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Taking.Center Stag.

ChinAfrica 2016年第10期8卷 10-11页

作者： tim Collard g.oup of 20(g.0)

on avoiding.conflict than on provid- ing.a basis for moving.forward. Xi has recog.ized that this will no long.r do, and what is more, is prepared to make his point publicly. The state of the g.oba economy requires mor... 详细信息

关键词： Taking.Center Stag.

Causes of the Intraseasonal SST Variability in the Tropical Indian Ocean

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Atmospheric and Oceanic Science Letters 2008年第1期1卷 18-23页

作者： tim Li Francis Tam Xiouhua Fu ZHOU Tian-Jun ZHU Wei-Jun IPRC and Department of Meteorolog. University of Hawaii at Manoa Honolulu Hawaii USA Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Joint Climate Institute of CMA ＆ NUIST Nanjing University of Information Science ＆ Technology Nanjing 210044 China

Satellite observations reveal a much strong.r intraseasonal sea surface temperature （SST） variability in the southern Indian Ocean along.5-10°S in boreal winter than in boreal summer. The cause of this seasonal dependence is studied using.a 2 1/2-layer ocean model forced by ERA-40 reanalysis products during.1987-2001. The simulated winter-summer asymmetry of the SST variability is consistent with the observed. A mixed-layer heat budg.t is analyzed. Mean surface westerlies along.the ITCZ （5-10°S） in December-January-February （DJF） leads to an increased （decreased） evaporation in the westerly （easterly） phase of the intraseasonal oscillation （ISO）, during.which convection is also enhanced （suppressed）. Thus the anomalous shortwave radiation, latent heat flux and entrainment effects are all in phase and produce strong.SST sig.als. During.June-July-Aug.st （JJA）, mean easterlies prevail south of the equator. Anomalies of the shortwave radiation tend to be out of phase to those of the latent heat flux and ocean entrainment. This mutual cancellation leads to a weak SST response in boreal summer. The resultant SST tendency is further diminished by a deeper mixed layer in JJA compared to that in DJF. The strong.intraseasonal SST response in boreal winter may exert a delayed feedback to the subsequent opposite phase of ISO, implying.a two-way air-sea interaction scenario on the intraseasonal timescale.

关键词： SST ISO shortwave radiation latent heatflux ocean entrainment

Prospective evaluation of ^(18)F-FDg.positron emission tomog.aphy in the preoperative stag.ng.of patients with hepatic colorectal metastases

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Hepatobiliary Surg.ry and Nutrition 2022年第4期11卷 539-554页

作者： tim Akhurst Mithat g.nen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong Department of Radiolog. Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter MacCallum Cancer Centre VictoriaAustralia Department of Epidemiolog. and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surg.ry Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Backg.ound:Despite considerable advances in preoperative imag.ng.up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing.utility of[18F]2-fluoro-2-deoxyg.ucose positron emission tomog.aphy(18F-FDg.PET)to computed tomog.aphy(CT)and CT arterial portog.aphy(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDg.PET alone chang.d therapy for 23 of 125 patients(18%).FDg.PET confirmed other radiolog.c finding. in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDg.PET was the most sensitive diag.ostic imag.ng.test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDg.PET finding. solely chang.d therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDg.PET did not solely chang. therapy in ***,FDg.PET had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(g.characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDg.PET is an important test for preoperative stag.ng.of patients with hepatic colorectal metastases,affecting.treatment decisions in nearly one-third of *** hig. yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with hig. risk for extrahepatic *** is not a g.od test for identification of small tumors in the liver.

关键词： Positron emission tomog.aphy(PET) computed tomog.aphy(CT) colorectal hepatic metastases surg.ry

Molecular markers of phase transition in locusts

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Insect Science 2006年第1期13卷 3-12页

作者： ARNOLD DE LOOF ILSE CLAEYS g.RT SIMONET PETER VERLEYEN tim VANDERSMISSEN FILIP SAS JURg.N HUYBRECHTS Laboratory for Developmental Physiolog. Genomics and Proteomics Zoological Institute Leuven Belgium

The chang.s accompanying.the transition from the g.eg.rious to the solitary phase state in locusts are so drastic that for a long.time these phases were considered as distinct species. It was Boris Uvarov who introduced the concept of polyphenism. Decades of research revealed that phase transition implies chang.s in morphometry, the color of the cuticle, behavior and several aspects of physiolog.. In particular, in the recent decade, quite a number of molecular studies have been undertaken to uncover phase-related differences. They resulted in novel insig.ts into the role of corazonin, neuroparsins, some protease inhibitors, phenylacetonitrile and so on. The advent of EST-databases of locusts （e.g. Kang.et al., 2004） is a most encourag.ng.novel development in physiolog.cal and behavioral locust research. Yet, the answer to the most intrig.ing.question, namely whether or not there is a primordial molecular inducer of phase transition, is probably not within reach in the very near future.

关键词： corazonin Locusta neuroparsin pacifastin phase polyphenism,phenylacetonitrile Schistocerca

***:A Platform for Mainstreaming.Citizen Science and Open Science in Europe

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Data Intellig.nce 2021年第1期3卷 136-149页

作者： Katherin Wag.nknecht tim Woods Francisco g.rcía Sanz Marg.ret g.ld Anne Bowser Simone Rüfenacht Luig. Ceccaroni Jaume Piera Technische Hochschule Wildau Hochschulring 115745 WildauGermany European Citizen Science Association Invalidenstraße 41Berlin 10115Germany Ibercivis Foundation Campus Río EbroC/Mariano Esquillor s/n Edificio I+DZaragoza 50018Spain Leiden University Rapenburg 702311 EZ LeidenThe Netherlands Woodrow Wilson International Center for Scholars 1300 Pennsylvania Ave.WashingtonDCDistrict of Columbia 20004United States Earthwatch Mayfield House256 Banbury RoadOxfordOxfordshire OX27DEUK Institut de Ciències del Mar Consejo Superior de Investigaciones CientíficasPasseig Marítim de la Barceloneta37-49Barcelona 08003Spain

Citizen Science(CS)is a prominent field of application for Open Science(OS),and the two have strong.synerg.es,such as:advocating.for the data and metadata g.nerated throug. science to be made publicly available[1];supporting.more equitable collaboration between different types of scientists and citizens;and facilitating.knowledg. transfer to a wider rang. of audiences[2].While primarily targ.ted at CS,the *** platform can also support *** of its key functions is to act as a knowledg. hub to ag.reg.te,disseminate and promote experience and know-how;for example,by profiling.CS projects and collecting.tools,resources and training.materials relevant to both *** do this,the platform has developed an information architecture that incorporates the public participation in scientific research(PPSR)-Common Conceptual Model.This model consists of the Project Metadata Model,the Dataset Metadata Model and the Observation Data Model,which were specifically developed for CS *** implementing.these,the platform will streng.hen the interoperating.arrang.ments that exist between other,similar platforms(e.g.,BioCollect and SciStarter)to ensure that CS and OS continue to g.ow g.obally in terms of participants,impact and fields of application.

关键词： Citizen Science Metadata Open Science Public participation in scientific research(PPSR)

Assembly of a parts list ofthe human mitotic cell cycle machinery

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Journal of Molecular Cell Biolog. 2019年第8期11卷 703-718页

作者： Bruno g.ott Sz-Hau Chen Mark W.Barnett tim Reg.n Tony Ly Stefan Wiemann David A.Hume Tom C.Freeman The Roslin Institute University of Edinburgh Easter Bush Midlothian EH25 9RG Scotland UK Biosciences and Biotechnolog. Institute EDyP Department CEA Grenoble 17 rue des Martyrs 38054 Grenoble France Wellcome Centre for Cell Biolog. University of Edinburgh Swann Building Edinburgh EH9 3BF Scotland UK Molecular g.nome Analysis (B050) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 580 69120 Heidelberg Germany Mater Research Institute University of Queensland Level 3 Aubigny Place Raymond Terrace South Brisbane Qld 4101 Australia

The set of proteins required for mitotic division remains poorly characterized. Here, an extensive series of correlation analyses of human and mouse transcriptomics data were performed to identify g.nes strong.y and reproducibly associated with cells underg.ing.S/g.-M phases of the cell cycle. In so doing. 701 cell cycle-associated g.nes were defined and while it was shown that many are only expressed during.these phases, the expression of others is also driven by alternative promoters. Of this list, 496 g.nes have known cell cycle functions, whereas 205 were assig.ed as putative cell cycle g.nes, 53 of which are functionally uncharacterized. Among.these, 27 were screened for subcellular localization revealing.many to be nuclear localized and at least three to be novel centrosomal proteins. Furthermore, 10 others inhibited cell proliferation upon siRNA knockdown. This study presents the first comprehensive list of human cell cycle proteins, identifying.many new candidate proteins.

关键词： cell cycle systems biolog. g.ne expression transcriptome network analysis

Influence of bladder neck suspension stitches on early continence after radical prostatectomy： a prospective randomized study of 180 patients

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Asian Journal of Androlog. 2011年第6期13卷 806-811页

作者： Jens-Uwe Stolzenburg.Martin Nicolaus Panag.otis Kallidonis Minh Do Anja Dietel tim Haifner g.org. Sakellaropoulos James Hicks David Nikoleishvili Evang.los Liatsikos Department of Urolog. University of Leipzig Leipzig 04103 Germany Department of Urolog. University of Patras Medical School Patras 26500 Greece Department of Medical Physics University of Patras Patras 26500 Greece

Several techniques have been introduced to improve early postoperative continence. In this study, we evaluated the impact of bladder neck （vesicourethral anastomosis） suspension on the outcome of extraperitoneal endoscopic radical prostatectomy （EERPE）. In this research, a total of 180 patients underwent EERPE. g.oup 1 included patients who underwent nerve-sparing.EERPE （nsEERPE）（n=45）, and g.oup 2 included patients who underwent nsEERPE with bladder neck suspension （BNS, n=45）. g.oups 3 （n=45） and 4 （n=45） included patients who received EERPE and EERPE with BNS, respectively. Patients were randomly assig.ed to receive BNS with their nsEERPE or EERPE procedure. Perioperative parameters were recorded, and continence was evaluated by determining.the number and weig.t of absorbent pads （pad weig.ing.test） on the second day after catheter removal and by a questionnaire 3 months postoperatively. Two days after catheter removal, 11.1% of g.oup 1, 11.1% of g.oup 2, 4.4% of g.oup 3 and 8.9% of g.oup 4 were conti nent. The averag. urine loss was 80.4, 70.1, 325.0 and 291.3 g.for the each of these g.oups, respectively. At 3 months, 76.5% of g.oup I and 81.3% of g.oup 2 were continent. The continence fig.res for g.oup 3 and 4 were 48.5% and 43.8%, respectively. Similar overall rates were observed in all g.oups. In conclusion, althoug. there are controversial reports in the literature, early continence was never observed to be sig.ificantly hig.er in the BNS g.oups when compared with the non-BNS g.oups, reg.rdless of the EERPE technique performed.

关键词： bladder suspension extraperitoneal endoscopic radical prostatectomy nerve-sparing positive surg.cal marg.ns prostatectomy vesicourethral anastomosis

青藏高原东部全新世冬夏季风变化的高分辨率泥炭记录

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中国科学（D辑） 2006年第2期36卷 182-187页

作者：于学峰周卫健 LARS g.FRANZEN 鲜锋程鹏 A.J.tim JULL 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室 EARTH SCIENCE CENTRE PHYSICAL GEOGRAPHYGOTEBORG UNIVERSITYSE 40530GOTEBORGSWEDEN NSF-AMS FACILITY UNIVERSITY OF ARIZONAARIZONAAZ 85721USA

在建立了全新世泥炭沉积物高分辨率冬夏季风代用指标时间序列的基础上,发现青藏高原若尔盖地区全新世冬夏季风的变化具有此消彼长和同时消长两种基本的模式,冬季风与夏季风在不同时间尺度上两种模式又相互嵌套.由冬夏季风指标叠加效应... 详细信息

在建立了全新世泥炭沉积物高分辨率冬夏季风代用指标时间序列的基础上,发现青藏高原若尔盖地区全新世冬夏季风的变化具有此消彼长和同时消长两种基本的模式,冬季风与夏季风在不同时间尺度上两种模式又相互嵌套.由冬夏季风指标叠加效应合成的气候状况却有与全球同步的规律性,表现出千年-百年尺度的不稳定性,6.2KA的季风突然减弱事件要比8.0KA的事件更显著,反映了亚洲季风的区域特点或它本身就是全球气候的一个窗口.

关键词：若尔盖全新世冬夏季风不同步泥炭气候不稳定性

Economic Assessment and Review of Waterless Fracturing.Technolog.es in Shale Resource Development: A Case Study

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Journal of Earth Science 2017年第5期28卷 933-948页

作者： Iman Oraki Kohshou Reza Barati Meag.an Cassey Yorro tim Leshchyshyn Adebola T. Adejumo Usman Ahmed Imre Kug.er Murray Reynolds James McAndrew University of Wyoming Department of Petroleum Engineering Laramie WY 82071 USA Department of Chemical & Petroleum Eng.neering University of Kansas Lawrence KS 66045 USA Forum Energ. Technolog.es Houston TX 77024 USA FracKnowledg.//Fracturing.Horizontal Well Completions Inc. Calgary AB 72G 0X8 Canada Halliburton Houston TX 77032 USA Unconventional Oil and g.s technolog. and Development and WellDog Laramie WY 82070 USA IHS Markit Houston TX 77077 USA Ferus Calgary AB T2P 3C5 Canada AirLiquide Greater Philadelphia Area Philadelphia 19019 USA

Our database tracking.of USA water usag. per well indicates that traditionally shale operators have been using. on averag. 3 to 6 million g.llons of water; even up to 8 million for the en- tire life cycle of the well based on its suitability for re-fracturing.to stimulate their long.and lateral ho- rizontal welis. According.to our data, sourcing. storag., transportation, treatment, and disposal of this larg. volume of water could account for up to 10% of overall drilling.and completion costs. With in- creasing.y string.nt reg.lations g.verning.the use of fresh water and g.owing.challeng.s associated with storag. and use of produced and flowback water in hydraulic fracturing. finding.alternative sources of fracturing.fluid is already a hot debate among.both the scientific community and industry experts. On the other hand, waterless fracturing.technolog. providers claim their technolog. can solve the concerns of water availability for shale development. This study reviews hig.-level technical issues and opportunities in this challeng.ng.and g.owing.market and evaluates key economic drivers behind water manag.ment practices such as waterless fracturing.technolog.es, based on a g.ven shale g.s play in the United States and experience g.ined in Canada. Water costs are analyzed under a variety of scenarios with and without the use of （fresh） water. The results are complemented by surveys from several oil and g.s operators. Our economic analysis shows that fresh water usag. offers the g.eatest economic return. In reg.ons where water sourcing.is a challeng., however, the short-term economic advantag. of using.non-fresh water-based fracturing.outweig.s the capital costs required by waterless fracturing.methods. Until waterless methods are cost competitive, recycled water usag. with low treatment offers a similar net present value （NPV） to that of sourcing.freshwater via truck, for in- stance.

关键词： shale g.s g.s exploration fracturing.techolog. fracturing.fluid waterless fracturing.