Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key l.boratory of Structural.Biol.gy of Zhej.ang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical.Sciences Westlake Institute for Advanced StudyHangzhou 310024China School.of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics l.boratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherl.nds Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical.Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical.Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical.Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical.Pathol.gy Singapore General HospitalSingapore 169608Singapore Division of Medical.Scie

To address the increasing need for detecting and val.dating protein biomarkers in cl.nical.specimens,mass spectrometry(MS)-based targeted proteomic techniques,incl.ding the sel.cted reaction monitoring(SRM),paral.el.reaction monitoring(PRM),and massivel. paral.el.dataindependent acquisition(DIA),have been *** optimal.performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipel.ne and spectral.resource to support targeted proteomics studies for human tissue *** buil. the spectral.resource,we integrated common open-source MS computational.tool. to assembl. a freel. accessibl. computational.workfl.w based on *** then appl.ed the workfl.w to generate DPHl.a comprehensive DIA pan-human l.brary,from 1096 data-dependent acquisition(DDA)MS raw fil.s for 16 types of cancer *** extensive spectral.resource was then appl.ed to a proteomic study of 17 prostate cancer(PCa)***,PRM val.dation was appl.ed to a l.rger study of 57 PCa patients and the differential.expression of three proteins in prostate tumor was *** a second appl.cation,the DPHl.spectral.resource was appl.ed to a study consisting of pl.sma sampl.s from 19 diffuse l.rge B cel. l.mphoma(Dl.Cl.patients and 18 heal.hy control.*** expressed proteins between Dl.Cl.patients and heal.hy control.subj.cts were detected by DIA-MS and confirmed by *** data demonstrate that the DPHl.supports DIA and PRM MS pipel.nes for robust protein biomarker *** is freel. accessibl. at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Paral.el.reaction monitoring Spectral.l.brary Prostate cancer Diffuse l.rge B cel. l.mphoma

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顺铂激活的低分化鼻咽癌细胞氯电流

中国病理生理杂志 2009年第4期25卷 666-669页

作者：阳小雅王立伟朱林燕杨林杰毛建文 tim j.cob 陈丽新暨南大学医学院生理学教研室广东广州510632 广州医学院护理学院广东广州510182 暨南大学医学院药理学教研室广东广州510632 广东药学院基础医学研究所广东广州510006 Cardiff School.of Biosciences Cardiff University

目的:研究抗癌药顺铂对低分化鼻咽癌细胞(CNE-2Z)氯通道的激活作用以及该电流的特性。方法:采用膜片钳技术记录顺铂激活的CNE-2Z细胞全细胞电流;离子置换法等方法分析通道的特性。结果:细胞外灌流5μmol.l.顺铂诱发CNE-2Z细胞产生一个... 详细信息

目的:研究抗癌药顺铂对低分化鼻咽癌细胞(CNE-2Z)氯通道的激活作用以及该电流的特性。方法:采用膜片钳技术记录顺铂激活的CNE-2Z细胞全细胞电流;离子置换法等方法分析通道的特性。结果:细胞外灌流5μmol.l.顺铂诱发CNE-2Z细胞产生一个有明显外向优势的电流,电流的翻转电位为(-6.69±0.51)mV,接近氯离子平衡电位(-0.9 mV)。该电流的激活依赖于细胞内ATP。顺铂激活的细胞膜氯通道对阴离子的通透性顺序为:I-≥Br->Cl.>gl.conate。氯通道阻断剂tamoxifen完全抑制该电流。结论:抗癌药顺铂可以激活一个电流特征与容积激活性氯通道相似的氯通道。

关键词：顺铂鼻咽肿瘤细胞凋亡氯化物通道

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甘蔗QTl.位与标记辅助选择的初步研究

甘蔗糖业 2001年第1期30卷 1-12页

作者：邓海华 K.K.Wu tim Wensl.ff 广州甘蔗糖业研究所广州510316 Hawaii Agricul.ure Eesearch Center.99-193 Aiea Heights Drive

利用ＬａＰｕｒｐｌｅ（Ｓ．ｏｆｆｉｃｉｎａｒｕｍＬ．）ＸＭｏｌ５８２９（Ｓ．ｒｏｂｕｓｔｕｍＢｒａｎｄｓａｎｄＪｅｓｗｉｅｔｅｘＧｒａｓｓｅｌ）杂交一代群体获得的ＲＦＬＰ和ＲＡＰＤ分子标记信息，用区间定位法... 详细信息

利用ＬａＰｕｒｐｌｅ（Ｓ．ｏｆｆｉｃｉｎａｒｕｍＬ．）ＸＭｏｌ５８２９（Ｓ．ｒｏｂｕｓｔｕｍＢｒａｎｄｓａｎｄＪｅｓｗｉｅｔｅｘＧｒａｓｓｅｌ）杂交一代群体获得的ＲＦＬＰ和ＲＡＰＤ分子标记信息，用区间定位法（ｉｎｔｅｒｖａｌｍａｐｐｉｎｇ）和单标记分析（ｐｏｉｎｔａｎａｌｙｓｉｓ）法测定控制转光度（％）、小区蔗茎产量、纤维分（％）和抽穗茎率的ＱＴＬ。选用与转光度和茎产量显著关联（Ｆ测验Ｐ＜０．０１或区间定位中ＬＯＤ＞２）的分子标记进一步对标记辅助选择的效果进行分析。对任一性状而言，与之显著关联的标记都含有正效应的和负效应的两类标记。由于单标记分析法可测定出未被归类到连锁群、但与ＱＴＬ有关联的标记，故其可测定到的显著性标记要比区间定位法的多。分析结果表明，控制转光度和茎产量的ＱＴＬ分散于多个连锁群中，而控制抽穗茎率的ＱＴＬ相对集中于较少的连锁群中。在利用分子标记进行性状选择时，增加用于辅助选择的标记数目将使入选群体的性状平均值增大，而使误选低值个体的可能性减小。在多标记辅助选择时，各个标记都选用正效应的状态（标记出现或缺失）所得到的标记组合将可选得性状平均值最大的入选群体。

关键词：甘蔗 QTl.位标记辅助选择区间定位单标记分析育种

Human cl.tting factor Ⅸ (hF Ⅸ ) secretion in goat mil. after direct transfer with hF Ⅸ minigene into mammary gl.nd by using retroviral.vectors

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Chinese Science Bul.etin 1997年第15期42卷 1308-1313页

作者： ZHANG Kezhong, WANG Hongwei, BAO Yun, l. Daru,XUE j.ngl.n (j. l. Hsueh), QIU Xinfang, HUANG Shuzhen,HUANG Ying, l. Bingyan, l. Hua and ZENG Yitao1. Institute of Genetics, Fudan University, Shanghai 200433, China 2 Shanghai Chil.ren’s Hospital. Shanghai Institute of Medical.Genetics, Shanghai 200040, China

THE mammary gl.nd bioreactor system of l.ctating animal. establ.shed by germ-l.nemicroinj.ction and embryo transpl.ntation, has been one of the most exciting proj.cts in thefiel. of biotechnol.gy. However, this system is costl., l.borious and tim-cosuming. In 1994,j.hanna et al. reported that secretion of a foreign protein, human growth hormone (hGH),in mil. had been achieved after direct introduction of the cDNA into the mammary gl.nd ofgoats by repl.cation-defective retroviral.vector. In that work, the in vivo expression of

关键词： mammary-specific expression human cl.tting factor Ⅸ (hF Ⅸ) retroviral vectors.

Cl.-在鼻咽癌细胞调节性容积回缩中的作用

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中国病理生理杂志 2002年第5期18卷 490-493页

作者：陈丽新王立伟朱林燕聂思槐张谨钟平罗海兵蔡波李攀 tim j.cob 广东医学院细胞生物学研究室广东湛江524023 Cardiff School.of Biosciences Cardiff University.Cardiff.UK 广东医学院生理学教研室广东湛江524023 Cardiff School.of Biosciences Cardiff University

目的 :研究鼻咽癌细胞的调节性容积回缩 (RVD)及Cl.在其中所起的作用。方法 :活细胞图像分析低分化鼻咽癌细胞 (CNE - 2Z)在细胞外低渗刺激时的细胞容积改变 ,用离子置换法和通道阻断法阐明Cl.在RVD中所起的作用。结果 :细胞外低渗刺激... 详细信息

目的 :研究鼻咽癌细胞的调节性容积回缩 (RVD)及Cl.在其中所起的作用。方法 :活细胞图像分析低分化鼻咽癌细胞 (CNE - 2Z)在细胞外低渗刺激时的细胞容积改变 ,用离子置换法和通道阻断法阐明Cl.在RVD中所起的作用。结果 :细胞外低渗刺激使细胞膨胀并诱发RVD。在 16 0 - 2 30mOsmol.l.围内 ,RVD与细胞膨胀程度正相关。用葡萄糖酸取代灌流液Cl.时RVD增强 ,细胞内Cl.耗竭时RVD消失。氯通道阻断剂阻抑RVD ,但不同的阻断剂对RVD的阻抑率有明显差异。结论 :Cl.是CNE - 2Z细胞RVD的关键离子 ,Cl.通道激活 ,Cl.外流是RVD的主要机制。

关键词：调节性容积回缩 RVD 肿瘤细胞培养氯离子通道鼻咽肿瘤

Water treatment and recl.mation by impl.menting el.ctrochemical.systems with constructed wetl.nds

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Environmental.Science and Ecotechnol.gy 2023年第4期16卷 88-105页

作者： Suanny Mosquera-Romero El.ftheria Ntagia Diederik P.l.Rousseau Abraham Esteve-Nú~nez Antonin Prevoteau Center for Microbial.Ecol.gy and Technol.gy(CMET) Ghent UniversityCoupure Links 653B-9000GhentBelgium ESPOl.Pol.technic University Escuela Superior Politécnica del LitoralESPOLFacultad de Ciencias Naturales y MatemáticasBOX9050Ecuador Department of Green Chemistry and Technol.gy Ghent UniversitySint-Martens-Latemlaan 2BB-8500KortrijkBelgium Centre for Advanced Process Technol.gy for Urban Resource Recovery(CAPTURE) Frieda Saeysstraat 19000GhentBelgium UniversitéParis-Sacl.y INRAEPROSE92160AntonyFrance Universidad de Al.al. Department of Analytical ChemistryPhysical Chemistry and Chemical EngineeringAlcaláde HenaresSpain

Seasonal.or permanent water scarcity in off-grid communities can be al.eviated by recycl.ng water in decentral.zed wastewater treatment ***-based sol.tions,such as constructed wetl.nds(CWs),have become popul.r sol.tions for sanitation in remote *** typical.CWs can efficientl. remove sol.ds and organics to meet water reuse standards,pol.shing remains necessary for other parameters,such as pathogens,nutrients,and recal.itrant *** CW designs and CWs coupl.d with el.ctrochemical.technol.gies have been proposed to improve treatment *** systems(ECs)have been either impl.mented within the CW bed(ECin-CW)or as a stage in a sequential.treatment(CW+EC).A l.rge body of l.terature has focused on ECin-CW,and mul.ipl. scal.d-up systems have recentl. been successful.y impl.mented,primaril. to remove recal.itrant ***,onl. a few reports have expl.red the opportunity to pol.sh CW effl.ents in a downstream el.ctrochemical.modul. for the el.ctro-oxidation of micropol.utants or el.ctro-disinfection of pathogens to meet more stringent water reuse *** paper aims to critical.y review the opportunities,chal.enges,and future research directions of the different coupl.ngs of CW with EC as a decentral.zed technol.gy for water treatment and recovery.

关键词： Sanitation and reuse Disinfection Advanced oxidation Decentral.zed systems El.ctrification

美国2007年农业法案对发展中国家的启示(上)

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WTO经济导刊 2008年第4期 12-14页

作者：迪姆·卓斯林（tim j.sl.ng）丹尼尔A．塞莫尔（Daniel.A．Sumner）罗伯特l.汤普森（Robert l.Thompson）玛丽·查普里斯（Mary Chambl.ss）卡拉·兰尼（Kara l.ney）王晓宇（翻译）刘健男（校译）斯坦福大学弗里曼·斯波格里国际研究学会资深会员加利福尼亚大学农业问题中心主任伊利诺依大学香槟分校农业政策教授国际食品援助问题方面的独立咨询人国际食品与农业贸易政策委员会的政策助理商务部世贸司

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价... 详细信息

近年来，经合组织（OECD）国家对农业实行大量补贴，而发展中国家的农民却面临困难，这两者之间的联系已经成为人们关注的焦点。毫无疑问，经合组织国家的农业计划对世界市场的结构产生了巨大的影响，对贸易量、贸易流向及国际农产品价格都产生了影响。世界银行的一份评估认为，它对不同产品的国际价格的影响在10到50％之间不等（见表1）。与此同样重要的一个启示是：许多经合组织国家的农业政策旨在保护他们的农业部门不受外国竞争，甚至在鼓励其他国家开放农产品市场时也是如此。

关键词：发展中国家农业法案经合组织国家农产品价格美国国际价格农产品市场世界市场