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Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 186-194页

作者： andreas Konrad Shahab Alizadeh Abdolhamid Daneshjoo Saman Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini Chris Edwards Carina Scharf David George Behm Institute of Human Movement Science Sport and HealthGraz UniversityGraz A-8010Austria School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(ROM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on ROM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through PubMed,Scopus,Web of Science,and SportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase ROM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;p<0.001;I^(2)=74.97).Subgroup analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater ROM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in ROM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize ROM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching Stretch training

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Fragile hearts:Unveiling the crucial layers of frailty in elderly patients undergoing percutaneous coronary interventions

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World Journal of Clinical Cases 2024年第26期12卷 5998-6000页

作者： andreas Mitsis Michael Myrianthefs Department of Cardiology Nicosia General HospitalNicosia 2026Cyprus

Wang and Liu's systematic review of frailty among elderly patients undergoing percutaneous coronary intervention(PCI)revealed that patients with frailty have significantly higher risks of all-cause and in-hospital death,major undesirable cardiovascular events,and major *** is associated with adverse events,prolonged hospital stays,increased complications,and elevated mortality risk due to diminished physiological *** frailty into risk assessment tools is crucial,and gait speed has emerged as a key predictor of *** the impact of frailty leads to personalized and informed decisionmaking,and frailty assessments should be *** holistic approach can inform tailored interventions,thereby optimizing outcomes for this vulnerable population undergoing PCI.

关键词： Frailty Elderly Percutaneous coronary intervention Outcomes Risk assessment tools

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release

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CCS Chemistry 2024年第8期6卷 1895-1907页

作者： Jilin Fan Kuan Zhang Mingjun Xuan Xiang Gao Rostislav Vinokur Robert Göstl Lifei Zheng andreas Herrmann DWI—Leibniz Institute for Interactive Materials 52056 Aachen Institute of Technical and Macromolecular Chemistry RWTH Aachen University52074 Aachen Wenzhou Institute University of Chinese Academy of Sciences325001 Wenzhou

Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule ***,the typical US frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological ***,high-intensity focused US(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBSPs)and microgels(MGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular *** reveal that HBSPs and MGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UMB).Moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in MGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.

关键词： mechanophores polymer mechanochemistry polymeric nanostructures ultrasound drug release sonopharmacology

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Electrochemical Realization of 3D Interconnected MoS_(3)/PPy Nanowire Frameworks as Sulfur-Equivalent Cathode Materials for Li-S Batteries

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Energy & Environmental Materials 2024年第2期7卷 9-17页

作者： Hongtao Yu andreas Siebert Shilin Mei Raul Garcia-Diez Roberto Félix Ting Quan Yaolin Xu Johannes Frisch Regan G.Wilks Marcus Bär Chun Pei Yan Lu Department for Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie GmbH(HZB)Hahn-Meitner Platz 114109 BerlinGermany Guangdong Province Key Laboratory of Durability for Marine Civil Engineering School of Civil EngineeringShenzhen UniversityShenzhenGuangdong 518060China Department of Interface Design HZBAlbert-Einstein-Str.1512489 BerlinGermany Energy Materials In-Situ Laboratory Berlin(EMIL) Albert-Einstein-Str.1512489 BerlinGermany Helmholtz-Institute Erlangen-Nürnberg for Renewable Energy(HI ERN) Albert-Einstein-Str.1512489 BerlinGermany Department of Chemistry and Pharmacy Friedrich-Alexander-Universität Erlangen-NürnbergEgerlandstr.391058Erlangen Germany Institute of Chemistry University of Potsdam14467Potsdam Germany

The development of freestanding and binder-free electrode is an effective approach to perform the inherent capacity of active materials and promote the mechanism study by minimizing the interference from ***,we construct a freestanding cathode composed of MoS_(3)/PPy nanowires(NWs)deposited on porous nickel foam(NF)(MoS_(3)/PPy/NF)through electrochemical methods,which can work efficiently as sulfur-equivalent cathode material for Li-S *** structural stability of the MoS_(3)/PPy/NF cathode is greatly enhanced due to its significant tolerance to the volume expansion of MoS_(3)during the lithiation process,which we ascribe to the flexible 3D framework of PPy NWs,leading to superior cycling performance compared to the bulk-MoS_(3)/NF *** the interference of binder and carbon additives,the evolution of the chemical and electronic structure of Mo and S species during the discharge/charge was studied by X-ray absorption near-edge spectroscopy(XANES).The formation of lithium polysulfides was excluded as the driving cathode reaction mechanism,suggesting the great potential of MoS_(3)as a promising sulfur-equivalent cathode material to evade the shuttle effect for Li-S *** present study successfully demonstrates the importance of structural design of freestanding electrode enhancing the cycling performances and revealing the corresponding mechanisms.

关键词： 3D-Network electrochemical lithium-sulfur battery MoS_(3) PPy

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Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?

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Neural Regeneration Research 2019年第10期14卷 1707-1708页

作者： Diego S. Ojeda andreas till Jorge Quarleri Instituto de Investigaciones Biomedicas en Retrovirus y SIDA (INBIRS) Universidad de Buenos Aires-CONICETArgentina Institute of Reconstructive Neurobiology Life & Brain CenterUniversity of BonnBonnGermany

Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes - the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown.

关键词： Acquired immune broad spectrum remain unknown

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基于PA66复合材料的产品系统设计流程研究

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机械设计 2024年第2期41卷 147-153页

作者：程文婷李俊 andreas Papenfuss 湖北工业大学工业设计学院湖北省武汉市430068

为探讨复合材料在产品设计流程中的应用优势,提出以单车车轮的设计开发为例,进行基于PA66复合材料的产品系统设计流程的实例研究。在任务说明阶段引入PA66复合材料,明确设计需求及限制约束;在概念说明阶段,运用层次分析法分析设计需求权... 详细信息

为探讨复合材料在产品设计流程中的应用优势,提出以单车车轮的设计开发为例,进行基于PA66复合材料的产品系统设计流程的实例研究。在任务说明阶段引入PA66复合材料,明确设计需求及限制约束;在概念说明阶段,运用层次分析法分析设计需求权重,输出多种车轮方案,并结合多个仿真软件进行最佳方案评估;在结构改进阶段,结合材料性能对车轮整体结构进行改进;在制造与仿真阶段,根据材料特性进行联合仿真测试,以获得最佳车轮设计。研究结果表明:在基于PA66复合材料的产品系统设计流程指导下,车轮整体满足结构强度要求,单轮质量减小最高可达16%,且轮辐壁厚每减小0.5 mm,可额外减小质量约6%,相较于初始方案减少了材料用量及生产成本。该研究方法可为同类产品的研发提供系统性理论指导。

关键词：产品设计复合材料系统设计流程仿真验证车轮设计

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Health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： Joanne Mathew Jordy Mehawej Ziyue Wang Taylor Orwig Eric Ding andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu Jane Saczynski David D.McManus Khanh-Van Tran Division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Department of Internal Medicine Central Michigan UniversityMount PleasantUSA Department of Pharmacy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGROUND Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2DS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer Health Activation Index,the Generalized Anxiety Disorder questionnaire,the 12-Item Short Form Health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

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In situ grazing-incidence small-angle X-ray scattering observation of block-copolymer templated formation of magnetic nanodot arrays and their magnetic properties

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Nano Research 2017年第2期10卷 456-471页

作者： andreas Meyer Norbert Franz Hans Peter Oepen Jan Perlich Gerardina Carbone till Hartmut Metzger Institut fiJr Physikalische Chemie Universitat Hamburg Grindelallee 117 20146 Ham burg Germany Institut for Nanostruktur und Festkorperphysik Universitat Hamburg Jungiusstr. 11a 20355 Hamburg Germany HASYLAB/Deutsches Elektronen Synchrotron Notkestr. 85 22603 Hamburg Germany European Synchrotron Radiation Facility 6 rue Jules Horowitz 38043 Grenoble France

The fabrication of bit-patterned media （BPM） is crucial for new types of hard disk drives. The development of methods for the production of BPM is progressing rapidly. Conventional lithography reaches the limit regarding lateral resolution, and new routes are needed. In this study, we mainly focus on the dependence of the size and shape of magnetic nanodots on the Ar＋-ion etching duration, using silica dots as masks. Two-dimensional （2D） arrays of magnetic nanostructures are created using silica-filled diblock-copolymer micelles as templates. After the self-assembly of the micelles into 2D hexagonal arrays, the polymer shell is removed, and the SiO2 cores are utilized to transform the morphology into a （Co/Pt）2-multilayer via ion etching under normal incidence. The number of preparation steps is kept as low as possible to simplify the formation of the nanostructure arrays. High-resolution in situ grazing-incidence small-angle X-ray scattering （GISAXS） investigations are performed during the Ar＋-ion etching to monitor and control the fabrication process. The in situ investigation provides information on how the etching conditions can be improved for further ex situ experiments. The GISAXS patterns are compared with simulations. We observe that the dots change in shape from cylindrical to conical during the etching process. The magnetic behavior is studied by utilizing the magneto-optic Kerr effect. The Co/Pt dots exhibit different magnetic behaviors depending on their size, interparticle distance, and etching time. They show ferromagnetism with an easy axis of magnetization perpendicular to the film. A systematic dependence of the coercivitv on the dot size is observed.

关键词： poly(styrene)-b-poly(vinyl pyridine) argon ion etching self-assembly grazing-incidence small-angle X-ray scattering(GISAXS) simulation magnetic nanodot coercivity

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Optimizing magneto-ionic performance in structure/composition-engineered ternary nitrides

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Journal of Materiomics 2024年第4期10卷 870-879页

作者： Zheng Ma P.Monalisha Zhengwei Tan Eva Pellicer Maciej O.Liedke Maik Butterling Ahmed G.Attallah Eric Hirschmann andreas Wagner Fatima Ibrahim Mairbek Chshiev Enric Menndez Jordi Sort Departament de Física Universitat Autònoma de BarcelonaCerdanyola del Vallès08193Spain Institute of Radiation Physics Helmholtz-Zentrum Dresden–RossendorfDresden01328Germany University of Grenoble Alpes CEACNRSSPINTECGrenoble38000France Institut Universitaire de France Paris75231France InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Pg.Lluís Companys 23Barcelona08010Spain

Magneto-ionics,an emerging approach to manipulate magnetism that relies on voltage-driven ion motion,holds the promise to boost energy efficiency in information technologies such as spintronic devices or future non-von Neumann computing *** this purpose,stability,reversibility,endurance,and ion motion rates need to be synergistically *** various ions,nitrogen has demonstrated superior magneto-ionic performance compared to classical species such as oxygen or ***,we show that ternary Co1−xFexN compound exhibits an unprecedented nitrogen magneto-ionic *** substitution of Co by Fe in binary CoN is shown to be favorable in terms of generated magnetization,cyclability and ion motion ***,the Co_(0.3)5Fe_(0.6)5N films exhibit an induced saturation magnetization of 1,500 emu/cm^(3),a magneto-ionic rate of 35.5 emu/(cm^(3)·s)and endurance exceeding 103 *** values significantly surpass those of other existing nitride and oxide *** improvement can be attributed to the larger saturation magnetization of Co_(0.35)Fe_(0.65) compared to individual Co and Fe,the nature and size of structural defects in as-grown films of different composition,and the dissimilar formation energies of Fe and Co with N in the various developed crystallographic structures.

关键词： Voltage control of magnetism Magneto-ionics Electrolyte gating Ternary nitrides Ion transport

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