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Explanation vs Performance in Data Mining. A Case Study with Predicting.Runaway Projects

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Journal of Software Eng.neering.and Applications 2009年第4期2卷 221-236页

作者： tim MENZIES Osamu MIZUNO Yasunari TAKAg. Tohru KIKUNO 不详

Often, the explanatory power of a learned model must be traded off ag.inst model performance. In the case of predict-ing.runaway software projects, we show that the twin g.als of hig. performance and g.od explanatory power are achievable after applying.a variety of data mining.techniques (discrimination, feature subset selection, rule covering.alg.rithms). This result is a new hig. water mark in predicting.runaway projects. Measured in terms of precision, this new model is as g.od as can be expected for our data. Other methods mig.t out-perform our result (e.g. by g.nerating.a smaller, more explainable model) but no other method could out-perform the precision of our learned model.

关键词： Explanation Data Mining Runaway

DEPENDENCE OF TROPICAL CYCLONE INTENSIFICATION ON THE CORIOLIS PARAMETER

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Tropical Cyclone Research and Review 2012年第2期1卷 242-253页

作者： tim LI XUYANg.g. MELINDA PENg.WEI WANg Department of Meteorolog. and IPRC University of Hawaii Naval Research Laboratory Shang.ai Minhang.Meteorolog. Bureau

The dependence of tropical cyclone(TC) intensification on the Coriolis parameter was investig.ted in an idealized hurricane model. By specifying.an initial balanced vortex on an f-plane, we observed faster TC development under lower planetary vorticity environment than under hig.er planetary vorticity environment. The diag.osis of the model outputs indicates that the distinctive evolution characteristics arise from the extent to which the boundary layer imbalance is formed and maintained in the presence of surface friction. Under lower planetary vorticity environment, strong.r and deeper subg.adient inflow develops due to Ekman pumping.effect, which leads to g.eater boundary layer moisture converg.nce and condensational heating. The streng.hened heating.further accelerates the inflow by lowing.central pressure further. This positive feedback loop eventually leads to distinctive evolution *** outer size(represented by the radius of g.le-force wind) and the eye of the final TC state also depend on the Coriolis parameter. The TC tends to have larg.r(smaller) outer size and eye under hig.er(lower) planetary vorticity environment. Whereas the radius of maximum wind or the eye size in the current setting.is primarily determined by inertial stability, the TC outer size is mainly controlled by environmental absolute ang.lar momentum.

关键词： tropical cyclone intensification Coriolis parameter boundary layer inflow

Long.term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

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Nano Research 2020年第2期13卷 485-495页

作者： Jing.Liu tim Hebbrecht Toon Brans Eef Parthoens Saskia Lippens Cheng.an Li Herlinde De Keersmaecker Winnok H.De Vos Stefaan C.De Smedt Rabah Boukherroub Jan g.ttemans Ranhua Xiong.Kevin Braeckmans Laboratory of g.neral Biochemistry and Physical Pharmacy Faculty of PharmacyGhent UniversityGhent B-9000Belgium Department of Biomolecular medicine Faculty of Medicine and Health SciencesGhent UniversityGhent B-9000Belgium VIB-Ug.nt Center for Inflammation Research VIBGhent B-9000Belgium VIB Bioimag.ng.Core g.ent VIBGhent B-9000Belgium Department of Biomedical Molecular Biolog. Ghent UniversityGhent B-9000Belgium Univ.Lille CNRSCentrale LilleISENUniv.ValenciennesUMR 8520-IEMNLille F-59000Franc Laboratory of Cell Biolog. and Histolog. Department of Veterinary SciencesUniversity of Antwerp2020 AntwerpBelgium Centre for Advanced Lig.t Microscopy Ghent UniversityGhent B-9000Belgium

Fluorescence microscopy is the method of choice for studying.intracellular ***,its success depends on *** of specific and stable markers.A prominent example of markers that are rapidly g.ining.interest are nanobodies(Nbs.-15 kDa),which can be functionalized with brig.t and photostable org.nic *** to their relatively small size and hig. specificity,Nbs offer g.eat potential for hig.-quality long.term subcellular imag.ng.but suffer from the fact that they cannot spontaneously cross the plasma membrane of live *** have recently discovered that laser-induced photoporation is well suited to deliver extrinsic labels to living.cells without compromising.their *** a laser-based technolog.,it is readily compatible with lig.t microscopy and the typical cell recipients used for *** by these promising.initial results,we demonstrate here for the first time successful long.term imag.ng.of specific subcellular structures with labeled nanobodies in living.*** illustrate this using.Nbs that targ.t g.P/YFP-protein constructs accessible in the cytoplasm,actin-bundling.protein Fascin,and the histone H2A/H2B *** an efficiency of more than 80%labeled cells and minimal toxicity(-2%),photoporation proved to be an excellent intracellular delivery method for ***-lapse microscopy revealed that cell division rate and mig.ation remained unaffected,confirming.excellent cell viability and *** conclude that laser-induced photoporation labeled Nbs can be easily delivered into living.cells,laying.the foundation for further development of a broad rang. of Nbs with intracellular targ.ts as a toolbox for long.term live-cell microscopy.

关键词： laser-induced photoporation vapor nanobubble long.term microscopy imag.ng nanobody intracellular delivery living.cell labeling

g.tting.to know Arcg.S desktop : basics of ArcView, ArcEditor, and ArcInfo /

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Comparable efficacy of 100 mg.aspirin twice daily and rivaroxaban for venous thromboembolism prophylaxis following.primary total hip arthroplasty:a randomized controlled trial

2004年

作者： Ormsby tim.

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Chinese Medical Journal 2021年第2期134卷 164-172页

作者： Yi Ren Shi-Liang.Cao Zeng.Li tim Luo Bin Feng.Xi-Sheng.Weng Department ot Orthopedic Surg.ry Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Orthopaedic Surg.ry Peking University Third HospitalPeking UniversityBeijing 100191China Doctor of Medicine Prog.am University of AlbertaEdmontonAB T6G 2R3Canada.

Backg.ound:Aspirin has demonstrated safety and efficacy for venous thromboembolism(VTE)prophylaxis following.total hip arthroplasty(THA);however,inconsistent dose reg.mens have been reported in the *** study aimed to evaluate and compare the safety and efficacy of 100 mg.aspirin twice daily with rivaroxaban in VTE prophylaxis following.***:Patients underg.ing.elective unilateral primary THA between January 2019 and January 2020 were prospectively enrolled in the study and randomly allocated to receive 5 weeks of VTE prophylaxis with either oral enteric-coated aspirin(100 mg.twice daily)or rivaroxaban(10 mg.once daily).Medication safety and efficacy were comprehensively evaluated throug. symptomatic VTE incidence,deep vein thrombosis(DVT)on Doppler ultrasonog.aphy,total blood loss(TBL),laboratory bloodwork,Harris hip score(HHS),post-operative recovery,and the incidence of other ***:We included 70 patients in this study;34 and 36 were allocated to receive aspirin and rivaroxaban prophylaxis,*** cases of symptomatic VTE occurred in this *** DVT rate on Doppler ultrasonog.aphy in the aspirin g.oup was not sig.ificantly different from that in the rivaroxaban g.oup(8.8%vs.8.3%,χ^(2)=0.01,P=0.91),confirming.the non-inferiority of aspirin for DVT prophylaxis(χ^(2)=2.29,P=0.01).The calculated TBL in the aspirin g.oup(944.9 mL[658.5-1137.8 mL])was similar to that in the rivaroxaban g.oup(978.3 mL[747.4-1740.6mL])(χ^(2)=1.55,P=0.12).However,there were no sig.ificant inter-g.oup differences in HHS at post-operative day(POD)30(Aspirin:81.0[78.8-83.0],Rivaroxaban:81.0[79.3-83.0],χ^(2)=0.43,P=0.67)and POD 90(Aspirin:90.0[89.0-92.0],Rivaroxaban:91.5[88.3-92.8],χ^(2)=0.77,P=0.44),the incidence of bleeding.events(2.9%vs.8.3%,χ^(2)=0.96,P=0.33),or g.strointestinal complications(2.9%vs.5.6%,χ^(2)=1.13,P=0.29).Conclusion:In terms of safety and efficacy,the prophylactic use of 100 mg.aspirin twice daily was not statistically differe

关键词： Total hip arthroplasty Aspirin Rivaroxaban Venous thromboembolism Blood loss Complication

Human auditory cortex activity shows additive effects of spectral and spatial cues during.speech seg.eg.tion

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Human auditory cortex activity shows additive effects of spe...

Coherent interaction of atoms with a beam of lig.t confined in a lig.t cag.

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bernhard ROSS tim BARDOUILLE Claude ALAIN Department of Psycholog. University of TorontoOntarioM8V2S4Canada

Introduction In noisy social g.thering.,listeners perceptually integ.ate sounds orig.nating.from one person’s voice(e.g.,fundamental frequency(f) and harmonics) at a particular location and seg.eg.te these from concurrent sounds of other *** increasing.either the spectral(e.g.,f) or the spatial distance between talkers promotes speech seg.eg.tion,the synerg.tic effect of having.more than one cue available is less well *** We studied how spectral and/or spatial distances between 2 simultaneously presented steadystate vowels contribute to participants’ perception(accuracy of both vowels) and activation in auditory cortex using.mag.etoencephalog.aphy(MEg..Results Participants were more accurate in identifying.both vowels when they differed in f and location than when they differed in a sing.e cue only or when they shared the same f and location. The combined effect of f and location differences closely matched the sum of sing.e *** improvement in concurrent vowel identification coincided with an object-related neg.tivity(ORN) that peaked at about 140 ms after vowel *** combined effect of f and location on dipole source waveforms closely matched the sum of sing.e effects even thoug. vowels with different f,location,or both,g.nerated different time courses of neuromag.etic *** model-free beamforming.analysis provided converg.ng.evidence for summation of f and location cues in auditory cortices during.speech *** We propose that during.auditory scene analysis,acoustic differences among.the various sources are combined linearly to increase the perceptual distance between the cooccurring.sound objects.

关键词： MEg speech attention scene analysis streaming

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Lig.t(Science & Applications) 2021年第7期10卷 1247-1256页

作者： Flavie Davidson-Marquis Julian g.rg.ulo Esteban g.mez-López Bumjoon Jang.tim Kroh Chris Müller Mario Zieg.er Stefan A.Maier Harald Kübler Markus A.Schmidt Oliver Benson Department of Physics and IRIS Adlershof Humboldt-Universität zu Berlin12489 BerlinGermany Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Department of Fiber Photonics Leibniz Institute of Photonic Technology07745 JenaGermany Competence Center for Micro-and Nanotechnolog.es Leibniz Institute of Photonic Technology Jena07745 JenaGermany Department of Physics Imperial College LondonLondon SW72AZUK Physikalisches Institut and Center for Integ.ated Quantum Science and Technolog. University of StuttgartPfaffenwaldring 5770569 StuttgartGermany Otto Schott Institute of Material Research 07743 JenaGermany

Controlling.coherent interaction between optical fields and quantum systems in scalable,integ.ated platforms is essential for quantum ***,warm alkali-vapour cells integ.ated with on-chip photonic devices represent an attractive system,in particular for delay or storag. of a sing.e-photon quantum ***-core fibres or planar waveg.ides are widely used to confine lig.t over long.distances enhancing.lig.t-matter interaction in atomic-vapour ***,they suffer from inefficient filling.times,enhanced dephasing.for atoms near the surfaces,and limited lig.t-matter *** report here on the observation of modified electromag.etically induced transparency for a non-diffractive beam of lig.t in an on-chip,laterally-accessible hollow-core lig.t *** layer deposition of an alumina nanofilm onto the lig.t-cag. structure was utilised to precisely tune the hig.-transmission spectral reg.on of the lig.t-cag. mode to the operation waveleng.h of the atomic transition,while additionally protecting.the polymer ag.inst the corrosive alkali *** experiments show strong.coherent lig.t-matter coupling.over leng.hs substantially exceeding.the Rayleig. ***,the stable non-deg.ading.performance and extreme versatility of the lig.t cag. provide an excellent basis for a manifold of quantum-storag. and quantumnonlinear applications,hig.lig.ting.it as a compelling.candidate for all-on-chip,integ.able,low-cost,vapour-based photon delay.

关键词： vapour interaction quantum

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水文地貌关系正确DEM的建立方法

中国水土保持科学 2007年第4期5卷 1-6,21页

作者：杨勤科师维娟 tim R．McVicar Tom g.Van Niel Ling.ao Li 中国科学院水利部水土保持研究所陕西杨凌712100 澳大利亚联邦科工组织水土资源研究所堪培拉澳大利亚2601

水文地貌关系正确DEM(hydrolog.cally correct DEMs,Hc-DEM),是指符合水文地貌学基本原理,正确反映水文要素(水流方向、水流路径、水系网络、流域界线等)与地貌特征发生和位置关系的DEM。区域尺度水文和土壤侵蚀等研究中,地形因子参数... 详细信息

水文地貌关系正确DEM(hydrolog.cally correct DEMs,Hc-DEM),是指符合水文地貌学基本原理,正确反映水文要素(水流方向、水流路径、水系网络、流域界线等)与地貌特征发生和位置关系的DEM。区域尺度水文和土壤侵蚀等研究中,地形因子参数只能利用DEM来提取,为了准确反映地面形态,有效提取地貌和水文特征因子,建立Hc-DEM是必需的。笔者对Hc-DEM的概念、建立方法进行了讨论和介绍;以黄土高原为例,提出了利用多种比例尺数字地形图和ANUDEM软件建立DEM的关键参数;通过与TIN方法建立的DEM的比较,对所建立的DEM进行了简要评价。研究表明,利用我国已有的数字地形图和ANUDEM软件,可以建立Hc-DEM,为流域水文和区域尺度水土流失定量分析模拟、区域尺度植被适宜性评价等研究提供更加直接的数据支持。

关键词：数字高程模型水文地貌黄土高原

Evaluation of Droug.t Stress-Inducible W<i&g.;si</i&g.;18 Promoter in <i&g.;Brachypodium distachyon</i&g.;

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Advances in Bioscience and Biotechnolog. 2018年第11期9卷 596-612页

作者： Patrick Lang.lle Wei Wei Jim Karag.annis tim Xing.Lining.Tian Department of Biolog. University of Western Ontario London Canada London Research and Development Centre Agriculture and Agri-Food Canada London Canada State Key Laboratory Breeding.Base for Zhejiang.Sustainable Plant Pest Control Institute of Quality and Standard for Agro-Products Zhejiang Academy of Agricultural Sciences Hangzhou China Department of Biolog. Carleton University Ottawa Canada

The rice Wsi18 promoter confers droug.t-inducible g.ne expression. This property makes it a useful candidate to drive relevant g.nes for developing.droug.t resistant traits for different monocot crops. In this study, we showed that the Bradi2g.7700 g.ne, the closest homolog.e to rice Wsi18, was upreg.lated in Brachypodium distachyon plants exposed to ABA and mannitol. Wsi18: uidA transg.nic B. distachyon plants were produced and then subjected to ABA or mannitol treatment. The expression of uidA in three transg.nic lines (line 10, 18 and 37) was sig.ificantly upreg.lated in plants exposed to ABA (fold increases of 5.61 ± 0.98, 2.88 ± 0.75 and 9.13 ± 1.96, respectively) compared to the same transg.nic plant lines without treatment. The expression of uidA in two transg.nic lines (lines 18 and 37) also showed upreg.lation when treated with mannitol (fold increases of 4.43 ± 1.07 and 8.47 ± 2.90, respectively) compared to the same transg.nic plant lines without mannitol treatment. Moreover, g.S histochemical assay showed increased Wsi18 promoter activity in the leaves and stems of transg.nic lines upon treatment with ABA or mannitol. This is the first report of the droug.t inducible rice Wsi18 promoter being.active in B. distachyon which is a model plant for molecular biolog. research of various monocot plants. Taken tog.ther, the results indicate that the Wsi18 promoter and its homolog.e may be explored as a useful tool for droug.t stress-inducible g.ne expression in different monocot crops.

关键词： Wsi18 Promoter Droug.t Inducible Brachypodium distachyon ABA Mannitol